Abstract:
:The photodynamic properties of a second-generation photodynamic sensitizer, meta-tetra(hydroxyphenyl)chlorin (mTHPC) were studied by dye-sensitized photoinactivation (650 nm) of HT29 human adenocarcinoma cells in culture. The photocytotoxicity of mTHPC in vitro depended on the presence of molecular oxygen. A strong inhibition of the photocytotoxicity of mTHPC was observed upon addition of sodium azide, a known singlet oxygen quencher. Photocytotoxicity was not inhibited by scavengers of superoxide anion radical, hydrogen peroxide and hydroxyl radicals. We suggest that mTHPC photosensitizes cell killing predominantly by type II, singlet oxygen-mediated photodynamic reactions. Illumination of cells preloaded with mTHPC induced peroxidation of membrane lipids. Inhibition of photoperoxidation by alpha-tocopherol (0.1 mM) present during illumination did not result in any decrease in toxicity, suggesting that reactions of lipid peroxidation play only a minor role in the overall photocytotoxic effect of mTHPC.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Melnikova VO,Bezdetnaya LN,Potapenko AY,Guillemin Fsubject
Has Abstractpub_date
1999-10-01 00:00:00pages
428-35issue
4eissn
0033-7587issn
1938-5404journal_volume
152pub_type
杂志文章abstract::The detection of (41)Ca atoms in tooth enamel using accelerator mass spectrometry is suggested as a method capable of reconstructing thermal neutron exposures from atomic bomb survivors in Hiroshima and Nagasaki. In general, (41)Ca atoms are produced via thermal neutron capture by stable (40)Ca. Thus any (41)Ca atoms ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2043.1
更新日期:2010-08-01 00:00:00
abstract::The increasingly wider use of microdosimetry in fields other than pure radiobiological research, especially in "practical" domains such as radiation protection and medical physics, has created a number of new practitioners who are not fully acquainted with many of the experimental pitfalls which beset the aspiring mic...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::1. A survival curve for the colony-forming ability of mouse bone marrow cells irradiated in vivo with Co60 gamma-rays has been obtained. The curve may be characterized by D0 of 95 rads and an extrapolation number of 1.5. 2. Comparison with the survival curve obtained for irradiated in vitro indicated a statistically s...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1962-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2127.1
更新日期:2010-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0424:tsgbac]2.0.co;2
更新日期:2002-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR13780.1
更新日期:2015-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::Molecular imaging is an evolving science that is concerned with the development of novel imaging probes and biomarkers that can be used to non-invasively image molecular and cellular processes. This special issue approaches molecular imaging in the context of radiation research, focusing on biomarkers and imaging meth...
journal_title:Radiation research
pub_type:
doi:10.1667/rr2959.1
更新日期:2012-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Thymic explant cultures were used to study the radiosensitivity of nonlymphoid thymic components in dogs. Thymic fragments from fetal (50 days gestation), newborn, and juvenile (70 days old) dogs were irradiated in vitro at 0, 0.5, 1, 2, or 4 Gy prior to culture. Colonies were classified as epithelial, spindle, or mix...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::The LD50 of 46 salts of metals and rare earths (lanthanoids) was determined in mice. Half the LD50 of the compounds was then combined with lethal radiation (10.5 Gy) and the modification of survival time was scored. Only the metals beryllium and indium and the rare earths cerium, lanthanum and scandium displayed activ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::If the limited life span of hematopoietic tissues in vitro is due to a finite proliferative capacity of individual stem cells, one might expect tissues of young donors to possess a greater proliferative capacity and to contain a larger population of primitive stem cells than those of older donors. To test this hypothe...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14686.1
更新日期:2017-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1677.1
更新日期:2009-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::Currently, there is a serious absence of pharmaceutically attractive small molecules that mitigate the lethal effects of an accidental or intentional public exposure to toxic doses of ionizing radiation. Moreover, cellular systems that emulate the radiobiologically relevant cell populations and that are suitable for h...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr2810.1
更新日期:2012-09-01 00:00:00
abstract::Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3203
更新日期:2004-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15013.1
更新日期:2018-09-01 00:00:00
abstract::Hyperthermic sensitivities of Escherichia coli B/r and Bs-1 were determined for lag-, midlog-, and stationary-phase cells at 47, 48, and 49 degrees C. In both strains midlog-phase cells were strikingly more heat sensitive (100-fold greater killing after 4 h at 48 degrees C) than stationary-phase cells, with intermedia...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1968-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3374
更新日期:2005-06-01 00:00:00
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journal_title:Radiation research
pub_type:
doi:10.1667/RR14810.1
更新日期:2017-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00