Abstract:
:An understanding of proton radiobiology is critical for optimization of both proton radiotherapy and assessment of carcinogenesis risk from space radiation. Although the physical aspects of proton beam radiobiology is well understood, the biological aspects, particularly the complex biological end points, have been underexplored and underexploited. This review focuses on the biological responses observed to date, across various scales, molecular, cellular and especially tissue levels. Proton-induced perturbations of gene expression, along with signaling and functional alterations in cell cycle, invasion, angiogenesis and metastasis are included. Particular emphasis is placed on differences noted in the literature between biological effects induced by protons and those induced by high-energy photons. An appreciation of the unique physical and biological characteristics of proton radiobiology should augment current strategies both to enhance therapeutic effectiveness and to quantify risk related to proton irradiation.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Girdhani S,Sachs R,Hlatky Ldoi
10.1667/RR2839.1subject
Has Abstractpub_date
2013-03-01 00:00:00pages
257-72issue
3eissn
0033-7587issn
1938-5404journal_volume
179pub_type
杂志文章,评审abstract::Radiation exposure causes DNA breaks leading to structural chromosome aberrations that can be carcinogenic. Lifetime cancer risks are elevated in irradiated children compared to similarly exposed adults. To determine the extent to which age influences the frequency and types of chromosome damage in response to ionizin...
journal_title:Radiation research
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doi:10.1667/RR13598.1
更新日期:2014-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3027
更新日期:2003-08-01 00:00:00
abstract::Intestinal microbiota affect cell responses to ionizing radiation at the molecular level and can be linked to the development of the immune system, controlled cell death or apoptosis. We have developed a microbiota mouse model and report here that high-linear energy transfer (LET) radiation induced the repair of chrom...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR13837.1
更新日期:2015-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR3010.1
更新日期:2013-02-01 00:00:00
abstract::Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::A dose of heat which renders 98% of a population of Chinese hamster ovary cells reproductively dead has no significant effect on their Na+, K+, or Mg2+ content by 28 h postheat. In contrast, the cellular Ca2+ content increases in a dose-dependent manner as observed at 22 h after heating for 15-35 min at 45 degrees C. ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract::The effect of exposure of human epidermal keratinocytes to ionizing radiation, both in vivo and in vitro, on the expression of the epidermal growth factor receptor (EGF-R) was studied on the protein, mRNA, and functional levels. Quantitative fluorometry of short-term organ cultures incubated with a monoclonal antibody...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::We have previously proposed that survival curves for cells of murine NFSa fibrosarcomas after exposure to fast neutrons might demonstrate curvature when the neutron doses reach a level high enough to cure the fibrosarcomas. We report here that this is the case. Murine NFSa fibrosarcomas growing in the hind legs of syn...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Groups of rats were administered different doses of X rays (7.5 and 15 Gy), and the effect on the permeability of their lungs was evaluated during a time frame within which radiation pneumonitis develops. Sham-exposed animals served as controls. End points surveyed included lung weight and increases in the total prote...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::We previously reported that a priming dose of 0.3 Gy on gestation day 11 significantly increased the rate of living fetuses and reduced the incidence of congenital malformations caused by exposure to 5 Gy X rays on gestation day 12 in ICR mice. In the present study, postnatal development of the live offspring was inve...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::The analysis of mitotic indices (MI) and chromosome breakages in metaphases of 50-hr lymphocyte cultures exposed to the calcium or zinc chelates of diethylenetriamine pentaacetic acid (DTPA) demonstrated: (1) an 80% reduction in MI in cultures from three women but no reduction in those from two men after in vitro expo...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Radiation research
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更新日期:2008-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3146
更新日期:2004-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2165.1
更新日期:2010-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR0663.1
更新日期:2006-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1684.1
更新日期:2009-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
abstract::To determine whether different agents that enhance the expression of potentially lethal X-ray damage (PLD) interact with the same or different lesions (or spectrum of lesions), cell killing was measured in three kinds of experiments: (1) When cells were irradiated in G1 phase and treated with caffeine or hydroxyurea a...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.2307/3579621
更新日期:1997-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
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journal_title:Radiation research
pub_type:
doi:
更新日期:1998-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-29 00:00:00