Abstract:
:The well-established process of potentially lethal damage (PLD) repair enhances plateau-phase cell survival after exposure to ionizing radiation. PLD repair requires that confluent cells be incubated prior to plating for a colony-forming assay rather than being plated immediately. Enhanced double-strand break (DSB) repair during this incubation period has been implicated in the enhanced survival, but the precise molecular mechanism and its biological significance remain largely unclear. Radiation has been recently reported to induce premature senescence, and increasing evidence suggests that DSBs commonly mediate cellular senescence. Here we successfully related these two biological phenomena using bovine aortic endothelial cells, and propose that enhanced DSB repair during the plateau-phase incubation prevents expression of the radiation-induced senescence-like phenotype, eventually leading to an enhanced colony-forming ability. This could be a novel biological interpretation of PLD repair.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Igarashi K,Miura Mdoi
10.1667/rr1423.1subject
Has Abstractpub_date
2008-10-01 00:00:00pages
534-9issue
4eissn
0033-7587issn
1938-5404journal_volume
170pub_type
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更新日期:2014-05-01 00:00:00
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journal_title:Radiation research
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journal_title:Radiation research
pub_type: 杂志文章
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doi:
更新日期:1991-12-01 00:00:00
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journal_title:Radiation research
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更新日期:1994-10-01 00:00:00
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更新日期:2007-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
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更新日期:2019-05-01 00:00:00
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更新日期:1999-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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更新日期:2007-03-01 00:00:00
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journal_title:Radiation research
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doi:
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更新日期:2001-05-01 00:00:00
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doi:
更新日期:1994-05-01 00:00:00
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更新日期:2002-04-01 00:00:00
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更新日期:2011-02-01 00:00:00
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更新日期:2012-09-01 00:00:00
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doi:
更新日期:1991-11-01 00:00:00
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