The reticuloendothelial system and macrophage-monocyte system in thorotrast patients.

abstract：:Abstract Double-strand breaks (DSBs) can be generated in the DNA of mammalian cells when heat-labile sites induced by ionizing radiation within a clustered DNA damage site are thermally transformed to single-strand breaks (SSBs) and combine with other SSBs or heat-labile sites in the opposite DNA strand. When this the...

journal_title：Radiation research

authors： Singh SK,Wu W,Wu W,Wang M,Iliakis G

更新日期：2009-08-01 00:00:00

abstract：:Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A dissolved in soybean oil to protect against the biological effects caused by internal radionuclides is investigated. The radiochemicals examined are DNA-binding 125...

journal_title：Radiation research

authors： Harapanhalli RS,Narra VR,Yaghmai V,Azure MT,Goddu SM,Howell RW,Rao DV

更新日期：1994-07-01 00:00:00

abstract：:The hyperthermic inhibition of cellular DNA synthesis, i.e., reduction in replicon initiation and delay in DNA chain elongation, was previously postulated to be involved in the induction of chromosomal aberrations believed to be largely responsible for killing S-phase cells. Utilizing asynchronous Chinese hamster ovar...

journal_title：Radiation research

authors： Wong RS,Thompson LL,Dewey WC

更新日期：1988-04-01 00:00:00

abstract：:Radon is recognized as a public health concern for indoor exposure. Precise quantification derived from occupational exposure in miners is still needed for estimating the risk and the factors that modify the dependence on cumulated exposure. The present paper reports on relationship between radon exposure and lung can...

journal_title：Radiation research

authors： Tomasek L,Rogel A,Tirmarche M,Mitton N,Laurier D

更新日期：2008-02-01 00:00:00

abstract：:This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together t...

journal_title：Radiation research

authors： Pierce DA,Shimizu Y,Preston DL,Vaeth M,Mabuchi K

更新日期：1996-07-01 00:00:00

abstract：:A formalism developed in the first paper in this series, based on the generalized Theory of Dual Radiation Action, is applied to survival data for cells exposed to soft X rays. It is shown that, in contrast to previous published analyses, this formalism--modified to account for the attenuation of dose across the sensi...

journal_title：Radiation research

authors： Brenner DJ,Zaider M

更新日期：1984-09-01 00:00:00

abstract：:Cytokines function in many roles that are highly relevant to radiation research. This review focuses on how cytokines are structurally organized, how they are induced by radiation, and how they orchestrate mesenchymal, epithelial and immune cell interactions in irradiated tissues. Pro-inflammatory cytokines are the ...

journal_title：Radiation research

authors： Schaue D,Kachikwu EL,McBride WH

更新日期：2012-12-01 00:00:00

abstract：:Base damage flanking a radiation-induced DNA double-strand break (DSB) may contribute to DSB complexity and affect break repair. However, to date, an isolated radiation-induced DSB has not been assessed for such structures at the molecular level. In this study, an authentic site-specific radiation-induced DSB was prod...

journal_title：Radiation research

authors： Datta K,Jaruga P,Dizdaroglu M,Neumann RD,Winters TA

更新日期：2006-11-01 00:00:00

abstract：:Dose-response relationships observed in laboratory animals can be used to identify possible human risk factors and may also be used in a quantitative manner when human data are not available. This paper presents an analysis of the dose dependency of osteosarcoma incidence in beagle dogs given a single inhalation expos...

journal_title：Radiation research

authors： Shyr LJ,Muggenburg BA

更新日期：1992-10-01 00:00:00

abstract：:Phosphorylated ATM immunofluorescence staining was used to investigate the dose-response relationship for the number of DNA double-strand breaks (DSBs) induced in primary normal human fibroblasts irradiated with doses from 1.2 to 200 mGy. The induction of DSBs showed a supralinear dose-response relationship. Radiation...

journal_title：Radiation research

authors： Ojima M,Ban N,Kai M

更新日期：2008-09-01 00:00:00

abstract：:Inhalation and ingestion of 137Cs and other long-lived radionuclides can occur after large-scale accidental or malicious radioactive contamination incidents, resulting in a complex temporal pattern of radiation dose/dose rate, influenced by radionuclide pharmacokinetics and chemical properties. High-throughput radiati...

