The Exploitation of Low-Energy Electrons in Cancer Treatment.

abstract：:Radiation exposure leads to a risk for long-term deterministic and stochastic late effects. Two individuals exposed to protracted photon radiation in the radiological accident at the Lilo Military site in Georgia in 1997 received follow-up treatment and resection of several chronic radiation ulcers in the Bundeswehr H...

journal_title：Radiation research

authors： Scherthan H,Abend M,Müller K,Beinke C,Braselmann H,Zitzelsberger H,Köhn FM,Pillekamp H,Schiener R,Das O,Peter RU,Herzog G,Tzschach A,Dörr HD,Fliedner TM,Meineke V

更新日期：2007-05-01 00:00:00

abstract：:Radiation of the esophagus of C3H/HeNsd mice with 35 or 37 Gy of 6 MV X rays induces significantly increased RNA transcription for interleukin 1 (Il1), tumor necrosis factor alpha (Tnf), interferon gamma inducing factor (Ifngr), and interferon gamma (Ifng). These elevations are associated with DNA damage that is detec...

journal_title：Radiation research

authors： Epperly MW,Gretton JA,DeFilippi SJ,Greenberger JS,Sikora CA,Liggitt D,Koe G

更新日期：2001-01-01 00:00:00

abstract：:We investigated delayed reproductive death and chromosome bridge formation in mitotic cells in colonies of normal human embryonic cells which survived exposure to 6 Gy of X rays. Eighteen primary clones each derived from control and irradiated cultures were isolated and secondary colonies were grown up. Six of the pri...

journal_title：Radiation research

authors： Suzuki K,Takahara R,Kodama S,Watanabe M

更新日期：1998-10-01 00:00:00

abstract：:Nonhuman organisms are being exposed to ionizing radiations at radionuclide-contaminated sites around the world. Direct methods are seldom available for measuring biologically relevant doses received by these organisms. Here we extend biological dosimetry techniques, which are much better developed for humans and a fe...

journal_title：Radiation research

authors： Ulsh BA,Mühlmann-Díaz MC,Whicker FW,Hinton TG,Congdon JD,Bedford JS

更新日期：2000-06-01 00:00:00

abstract：:The photodynamic properties of a second-generation photodynamic sensitizer, meta-tetra(hydroxyphenyl)chlorin (mTHPC) were studied by dye-sensitized photoinactivation (650 nm) of HT29 human adenocarcinoma cells in culture. The photocytotoxicity of mTHPC in vitro depended on the presence of molecular oxygen. A strong in...

journal_title：Radiation research

authors： Melnikova VO,Bezdetnaya LN,Potapenko AY,Guillemin F

更新日期：1999-10-01 00:00:00

abstract：:The mechanisms underlying hepatocellular damage after irradiation are obscure. We identified genes induced by radiation in isolated rat hepatocytes in vitro by cDNA array gene expression analysis and then screened in vivo experiments with those same genes using real-time PCR and Western blotting. Hepatocytes were irra...

journal_title：Radiation research

authors： Christiansen H,Batusic D,Saile B,Hermann RM,Dudas J,Rave-Frank M,Hess CF,Schmidberger H,Ramadori G

更新日期：2006-03-01 00:00:00

abstract：:This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together t...

journal_title：Radiation research

authors： Pierce DA,Shimizu Y,Preston DL,Vaeth M,Mabuchi K

更新日期：1996-07-01 00:00:00

abstract：:To evaluate the function of the reticuloendothelial system and macrophage-monocyte system, blood samples from Thorotrast patients and age-matched healthy controls were used to determine the titer of plasma antibodies to lipid A and the numbers of several lymphocyte subclasses in peripheral blood and for an autoradiogr...

journal_title：Radiation research

authors： Abe H,Kawahara T,Gondou K,Sakisaka S,Sata M

更新日期：1999-12-01 00:00:00

abstract：:The relationship between intracellular and extracellular pH was investigated in a murine tumor and normal tissue, prior to and following glucose injection. Isotransplants of the murine tumor FSa-II in the dorsum of the hind foot and leg muscle, were investigated in nonanesthetized mice. Extracellular pH was measured w...

journal_title：Radiation research

authors： Gerweck LE,Rhee JG,Koutcher JA,Song CW,Urano M

更新日期：1991-05-01 00:00:00

abstract：:The growth of certain UV-radiation-induced tumors is suppressed by T lymphocytes, but it has been proposed that non-T lymphocytes stimulate the growth of several of these tumors. In this study, the indirect effects of X irradiation on the growth of one such tumor in T-cell-deficient nude mice was tested. Even when the...

