Abstract：
:Experiments were performed to test whether significant amounts of pyrimidine dimers are produced in cultured cells of tobacco (Nicotiana tabacum L. var. Xanthi) and of Haplopappus gracilis by ultraviolet light in the biological dose range and whether either or both dark and light repair systems exist in these cells. Thymine-containing dimers were found to be formed quite readily in both kinds of cells, but neither kind appeared to possess the excision repair system. Results indicated that UV-induced growth inhibition of tobacco cells could be photoreactivated and that tobacco cells could monomerize UV-induced, thymine-containing dimers in the DNA. On the other hand, neither increase in growth nor monomerization of dimers was observed in the UV-irradiated Haplopappus cell culture after treatment with photoreactivating light.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Trosko JE,Mansour VHsubject
Has Abstractpub_date
1968-11-01 00:00:00pages
333-43issue
2eissn
0033-7587issn
1938-5404journal_volume
36pub_type
杂志文章abstract：:There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodel...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14403.2
更新日期：2016-11-01 00:00:00
abstract：:Radiation therapy for the treatment of thoracic cancers may be associated with radiation-induced heart disease (RIHD), especially in long-term cancer survivors. Mechanisms by which radiation causes heart disease are largely unknown. To identify potential long-term contributions of mitochondria in the development of ra...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13452.1
更新日期：2014-03-01 00:00:00
abstract：:A spherical graphite calorimeter was used to determine the ratio of kerma to influence (kerma factor) for neutrons whose mean energy was approximately 14.6 MeV. The calorimeter was used to measure carbon kerma, while activation foils of Al and Au were used to determine the neutron fluence. The calorimeter was construc...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Current and potential shortfalls in the number of radiation scientists stand in sharp contrast to the emerging scientific opportunities and the need for new knowledge to address issues of cancer survivorship and radiological and nuclear terrorism. In response to these challenges, workshops organized by the Radiation R...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3096
更新日期：2003-12-01 00:00:00
abstract：:The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:The concept of curvature in dose-response relationships figures prominently in radiation biology, encompassing a wide range of interests including radiation protection, radiotherapy and fundamental models of radiation action. In this context, the ability to detect even small amounts of curvature becomes important. Sta...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14520.1
更新日期：2017-01-01 00:00:00
abstract：:Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is partially manifested by increased leukocyte-endothelial (L/E) intera...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14896.1
更新日期：2018-07-01 00:00:00
abstract：:A nested case-control study was conducted among workers at five U.S. nuclear facilities to evaluate leukemia mortality risk (excluding chronic lymphocytic) from ionizing radiation using worksite doses and adjusting for potential confounding. Conditional logistic regression was used to estimate the relative risk (RR) o...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr0724.1
更新日期：2007-02-01 00:00:00
abstract：:Accurate assessment of risks of long-term space missions is critical for human space exploration. It is essential to have a detailed understanding of the biological effects on humans living and working in deep space. Ionizing radiation from galactic cosmic rays (GCR) is a major health risk factor for astronauts on ext...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15062.1
更新日期：2018-06-01 00:00:00
abstract：:Radon is recognized as a public health concern for indoor exposure. Precise quantification derived from occupational exposure in miners is still needed for estimating the risk and the factors that modify the dependence on cumulated exposure. The present paper reports on relationship between radon exposure and lung can...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0848.1
更新日期：2008-02-01 00:00:00
abstract：:Results from several laboratories, including ours, have suggested that measurements of radiation-induced DNA strand breaks and DNA-protein crosslinks (DPCs) may be used to estimate the hypoxic fraction or fractional hypoxic volume of tumors and normal tissues. This suggestion has been predicted on both published and u...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:The reactions of free and DNA-bound 2,2,5,5-tetramethylpyrrolidine-N-oxyl (PROXYL) probes with radicals generated during radiolysis of dilute aqueous solutions of DNA were examined. For the free PROXYL probe in deaerated solution with each of the four nucleotides (dAMP, dCMP, dGMP, and TMP) it was found that the pyrim...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:In this study, we sought to determine how diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) features are associated with histopathological results, and explored the cellular mechanisms of DWI and 1H-MRS in early radiosensitivity of transplanted liver tumors. VX2 tumors were implanted...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15140.1
更新日期：2019-01-01 00:00:00