journal_title：Radiation research

authors： Shuryak I,Ghandhi SA,Turner HC,Weber W,Melo D,Amundson SA,Brenner DJ

更新日期：2020-10-16 00:00:00

abstract：:Tumor radiotherapy with large-field irradiation results in an increase of p53-dependent apoptosis of the radiosensitive hematopoietic stem cells. Proapoptotic PUMA is a transcriptional target of p53. Thus suppression of PUMA expression by gene therapy with the transcription repressor SNAI2 as transgene might be a pote...

journal_title：Radiation research

authors： Maier P,Herskind C,Barzan D,Zeller WJ,Wenz F

更新日期：2010-05-01 00:00:00

abstract：:We investigated delayed reproductive death and chromosome bridge formation in mitotic cells in colonies of normal human embryonic cells which survived exposure to 6 Gy of X rays. Eighteen primary clones each derived from control and irradiated cultures were isolated and secondary colonies were grown up. Six of the pri...

journal_title：Radiation research

authors： Suzuki K,Takahara R,Kodama S,Watanabe M

更新日期：1998-10-01 00:00:00

abstract：:Radiation is an independent risk factor for cardiovascular and cerebrovascular disease in cancer patients. Modern radiotherapy techniques reduce the volume of the heart and major coronary vessels exposed to high doses, but some exposure is often unavoidable. Radiation damage to the myocardium is caused primarily by in...

journal_title：Radiation research

authors： Stewart FA,Hoving S,Russell NS

更新日期：2010-12-01 00:00:00

abstract：:Based on murine survival studies, endogenous hemopoietic spleen colony formation (E-CFU), and recovery of bone marrow and splenic granulocyte-macrophage colony-forming cells (GM-CFC), it was demonstrated that the postirradiation administration of glucan, an immunomodulator and hemopoietic stimulant, enhances the radio...

journal_title：Radiation research

authors： Patchen ML,MacVittie TJ,Jackson WE

更新日期：1989-01-01 00:00:00

abstract：:The presence of oxygen-deficient tumor cells is a critical issue in cancer therapy. To identify tumor hypoxia, tissue partial oxygen pressure (pO2) can be measured directly. The OxyLite system allows determination of pO2 in tumors and permits continuous measurements of pO2 at a fixed point. In this study, this system ...

journal_title：Radiation research

authors： Wen B,Urano M,O'Donoghue JA,Ling CC

更新日期：2006-09-01 00:00:00

abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...

journal_title：Radiation research

authors： Thome C,Mitz C,Hulley EN,Somers CM,Manzon RG,Wilson JY,Boreham DR

更新日期：2017-10-01 00:00:00

abstract：:The effectiveness of 5-fluorouracil (5-FU), FT-207 and FT-207 + uracil in combination with two repetitions of 43 degrees C hyperthermia in the treatment of the Meth-A-Fibrosarcoma and Sarcoma-180 was examined in vivo in BALB/c mice. The antitumor effect was evaluated in terms of inhibition of tumor growth by measuring...

journal_title：Radiation research

authors： Harada S,Ping L,Obara T,Oikawa H,Miyata M,Matsuo M,Takahashi T,Yanagisawa T

更新日期：1995-05-01 00:00:00

abstract：:Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Ca...

journal_title：Radiation research

authors： Boissière A,Champion C,Touati A,Hervé du Penhoat MA,Sabatier L,Chatterjee A,Chetioui A

更新日期：2007-04-01 00:00:00

abstract：:New Zealand rabbits, fasted for 12 hours, were subjected to 500 rads of whole-body irradiation. K+-palmitate-1-14C oxidation was assayed with the 600 X g supernatant of thymus and liver homogenates, in the presence of ATP, at various time intervals from irradiation. For a period of 24 hours following irradiation, oxid...

journal_title：Radiation research

authors： Miras CJ,Mantzos JD,Legakis NJ,Levis GM

更新日期：1968-11-01 00:00:00

abstract：:A standardized dichlorofluorescin (DCF) fluorometric assay capable of measuring radiation-induced oxidative stress was used to determine the effectiveness of protons and high-mass, high-atomic number (Z) and high-energy (HZE) particles to produce oxidative stress in vitro. Protons were found to be about equally as eff...

