Performance of silicon microdosimetry detectors in boron neutron capture therapy.

abstract：:It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments with concomitant changes in dendritic complexity, spine density and inflammatio...

journal_title：Radiation research

authors： Hinzman CP,Baulch JE,Mehta KY,Gill K,Limoli CL,Cheema AK

更新日期：2018-11-01 00:00:00

abstract：:Takagaki, M., Ono, K., Masunaga, S-I., Kinashi, Y., Oda, Y., Miyatake, S-I., Hashimoto, N., Powell, W., Sood, A. and Spielvogel, B. F. Boronated Dipeptide Borotrimethylglycylphenylalanine as a Potential Boron Carrier in Boron Neutron Capture Therapy for Malignant Brain Tumors. Radiat. Res. 156, 118-122 (2001).A borona...

journal_title：Radiation research

authors： Takagaki M,Powell W,Sood A,Spielvogel BF,Hosmane NS,Kirihata M,Ono K,Masunaga SI,Kinashi Y,Miyatake SI,Hashimoto N

更新日期：2001-07-01 00:00:00

abstract：:Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortm...

journal_title：Radiation research

authors： Chernikova SB,Wells RL,Elkind MM

更新日期：1999-02-01 00:00:00

abstract：:Tritium that is bound to organic molecules is of special risk for living systems, in particular when such molecules are components of the cell nucleus. Therefore, [3H]thymidine and [3H]arginine were studied for radiotoxicity in early mammalian embryo development. Starting with the two-cell stage, mouse embryos were in...

journal_title：Radiation research

authors： Müller WU,Streffer C,Molls M,Glück L

更新日期：1987-05-01 00:00:00

abstract：:In this study, we sought to determine how diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) features are associated with histopathological results, and explored the cellular mechanisms of DWI and 1H-MRS in early radiosensitivity of transplanted liver tumors. VX2 tumors were implanted...

journal_title：Radiation research

authors： Li Y,Lin D,Weng Y,Weng S,Yan C,Xu X,Chen J,Ye R,Hong J

更新日期：2019-01-01 00:00:00

abstract：:In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest...

journal_title：Radiation research

authors： Wedenberg M,Lind BK,Toma-Daşu I,Rehbinder H,Brahme A

更新日期：2010-10-01 00:00:00

abstract：:Single crystals of disodium beta-glycerophosphate pentahemihydrate (betaGP), Na2x(HO)CH2CH(PO(4)2-)CH2(OH)x5 1/2H2O, were X-irradiated at 77 and 280 K. EPR, ENDOR and FSE techniques were used to study the formation of free radicals in these irradiated crystals to characterize possible reaction mechanisms leading to de...

journal_title：Radiation research

authors： Baine TJ,Sagstuen E

更新日期：1998-08-01 00:00:00

abstract：:Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to DNA crosslinking agents. Clinically, FA is associated with high risk for marrow failure, leukemia and head and neck squamous cell carcinoma (HNSCC). Radiosensitivity in FA patients compromises the use of tota...

journal_title：Radiation research

authors： Bernard ME,Kim H,Berhane H,Epperly MW,Franicola D,Zhang X,Houghton F,Shields D,Wang H,Bakkenist CJ,Frantz MC,Forbeck EM,Goff JP,Wipf P,Greenberger JS

更新日期：2011-11-01 00:00:00

abstract：:Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in Sfpi1 on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of the Sfpi1 gene (DSG) and point mutation of the allele Sfpi1 gene (PMASG). In this study, we ...

journal_title：Radiation research

authors： Ojima M,Hirouchi T,Etani R,Ariyoshi K,Fujishima Y,Kai M

更新日期：2019-12-01 00:00:00

abstract：:Studies were conducted to determine the effects of BeSO4 or X rays, alone and in combination, on cell cycle kinetics, cell killing, and the production of chromosome aberrations in Chinese hamster ovary (CHO) cells. The concentration of BeSO4 required to kill 50% of CHO cells exposed to BeSO4 for 20 h was determined to...

