Validation of a metabolic model for tritium.

abstract：:Experiments were performed to test whether significant amounts of pyrimidine dimers are produced in cultured cells of tobacco (Nicotiana tabacum L. var. Xanthi) and of Haplopappus gracilis by ultraviolet light in the biological dose range and whether either or both dark and light repair systems exist in these cells. T...

journal_title：Radiation research

authors： Trosko JE,Mansour VH

更新日期：1968-11-01 00:00:00

abstract：:The effect of extremely low-frequency electromagnetic field (ELF EMF) exposures to human health has been widely debated. Epidemiological studies have found a possible correlation between increased cancer incidence and environmental ELF EMF exposures. Results from in vitro studies performed to examine the possible unde...

journal_title：Radiation research

authors： Morehouse CA,Owen RD

更新日期：2000-05-01 00:00:00

abstract：:There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodel...

journal_title：Radiation research

authors： Rabender C,Mezzaroma E,Mauro AG,Mullangi R,Abbate A,Anscher M,Hart B,Mikkelsen R

更新日期：2016-11-01 00:00:00

abstract：:We studied the role of cysteine as an intracellular radiation protector under conditions in which both oxygen and thiols were monitored at 37 degrees C. In HCT-116 human colon cancer cells, the intracellular cysteine content affects the radiation survival dramatically at intermediate oxygen levels, but not at zero or ...

journal_title：Radiation research

authors： Horan AD,Koch CJ

更新日期：2001-10-01 00:00:00

abstract：:While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the jo...

journal_title：Radiation research

authors： Egawa H,Furukawa K,Preston D,Funamoto S,Yonehara S,Matsuo T,Tokuoka S,Suyama A,Ozasa K,Kodama K,Mabuchi K

更新日期：2012-09-01 00:00:00

abstract：:Terahertz radiation is increasingly being applied in new and evolving technologies applied in areas such as homeland security and medical imaging. Thus a timely assessment of the potential hazards and health effects of occupational and general population exposure to THz radiation is required. We applied continuous-wav...

journal_title：Radiation research

authors： Korenstein-Ilan A,Barbul A,Hasin P,Eliran A,Gover A,Korenstein R

更新日期：2008-08-01 00:00:00

abstract：:The well-established process of potentially lethal damage (PLD) repair enhances plateau-phase cell survival after exposure to ionizing radiation. PLD repair requires that confluent cells be incubated prior to plating for a colony-forming assay rather than being plated immediately. Enhanced double-strand break (DSB) re...

journal_title：Radiation research

authors： Igarashi K,Miura M

更新日期：2008-10-01 00:00:00

abstract：:Radiation exposure causes DNA breaks leading to structural chromosome aberrations that can be carcinogenic. Lifetime cancer risks are elevated in irradiated children compared to similarly exposed adults. To determine the extent to which age influences the frequency and types of chromosome damage in response to ionizin...

journal_title：Radiation research

authors： Bakhmutsky MV,Joiner MC,Jones TB,Tucker JD

更新日期：2014-06-01 00:00:00

abstract：:The concentrations of uranium isotopes and their decay products 226Ra, 222Rn, 210Pb and 210po have been analyzed in the mineral spring waters of a highly radioactive region of Brazil: Aguas da Prata. This region is located in the Poços de Caldas Plateau, one of the largest weathered alkaline intrusions in the world. D...

journal_title：Radiation research

authors： Mazzilli B,Camargo IM,Oliveira J,Nieri A,Sampa MH,Silva BL

更新日期：1998-08-01 00:00:00

abstract：:The nitroxide Tempol, a stable free radical, has recently been shown to protect mammalian cells against several forms of oxidative stress including radiation-induced cytotoxicity. To extend this observation, six additional water-soluble nitroxides with different structural features were evaluated for potential radiopr...

journal_title：Radiation research

authors： Hahn SM,Wilson L,Krishna CM,Liebmann J,DeGraff W,Gamson J,Samuni A,Venzon D,Mitchell JB

