X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons.

abstract：:Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy and environmental nuclear contamination as well as for Earth-orbit and space missions. Analyses of transcriptome prof...

journal_title：Radiation research

authors： Lowe XR,Bhattacharya S,Marchetti F,Wyrobek AJ

更新日期：2009-01-01 00:00:00

abstract：:Radiation exposure from a number of terrestrial sources is associated with an increased risk for atherosclerosis. Recently, concern over whether exposure to cosmic radiation might pose a similar risk for astronauts has increased. To address this question, we examined the effect of 2 to 5 Gy iron ions ((56)Fe), a parti...

journal_title：Radiation research

authors： Yu T,Parks BW,Yu S,Srivastava R,Gupta K,Wu X,Khaled S,Chang PY,Kabarowski JH,Kucik DF

更新日期：2011-06-01 00:00:00

abstract：:Abstract Pataky, K., Villanueva, G., Liani, A., Zgheib, O., Jenkins, N., Halazonetis, D. J., Halazonetis, T. D. and Brugger, J. Microcollimator for Micrometer-Wide Stripe Irradiation of Cells Using 20-30 keV X Rays. Radiat. Res. 172, 252-259 (2009). The exposure of subnuclear compartments of cells to ionizing radiatio...

journal_title：Radiation research

authors： Pataky K,Villanueva G,Liani A,Zgheib O,Jenkins N,Halazonetis DJ,Halazonetis TD,Brugger J

更新日期：2009-08-01 00:00:00

abstract：:The mechanisms underlying the hyper-radiosensitivity of AT cells were investigated by analyzing chromosome aberrations in the G(2) and M phases of the cell cycle using a combination of chemically induced premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with chromosome painting prob...

journal_title：Radiation research

authors： Kawata T,Ito H,George K,Wu H,Uno T,Isobe K,Cucinotta FA

更新日期：2003-05-01 00:00:00

abstract：:The percentage of T lymphocytes of atomic bomb survivors showed no change as a function of age or exposure dose. The percentage of T cells was slightly lower in malignant-tumor patients than in the control group, but was significantly higher in the group with chromosomal aberrations than in the control group. The perc...

journal_title：Radiation research

authors： Akiyama M,Yamakido M,Kobuke K,Dock DS,Hamilton HB,Awa AA,Kato H

更新日期：1983-03-01 00:00:00

abstract：:Several lines of correlative evidence link transforming growth factor alpha (Tgfa, also known as TGF-alpha) to proliferative activity in jejunal crypt cells. It is therefore tempting to hypothesize that, as a ligand of the epidermal growth factor, it mediates the compensatory proliferative burst in the crypts after ra...

journal_title：Radiation research

authors： Evans SC,Mack DC,Mason KA,Thames HD

更新日期：2001-06-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:In previous studies, flavonoids, orientin and vicenin, that were isolated from the leaf extract of Ocimum sanctum, were found to protect mice against radiation injury. Several flavonoids are known to be good antioxidants. Therefore, the effect of orientin and vicenin on radiation-induced lipid peroxidation in vivo and...

journal_title：Radiation research

authors： Uma Devi P,Ganasoundari A,Vrinda B,Srinivasan KK,Unnikrishnan MK

更新日期：2000-10-01 00:00:00

abstract：:Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortm...

journal_title：Radiation research

authors： Chernikova SB,Wells RL,Elkind MM

更新日期：1999-02-01 00:00:00

abstract：:The alveolar type II cell is one of the critical cells for radiation damage in the lungs after inhalation of radioactive aerosols. With the aid of a Quantimet-970 image analyzer and a VAX-11/780 computer, we calculated the radiation dose to rat alveolar type II cells from alpha particles emitted by 239PuO2. A series o...

journal_title：Radiation research

authors： Shen ZY,Ye CQ,Wu DC

更新日期：1989-11-01 00:00:00

abstract：:The reactions of free and DNA-bound 2,2,5,5-tetramethylpyrrolidine-N-oxyl (PROXYL) probes with radicals generated during radiolysis of dilute aqueous solutions of DNA were examined. For the free PROXYL probe in deaerated solution with each of the four nucleotides (dAMP, dCMP, dGMP, and TMP) it was found that the pyrim...

