Evaluation of lactate as a 1H nuclear magnetic resonance spectroscopy index for noninvasive prediction and early detection of tumor response to radiation therapy in EMT6 tumors.

abstract：:The hypothesis of boron neutron capture therapy (BNCT) research has been that the short-range, high-linear energy transfer radiation produced by the capture of thermal neutrons by (10)B will potentially control tumor and spare normal tissue only if the boron compound selectively targets tumor tissue within the treatme...

journal_title：Radiation research

authors： Trivillin VA,Heber EM,Nigg DW,Itoiz ME,Calzetta O,Blaumann H,Longhino J,Schwint AE

更新日期：2006-08-01 00:00:00

abstract：:Radiation-induced complications in bone and cartilage are of increasing concern due to potential long-term effects in cancer survivors. Healthy articular cartilage may be exposed to radiation during either chondrosarcoma treatment or in-field radiotherapy of tumors located in close proximity to articulation. Cartilage...

journal_title：Radiation research

authors： Saintigny Y,Cruet-Hennequart S,Hamdi DH,Chevalier F,Lefaix JL

更新日期：2015-02-01 00:00:00

abstract：:We have been investigating radiation-induced neoplastic transformants of C3H 10T1/2 mouse fibroblasts for evidence of heritable changes. C3H 10T1/2 cells were treated with 8 Gy X rays. After approximately 8 weeks of culture, type II/III foci were isolated from the monolayer using cloning rings. Cell lines developed fr...

journal_title：Radiation research

authors： Crompton NE,Sigg M,Jaussi R

更新日期：1994-04-01 00:00:00

abstract：:Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...

journal_title：Radiation research

authors： Chomentowski M,Kellerer AM,Pierce DA

更新日期：2000-03-01 00:00:00

abstract：:We have studied the effect on sister chromatid exchange (SCE) induction in 9L rat brain tumor cells caused by combination treatment with BCNU and X rays. Over the dose and concentration ranges used in these experiments, BCNU induced relatively large numbers of SCEs, while X rays induced few SCEs. When cells were X irr...

journal_title：Radiation research

authors： Tofilon PJ,Deen DF

更新日期：1984-01-01 00:00:00

abstract：:We describe a rapid assay to predict intrinsic radiosensitivity of normal tissues based on the radiation-induced cytotoxic response of a number of types of white blood cells. Twenty-four hours after irradiation, leukocytes were prepared for analysis by flow cytometry. Radiation-induced cytotoxicity was characterized b...

journal_title：Radiation research

authors： Crompton NE,Ozsahin M

更新日期：1997-01-01 00:00:00

abstract：:The placental transfer and distribution of 241Am in the feto-placental system were studied in pregnant rats. Rats were injected intravenously with 241Am citrate at 15 or 18 days of gestation. Groups injected at 15 days of gestation were sacrificed 2, 24, 48, or 120 hr after injection, and the group injected at 18 days...

journal_title：Radiation research

authors： Hisamatsu S,Takizawa Y

更新日期：1983-04-01 00:00:00

abstract：:Acute thermotolerance was induced in Chinese hamster ovary cells by heating at 43 degrees C for 45 min followed by incubation at 37 degrees C for up to 85 h. The degree of thermotolerance induced was quantified by a second heat exposure at 43 degrees C. To study the interaction of thermotolerance and thermosensitizati...

journal_title：Radiation research

authors： Jung H

更新日期：1994-09-01 00:00:00

abstract：:Cells that have been grown as multicell tumor spheroids exhibit radioresistance compared to the same cells grown in monolayers. Comparison of potentially lethal damage (PLD) repair and its kinetics was made between 9L cells grown as spheroids and confluent monolayers. Survival curves of cells plated immediately after ...

journal_title：Radiation research

authors： Rodriguez A,Alpen EL,Mendonca M,DeGuzman RJ

更新日期：1988-06-01 00:00:00

abstract：:In the decade after the bombings of Hiroshima and Nagasaki, several large cohorts of survivors were organized for studies of radiation health effects. The U.S. Atomic Bomb Casualty Commission (ABCC) and its U.S./Japan successor, the Radiation Effects Research Foundation (RERF), have performed continuous studies since ...

