Abstract:
:In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there exists the real possibility that safety of nuclear power reactors could be compromised by natural (such as the tsunami and subsequent Fukushima accident in Japan in March, 2011) or accidental (Three Mile Island, 1979 and Chernobyl, 1986) events. Although progress has been made by governments around the world to prepare for these events, including the stockpiling of radiation countermeasures, there are still challenges concerning care of patients injured during a radiation incident. Because the deleterious and pathological effects of radiation are so broad, it is desirable to identify medical countermeasures that can have a beneficial impact on several tissues and organ systems. Cellular therapies have the potential to impact recovery and tissue/organ regeneration for both early and late complications of radiation exposure. These therapies, which could include stem or blood progenitor cells, mesenchymal stromal cells (MSCs) or cells derived from other tissues (e.g., endothelium or placenta), have shown great promise in treating other nonradiation injuries to and diseases of the bone marrow, skin, gastrointestinal tract, brain, lung and heart. To explore the potential use of these therapies in the treatment of victims after acute radiation exposure, the National Institute of Allergy and Infectious Diseases co-sponsored an international workshop in July, 2015 in Paris, France with the Institut de Radioprotection et de Sûreté Nucléaire. The workshop included discussions of data available from testing in preclinical models of radiation injury to different organs, logistics associated with the practical use of cellular therapies for a mass casualty incident, as well as international regulatory requirements for authorizing such drug products to be legally and readily used in such incidents. This report reviews the data presented, as well as key discussion points from the meeting.
journal_name
Radiat Resjournal_title
Radiation researchauthors
DiCarlo AL,Tamarat R,Rios CI,Benderitter M,Czarniecki CW,Allio TC,Macchiarini F,Maidment BW,Jourdain JRdoi
10.1667/RR14810.1subject
Has Abstractpub_date
2017-08-01 00:00:00pages
e54-e75issue
2eissn
0033-7587issn
1938-5404journal_volume
188pub_type
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doi:
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journal_title:Radiation research
pub_type: 杂志文章
doi:
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journal_title:Radiation research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:10.1667/RR14653.1
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0523:ddamii]2.0.co;2
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pub_type: 杂志文章
doi:
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doi:10.1667/rr3395.1
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journal_title:Radiation research
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doi:10.1667/0033-7587(2003)159[0775:eotsmf]2.0.co;2
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doi:10.1667/rr3360
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
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doi:
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doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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journal_title:Radiation research
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doi:
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