Abstract:
:Several lines of correlative evidence link transforming growth factor alpha (Tgfa, also known as TGF-alpha) to proliferative activity in jejunal crypt cells. It is therefore tempting to hypothesize that, as a ligand of the epidermal growth factor, it mediates the compensatory proliferative burst in the crypts after radiation-induced cell killing. We have tested this hypothesis by comparing the repopulation response of wild-type and Tgfa-null mice, using the microcolony assay. Mice were exposed whole-body to (137)Cs gamma rays at a dose of approximately 1.6 Gy/min. Single doses and equal doses separated by 4 and 54 h were given. The rightward shift of the dose-response curves for 54 h was identical for wild-type and Tgfa-null mice, and there was no indication of a difference in radiosensitivity. This result indicates that Tgfa is not an essential component of the proliferative response of tissue to radiation-induced cell killing.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Evans SC,Mack DC,Mason KA,Thames HDdoi
10.1667/0033-7587(2001)155[0866:tpromj]2.0.co;2subject
Has Abstractpub_date
2001-06-01 00:00:00pages
866-9issue
6eissn
0033-7587issn
1938-5404journal_volume
155pub_type
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journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1128.1
更新日期:2007-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2001)156[0186:geohei]2.0.co;2
更新日期:2001-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1667/RR3010.1
更新日期:2013-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1487.1
更新日期:2009-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr2456.1
更新日期:2011-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3169
更新日期:2004-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1667/RR1398.1
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
abstract::Although conclusive evidence has been obtained for the presence of radiation-induced bystander effects, the mechanisms that trigger and regulate these processes are still largely unknown. The bystander effect may play a critical role in determining the biological effectiveness of low-dose exposures, but questions on h...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3319
更新日期:2005-03-01 00:00:00
abstract::Alteration of adhesion molecule expression on endothelial cells has a direct connection with ionizing radiation-induced atherosclerosis, which is an adverse effect observed after radiotherapy. However, minimal attention has been given to monocytes/macrophages role in atherosclerosis development, which are exposed to t...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR3119.1
更新日期:2013-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
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journal_title:Radiation research
pub_type: 评论,杂志文章
doi:10.1667/rr3174
更新日期:2004-05-01 00:00:00