Microdosimetry of rat alveolar type II cells irradiated with alpha particles from 239PuO2.

abstract：:In this study, we sought to determine how diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) features are associated with histopathological results, and explored the cellular mechanisms of DWI and 1H-MRS in early radiosensitivity of transplanted liver tumors. VX2 tumors were implanted...

journal_title：Radiation research

authors： Li Y,Lin D,Weng Y,Weng S,Yan C,Xu X,Chen J,Ye R,Hong J

更新日期：2019-01-01 00:00:00

abstract：:Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...

journal_title：Radiation research

authors： Chomentowski M,Kellerer AM,Pierce DA

更新日期：2000-03-01 00:00:00

abstract：:We studied the effects of extremely low-frequency (50 Hz) electromagnetic fields (EMFs) on peripheral human blood lymphocytes and DBY747 Saccharomyces cerevisiae. Graded exposure to 50 Hz magnetic flux density was obtained with a Helmholtz coil system set at 1, 10 or 100 microT for 18 h. The effects of EMFs on DNA dam...

journal_title：Radiation research

authors： Luceri C,De Filippo C,Giovannelli L,Blangiardo M,Cavalieri D,Aglietti F,Pampaloni M,Andreuccetti D,Pieri L,Bambi F,Biggeri A,Dolara P

更新日期：2005-09-01 00:00:00

abstract：:In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The comparative effects of liposomal and free DTP...

journal_title：Radiation research

authors： Grémy O,Miccoli L,Lelan F,Bohand S,Cherel M,Mougin-Degraef M

更新日期：2018-05-01 00:00:00

abstract：:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here...

journal_title：Radiation research

authors： Yokoyama K,Miyatake S,Kajimoto Y,Kawabata S,Doi A,Yoshida T,Okabe M,Kirihata M,Ono K,Kuroiwa T

更新日期：2007-01-01 00:00:00

abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...

journal_title：Radiation research

authors： Takahashi S,Patrick G

更新日期：1987-06-01 00:00:00

abstract：:Previously, we described the radiation-induced (RI) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) effect as the increased MTT metabolization at the intermediate dose region after the irradiation of an MCF-7/6 cell monolayer with an X-ray dose gradient. We wondered if the cell monolayer at the inte...

journal_title：Radiation research

authors： Blockhuys S,Vanhoecke B,Smet J,De Paepe B,Van Coster R,Bracke M,De Wagter C

更新日期：2013-04-01 00:00:00

abstract：:Pulmonary carcinomas were recorded in a life-span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality-corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon-daughter inhalations in the sa...

journal_title：Radiation research

authors： Chmelevsky D,Kellerer AM,Lafuma J,Morin M,Masse R

更新日期：1984-06-01 00:00:00

abstract：:The radiation dose received by crew members in interplanetary space is influenced by the stage of the solar cycle. Using the recently developed models of the galactic cosmic radiation (GCR) environment and the energy-dependent radiation transport code, we have calculated the dose at 0 and 5 cm water depth; using a com...

journal_title：Radiation research

authors： Badhwar GD,Cucinotta FA,O'Neill PM

更新日期：1994-05-01 00:00:00

abstract：:Tissue oxygenation influences the radiation response of tumors. To further investigate the underlying mechanisms of tumor hypoxia, the spatial distribution of hypoxic cells in relation to the vasculature was studied. In a panel of three human glioma xenograft lines (E2, E102, E106) with different growth characteristic...

journal_title：Radiation research

authors： Rijken PF,Peters JP,Van der Kogel AJ

更新日期：2002-06-01 00:00:00

abstract：:Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues to identify reliable biomarkers of individual radiation sensitivity. Herein, w...

journal_title：Radiation research

authors： Bryant J,White L,Coen N,Shields L,McClean B,Meade AD,Lyng FM,Howe O

更新日期：2020-06-01 00:00:00

abstract：:Current and potential shortfalls in the number of radiation scientists stand in sharp contrast to the emerging scientific opportunities and the need for new knowledge to address issues of cancer survivorship and radiological and nuclear terrorism. In response to these challenges, workshops organized by the Radiation R...

journal_title：Radiation research

authors： Coleman CN,Stone HB,Alexander GA,Barcellos-Hoff MH,Bedford JS,Bristow RG,Dynlacht JR,Fuks Z,Gorelic LS,Hill RP,Joiner MC,Liu FF,McBride WH,McKenna WG,Powell SN,Robbins ME,Rockwell S,Schiff PB,Shaw EG,Siemann DW,Tr

更新日期：2003-12-01 00:00:00

abstract：:After exposure to 10 or 20 J/m2 UVC light, cells of the UMN-PIE-1181 line, an embryonic cell line derived from the Indian meal moth, Plodia interpunctella, exhibited a rapid and prolonged depression in the rate of incorporation of [3H]thymidine, whereas cells of the TN-368 line, an ovarian cell line derived from Trich...

journal_title：Radiation research

authors： Styer SC,Griffiths TD

更新日期：1992-04-01 00:00:00

abstract：:Radiation exposure causes DNA breaks leading to structural chromosome aberrations that can be carcinogenic. Lifetime cancer risks are elevated in irradiated children compared to similarly exposed adults. To determine the extent to which age influences the frequency and types of chromosome damage in response to ionizin...

journal_title：Radiation research

authors： Bakhmutsky MV,Joiner MC,Jones TB,Tucker JD

更新日期：2014-06-01 00:00:00

abstract：:We have tested an 836.55 MHz field with North American Digital Cellular (NADC) modulation in a 2-year animal bioassay that included fetal exposure. In offspring of pregnant Fischer 344 rats, we tested both spontaneous tumorigenicity and the incidence of induced central nervous system (CNS) tumors after a single dose o...