journal_title：Radiation research

authors： Brooks AL,Griffith WC,Johnson NF,Finch GL,Cuddihy RG

更新日期：1989-12-01 00:00:00

abstract：:Alteration of the radiation-induced changes in wound contraction, collagen synthesis and wound histology by ascorbic acid was studied in mice exposed to 10, 16 and 20 Gy of fractionated (2 Gy/fraction) gamma radiation. The animals were given double-distilled water or ascorbic acid daily before exposure to 2 Gy/day of ...

journal_title：Radiation research

authors： Jagetia GC,Rajanikant GK,Rao SK

更新日期：2003-03-01 00:00:00

abstract：:We have investigated how radiation quality affects the induction of chromosomal aberrations in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated high charge and energy (HZE) particles including oxygen, neon, silicon, titanium and iron. Chromosome damage was assessed using thr...

journal_title：Radiation research

authors： George KA,Hada M,Chappell L,Cucinotta FA

更新日期：2013-07-01 00:00:00

abstract：:Groups of rats were administered different doses of X rays (7.5 and 15 Gy), and the effect on the permeability of their lungs was evaluated during a time frame within which radiation pneumonitis develops. Sham-exposed animals served as controls. End points surveyed included lung weight and increases in the total prote...

journal_title：Radiation research

authors： Gurley LR,London JE,Tietjen GL,van der Kogel AJ,Dethloff LA,Lehnert BE

更新日期：1993-05-01 00:00:00

abstract：:To examine more fully the nature of chromosomal radiosensitivity in ataxia telangiectasia (AT) cells, we employed 24-color combinatorial painting to visualize 137Cs gamma-ray-induced chromosome-type aberrations in cells of two AT and one normal primary human fibroblast strains irradiated in log-phase growth. As a meas...

journal_title：Radiation research

authors： Loucas BD,Cornforth MN

更新日期：2004-11-01 00:00:00

abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...

journal_title：Radiation research

authors： Baddour AAD,Apodaca LA,Alikhani L,Lu C,Minasyan H,Batra RS,Acharya MM,Baulch JE

更新日期：2020-01-01 00:00:00

abstract：:To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study o...

journal_title：Radiation research

authors： Fujiwara S,Kusumi S,Cologne J,Akahoshi M,Kodama K,Yoshizawa H

更新日期：2000-07-01 00:00:00

abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...

journal_title：Radiation research

authors： Beinke C,Barnard S,Boulay-Greene H,De Amicis A,De Sanctis S,Herodin F,Jones A,Kulka U,Lista F,Lloyd D,Martigne P,Moquet J,Oestreicher U,Romm H,Rothkamm K,Valente M,Meineke V,Braselmann H,Abend M

更新日期：2013-08-01 00:00:00

abstract：:Ionizing radiation can induce chromosome instability that is transmitted over many generations after irradiation in the progeny of surviving cells, but it remains unclear why this instability can be transmitted to the progeny. To acquire knowledge about the transmissible nature of genomic instability, we transferred a...

journal_title：Radiation research

authors： Mukaida N,Kodama S,Suzuki K,Oshimura M,Watanabe M

更新日期：2007-06-01 00:00:00

abstract：:To accurately quantify the number of single-strand breaks (SSBs) induced in plasmid DNA molecules after irradiation, a new type of assay methodology has been explored. The new method is based on the TUNEL (terminal deoxynucleotide transferase dUTP nick end-labeling) assay that was adopted for use under ELISA (enzyme-l...

journal_title：Radiation research

authors： Smiałek MA,Moore SA,Mason NJ,Shuker DE

更新日期：2009-11-01 00:00:00

abstract：:The radiation dose received by crew members in interplanetary space is influenced by the stage of the solar cycle. Using the recently developed models of the galactic cosmic radiation (GCR) environment and the energy-dependent radiation transport code, we have calculated the dose at 0 and 5 cm water depth; using a com...

journal_title：Radiation research

authors： Badhwar GD,Cucinotta FA,O'Neill PM

更新日期：1994-05-01 00:00:00

abstract：:Cells from patients with ataxia telangiectasia (AT) are abnormal in their response to irradiation as judged by clonogenic survival and accumulation in G2 phase. The relationship of the results of these two assays, however, is still a matter of controversy. Flow cytometry was used to measure the distribution of cells i...