journal_title：Radiation research

authors： Swarts SG,Sevilla MD

更新日期：1987-10-01 00:00:00

abstract：:The influence of Trp53 on the radiation-induced elevation of T-cell receptor (TCR) variant fractions was examined in splenic T lymphocytes of Trp53-proficient and -deficient mice. Wild-type Trp53+/+, heterozygous Trp53+/- and null Trp53-/- mice were exposed to 3 Gy of X rays at 8 weeks of age. The fraction of TCR-defe...

journal_title：Radiation research

authors： Igari K,Igari Y,Okazaki R,Kato F,Ootsuyama A,Norimura T

更新日期：2006-07-01 00:00:00

abstract：:Isogenic Escherichia coli strains carrying single DNA-repair mutations were compared for their capacity for (i) the repair of X-ray-induced DNA double-strand breaks (DSB) as measured using neutral sucrose gradients; (ii) medium-dependent resistance, i.e., a recA-dependent X-ray survival phenomenon that correlates clos...

journal_title：Radiation research

authors： Sargentini NJ,Smith KC

更新日期：1986-07-01 00:00:00

abstract：:The response of the testes of two strains of adult rats (Sprague-Dawley and Wistar) to graded single doses and split doses of 230 kVp X rays has been investigated. A marked difference was noted between the strains in the response of the clonogenic spermatogonia to irradiation, as measured histologically by the repopul...

journal_title：Radiation research

authors： Delic JI,Schlappack OK,Harwood JR,Stanley JA

更新日期：1987-10-01 00:00:00

abstract：:In an effort to identify proteomic changes that may be useful for radiation biodosimetry, human cells of hematological origin were treated with ionizing radiation or mock-irradiated and then harvested at different times after treatment. Protein lysates were generated from these cells and evaluated by Western blotting ...

journal_title：Radiation research

authors： Ivey RG,Subramanian O,Lorentzen TD,Paulovich AG

更新日期：2009-05-01 00:00:00

abstract：:A subline of a rat mammary carcinoma (MATB 13762), selected for resistance to melphalan, is cross-resistant to other alkylating drugs, to unrelated drugs and to ionizing radiation. The difference in radioresponse between the sensitive wild-type cell line and the melphalan- and radiation-resistant line (MLNr) is relate...

journal_title：Radiation research

authors： Lehnert S,Vestergaard J,Batist G,Aloui-Jamali MA

更新日期：1994-08-01 00:00:00

abstract：:Mutation and killing induced by X radiation and 60CO gamma radiation were studied in six different histidine-requiring auxotrophs of Salmonella typhimurium. Strain TA100, which is sensitive to base-pair substitutions, and strains TA2637 and TA98, which are sensitive to frameshifts, carry the pKM101 plasmid and exhibit...

journal_title：Radiation research

authors： Isildar M,Bakale G

更新日期：1984-11-01 00:00:00

abstract：:We have investigated how radiation quality affects the induction of chromosomal aberrations in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated high charge and energy (HZE) particles including oxygen, neon, silicon, titanium and iron. Chromosome damage was assessed using thr...

journal_title：Radiation research

authors： George KA,Hada M,Chappell L,Cucinotta FA

更新日期：2013-07-01 00:00:00

abstract：:The effect of sodium bisulfite, a specific inhibitor of chromatin proteolysis, on radiation damage in rat thymocytes in vitro was examined. Rat thymocytes irradiated with 1 kR X rays in vitro were incubated at 37 degrees C with 10 mM glucose for 4 to 6 hr. During that time development of interphase death as judged by ...

journal_title：Radiation research

authors： Ohyama H,Shimizu M,Yamada T

更新日期：1983-07-01 00:00:00

abstract：:The toxicity of 137Cs in the beagle dog was investigated at the Inhalation Toxicology Research Institute (ITRI) and Argonne National Laboratory (ANL) as part of programs to evaluate the biological effects of both radionuclides in atomic bomb fallout and internally deposited fission-product radionuclides. In the ITRI s...