journal_title：Radiation research

authors： Wan XS,Bloch P,Ware JH,Zhou Z,Donahue JJ,Guan J,Stewart J,Kennedy AR

更新日期：2005-04-01 00:00:00

abstract：:Previous surveys of radiation therapy among the Life Span Study (LSS) population at the Radiation Effects Research Foundation (RERF) revealed that 1,670 (1.4%) of the LSS participants received radiation treatments before 1984. The data on therapeutic radiation doses are indispensable for studying the relationship betw...

journal_title：Radiation research

authors： Kato K,Antoku S,Kodama K,Kawamura S,Fujita Y,Komatsu K,Awa AA

更新日期：2001-06-01 00:00:00

abstract：:The concept of curvature in dose-response relationships figures prominently in radiation biology, encompassing a wide range of interests including radiation protection, radiotherapy and fundamental models of radiation action. In this context, the ability to detect even small amounts of curvature becomes important. Sta...

journal_title：Radiation research

authors： Shuryak I,Loucas BD,Cornforth MN

更新日期：2017-01-01 00:00:00

abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...

journal_title：Radiation research

authors： Beinke C,Barnard S,Boulay-Greene H,De Amicis A,De Sanctis S,Herodin F,Jones A,Kulka U,Lista F,Lloyd D,Martigne P,Moquet J,Oestreicher U,Romm H,Rothkamm K,Valente M,Meineke V,Braselmann H,Abend M

更新日期：2013-08-01 00:00:00

abstract：:Currently available treatments for radiation-induced nausea and vomiting either are ineffective or reduce performance. The new antiemetic and gastrokinetic agent zacopride was tested in rhesus monkeys to assess its behavioral toxicity and its ability to inhibit radiation-induced emesis. Zacopride (intragastric, 0.3 mg...

journal_title：Radiation research

authors： Dubois A,Fiala N,Boward CA,Bogo V

更新日期：1988-09-01 00:00:00

abstract：:Proteinase-activated receptor 2 (Par2, F2rl1, also designated PAR-2 or PAR2) is prominently expressed in the intestine and has been suggested as a mediator of inflammatory, mitogenic and fibrogenic responses to injury. Mast cell proteinases and pancreatic trypsin, both of which have been shown to affect the intestinal...

journal_title：Radiation research

authors： Wang J,Zheng H,Hollenberg MD,Wijesuriya SJ,Ou X,Hauer-Jensen M

更新日期：2003-11-01 00:00:00

abstract：:The relationship of ionizing radiation to the age-related ophthalmological findings of the 1978-1980 ophthalmological examination of A-bomb survivors of Hiroshima and Nagasaki has been reanalyzed using DS86 eye organ dose estimates. The main purpose of this reevaluation was to determine whether age and radiation expos...

journal_title：Radiation research

authors： Otake M,Finch SC,Choshi K,Takaku I,Mishima H,Takase T

更新日期：1992-09-01 00:00:00

abstract：:Diethylenetriaminepentaacetic acid (DTPA) is currently still the only known chelating drug that can be used for decorporation of internalized plutonium (Pu) and americium (Am). It is generally assumed that chelation occurs only in biological fluids, thus preventing Pu/Am deposition in target tissues. We postulate that...

journal_title：Radiation research

authors： Grémy O,Laurent D,Coudert S,Griffiths NM,Miccoli L

更新日期：2016-06-01 00:00:00

abstract：:Bcl-X(S) is a pro-apoptosis member of the Bcl2 family that has been shown to induce cell death and enhance chemosensitivity. We have investigated the effect of Bcl-X(S) overexpression on radiation sensitivity. Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and ...

journal_title：Radiation research

authors： Morgan MA,Poynter JN,Maybaum J,Lawrence TS

更新日期：2004-05-01 00:00:00

abstract：:To date, there are no safe and effective drugs available for protection against ionizing radiation damage. Therefore, a great need exists to identify and develop non-toxic agents that will be useful as radioprotectors or postirradiation therapies under a variety of operational scenarios. We have developed a new pharma...

journal_title：Radiation research

authors： Singh VK,Ducey EJ,Fatanmi OO,Singh PK,Brown DS,Purmal A,Shakhova VV,Gudkov AV,Feinstein E,Shakhov A

更新日期：2012-05-01 00:00:00