Abstract:
:Tritium that is bound to organic molecules is of special risk for living systems, in particular when such molecules are components of the cell nucleus. Therefore, [3H]thymidine and [3H]arginine were studied for radiotoxicity in early mammalian embryo development. Starting with the two-cell stage, mouse embryos were incubated in vitro with [3H]thymidine or [3H]arginine at either 370 Bq/ml (10 nCi/ml) or 925 Bq/ml (25 nCi/ml). Development in vitro was followed up to the formation of the inner cell mass at 192 h postconception (p.c.). There was no difference in radiotoxicity of the two substances with respect to cell proliferation; however, formation of blastocysts, hatching of blastocysts, trophoblast outgrowth, and formation of inner cell mass were impaired more strongly by [3H]arginine than by [3H]thymidine when the external exposure concentrations were the same. Similarly, micronuclei were seen in blastocysts at 96 h p.c. at higher frequency after incubation with [3H]arginine. However, uptake of [3H]arginine by the embryos was considerably faster than that of [3H]thymidine, and this most probably accounts for the apparent difference in radiotoxicity.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Müller WU,Streffer C,Molls M,Glück Lsubject
Has Abstractpub_date
1987-05-01 00:00:00pages
192-8issue
2eissn
0033-7587issn
1938-5404journal_volume
110pub_type
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journal_title:Radiation research
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journal_title:Radiation research
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更新日期:1986-03-01 00:00:00
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更新日期:2012-04-01 00:00:00
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journal_title:Radiation research
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更新日期:1994-10-01 00:00:00
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doi:
更新日期:1999-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
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doi:
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
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journal_title:Radiation research
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doi:
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更新日期:1995-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Radiation research
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更新日期:1986-02-01 00:00:00
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journal_title:Radiation research
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doi:
更新日期:1998-07-01 00:00:00