journal_title：Radiation research

authors： Nikula KJ,Muggenburg BA,Griffith WC,Carlton WW,Fritz TE,Boecker BB

更新日期：1996-11-01 00:00:00

abstract：:To compare the effects of exposure to a near-resonant frequency of microwaves at two orientations with a higher frequency exposure, five rhesus monkeys were exposed for 4 hr to 225 MHz, electric field oriented parallel to the long axis of the body (225 MHz-E), and to 225 MHz, magnetic field orientation (225 MHz-H), or...

journal_title：Radiation research

authors： Lotz WG

更新日期：1985-04-01 00:00:00

abstract：:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT ut...

journal_title：Radiation research

authors： Prezado Y,Deman P,Varlet P,Jouvion G,Gil S,Le Clec'H C,Bernard H,Le Duc G,Sarun S

更新日期：2015-09-01 00:00:00

abstract：:At the outset of the accident at Fukushima Daiichi Nuclear Power Plant in March 2011, the radiation doses experienced by residents were calculated from the readings at monitoring posts, with several assumptions being made from the point of view of protection and safety. However, health effects should also be estimated...

journal_title：Radiation research

authors： Nagataki S,Takamura N,Kamiya K,Akashi M

更新日期：2013-11-01 00:00:00

abstract：:Human cancers have multiple alterations in cell signaling pathways that promote resistance to cytotoxic therapy such as X rays. Parthenolide is a sesquiterpene lactone that has been shown to inhibit several pro-survival cell signaling pathways, induce apoptosis, and enhance chemotherapy-induced cell killing. We invest...

journal_title：Radiation research

authors： Mendonca MS,Chin-Sinex H,Gomez-Millan J,Datzman N,Hardacre M,Comerford K,Nakshatri H,Nye M,Benjamin L,Mehta S,Patino F,Sweeney C

更新日期：2007-12-01 00:00:00

abstract：:The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...

journal_title：Radiation research

authors： Kochevar IE,Walsh AA,Held KD,Gallo RL,Mirro J

更新日期：1990-05-01 00:00:00

abstract：:Single crystals of guanine hydrochloride monohydrate, guanine hydrochloride dihydrate and anhydrous guanine dihydrochloride, doped with thioguanine, were irradiated with X and gamma rays. In all three systems the dominant radicals were associated with thioguanine. In the former two systems the stabilized species is th...

journal_title：Radiation research

authors： Herak JN,Sanković K,Krilov D,Hüttermann J

更新日期：1999-03-01 00:00:00

abstract：:The photodynamic properties of a second-generation photodynamic sensitizer, meta-tetra(hydroxyphenyl)chlorin (mTHPC) were studied by dye-sensitized photoinactivation (650 nm) of HT29 human adenocarcinoma cells in culture. The photocytotoxicity of mTHPC in vitro depended on the presence of molecular oxygen. A strong in...

journal_title：Radiation research

authors： Melnikova VO,Bezdetnaya LN,Potapenko AY,Guillemin F

更新日期：1999-10-01 00:00:00

abstract：:To compare the genotoxic effects of high-LET ionizing radiation to those of low-LET radiation, we investigated the responses of human lymphoblastoid cells to DNA damage TK6 after treatment with either low-LET X rays or high-LET iron ions (1000 keV/microm). A highly localized distribution of gammaH2AX/RAD51 foci was ob...

journal_title：Radiation research

authors： Goto S,Watanabe M,Yatagai F

更新日期：2002-12-01 00:00:00

abstract：:The relationship between the intracellular glutathione (GSH) concentration and the aerobic radiation response was studied in Chinese hamster ovary cells. Various degrees of GSH depletion were produced by exposure to buthionine sulfoximine (BSO) and/or diethyl maleate (DEM). Diethyl maleate did not act as a classical r...

journal_title：Radiation research

authors： Saunders EL,Meredith MJ,Eisert DR,Freeman ML

更新日期：1991-03-01 00:00:00

abstract：:Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy ...

journal_title：Radiation research

authors： Fanton JW,Golden JG

更新日期：1991-05-01 00:00:00