Abstract:
:The microdosimetry of (10)B thermal neutron capture reactions should be considered as an essential step to be followed before studying the radiobiological aspects of boron neutron capture therapy. The boron dose itself is insufficient as the only quantity used to describe the biological effectiveness of the (10)B reaction for two important reasons: the specific microdistribution that the (10)B carrier compound exhibits at the cellular level and the primarily stochastic nature of the energy deposition process, which influences the biological response to the particulate radiation. In this work, these two aspects are analyzed in detail and an innovative rigorous analytical framework is developed in the microdosimetry domain. This formalism provides the necessary microdosimetric tools for more precisely describing the (10)B dose distribution deposited in sensitive microscopic structures and offers improved approaches for analyzing the biological dose--effect relationship of (10)B reactions.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Santa Cruz GA,Zamenhof RGdoi
10.1667/rr3257subject
Has Abstractpub_date
2004-12-01 00:00:00pages
702-10issue
6eissn
0033-7587issn
1938-5404pii
RR3257journal_volume
162pub_type
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