journal_title：Radiation research

authors： Cullings HM,Fujita S,Funamoto S,Grant EJ,Kerr GD,Preston DL

更新日期：2006-07-01 00:00:00

abstract：:X rays have been shown to induce two forms of potentially lethal damage (PLD), "fast-repairing" PLD and "slowly repairing" PLD, whose repair is completed in 1 h and 4-6 h, respectively. In this study three modes of treatment with hypertonic solutions containing different NaCl concentrations for different durations (0....

journal_title：Radiation research

authors： Ikebuchi M,Kimura H,Hill CK,Aoyama T

更新日期：1995-01-01 00:00:00

abstract：:The primary risk factors of multiple myeloma are age, race and sex, but several studies have found an association between radiological hazards and multiple myeloma. The purpose of this nested case-control study was to investigate whether workers with chronic low-level exposure to internally deposited uranium at the Oa...

journal_title：Radiation research

authors： Yiin JH,Anderson JL,Daniels RD,Seel EA,Fleming DA,Waters KM,Chen PH

更新日期：2009-06-01 00:00:00

abstract：:Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to DNA crosslinking agents. Clinically, FA is associated with high risk for marrow failure, leukemia and head and neck squamous cell carcinoma (HNSCC). Radiosensitivity in FA patients compromises the use of tota...

journal_title：Radiation research

authors： Bernard ME,Kim H,Berhane H,Epperly MW,Franicola D,Zhang X,Houghton F,Shields D,Wang H,Bakkenist CJ,Frantz MC,Forbeck EM,Goff JP,Wipf P,Greenberger JS

更新日期：2011-11-01 00:00:00

abstract：:Late radiation damage to pig skin has been assessed at 104 weeks after exposure to sources of 90Sr/90Y (Emax 2.2 MeV) and 170Tm (Emax 0.9 MeV). Damage was assessed from measurements of dermal thickness in histological sections of irradiated skin and was compared with that of unirradiated skin to establish the relative...

journal_title：Radiation research

authors： Hopewell JW,Sieber VK,Heryet JC,Wells J,Charles MW

更新日期：1993-03-01 00:00:00

abstract：:To ensure the high-fidelity transmission by reproductive cells of genetic information from generation to generation, cells have evolved surveillance systems to eliminate genomic lesions by inducing cell suicide and/or DNA repair. In this report, gamma-ray-induced cell death was investigated using the medaka fish, Oryz...

journal_title：Radiation research

authors： Kuwahara Y,Shimada A,Mitani H,Shima A

更新日期：2002-04-01 00:00:00

abstract：:The microdosimetry of (10)B thermal neutron capture reactions should be considered as an essential step to be followed before studying the radiobiological aspects of boron neutron capture therapy. The boron dose itself is insufficient as the only quantity used to describe the biological effectiveness of the (10)B reac...

journal_title：Radiation research

authors： Santa Cruz GA,Zamenhof RG

更新日期：2004-12-01 00:00:00

abstract：:Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need t...

journal_title：Radiation research

authors： Robbins ME,Brunso-Bechtold JK,Peiffer AM,Tsien CI,Bailey JE,Marks LB

更新日期：2012-04-01 00:00:00

abstract：:Pepleomycin is a derivative of bleomycin, which is less toxic to the host but possesses greater antitumor activity. Experiments are described here in which Chinese hamster V-79 cells in culture and a murine squamous cell carcinoma in vivo have been used to obtain survival curves for pepleomycin alone or in combination...

journal_title：Radiation research

authors： Sakamoto K,Komatsu K,Matsumoto Y

更新日期：1985-05-01 00:00:00

abstract：:The A31-11 mouse BALB/3T3 cell system was adapted for the study of malignant transformation induced by 5.3 MeV alpha particles from a specially constructed 238Pu source. The biologic effects were compared to those of 220 kVp X rays. The alpha-radiation survival curve showed a D0 of 70 rad and a relative biological eff...

journal_title：Radiation research

authors： Robertson JB,Koehler A,George J,Little JB

更新日期：1983-11-01 00:00:00

abstract：:Experiments were performed to test whether significant amounts of pyrimidine dimers are produced in cultured cells of tobacco (Nicotiana tabacum L. var. Xanthi) and of Haplopappus gracilis by ultraviolet light in the biological dose range and whether either or both dark and light repair systems exist in these cells. T...

