A lower dose threshold for the in vivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice.

abstract：:Nearly 2% of the male population of Estonia aged 20-39 years were sent to Chernobyl to assist in the cleanup activities after the reactor accident. A cohort of 4,833 cleanup workers was assembled based on multiple and independent sources of information. Information obtained from 3,704 responses to a detailed questionn...

journal_title：Radiation research

authors： Tekkel M,Rahu M,Veidebaum T,Hakulinen T,Auvinen A,Rytömaa T,Inskip PD,Boice JD Jr

更新日期：1997-05-01 00:00:00

abstract：:Radiation-induced heart disease (RIHD) is a serious side effect of radiotherapy for intrathoracic and chest wall tumors. The threshold dose for development of clinically significant RIHD is believed to be lower than previously assumed. Therefore, research into mechanisms of RIHD has gained substantial momentum. RIHD b...

journal_title：Radiation research

authors： Boerma M

更新日期：2012-07-01 00:00:00

abstract：:Currently available treatments for radiation-induced nausea and vomiting either are ineffective or reduce performance. The new antiemetic and gastrokinetic agent zacopride was tested in rhesus monkeys to assess its behavioral toxicity and its ability to inhibit radiation-induced emesis. Zacopride (intragastric, 0.3 mg...

journal_title：Radiation research

authors： Dubois A,Fiala N,Boward CA,Bogo V

更新日期：1988-09-01 00:00:00

abstract：:Previous surveys of radiation therapy among the Life Span Study (LSS) population at the Radiation Effects Research Foundation (RERF) revealed that 1,670 (1.4%) of the LSS participants received radiation treatments before 1984. The data on therapeutic radiation doses are indispensable for studying the relationship betw...

journal_title：Radiation research

authors： Kato K,Antoku S,Kodama K,Kawamura S,Fujita Y,Komatsu K,Awa AA

更新日期：2001-06-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are 2.9 times more frequently induced in yeast cells exposed to sparsely ionizing 30-MeV electrons under oxic compared to anoxic conditions. The rejoining of DSBs induced under anoxic conditions was investigated under conditions allowing repair of potentially lethal damage and compared ...

journal_title：Radiation research

authors： Frankenberg-Schwager M,Frankenberg D,Harbich R

更新日期：1991-12-01 00:00:00

abstract：:Although tissue mast cells are derived from the bone marrow, some descendants of bone marrow-derived precursors retain the ability to proliferate and differentiate into mast cells even after localization in the skin. The purpose of the present study was to determine the D0 values for mast-cell precursors in the bone m...

journal_title：Radiation research

authors： Kitamura Y,Yokoyama M,Sonoda T,Mori KJ

更新日期：1983-01-01 00:00:00

abstract：:The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-assessment performances using gene expression assays. Lithium-heparin...

journal_title：Radiation research

authors： Badie C,Kabacik S,Balagurunathan Y,Bernard N,Brengues M,Faggioni G,Greither R,Lista F,Peinnequin A,Poyot T,Herodin F,Missel A,Terbrueggen B,Zenhausern F,Rothkamm K,Meineke V,Braselmann H,Beinke C,Abend M

更新日期：2013-08-01 00:00:00

abstract：:A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after gamma irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a...

journal_title：Radiation research

authors： Mühlmann-Díaz MC,Bedford JS

更新日期：1995-08-01 00:00:00

abstract：:In a patient with Morbus Hodgkin, structural aberrations of the chromosome type in peripheral lymphocytes were analyzed during radiation therapy (accumulated target dose 44.6 Gy: 22 fractions of 1.8 Gy each and 2 fractions of 2.5 Gy each at the end of the therapy). The blood was sampled about 5 min after a fraction an...

journal_title：Radiation research

authors： Diener A,Stephan G,Vogl T,Lissner J

更新日期：1988-06-01 00:00:00

abstract：:The mutagenic activity of green (532 nm) and infrared (1064 nm) ultra-short laser light pulses was tested in cultured Syrian hamster fibroblasts by a hypoxanthine phosphoribosyl-transferase (HPRT) mutagenesis assay. In 18 irradiation trials, cells were exposed to eight consecutive 100-ps pulses of either 532 nm or 106...

