The complexity of double-strand break ends is a factor in the repair pathway choice.

abstract：:The late effects of heavy-ion irradiation on the spinal cord of the rat were investigated histologically and morphometrically. After a single exposure of each animal's lower thoracic and lumbar spinal cord to a carbon-ion beam, the animals were observed clinically for up to 69 weeks and their spinal cords were examine...

journal_title：Radiation research

authors： Okada S,Okeda R,Matsushita S,Kawano A

更新日期：1998-09-01 00:00:00

abstract：:We previously reported that a priming dose of 0.3 Gy on gestation day 11 significantly increased the rate of living fetuses and reduced the incidence of congenital malformations caused by exposure to 5 Gy X rays on gestation day 12 in ICR mice. In the present study, postnatal development of the live offspring was inve...

journal_title：Radiation research

authors： Wang B,Ohyama H,Haginoya K,Odaka T,Itsukaichi H,Nose M,Nakajima T,Yukawa O,Yamada T,Hayata I

更新日期：1999-08-01 00:00:00

abstract：:The functional and morphological response of the remaining hypertrophied kidney in unilaterally nephrectomized rats to single doses of 0-20 Gy X rays was investigated. Functional and histological end points were assessed serially 4-24 weeks postirradiation. Renal irradiation led to time- and dose-dependent reductions ...

journal_title：Radiation research

authors： Robbins ME,O'Malley Y,Zhao W,Davis CS,Bonsib SM

更新日期：2001-03-01 00:00:00

abstract：:Octacalcium phosphate (OCP) {Ca8H2(PO4)6×5H2O] has attracted increasing attention over the last decade as a transient intermediate to the biogenic apatite for bone engineering and in studies involving the processes of pathological calcification. In this work, OCP powders obtained by hydrolysis of dicalcium phosphate d...

journal_title：Radiation research

authors： Shurtakova DV,Yavkin BV,Mamin GV,Orlinskii SB,Sirotinkin VP,Fedotov AY,Shinkarev A,Antuzevics A,Smirnov IV,Tovtin VI,Starostin EE,Gafurov MR,Komlev VS

更新日期：2020-12-10 00:00:00

abstract：:Radiation is an independent risk factor for cardiovascular and cerebrovascular disease in cancer patients. Modern radiotherapy techniques reduce the volume of the heart and major coronary vessels exposed to high doses, but some exposure is often unavoidable. Radiation damage to the myocardium is caused primarily by in...

journal_title：Radiation research

authors： Stewart FA,Hoving S,Russell NS

更新日期：2010-12-01 00:00:00

abstract：:The basic 30-nm chromatin fiber in the mammalian cell consists of an unknown (possibly helical) arrangement of nucleosomes, with about 1.2 kb of DNA per 10-nm length of fiber. Track-structure considerations suggest that interactions of single delta rays or high-LET particles with the chromatin fiber might result in th...

journal_title：Radiation research

authors： Rydberg B

更新日期：1996-02-01 00:00:00

abstract：:Synthetic lysophospholipids represent a variety of analogs of the naturally occurring 2-lysophosphatidylcholine. Some of these compounds showed significant therapeutic effects on the survival of mice following radiation injury when administered after various doses of whole-body X irradiation. Such therapeutic effects ...

journal_title：Radiation research

authors： Berdel WE,Schick P,Sedlmeier H,Fink U,Rastetter J,Messerschmidt O

更新日期：1983-04-01 00:00:00

abstract：:We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions. Here we present data...

journal_title：Radiation research

authors： Desai N,Davis E,O'Neill P,Durante M,Cucinotta FA,Wu H

更新日期：2005-10-01 00:00:00

abstract：:Dose-spread kernels can be used to calculate the dose distribution in a photon beam by convolving the kernel with the primary fluence distribution. The theoretical relationships between various types and components of dose-spread kernels relative to photon attenuation coefficients are explored. These relations can be ...

journal_title：Radiation research

authors： Boyer AL

更新日期：1988-02-01 00:00:00

abstract：:Relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) values of different neutron beams produced at the variable energy cyclotron "Cyclone" of Louvain-la-Neuve (Belgium) were determined. The neutrons were obtained by bombarding a beryllium target with 34-, 45-, 65-, or 75-MeV protons or with 50-Me...

