Abstract:
:This study demonstrates that mice, similar to humans, have a common mitochondrial DNA deletion (3,860 bp) that encodes 5 transfer RNA genes and 5 polypeptide genes that is related to aging, tissue type and radiotoxicity. Our research indicates that the deletion ratio in the liver was significantly higher than in the brain and gut tissues of 8-month-old mice, as compared to 8-week-old mice. Our results also demonstrate that tissue type, oxidative metabolic capacity and radiosensitivity influence the 3,860-bp deletion level. Therefore, this 3,860-bp deletion content may serve as a biomarker of aging and oxidative damage in mice.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Zhang SB,Maguire D,Zhang M,Zhang Z,Zhang A,Yin L,Zhang L,Huang L,Vidyasagar S,Swarts S,Okunieff Pdoi
10.1667/RR3373.1subject
Has Abstractpub_date
2013-10-01 00:00:00pages
407-13issue
4eissn
0033-7587issn
1938-5404journal_volume
180pub_type
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