journal_title：Radiation research

authors： Seung LP,Weichselbaum RR,Toledano A,Schreiber K,Schreiber H

更新日期：1996-12-01 00:00:00

abstract：:Changes in the free-cell population of the lungs of two strains of mice (SAS/4 and CBA/H) were studied up to 4 months after inhalation exposure to a sized fraction of 239PuO2 particles (1.5 micron AMAD) to give initial alveolar depositions (IADs) ranging from 17 to 810 Bq. A sample of the free-cell population of the l...

journal_title：Radiation research

authors： Moores SR,Talbot RJ,Evans N,Lambert BE

更新日期：1986-03-01 00:00:00

abstract：:The International Commission on Radiation Protection (ICRP) has lowered the dose limits for workers and for the general public exposed to ionizing radiation. Consequently, a reliable dosimetric method for monitoring possible radiation-induced damage is of great importance in radioprotection. The counting of dicentric ...

journal_title：Radiation research

authors： Amendola R,Basso E,Pacifici PG,Piras E,Giovanetti A,Volpato C,Romeo G

更新日期：2006-05-01 00:00:00

abstract：:Single crystals of guanine hydrobromide monohydrate, in which the guanine base is protonated at N7, were X-irradiated at 8 and 65 K. Using K-band ESR, ENDOR, and field-swept-ENDOR (FSE) techniques, the crystals were studied between 8 K and room temperature. There was evidence for five different radicals, RI-RV, immedi...

journal_title：Radiation research

authors： Hole EO,Sagstuen E,Nelson WH,Close DM

更新日期：1991-02-01 00:00:00

abstract：:Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approximately 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a ...

journal_title：Radiation research

authors： Choofong S,Cloutier P,Sanche L,Wagner JR

更新日期：2016-11-01 00:00:00

abstract：:The German Thorotrast study comprises 2,326 patients and 1,890 controls. Forty-eight Thorotrast patients and 239 controls are still alive and are invited for a follow-up examination every 2 years. In the deceased patients, the following neoplastic diseases with excess rates were registered (Thorotrast/controls): liver...

journal_title：Radiation research

authors： van Kaick G,Dalheimer A,Hornik S,Kaul A,Liebermann D,Lührs H,Spiethoff A,Wegener K,Wesch H

更新日期：1999-12-01 00:00:00

abstract：:Proton exposure induces mutations and cancer, which are presumably linked. Because protons are abundant in the space environment and significant uncertainties exist for the effects of space travel on human health, the purpose of this study was to identify the types of mutations induced by exposure of mammalian cells t...

journal_title：Radiation research

authors： Turker MS,Grygoryev D,Dan C,Eckelmann B,Lasarev M,Gauny S,Kwoh E,Kronenberg A

更新日期：2013-05-01 00:00:00

abstract：:There has been increased interest in the immune stimulatory properties of ionizing radiation based on several preclinical models and recently completed clinical studies performed in combination with checkpoint inhibitors. This is a paradigm shift in that it considers the role of radiation beyond its direct cytotoxic e...

journal_title：Radiation research

authors： Iyer SP,Hunt CR,Pandita TK

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to test the efficacy of captopril, an angiotensin-converting enzyme inhibitor and a known suppressor of fibrosis, in preventing late radiation-induced cardiac pathology. Myocardial functional, histochemical and ultrastructural-morphometric studies were done on perfused hearts of rats isolated...

journal_title：Radiation research

authors： Yarom R,Harper IS,Wynchank S,van Schalkwyk D,Madhoo J,Williams K,Salie R,Genade S,Lochner A

更新日期：1993-02-01 00:00:00

abstract：:Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in Sfpi1 on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of the Sfpi1 gene (DSG) and point mutation of the allele Sfpi1 gene (PMASG). In this study, we ...

journal_title：Radiation research

authors： Ojima M,Hirouchi T,Etani R,Ariyoshi K,Fujishima Y,Kai M

更新日期：2019-12-01 00:00:00

abstract：:Very low doses of ionizing radiation, 5 to 100 mGy, can induce adaptive responses characterized by elevation in cell survival and reduction in micronuclei formation. Utilizing these end points, RKO human colon carcinoma and transformed mouse embryo fibroblasts (MEF), wild-type or knockout cells missing TNF receptors 1...