journal_title：Radiation research

authors： Adey WR,Byus CV,Cain CD,Higgins RJ,Jones RA,Kean CJ,Kuster N,MacMurray A,Stagg RB,Zimmerman G,Phillips JL,Haggren W

更新日期：1999-09-01 00:00:00

abstract：:Cell-cell contact is thought to be critically involved in mechanisms leading to radioresistance. Here, we assessed the influence of confluent compared to subconfluent cell culture conditions and the radiosensitizing ability of E-cadherin inhibition alone or in combination with C225-mediated EGFR inhibition in human sq...

journal_title：Radiation research

authors： Mazzeo E,Hehlgans S,Valentini V,Baumann M,Cordes N

更新日期：2012-09-01 00:00:00

abstract：:A computer model that simulates the killing of exponentially growing cells by low-dose-rate radiation is described. The model incorporates cell killing by single-hit damage and double-hit (sublethal) damage, as well as repair of sublethal damage, delay of cell cycle progression, blockage and increased sensitivity of c...

journal_title：Radiation research

authors： Dillehay LE

更新日期：1990-11-01 00:00:00

abstract：:This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 L...

journal_title：Radiation research

authors： Ozasa K,Shimizu Y,Suyama A,Kasagi F,Soda M,Grant EJ,Sakata R,Sugiyama H,Kodama K

更新日期：2012-03-01 00:00:00

abstract：:Trp53 heterozygous mice are radiation-sensitive and cancer-prone. Groups of 7-8-week-old female Trp53 heterozygous mice were exposed to 4 Gy of 60Co gamma radiation at high (0.5 Gy/min) or low (0.5 mGy/min) dose rate. Other groups received 10 or 100 mGy at low dose rate 24 h prior to the 4-Gy dose. Tumor frequency and...

journal_title：Radiation research

authors： Mitchel RE,Jackson JS,Carlisle SM

更新日期：2004-07-01 00:00:00

abstract：:The effect of transgenerational exposure to low dose rate (2.4 and 21 mGy/day) gamma irradiation on the yield of DNA double-strand breaks and oxidized guanine (8-hydroxyguanine) has been studied in the muscle and liver tissue of a model organism, the Japanese medaka fish. We found the level of unrepaired 8-hydroxyguan...

journal_title：Radiation research

authors： Grygoryev D,Moskalenko O,Hinton TG,Zimbrick JD

更新日期：2013-09-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) is an aggressive disease with a high risk of recurrence and death. Here, we present a novel strategy to enhance the radiotherapy of TNBC by combining gold nanoparticles (AuNPs) with pentamidine, a clinically approved anti-parasitic agent with anti-cancer properties. The radiosensit...

journal_title：Radiation research

authors： Her S,Cui L,Bristow RG,Allen C

更新日期：2016-05-01 00:00:00

abstract：:The purpose of this work was to determine how fractionated radiation used in the treatment of tumors affects the ability of cancer as well as normal cells to repair induced DNA double-strand breaks (DSBs) and how cells that have lost this ability die. Lymphocytic leukemia cells (MOLT4) were used as an experimental mod...

journal_title：Radiation research

authors： Rezáčová M,Rudolfová G,Tichý A,Bačíková A,Mutná D,Havelek R,Vávrová J,Odrážka K,Lukášová E,Kozubek S

更新日期：2011-06-01 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 typ...

journal_title：Radiation research

authors： Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Y

更新日期：2003-06-01 00:00:00

abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...

journal_title：Radiation research

authors： Maeda J,Bell JJ,Genet SC,Fujii Y,Genet MD,Brents CA,Genik PC,Kato TA

更新日期：2014-10-01 00:00:00

abstract：:The electroporation of restriction enzymes into mammalian cells results in DNA double-strand breaks that can lead to chromosome aberrations. Four chemicals known to interfere with cellular responses to DNA damage were investigated for their effects on chromosome aberrations induced by AluI and Sau3AI; in addition, the...

journal_title：Radiation research

authors： Chung HW,Phillips JW,Winegar RA,Preston RJ,Morgan WF

更新日期：1991-01-01 00:00:00

abstract：:We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7-9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardio...

journal_title：Radiation research

authors： Unthank JL,Ortiz M,Trivedi H,Pelus LM,Sampson CH,Sellamuthu R,Fisher A,Chua HL,Plett A,Orschell CM,Cohen EP,Miller SJ

更新日期：2019-05-01 00:00:00

abstract：:The effect of sodium bisulfite, a specific inhibitor of chromatin proteolysis, on radiation damage in rat thymocytes in vitro was examined. Rat thymocytes irradiated with 1 kR X rays in vitro were incubated at 37 degrees C with 10 mM glucose for 4 to 6 hr. During that time development of interphase death as judged by ...

journal_title：Radiation research

authors： Ohyama H,Shimizu M,Yamada T

更新日期：1983-07-01 00:00:00

abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...

journal_title：Radiation research

authors： Ivey RG,Moore HD,Voytovich UJ,Thienes CP,Lorentzen TD,Pogosova-Agadjanyan EL,Frayo S,Izaguirre VK,Lundberg SJ,Hedin L,Badiozamani KR,Hoofnagle AN,Stirewalt DL,Wang P,Georges GE,Gopal AK,Paulovich AG

更新日期：2011-03-01 00:00:00

abstract：:Single crystals of anhydrous inosine were studied subsequent to exposure to high and low doses of X radiation at 10 K using K-band, EPR, ENDOR, and field-swept-ENDOR (FSE) techniques. Immediately following high radiation doses at 10 K at least eight different radicals, RI-RVIII, were observed. All radicals, except for...

journal_title：Radiation research

authors： Hole EO,Nelson WH,Sagstuen E,Close DM

更新日期：1992-05-01 00:00:00