Abstract:
:Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Carlo track simulations. The probability that a core ionization leads to cell inactivation is deduced from experimental values of the RBEs of ultrasoft X rays. The contribution to V79 cell inactivation solely due to the core ionizations in DNA is found to be 75 +/- 27% for energetic electrons and gamma rays. This surprisingly large contribution strongly suggests the presence of new mechanisms associated with critical lesions for cell inactivation.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Boissière A,Champion C,Touati A,Hervé du Penhoat MA,Sabatier L,Chatterjee A,Chetioui Adoi
10.1667/RR0451.1subject
Has Abstractpub_date
2007-04-01 00:00:00pages
493-500issue
4eissn
0033-7587issn
1938-5404pii
RR0451journal_volume
167pub_type
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