journal_title：Radiation research

authors： Leavitt J,Fatone M,Hestdalen C,Obringer JW,Tillinghast HS Jr

更新日期：1997-04-01 00:00:00

abstract：:A dose-response relationship was established in normal unanesthetized cats for emetic incidence, latency to onset of vomiting, and duration of emetic activity over a period of 24 h after whole-body exposure to 60Co radiation at selected doses between 7.5 and 90 Gy. Each episode of vomiting, i.e., retching and expulsio...

journal_title：Radiation research

authors： Borison HL,McCarthy LE,Douple EB,Johnson J,Borison R

更新日期：1987-03-01 00:00:00

abstract：:It is commonly accepted that ionizing radiation induces genomic instability by changes in genomic structure, epigenetic regulation and gene expression. Human endogenous retroviruses (HERV)-R also are often differentially expressed between normal and disease tissues under unstable genomic conditions and are implicated ...

journal_title：Radiation research

authors： Lee JR,Ahn K,Kim YJ,Jung YD,Kim HS

更新日期：2012-11-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) is frequently associated with a variety of cancers, including breast cancer. We and others have demonstrated that radiation-induced rat mammary cancer exhibits a characteristic gene expression profile and a random increase in aberrant DNA copy number; however, the role of aber...

journal_title：Radiation research

authors： Iizuka D,Imaoka T,Nishimura M,Kawai H,Suzuki F,Shimada Y

更新日期：2013-02-01 00:00:00

abstract：:Experimental work indicates that one of the mechanisms of tumor control by hyperthermia may be damage to blood vessels, resulting in decreased blood flow to the neoplasms. Among the various elements of the microvasculature, endothelial cells are the most important possible targets of thermal injury. Furthermore, neopl...

journal_title：Radiation research

authors： Fajardo LF,Schreiber AB,Kelly NI,Hahn GM

更新日期：1985-08-01 00:00:00

abstract：:Angiogenesis defines the many steps involved in the growth and migration of endothelial cell-derived blood vessels. This process is necessary for the growth and metastasis of tumors, and considerable effort is being expended to find inhibitors of tumor angiogenesis. This usually involves screening of potential anti-an...

journal_title：Radiation research

authors： Newton DL,Kaur G,Rhim JS,Sausville EA,Rybak SM

更新日期：2001-01-01 00:00:00

abstract：:The effect of exposure of human epidermal keratinocytes to ionizing radiation, both in vivo and in vitro, on the expression of the epidermal growth factor receptor (EGF-R) was studied on the protein, mRNA, and functional levels. Quantitative fluorometry of short-term organ cultures incubated with a monoclonal antibody...

journal_title：Radiation research

authors： Peter RU,Beetz A,Ried C,Michel G,van Beuningen D,Ruzicka T

更新日期：1993-10-01 00:00:00

abstract：:Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell ("initiation"), followed by the clonal expansion of this cell ("promotion") and by the acquisition of other genetic alterations leading to malignancy ("progression"). The initiation ...

journal_title：Radiation research

authors： Trosko JE,Chang CC,Madhukar BV

更新日期：1990-09-01 00:00:00

abstract：:In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest...

journal_title：Radiation research

authors： Wedenberg M,Lind BK,Toma-Daşu I,Rehbinder H,Brahme A

更新日期：2010-10-01 00:00:00

abstract：:The repair of X-ray-induced DNA damage related to the proliferating cell nuclear antigen (PCNA) was characterized in human diploid fibroblasts by an indirect immunofluorescence method. PCNA staining induced by X rays was lost after DNase I treatment but not after RNase treatment. The staining was not induced when ATP ...

journal_title：Radiation research

authors： Miura M,Sasaki T,Takasaki Y

更新日期：1996-01-01 00:00:00

abstract：:At the outset of the accident at Fukushima Daiichi Nuclear Power Plant in March 2011, the radiation doses experienced by residents were calculated from the readings at monitoring posts, with several assumptions being made from the point of view of protection and safety. However, health effects should also be estimated...

journal_title：Radiation research

authors： Nagataki S,Takamura N,Kamiya K,Akashi M

更新日期：2013-11-01 00:00:00

abstract：:We present measurements of low-energy (<18 eV) electron-stimulated desorption of anions from acetamide (CH(3)CONH(2)) and dimethyl disulfide [DMDS: (CH(3)S)(2)] films. Electron irradiation of physisorbed CH(3)CONH(2) produces H(-), CH(3)(-) and O(-) anions, whereas the H(-), CH(2)(-), CH(3)(-), S(-), SH(-) and SCH(3)(...

