Abstract：
:Tritium that is bound to organic molecules is of special risk for living systems, in particular when such molecules are components of the cell nucleus. Therefore, [3H]thymidine and [3H]arginine were studied for radiotoxicity in early mammalian embryo development. Starting with the two-cell stage, mouse embryos were incubated in vitro with [3H]thymidine or [3H]arginine at either 370 Bq/ml (10 nCi/ml) or 925 Bq/ml (25 nCi/ml). Development in vitro was followed up to the formation of the inner cell mass at 192 h postconception (p.c.). There was no difference in radiotoxicity of the two substances with respect to cell proliferation; however, formation of blastocysts, hatching of blastocysts, trophoblast outgrowth, and formation of inner cell mass were impaired more strongly by [3H]arginine than by [3H]thymidine when the external exposure concentrations were the same. Similarly, micronuclei were seen in blastocysts at 96 h p.c. at higher frequency after incubation with [3H]arginine. However, uptake of [3H]arginine by the embryos was considerably faster than that of [3H]thymidine, and this most probably accounts for the apparent difference in radiotoxicity.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Müller WU,Streffer C,Molls M,Glück Lsubject
Has Abstractpub_date
1987-05-01 00:00:00pages
192-8issue
2eissn
0033-7587issn
1938-5404journal_volume
110pub_type
杂志文章abstract：:Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative to normal cells, cancer cells are believed to exist under a condition of chronic mitochondrial oxidative stress that is compensated for by increases in gluc...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14668.1
更新日期：2017-06-01 00:00:00
abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14574.1
更新日期：2017-10-01 00:00:00
abstract：:The dependence of relative biological effectiveness (RBE) on photon energy is a topic of extensive discussions. The increasing amount of in vitro data in the low-energy region indicates this to be a complex dependence that is influenced by the end point and cell line studied. In the present investigation, the RBE of 1...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0874.1
更新日期：2008-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2478.1
更新日期：2011-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1667/RR15017.1
更新日期：2018-10-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RADE-20-00102.1
更新日期：2021-01-29 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1677.1
更新日期：2009-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)153[0587:aeowbp]2.0.co;2
更新日期：2000-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章,评审
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更新日期：2012-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3503.1
更新日期：2006-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Acute thermotolerance was induced in Chinese hamster ovary cells by heating at 43 degrees C for 45 min followed by incubation at 37 degrees C for up to 85 h. The degree of thermotolerance induced was quantified by a second heat exposure at 43 degrees C. To study the interaction of thermotolerance and thermosensitizati...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14191.1
更新日期：2015-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)154[0326:todiiq]2.0.co;2
更新日期：2000-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
