Abstract:
:Trp53 heterozygous mice are radiation-sensitive and cancer-prone. Groups of 7-8-week-old female Trp53 heterozygous mice were exposed to 4 Gy of 60Co gamma radiation at high (0.5 Gy/min) or low (0.5 mGy/min) dose rate. Other groups received 10 or 100 mGy at low dose rate 24 h prior to the 4-Gy dose. Tumor frequency and latency were measured over the animals' life span. Exposure to 10 mGy prior to 4 Gy resulted in a small (approximately 5%) but significant life-span regain and increased latency (approximately 9%) for all malignant tumors taken together, but 100 mGy further reduced life span slightly (approximately 7%). Latency responses were tumor type-specific. The prior 10-mGy exposure resulted in a small (approximately 7%) regain in latency for lymphomas but no change in latency for spinal osteosarcomas. Increasing the adapting dose to 100 mGy eliminated the increase in lymphoma latency and further reduced life span (approximately 8%). A 10-mGy dose prior to 4 Gy at low dose rate had no effects. Adapting exposures had no significant effect on tumor frequency. We conclude that a single low dose induced a small protective response in vivo in Trp53+/- mice, reducing the carcinogenic effects of a subsequent large, high-dose-rate exposure by increasing tumor latency. The upper dose threshold at which low-dose protective effects gave way to detrimental effects was tumor type-specific, as found previously for spontaneous tumors in these same cancer-prone mice (Radiat. Res. 159, 320-327, 2003). However, the upper dose thresholds appear to be lower (below 100 mGy) for radiation-induced tumors than for the same tumors appearing spontaneously.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Mitchel RE,Jackson JS,Carlisle SMdoi
10.1667/rr3190subject
Has Abstractpub_date
2004-07-01 00:00:00pages
20-30issue
1eissn
0033-7587issn
1938-5404pii
RR3190journal_volume
162pub_type
杂志文章abstract::Nuclear protein and DNA content of HeLa cells was determined as a function of time following hyperthermia by staining isolated nuclei with two fluorescent dyes: fluorescein isothiocyanate (FITC) for protein content and propidium iodide (PI) for DNA content. Bivariate FITC and PI histograms were obtained by flow cytome...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract::The purpose of this study was to determine the antimutagenicity of WR-1065 added after irradiation of cells of cell lines differing in their ability to rejoin radiation-induced DNA double-strand breaks (DSBs). The postirradiation antimutagenicity of WR-1065 at the thymidine kinase locus was demonstrated for L5178Y (LY...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Experimental data from laboratory animals indicate that the same extent of DNA damage or the same mutations in oncogenes and tumor suppressor genes in different hosts result in widely differing cancer development because of numerous polymorphic tumor susceptibility genes. Similarly, recent epidemiological data indicat...
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pub_type: 杂志文章,评审
doi:10.1667/rr3333.1
更新日期:2005-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::Mixed radiation fields comprise the most common form of radiation exposure. Given their relevance in radiation protection, cancer radiotherapy and space research, accurate predictions of the corresponding radiation effects are essential. The local effect model (LEM) allows the prediction of cell survival after ion irr...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15456.1
更新日期:2020-02-01 00:00:00
abstract::Trypanothione is a unique diglutathionyl-spermidine conjugate found in abundance in trypanosomes but not in other eukaryotes. Because trypanothione is a naturally occurring polyamine thiol reminiscent of the synthetic drug amifostine, it may be a useful protector against radiation and oxidative stress. For these reaso...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2235.1
更新日期:2010-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr1977.1
更新日期:2011-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1255.1
更新日期:2008-09-01 00:00:00
abstract::Dose-response curves for micronucleus (MN) formation were measured in Chinese hamster V79 and xrs6 (Ku80(-)) cells and in human mammary epithelial MCF10A cells in the dose range of 0.05-1 Gy. The Chinese hamster cells were exposed to 1 GeV/nucleon iron ions, 600 MeV/nucleon iron ions, and 300 MeV/nucleon iron ions (LE...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR0967.1
更新日期:2007-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::The mechanisms underlying the hyper-radiosensitivity of AT cells were investigated by analyzing chromosome aberrations in the G(2) and M phases of the cell cycle using a combination of chemically induced premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with chromosome painting prob...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2003)159[0597:rcaiat]2.0.co;2
更新日期:2003-05-01 00:00:00
abstract::Asynchronously growing V79 cells were assayed for mutation induction following exposure to hyperthermia either immediately before or after being irradiated with 60Co gamma rays. Hyperthermia exposures consisted of either 43.5 degrees C for 30 min or 45 degrees C for 10 min. Each of these heat treatments resulted in a ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::There is strong evidence that biological response to ionizing radiation has a contribution from unirradiated "bystander" cells that respond to signals emitted by irradiated cells. We discuss here an approach incorporating a radiobiological bystander response, superimposed on a direct response due to direct energy depo...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2001)155[0402:tbeiro]2.0.co;2
更新日期:2001-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR0774.1
更新日期:2007-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Existence of a substantial fraction of replicon initiation events refractory to the effects of X irradiation in Chinese hamster cells has been reported by several laboratories. The work reported here examined whether this apparently refractive fraction resulted from a delayed inhibition of initiation events. Data obta...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::Aqueous solutions of calf thymus deoxyribonucleic acid (DNA) were exposed to hydrogen peroxide in the presence of air. Base products formed in DNA were identified and quantitated following acid hydrolysis and trimethylsilylation using gas chromatography-mass spectrometry. The yields of these products were dependent up...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr0724.1
更新日期:2007-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Ionizing radiation can induce chromosome instability that is transmitted over many generations after irradiation in the progeny of surviving cells, but it remains unclear why this instability can be transmitted to the progeny. To acquire knowledge about the transmissible nature of genomic instability, we transferred a...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR0835.1
更新日期:2007-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::The monohydroxylated fatty acid content of peripheral blood mononuclear cells from 23 cleanup workers and 16 unexposed individuals was studied in relation to their immune status after the Chernobyl accident. Men with absorbed doses below 0.32 Gy showed higher levels of free and esterified 12-hydroxyeicosatetraenoic ac...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2001)156[0476:mfacip]2.0.co;2
更新日期:2001-11-01 00:00:00
abstract::A significant fraction of DNA damage produced by ionizing radiation comes from free radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl radical, the principal damaging species, produces single-strand breaks and a plethora of base and sugar lesions that can be cytotoxic or muta...
journal_title:Radiation research
pub_type: 杂志文章,评审
doi:
更新日期:1998-11-01 00:00:00
abstract::We collected initial quantitative information on the effects of high-dose carbon (12C) ions compared to photons on vascular damage in anaplastic rat prostate tumors, with the goal of elucidating differences in response to high-LET radiation, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Syngene...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15459.1
更新日期:2020-01-01 00:00:00
abstract::The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irr...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Both plant senescence and plant response to ionizing radiation involve changes in gene expression and epigenetic profiles, that rely on the formation of reactive oxygen species. However, how the developmental stage of a plant affects its response to ionizing radiation has not been extensively studied. In this study, o...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR13840.1
更新日期:2015-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14305.1
更新日期:2016-07-01 00:00:00