journal_title：Radiation research

authors： Beauduin M,Gueulette J,Vynckier S,Wambersie A

更新日期：1989-02-01 00:00:00

abstract：:It was reported by others that hands-free accessories increase the absorption of RF energy in a human head compared to a handset alone. The results of this study show that the opposite is observed when proper dosimetric methods are employed. It is pointed out that for correct estimation of the exposure level it is nec...

journal_title：Radiation research

authors： Bit-Babik G,Chou CK,Faraone A,Gessner A,Kanda M,Balzano Q

更新日期：2003-04-01 00:00:00

abstract：:We previously described an enhanced sensitivity for cell killing and gamma-H2AX focus induction after both high-dose-rate and continuous low-dose-rate gamma irradiation in 14 primary fibroblast strains derived from hereditary-type retinoblastoma family members (both affected RB1(+/-) probands and unaffected RB1(+/+) p...

journal_title：Radiation research

authors： Wilson PF,Nagasawa H,Fitzek MM,Little JB,Bedford JS

更新日期：2010-01-01 00:00:00

abstract：:The relative biological effectiveness was determined using sex-linked recessive lethals induced in Drosophila spermatozoa as the biological effect. The sex-linked recessive lethal test, a measure of mutations induced in germ cells and transmitted through successive generations, yields a linear dose-response curve in t...

journal_title：Radiation research

authors： Byrne BJ,Lee WR

更新日期：1989-03-01 00:00:00

abstract：:The induction of chromosome aberrations in human lymphocytes irradiated in vitro with X rays generated at a tube voltage of 29 kV was examined to assess the maximum low-dose RBE (RBE(M)) relative to higher-energy X rays or 60Co gamma rays. Since blood was taken from the same male donor whose blood had been used for pr...

journal_title：Radiation research

authors： Schmid E,Regulla D,Kramer HM,Harder D

更新日期：2002-12-01 00:00:00

abstract：:Mycoplasma infection of mammalian cells in culture is a common occurrence that can affect the results of experimental protocols. Current methods of eliminating mycoplasma from cell cultures are usually tedious, time-consuming, and sometimes unsuccessful. In the present study, four cultured brain tumor cell lines (huma...

journal_title：Radiation research

authors： Ho JT,Deen DF

更新日期：1991-09-01 00:00:00

abstract：:The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...

journal_title：Radiation research

authors： Kochevar IE,Walsh AA,Held KD,Gallo RL,Mirro J

更新日期：1990-05-01 00:00:00

abstract：:Human keratinocytes show a bystander effect when exposed to low doses of low-LET radiation. In this paper, data are presented showing a method of correcting the overall survival curve to enable analysis of the relative contributions of the bystander effect and the effect attributable to direct interaction of the radia...

journal_title：Radiation research

authors： Seymour CB,Mothersill C

更新日期：2000-05-01 00:00:00

abstract：:Numerous studies have shown that histone deacetylase inhibitors (HDACis) improve cellular acetylation while also enhancing the radiation sensitivity. In this work, however, we confirmed that low-dose trichostatin A (TSA) as a typical HDACi could reduce rather than increase the radiosensitivity of cancer cells, while t...

journal_title：Radiation research

authors： Zhang F,Shao C,Chen Z,Li Y,Jing X,Huang Q

更新日期：2021-01-29 00:00:00

abstract：:Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently, the range of science projects requiring an underground experiment site has gr...

journal_title：Radiation research

authors： Morciano P,Cipressa F,Porrazzo A,Esposito G,Tabocchini MA,Cenci G

更新日期：2018-09-01 00:00:00

abstract：:The hypothesis of boron neutron capture therapy (BNCT) research has been that the short-range, high-linear energy transfer radiation produced by the capture of thermal neutrons by (10)B will potentially control tumor and spare normal tissue only if the boron compound selectively targets tumor tissue within the treatme...

