Abstract：
:Radiation-induced heart disease (RIHD) is a serious side effect of radiotherapy for intrathoracic and chest wall tumors. The threshold dose for development of clinically significant RIHD is believed to be lower than previously assumed. Therefore, research into mechanisms of RIHD has gained substantial momentum. RIHD becomes clinically apparent ten to fifteen years after radiation exposure. Chronic manifestations of RIHD include accelerated atherosclerosis, cardiomyopathy, and valve abnormalities. Reducing exposure of the heart during radiotherapy is the only known method of preventing RIHD, and there are no approaches to reverse RIHD once it occurs. We use a combination of pharmacological and genetic animal models to determine biological mechanisms of RIHD. Major technological advances in small animal research have made this type of study more valuable. The long-term goal of this work is to identify targets for intervention in RIHD, thereby enhancing the efficacy and safety of thoracic radiotherapy.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Boerma Mdoi
10.1667/rr2933.1subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1-6issue
1eissn
0033-7587issn
1938-5404pii
10.1667/RR2933.1journal_volume
178pub_type
杂志文章,评审abstract：:Some recent epidemiological studies have shown a positive association between cancer incidence and exposure to electromagnetic (EM) fields. Evidence from in vitro studies indicates that this effect could be due to synergistic interaction between EM fields and tumor promoters. However, no dose-response data related dir...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:Braun, R. D., Lanzen, J. L., Turnage, J. A., Rosner, G. and Dewhirst, M. W. Effects of the Interaction between Carbogen and Nicotinamide on R3230 Ac Tumor Blood Flow in Fischer 344 Rats. Radiat. Res. 155, 724-733 (2001). The purpose of this study was to determine whether there are interactions between carbogen breathi...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0724:eotibc]2.0.co;2
更新日期：2001-05-01 00:00:00
abstract：:The modification of methylglyoxal bis(guanylhydrazone) (MGBG) by 42 degrees C hyperthermia-and/or radiation-induced cell killing was examined in Chinese hamster V-79 cells. At concentrations of more than 10 microM, cell survival decreased exponentially with increased MGBG exposure times. Cell lethality of MGBG (10 mic...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:The recent demonstration of nanoscale scintillators has led to interest in the combination of radiation and photodynamic therapy. In this model, scintillating nanoparticles conjugated to photosensitizers and molecular targeting agents would enhance the targeting and improve the efficacy of radiotherapy and extend the ...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/RR1470.1
更新日期：2009-02-01 00:00:00
abstract：:The susceptibility to inducible SOS repair of 5,6-dihydroxy-dihydrothymine (t') damage in single-stranded phi X174 DNA has been measured. Following exposure to osmium tetroxide, which introduces t' damage in DNA under the conditions used, biological survival of the DNA infected into spheroplasts of Escherichia coli wh...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:Fanconi anemia is a genetically heterogeneous recessive disease characterized mainly by bone marrow failure and cancer predisposition. Although it is accepted that Fanconi cells are highly sensitive to DNA crosslinking agents, their response to ionizing radiation is still unclear. Using pulsed-field gel electrophoresi...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3395.1
更新日期：2005-11-01 00:00:00
abstract：:There is growing scientific, regulatory and public concern over anthropogenic input of radionuclides to the aquatic environment, especially given the issues surrounding existing nuclear waste, future energy demand and past or potential nuclear accidents. A change in the approach to how we protect the environment from ...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/rr2687.1
更新日期：2012-05-01 00:00:00
abstract：:Alteration of adhesion molecule expression on endothelial cells has a direct connection with ionizing radiation-induced atherosclerosis, which is an adverse effect observed after radiotherapy. However, minimal attention has been given to monocytes/macrophages role in atherosclerosis development, which are exposed to t...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3119.1
更新日期：2013-01-01 00:00:00
abstract：:C57BL/6J male mice were inoculated with 5 X 10(5) B16a melanoma cells. Seven days post-inoculation, when the tumor had grown to 8.0-10.0 mm in diameter, 120 tumor-bearing mice were randomly divided into three groups: (1) sham-irradiated controls, (2) mice receiving 200 cGy five times a week for 6 weeks, and (3) mice r...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:Plutonium is considered to be a carcinogen because it emits alpha particles that may result in the irradiation of stem cell population. In the present study we show that plutonium can also catalyze reactions that induce hydroxyl radicals in the absence of significant alpha-particle irradiation. Using the low specific ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The filter elution technique using nondenaturing conditions is widely used to assay DNA double-strand break (DSB) induction and repair. It has been reported that in the measurement of strand breaks higher rates of elution and of initial rejoining are obtained at pH 9.6 compared to pH 7.2. In the present experiments ne...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:The molecular basis of radiotherapy-related multidrug resistance (MDR) is still unclear. Here we report on a study investigating the effect of fractionated irradiation on expression of the MDR-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance-related protein ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0986.1
更新日期：2008-07-01 00:00:00
abstract：:Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy and environmental nuclear contamination as well as for Earth-orbit and space missions. Analyses of transcriptome prof...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1389.1