abstract：:The present study was undertaken to assess the protective effect of dimethyl sulfoxide (DMSO) against the induction and rejoining of DNA double-strand breaks (DSBs) and inactivation of V79-4 Chinese hamster cells by both high- and low-linear energy transfer (LET) radiations. The cells were exposed under aerobic condit...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:A recently developed method for the direct measurement of the restricted dose mean LET (cutoff energy = 500 eV) of an unspecified photon or electron radiation field with the high-pressure ionization chamber has been utilized to investigate the variation of this radiobiologically important parameter outside the primary...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:Caffeine is a model radiosensitizing agent that is thought to work by abrogating the radiation-induced G(2)-phase checkpoint. In this study, we examined the effect that various concentrations of caffeine had on cell cycle checkpoints and apoptosis in cells of a human lung carcinoma cell line and found that a concentra...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2002)157[0166:citigp]2.0.co;2
更新日期：2002-02-01 00:00:00
abstract：:This study was designed to determine changes in cell numbers, proliferation (using Ki-67) and EGFR expression in mouse bladder urothelium during the early and late radiation response. Groups of mice were irradiated with a single dose of 20 Gy and assayed 0-360 days later. Urothelial cells were counted. After immunohis...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1759.1
更新日期：2010-04-01 00:00:00
abstract：:Experimental data from laboratory animals indicate that the same extent of DNA damage or the same mutations in oncogenes and tumor suppressor genes in different hosts result in widely differing cancer development because of numerous polymorphic tumor susceptibility genes. Similarly, recent epidemiological data indicat...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/rr3333.1
更新日期：2005-10-01 00:00:00
abstract：:The induction of thymic lymphomas by whole-body X irradiation with four doses of 1.8 Gy (total dose: 7.2 Gy) in C57BL/6 mice was suppressed from a high frequency (90%) to 63% by preirradiation with 0.075 Gy X rays given 6 h before each 1.8-Gy irradiation. This level was further suppressed to 43% by continuous whole-bo...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3289
更新日期：2005-02-01 00:00:00
abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13744.1
更新日期：2014-10-01 00:00:00
abstract：:In a recent study (Int. J. Radiat. Oncol. Biol. Phys. 36, 635-639, 1996), 1H nuclear magnetic resonance (NMR) spectroscopy was used to demonstrate significant decreases in lactate levels after gamma irradiation of radiosensitive RIF-1 tumors in vitro. For comparison, we have examined the effects of gamma radiation on ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2402.1
更新日期：2011-03-01 00:00:00
abstract：:Single crystals of anhydrous inosine were studied subsequent to exposure to high and low doses of X radiation at 10 K using K-band, EPR, ENDOR, and field-swept-ENDOR (FSE) techniques. Immediately following high radiation doses at 10 K at least eight different radicals, RI-RVIII, were observed. All radicals, except for...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Exposure of humans and rodents to radiofrequency (RF) cell phone fields has been reported to alter a number of stress- related parameters. To study this potential relationship in more detail, tube-restrained immobilized Fischer 344 rats were exposed in the near field in a dose-dependent manner to pulse-modulated (11 p...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0584:eoiace]2.0.co;2
更新日期：2001-04-01 00:00:00
abstract：:In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The comparative effects of liposomal and free DTP...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14968.1
更新日期：2018-05-01 00:00:00
abstract：:The relationship between apoptosis induced by gamma radiation and glutathione in cells of two human cancer cell lines, HeLa from cervix carcinoma and MCF-7 from mammary carcinoma, was examined. MCF-7 cells appeared to be more radioresistant than HeLa cells, and radiation-induced apoptosis, which was monitored by asses...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0578.1
更新日期：2007-03-01 00:00:00
abstract：:The distribution and kinetics of proximal tubular cells with abnormally large nuclei, which were observed in irradiated mouse kidneys before any other obvious histological effects, were investigated. Six months after the administration of 13 or 15 Gy, little histopathological change was noted, in the kidneys of C3H mi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:We present theoretical arguments to explain observations of a "reversal" of the RBE at relatively large doses; that is, the RBE of high-LET vs low-LET radiation is less than one. Numerical examples are given and the results of Bogo et al. (Radiat. Res. 118, 341-352, 1989) are discussed qualitatively. ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Nuclear protein and DNA content of HeLa cells was determined as a function of time following hyperthermia by staining isolated nuclei with two fluorescent dyes: fluorescein isothiocyanate (FITC) for protein content and propidium iodide (PI) for DNA content. Bivariate FITC and PI histograms were obtained by flow cytome...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：:In pathogen-free mice, but not standard conventionally housed laboratory rodents, two distinctly different modes of early radiation lethality can be identified by modifying the irradiation technique (total-body versus abdominal irradiation) or by therapeutic intervention such as rescue of total-body-irradiated mice wi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