更新日期：1992-10-01 00:00:00

abstract：:Three somatic mutation assays were evaluated in men exposed to low-dose, whole-body, ionizing radiation. Blood samples were obtained between 1992 and 1999 from 625 Russian Chernobyl cleanup workers and 182 Russian controls. The assays were chromosome translocations in lymphocytes detected by FISH, hypoxanthine phospho...

journal_title：Radiation research

authors： Jones IM,Galick H,Kato P,Langlois RG,Mendelsohn ML,Murphy GA,Pleshanov P,Ramsey MJ,Thomas CB,Tucker JD,Tureva L,Vorobtsova I,Nelson DO

更新日期：2002-10-01 00:00:00

abstract：:Many studies have shown the importance of altered cellular proto-oncogene expression in contributing to changes in cell survival, cell transformation, and cell cycle progression. In these experiments we examined the effects of total-body exposure of BCF1 mice to gamma rays (3 Gy) in modulating expression of cellular o...

journal_title：Radiation research

authors： Anderson A,Woloschak GE

更新日期：1992-06-01 00:00:00

abstract：:Gleevec, a selective tyrosine kinase inhibitor, retarded the growth of anaplastic thyroid cancer cell lines in vitro and in vivo through selective inhibition of ABL tyrosine kinase activity. In the present study, we investigated the ability of Gleevec to modulate the in vitro and in vivo radiation response of anaplast...

journal_title：Radiation research

authors： Podtcheko A,Ohtsuru A,Namba H,Saenko V,Starenki D,Palona I,Sedliarou I,Rogounovitch T,Yamashita S

更新日期：2006-01-01 00:00:00

abstract：:Human erythrocytes were isolated from the blood of healthy donors and then incubated in the presence of suspensions of alpha-tocopherol for 30 min at 37 degrees C. Unabsorbed tocopherol was removed by centrifugation using several washes of isotonic phosphate-buffered saline. Washed erythrocytes were resuspended to 0.0...

journal_title：Radiation research

authors： Brown MA

更新日期：1983-08-01 00:00:00

abstract：:Abstract The present study was undertaken to investigate the ability of dietary supplements to reduce the formation and severity of cataracts in mice irradiated with high-energy protons or iron ions, which are important components of the radiation encountered by astronauts during space travel. The mice were exposed to...

journal_title：Radiation research

authors： Davis JG,Wan XS,Ware JH,Kennedy AR

更新日期：2010-03-01 00:00:00

abstract：:We present measurements of low-energy (<18 eV) electron-stimulated desorption of anions from acetamide (CH(3)CONH(2)) and dimethyl disulfide [DMDS: (CH(3)S)(2)] films. Electron irradiation of physisorbed CH(3)CONH(2) produces H(-), CH(3)(-) and O(-) anions, whereas the H(-), CH(2)(-), CH(3)(-), S(-), SH(-) and SCH(3)(...

journal_title：Radiation research

authors： Abdoul-Carime H,Cecchini S,Sanche L

更新日期：2002-07-01 00:00:00

abstract：:X rays have been shown to induce two forms of potentially lethal damage (PLD), "fast-repairing" PLD and "slowly repairing" PLD, whose repair is completed in 1 h and 4-6 h, respectively. In this study three modes of treatment with hypertonic solutions containing different NaCl concentrations for different durations (0....

journal_title：Radiation research

authors： Ikebuchi M,Kimura H,Hill CK,Aoyama T

更新日期：1995-01-01 00:00:00

abstract：:Incorporation of bromodeoxyuridine (BrdU) into DNA in both Chinese hamster ovary (CHO) cells and human melanoma (U1) cells reduced the rate of DNA migration in transverse alternating-field electrophoresis (TAFE) agarose gel optimized for separating molecules larger than 2 Mb. This "BrdU migration effect" was independe...

journal_title：Radiation research

authors： Latz DL,Trinh MM,Thompson LL,Gardiner K,Zhu Y,Bodell WJ,Dewey WC

更新日期：1994-04-01 00:00:00

abstract：:The flow cytometry mutation assay is based on detecting mutations in the CD59 gene on human chromosome 11 in CHO A(L) cells with flow cytometry, but the kinetics of mutant expression and the histogram region for mutant selection have not been studied in detail. CHO A(L) cells were analyzed by flow cytometry for CD59 e...