更新日期：2009-01-01 00:00:00
abstract：:We have evaluated the effect of X irradiation on the mesenchymal tissue growth (blood capillaries and stromal cells) in an angiogenesis system in the mouse. This was accomplished by implanting a polyvinyl alcohol sponge disc in the subcutis of the thorax, and quantifying the extent of growth reduction of capillaries a...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:In a series of Russian and Ukrainian papers published from 1974-1986, it was reported that 30-day whole-body exposures to continuous-wave (CW) radiofrequency (RF) radiation at 2375 MHz and 5 W/m(2) disrupted the antigenic structure of rat brain tissue. The authors suggested that this action caused an autoimmune respon...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1541.1
更新日期：2009-11-01 00:00:00
abstract：:We have investigated how radiation quality affects the induction of chromosomal aberrations in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated high charge and energy (HZE) particles including oxygen, neon, silicon, titanium and iron. Chromosome damage was assessed using thr...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3291.1
更新日期：2013-07-01 00:00:00
abstract：:Puskin, J. S. What Can Epidemiology Tell Us about Risks at Low Doses? Radiat. Res. 169, 122-124 (2008). Limitations on statistical power preclude direct detection and quantification of radiogenic cancer risks at very low (environmental) levels of low-LET radiation through epidemiological studies. Given this limitation...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1187.1
更新日期：2008-01-01 00:00:00
abstract：:A radiation-induced bystander response, which is generally defined as a cellular response that is induced in nonirradiated cells that received bystander signals from directly irradiated cells within an irradiated cell population. In our earlier X-ray microbeam studies, bystander cell killing in normal human fibroblast...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3010.1
更新日期：2013-02-01 00:00:00
abstract：:Chinese hamster ovary (CHO) cells became thermotolerant after treatment with either heat for 10 min at 45.5 degrees C or incubation in 100 microM sodium arsenite for 1 h at 37 degrees C. Thermotolerance was tested using heat treatment at 45 degrees C or 43 degrees C administered 6-12 h after the inducing agent. At 45 ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Radiation-induced endothelial cell apoptosis is involved in the development of many radiation injuries, including radiation-induced skin ulcers. The proangiogenic growth factors basic fibroblast growth factor (bFGF, NUDT6) and VEGF enhance endothelial cell survival. In the present study, we used primary cultured human...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3158
更新日期：2004-06-01 00:00:00
abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1519.1
更新日期：2009-09-01 00:00:00
abstract：:The induction of intracellular DNA strand breaks by X rays and various heavy charged particles was measured by the alkaline unwinding and alkaline and neutral filter elution techniques. No variations in strand break induction were found between the different cell lines under investigation. For a given particle, both t...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:1-(2-Fluoro-4-iodo-2,4-dideoxy-beta-L-xylopyranosyl)-2-nitroimidazole (FIAZP) has been synthesized and labeled with radioiodine (125I). Radioiodinated FIAZP is one of a series of sugar-coupled 2-nitroimidazoles developed in our laboratory as probes for noninvasive scintigraphic assessment of tumor hypoxia. An in vivo ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) is one of the important responses of cells to an external stress such as ionizing radiation. We studied radiation-induced NF-kappaB activation in vivo in male BALB/c mice. After the mice were exposed to 8.5 Gy total-body gamma irradiation, the sp...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:At the Swiss Institute for Nuclear Research (SIN) cancer patients are irradiated with negatively charged pi mesons using a 60-beam medical pion generator, the Piotron. A low-pressure tissue-equivalent proportional counter was used to measure absorbed dose and microdosimetric spectra. A method was developed to allow di...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Beagle dogs had signs of restrictive lung disease 1 to 5 years after exposure by inhalation to 239PuO2 aerosols. The 239PuO2 aerosols were monodisperse with activity median aerodynamic diameters of 0.75, 1.5, or 3.0 microns. The plutonium particles produced protracted alpha irradiation of the lungs. Ten dogs had speci...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:The growth of certain UV-radiation-induced tumors is suppressed by T lymphocytes, but it has been proposed that non-T lymphocytes stimulate the growth of several of these tumors. In this study, the indirect effects of X irradiation on the growth of one such tumor in T-cell-deficient nude mice was tested. Even when the...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:The incidence of breast cancer was determined in 4940 women treated for tuberculosis between 1925 and 1954 in Massachusetts. Among 2573 women examined by X-ray fluoroscopy an average of 88 times during lung collapse therapy and followed for an average of 30 years, 147 breast cancers occurred in contrast to 113.6 expec...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The human breast is sensitive to radiation carcinogenesis, and genomic instability occurs early in breast cancer development. This study tests the hypothesis that ionizing radiation elicits genomic instability in finite life-span human mammary epithelial cells (HMEC) and asks whether densely ionizing radiation is a mo...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1317.1
更新日期：2008-07-01 00:00:00
abstract：:Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A dissolved in soybean oil to protect against the biological effects caused by internal radionuclides is investigated. The radiochemicals examined are DNA-binding 125...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