journal_title：Radiation research

authors： Grdina DJ,Murley JS,Miller RC,Mauceri HJ,Sutton HG,Thirman MJ,Li JJ,Woloschak GE,Weichselbaum RR

更新日期：2013-02-01 00:00:00

abstract：:The immunocytochemical response to DNA damage induced by low-energy bismuth and carbon ions was investigated in normal human fibroblasts. Inside the nuclei, the traversing charged particles lead to the accumulation of proteins related to DNA lesions and repair along the ion trajectories. Irradiation under a standard g...

journal_title：Radiation research

authors： Jakob B,Scholz M,Taucher-Scholz G

更新日期：2003-05-01 00:00:00

abstract：:The effects of amiloride (an inhibitor of Na+/H+ antiport), DIDS (an inhibitor of Na(+)-coupled and Na(+)-independent HCO3-/Cl- exchange) and nigericin (K+/H+ ionophore) alone and in various combinations on the intracellular pH (pHi) and thermosensitivity of SCK tumor cells were studied. Hyperthermia alone at 43 degre...

journal_title：Radiation research

authors： Lyons JC,Kim GE,Song CW

更新日期：1992-01-01 00:00:00

abstract：:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...

journal_title：Radiation research

authors： Wang K,Zha Y,Lei H,Xu X

更新日期：2018-02-01 00:00:00

abstract：:At the outset of the accident at Fukushima Daiichi Nuclear Power Plant in March 2011, the radiation doses experienced by residents were calculated from the readings at monitoring posts, with several assumptions being made from the point of view of protection and safety. However, health effects should also be estimated...

journal_title：Radiation research

authors： Nagataki S,Takamura N,Kamiya K,Akashi M

更新日期：2013-11-01 00:00:00

abstract：:Puskin, J. S. What Can Epidemiology Tell Us about Risks at Low Doses? Radiat. Res. 169, 122-124 (2008). Limitations on statistical power preclude direct detection and quantification of radiogenic cancer risks at very low (environmental) levels of low-LET radiation through epidemiological studies. Given this limitation...

journal_title：Radiation research

authors： Puskin JS

更新日期：2008-01-01 00:00:00

abstract：:The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the intestine after total body irradiation (TBI) have not been systematically studied in this model. Here we report on our current study of TBI-induced intestinal s...

journal_title：Radiation research

authors： Wang J,Shao L,Hendrickson HP,Liu L,Chang J,Luo Y,Seng J,Pouliot M,Authier S,Zhou D,Allaben W,Hauer-Jensen M

更新日期：2015-11-01 00:00:00

abstract：:It has been shown that several X-ray-sensitive Chinese hamster cell mutants defective in repair of DNA double-strand breaks (DSBs) are also impaired in the process of V(D)J recombination. The hamster mutants with this phenotype represent three distinct complementation groups, represented by the xrs series, XR-1 and V-...

journal_title：Radiation research

authors： Zdzienicka MZ,Jongmans W,Oshimura M,Priestley A,Whitmore GF,Jeggo PA

更新日期：1995-09-01 00:00:00

abstract：:The analysis of mitotic indices (MI) and chromosome breakages in metaphases of 50-hr lymphocyte cultures exposed to the calcium or zinc chelates of diethylenetriamine pentaacetic acid (DTPA) demonstrated: (1) an 80% reduction in MI in cultures from three women but no reduction in those from two men after in vitro expo...

journal_title：Radiation research

authors： Littlefield LG,Joiner EE,Colyer SP,DuFrain RJ,Washburn LC

更新日期：1984-07-01 00:00:00

abstract：:In the decade after the bombings of Hiroshima and Nagasaki, several large cohorts of survivors were organized for studies of radiation health effects. The U.S. Atomic Bomb Casualty Commission (ABCC) and its U.S./Japan successor, the Radiation Effects Research Foundation (RERF), have performed continuous studies since ...

journal_title：Radiation research

authors： Cullings HM,Fujita S,Funamoto S,Grant EJ,Kerr GD,Preston DL

更新日期：2006-07-01 00:00:00

abstract：:Radiation exposure causes DNA breaks leading to structural chromosome aberrations that can be carcinogenic. Lifetime cancer risks are elevated in irradiated children compared to similarly exposed adults. To determine the extent to which age influences the frequency and types of chromosome damage in response to ionizin...

journal_title：Radiation research

authors： Bakhmutsky MV,Joiner MC,Jones TB,Tucker JD

更新日期：2014-06-01 00:00:00