journal_title：Radiation research

authors： Abdoul-Carime H,Cecchini S,Sanche L

更新日期：2002-07-01 00:00:00

abstract：:Ionizing radiation induces clustered DNA damage sites, whereby two or more individual DNA lesions are formed within one or two helical turns of DNA by a single radiation track. A subset of DNA clustered damage sites exist in which the lesions are located in tandem on the same DNA strand. Recent studies have establishe...

journal_title：Radiation research

authors： Lomax ME,Salje H,Cunniffe S,O'Neill P

更新日期：2005-01-01 00:00:00

abstract：:The potential for radiogenic neoplasia from charged-particle irradiation has been estimated using the Harderian gland of the mouse as a test system. Particles ranging in Z from Z = 1 (proton) to Z = 41 (niobium), in energy from 228 to 670A MeV, and in LET from 0.4 to 464 keV/microns were produced at the Lawrence Berke...

journal_title：Radiation research

authors： Alpen EL,Powers-Risius P,Curtis SB,DeGuzman R

更新日期：1993-12-01 00:00:00

abstract：:Keratinocyte growth factor (FGF7, also known as KGF) ameliorates the radiation response of mouse oral mucosa and other epithelial tissues. However, the precise mechanisms remain unclear. The aim of the present study was to investigate the effect of FGF7 on the survival and colony size of normal human epidermal keratin...

journal_title：Radiation research

authors： Slonina D,Hoinkis C,Dörr W

更新日期：2001-12-01 00:00:00

abstract：:The human breast is sensitive to radiation carcinogenesis, and genomic instability occurs early in breast cancer development. This study tests the hypothesis that ionizing radiation elicits genomic instability in finite life-span human mammary epithelial cells (HMEC) and asks whether densely ionizing radiation is a mo...

journal_title：Radiation research

authors： Sudo H,Garbe J,Stampfer MR,Barcellos-Hoff MH,Kronenberg A

更新日期：2008-07-01 00:00:00

abstract：:Data are presented for a subset of lymphocytes characterized by FISH as missing painted chromosomal material. These lymphocytes occur in both control and irradiated subjects. These cells have a much greater frequency of one-way translocations than cells in which all of the painted chromosomal material is present. Thei...

journal_title：Radiation research

authors： Edwards A,Maznik N,Moquet J,Hone P,Vinnikov V,Lloyd D,Cox R

更新日期：2002-04-01 00:00:00

abstract：:A rare T-cell subpopulation, CD4-8- alpha beta T cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4+ or CD8+ T cells. In the present study, the frequencies of CD4-8-T cells in peripheral-blood alpha beta T cells in 409 atomic bomb survivors (160 estimated to ...

journal_title：Radiation research

authors： Kusunoki Y,Kyoizumi S,Hirai Y,Fujita S,Akiyama M

更新日期：1994-07-01 00:00:00

abstract：:Cytoglobin is a recently identified vertebrate globin whose functions include scavenging reactive oxygen and nitrosative species. In tumor cells, CYGB may function as a tumor suppressor gene. Here we show that knockdown of cytoglobin expression can sensitize human glioma cells to oxidative stress induced by chemical i...

journal_title：Radiation research

authors： Fang J,Ma I,Allalunis-Turner J

更新日期：2011-08-01 00:00:00

abstract：:The lactose operon functions under the control of the repressor-operator system. Binding of the repressor to the operator prevents the expression of the structural genes. This interaction can be destroyed by the binding of an inducer to the repressor. If ionizing radiations damage the partners, a dramatic dysfunction ...

journal_title：Radiation research

authors： Gillard N,Spotheim-Maurizot M,Charlier M

更新日期：2005-04-01 00:00:00

abstract：:Human keratinocytes show a bystander effect when exposed to low doses of low-LET radiation. In this paper, data are presented showing a method of correcting the overall survival curve to enable analysis of the relative contributions of the bystander effect and the effect attributable to direct interaction of the radia...

journal_title：Radiation research

authors： Seymour CB,Mothersill C

更新日期：2000-05-01 00:00:00