journal_title：Radiation research

authors： Trosko JE,Mansour VH

更新日期：1968-11-01 00:00:00

abstract：:The effects of X irradiation on oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells derived from different regions of the perinatal central nervous system (CNS) of rats were investigated in vitro. The O-2A progenitor cells can differentiate into either oligodendrocytes or type-2 astrocytes. The depletion of these...

journal_title：Radiation research

authors： van der Maazen RW,Kleiboer BJ,Verhagen I,van der Kogel AJ

更新日期：1991-10-01 00:00:00

abstract：:We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated ...

journal_title：Radiation research

authors： Asakawa J,Kuick R,Kodaira M,Nakamura N,Katayama H,Pierce D,Funamoto S,Preston D,Satoh C,Neel JV,Hanash S

更新日期：2004-04-01 00:00:00

abstract：:Fanconi anemia is a genetically heterogeneous recessive disease characterized mainly by bone marrow failure and cancer predisposition. Although it is accepted that Fanconi cells are highly sensitive to DNA crosslinking agents, their response to ionizing radiation is still unclear. Using pulsed-field gel electrophoresi...

journal_title：Radiation research

authors： Casado JA,Núñez MI,Segovia JC,Ruiz de Almodóvar JM,Bueren JA

更新日期：2005-11-01 00:00:00

abstract：:The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-assessment performances using gene expression assays. Lithium-heparin...

journal_title：Radiation research

authors： Badie C,Kabacik S,Balagurunathan Y,Bernard N,Brengues M,Faggioni G,Greither R,Lista F,Peinnequin A,Poyot T,Herodin F,Missel A,Terbrueggen B,Zenhausern F,Rothkamm K,Meineke V,Braselmann H,Beinke C,Abend M

更新日期：2013-08-01 00:00:00

abstract：:Water:n-octanol partition coefficients (KD) were determined for a series of radioprotective thiols to ascertain whether these could be used to estimate reliably their rates of uptake into mammalian cells by passive diffusion. Values of KD determined for thiols in 0.1 M potassium phosphate, pH 7.4, at 22 degrees C were...

journal_title：Radiation research

authors： Newton GL,Aguilera JA,Kim T,Ward JF,Fahey RC

更新日期：1996-08-01 00:00:00

abstract：:Human T lymphocytes can be used to determine the frequency and molecular spectrum of somatic cell gene mutations induced by ionizing radiations both in vivo and in vitro. In vitro exposure of these G0 cells to low-LET 137Cs gamma rays results in the induction of HPRT mutations and a predominant molecular spectrum of D...

journal_title：Radiation research

authors： Albertini RJ,Clark LS,Nicklas JA,O'Neill JP,Hui TE,Jostes R

更新日期：1997-11-01 00:00:00

abstract：:A standardized dichlorofluorescin (DCF) fluorometric assay capable of measuring radiation-induced oxidative stress was used to determine the effectiveness of protons and high-mass, high-atomic number (Z) and high-energy (HZE) particles to produce oxidative stress in vitro. Protons were found to be about equally as eff...

journal_title：Radiation research

authors： Wan XS,Bloch P,Ware JH,Zhou Z,Donahue JJ,Guan J,Stewart J,Kennedy AR

更新日期：2005-04-01 00:00:00

abstract：:Using an electron storage ring as a source of radiation, the wavelength dependence of inactivation and membrane damage in yeast cells (Saccharomyces cerevisiae) was investigated in the range from 145 to 254 nm, with special reference to the effects of vacuum-uv radiation. The cells were irradiated on a Millipore filte...

journal_title：Radiation research

authors： Ito T,Ito A,Hieda K,Kobayashi K

更新日期：1983-12-01 00:00:00

abstract：:Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing doubl...

journal_title：Radiation research

authors： Box HC,Freund HG,Budzinski EE,Wallace JC,Maccubbin AE

更新日期：1995-01-01 00:00:00

abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...

journal_title：Radiation research

authors： Monzen S,Osuda K,Miyazaki Y,Hayashi N,Takahashi K,Kashiwakura I

更新日期：2009-09-01 00:00:00