journal_title：Radiation research

authors： Trivillin VA,Heber EM,Nigg DW,Itoiz ME,Calzetta O,Blaumann H,Longhino J,Schwint AE

更新日期：2006-08-01 00:00:00

abstract：:Phosphorylated ATM immunofluorescence staining was used to investigate the dose-response relationship for the number of DNA double-strand breaks (DSBs) induced in primary normal human fibroblasts irradiated with doses from 1.2 to 200 mGy. The induction of DSBs showed a supralinear dose-response relationship. Radiation...

journal_title：Radiation research

authors： Ojima M,Ban N,Kai M

更新日期：2008-09-01 00:00:00

abstract：:Three somatic mutation assays were evaluated in men exposed to low-dose, whole-body, ionizing radiation. Blood samples were obtained between 1992 and 1999 from 625 Russian Chernobyl cleanup workers and 182 Russian controls. The assays were chromosome translocations in lymphocytes detected by FISH, hypoxanthine phospho...

journal_title：Radiation research

authors： Jones IM,Galick H,Kato P,Langlois RG,Mendelsohn ML,Murphy GA,Pleshanov P,Ramsey MJ,Thomas CB,Tucker JD,Tureva L,Vorobtsova I,Nelson DO

更新日期：2002-10-01 00:00:00

abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...

journal_title：Radiation research

authors： Thome C,Mitz C,Hulley EN,Somers CM,Manzon RG,Wilson JY,Boreham DR

更新日期：2017-10-01 00:00:00

abstract：:The Escherichia coli nth gene encodes endonuclease III, which catalyses the glycolytic removal of various oxidized thymine residues from DNA. A truncated version of nth, with the prokaryotic regulatory sequences removed, was ligated into the retrovirus-based vector pZipneoSV(X)1 and transfected into the radiosensitive...

journal_title：Radiation research

authors： Harrison L,Skorvaga M,Cunningham RP,Hendry JH,Margison GP

更新日期：1992-10-01 00:00:00

abstract：:The presence of low levels of oxygen may have profound effects on the cytotoxic activity of radiation, radiosensitizers, and bioreductive alkylating agents. As others have shown, low oxygen tensions may significantly alter rates of cellular and chemical oxygen consumption. When experiments are performed at very low ox...

journal_title：Radiation research

authors： Marshall RS,Koch CJ,Rauth AM

更新日期：1986-10-01 00:00:00

abstract：:Radiation therapy for the treatment of thoracic cancers may be associated with radiation-induced heart disease (RIHD), especially in long-term cancer survivors. Mechanisms by which radiation causes heart disease are largely unknown. To identify potential long-term contributions of mitochondria in the development of ra...

journal_title：Radiation research

authors： Sridharan V,Aykin-Burns N,Tripathi P,Krager KJ,Sharma SK,Moros EG,Corry PM,Nowak G,Hauer-Jensen M,Boerma M

更新日期：2014-03-01 00:00:00

abstract：:There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sa...

journal_title：Radiation research

authors： Cheda A,Wrembel-Wargocka J,Lisiak E,Nowosielska EM,Marciniak M,Janiak MK

更新日期：2004-03-01 00:00:00

abstract：:Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources. The influence of cel...

journal_title：Radiation research

authors： Hawkins RB,Inaniwa T

更新日期：2014-07-01 00:00:00

abstract：:Water:n-octanol partition coefficients (KD) were determined for a series of radioprotective thiols to ascertain whether these could be used to estimate reliably their rates of uptake into mammalian cells by passive diffusion. Values of KD determined for thiols in 0.1 M potassium phosphate, pH 7.4, at 22 degrees C were...

journal_title：Radiation research

authors： Newton GL,Aguilera JA,Kim T,Ward JF,Fahey RC

更新日期：1996-08-01 00:00:00

abstract：:An understanding of proton radiobiology is critical for optimization of both proton radiotherapy and assessment of carcinogenesis risk from space radiation. Although the physical aspects of proton beam radiobiology is well understood, the biological aspects, particularly the complex biological end points, have been un...

journal_title：Radiation research

authors： Girdhani S,Sachs R,Hlatky L

更新日期：2013-03-01 00:00:00