journal_title：Radiation research

authors： Hong JH,Gatti RA,Huo YK,Chiang CS,McBride WH

更新日期：1994-10-01 00:00:00

abstract：:Growth retardation due to exposure to the atomic bomb has been evaluated using repeated measurements of stature from 10 to 18 years of age. A highly significant growth retardation due to the DS86 uterine dose was observed in all trimesters combined and in the first and second trimesters of pregnancy. In the first trim...

journal_title：Radiation research

authors： Otake M,Fujikoshi Y,Schull WJ,Izumi S

更新日期：1993-04-01 00:00:00

abstract：:Recent evidence has shown that translocation frequencies decline over time. This phenomenon might be explained by the co-occurrence of translocations in cells that also contain dicentrics, in which case translocations would be eliminated as a by-product of selection against dicentrics. Alternatively, a fraction of tra...

journal_title：Radiation research

authors： Gardner SN,Tucker JD

更新日期：2002-05-01 00:00:00

abstract：:Irradiation from internally deposited radionuclides induces malignant tumors. Ingested long-lived radionuclides accumulate in specific organs that are irradiated throughout life. To elucidate why the development of malignant tumors requires long-term internal exposure, of the order of decades, despite the fact that ir...

journal_title：Radiation research

authors： Yamamoto Y,Usuda N,Takatsuji T,Kuwahara Y,Fukumoto M

更新日期：2009-04-01 00:00:00

abstract：:Neurons are essential components of neural circuits and provide brain function organization. We previously reported that X irradiation induces apoptosis in immature neurons. To the best of our knowledge, there have been few reports investigating the effects of X irradiation on mature neurons. We analyzed the effects o...

journal_title：Radiation research

authors： Shirai K,Mizui T,Suzuki Y,Okamoto M,Hanamura K,Yoshida Y,Hino M,Noda SE,Al-jahdari WS,Chakravarti A,Shirao T,Nakano T

更新日期：2013-06-01 00:00:00

abstract：:Infusions of boronophenylalanine-fructose complex (BPA-F), at doses up to 900 mg/kg of BPA and 860 mg/kg of fructose, have been used to deliver boron to cancer tissue for boron neutron capture therapy (BNCT). In patients with phenylketonuria (PKU), phenylalanine accumulates, which is harmful in the long run. PKU has b...

journal_title：Radiation research

authors： Laakso J,Ruokonen I,Lapatto R,Kallio M

更新日期：2003-11-01 00:00:00

abstract：:An analytical expression is developed for calculating the average energy deposited by an ion in a volume with dimensions less than the range of the secondary electrons produced. The expression is obtained by including two additional terms in an energy-restricted linear-energy-transfer equation. The usual energy-restri...

journal_title：Radiation research

authors： Xapsos MA

更新日期：1992-12-01 00:00:00

abstract：:Ionizing radiation induces clustered DNA damage sites, whereby two or more individual DNA lesions are formed within one or two helical turns of DNA by a single radiation track. A subset of DNA clustered damage sites exist in which the lesions are located in tandem on the same DNA strand. Recent studies have establishe...

journal_title：Radiation research

authors： Lomax ME,Salje H,Cunniffe S,O'Neill P

更新日期：2005-01-01 00:00:00

abstract：:The percentage of T lymphocytes of atomic bomb survivors showed no change as a function of age or exposure dose. The percentage of T cells was slightly lower in malignant-tumor patients than in the control group, but was significantly higher in the group with chromosomal aberrations than in the control group. The perc...

journal_title：Radiation research

authors： Akiyama M,Yamakido M,Kobuke K,Dock DS,Hamilton HB,Awa AA,Kato H

更新日期：1983-03-01 00:00:00

abstract：:To determine whether exposure to radiofrequency (RF) radiation can induce DNA damage or apoptosis, Molt-4 T lymphoblastoid cells were exposed with RF fields at frequencies and modulations of the type used by wireless communication devices. Four types of frequency/modulation forms were studied: 847.74 MHz code-division...

journal_title：Radiation research

authors： Hook GJ,Zhang P,Lagroye I,Li L,Higashikubo R,Moros EG,Straube WL,Pickard WF,Baty JD,Roti Roti JL

更新日期：2004-02-01 00:00:00