Comparison of gamma-ray-induced chromosome ring and inversion frequencies.

Abstract:

:A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after gamma irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a frequency equal to that of their easily measured asymmetrical counterpart, the interstitial deletion. Our experiments confirm this expectation. The results also demonstrate, as others have suggested, that in protocols where SCEs have been reported in the first postirradiation mitosis after incorporation of BrdU in the previous cell cycle, the X- or gamma-ray treatment of G0- or G1-phase cells produces virtually no true SCEs.

journal_name

Radiat Res

journal_title

Radiation research

authors

Mühlmann-Díaz MC,Bedford JS

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

175-80

issue

2

eissn

0033-7587

issn

1938-5404

journal_volume

143

pub_type

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