journal_title：Radiation research

authors： Ross CD,Fox MH

更新日期：2008-11-01 00:00:00

abstract：:Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Ca...

journal_title：Radiation research

authors： Boissière A,Champion C,Touati A,Hervé du Penhoat MA,Sabatier L,Chatterjee A,Chetioui A

更新日期：2007-04-01 00:00:00

abstract：:To compare the genotoxic effects of high-LET ionizing radiation to those of low-LET radiation, we investigated the responses of human lymphoblastoid cells to DNA damage TK6 after treatment with either low-LET X rays or high-LET iron ions (1000 keV/microm). A highly localized distribution of gammaH2AX/RAD51 foci was ob...

journal_title：Radiation research

authors： Goto S,Watanabe M,Yatagai F

更新日期：2002-12-01 00:00:00

abstract：:The intrinsic radiosensitivity of tumor cells is most frequently reported for asynchronous populations, although cell cycle variation in radiosensitivity is known to be significant. Linear-quadratic analyses of survival data for asynchronous human tumor cells show wide variations in the alpha coefficient with smaller ...

journal_title：Radiation research

authors： Biade S,Stobbe CC,Chapman JD

更新日期：1997-04-01 00:00:00

abstract：:This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together t...

journal_title：Radiation research

authors： Pierce DA,Shimizu Y,Preston DL,Vaeth M,Mabuchi K

更新日期：1996-07-01 00:00:00

abstract：:Pulse radiolysis and 60Co gamma radiolysis were used to study the effects of ionizing radiations on the activity of glutamate dehydrogenase. Hydroxyl radicals are considerably more effective than hydrated electrons in causing loss of enzymatic activity. Evidence is also presented that the free radical anions (SCN)-.2,...

journal_title：Radiation research

authors： Abu El Failat RR,Moore JS,Davies JV

更新日期：1983-01-01 00:00:00

abstract：:In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest...

journal_title：Radiation research

authors： Wedenberg M,Lind BK,Toma-Daşu I,Rehbinder H,Brahme A

更新日期：2010-10-01 00:00:00

abstract：:We examined the effects of X irradiation on activation of the promoter of the human HSP70B gene, which is activated only after heat shock. The HSP70B promoter was ligated to the bacterial beta-galactosidase (beta-gal) gene, and the reporter plasmid was transfected into NCI-H1299 carcinoma cells. The expression of the ...

journal_title：Radiation research

authors： Suzuki K,Kodama S,Watanabe M

更新日期：1998-02-01 00:00:00

abstract：:The acute effects of proton whole-body irradiation on the distribution and function of leukocyte populations in the spleen and blood were examined and compared to the effects of photons derived from a (60)Co gamma-ray source. Adult female C57BL/6 mice were exposed to a single dose (3 Gy at 0.4 Gy/min) of protons at sp...

journal_title：Radiation research

authors： Kajioka EH,Andres ML,Li J,Mao XW,Moyers MF,Nelson GA,Slater JM,Gridley DS

更新日期：2000-05-01 00:00:00

abstract：:In boron neutron capture therapy, the absorbed dose from the (10)B(n,alpha)(7)Li reaction depends on the (10)B concentration and (10)B distribution in the irradiated volume. Thus compounds used in BNCT should have tumor-specific uptake and low accumulation in normal tissues. This study compares in a mouse model the (1...

journal_title：Radiation research

authors： Wittig A,Huiskamp R,Moss RL,Bet P,Kriegeskotte C,Scherag A,Hilken G,Sauerwein WA

更新日期：2009-10-01 00:00:00

abstract：:We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas ...

journal_title：Radiation research

authors： Berrada M,Yang Z,Lehnert SM

更新日期：2004-07-01 00:00:00

abstract：:Experiments were performed with three different cell lines, mouse fibroblast LM cells, HeLa S3 cells, and Ehrlich Ascites Tumor (EAT) cells, to establish the possible importance of hyperthermic-induced alterations in cellular K+ content in the mechanism of cell killing by heat. At different time points after the hyper...

journal_title：Radiation research

authors： Ruifrok AC,Kanon B,Konings AW

更新日期：1987-02-01 00:00:00