Oncogenic transformation of C3H 10T1/2 cells by acute and protracted exposures to monoenergetic neutrons.

abstract：:The German Thorotrast study comprises 2,326 patients and 1,890 controls. Forty-eight Thorotrast patients and 239 controls are still alive and are invited for a follow-up examination every 2 years. In the deceased patients, the following neoplastic diseases with excess rates were registered (Thorotrast/controls): liver...

journal_title：Radiation research

authors： van Kaick G,Dalheimer A,Hornik S,Kaul A,Liebermann D,Lührs H,Spiethoff A,Wegener K,Wesch H

更新日期：1999-12-01 00:00:00

abstract：:Cellular and molecular repair was studied at 23 degrees C using split-dose recovery and alkaline elution techniques, respectively, as a function of cellular oxygen and nutrient conditions. Hypoxic cells (0.001% O2) in full medium showed a partial reduction in the level of sublethal damage (SLD) repair relative to aera...

journal_title：Radiation research

authors： Spiro IJ,Kennedy KA,Stickler R,Ling CC

更新日期：1985-01-01 00:00:00

abstract：:The flow cytometry mutation assay is based on detecting mutations in the CD59 gene on human chromosome 11 in CHO A(L) cells with flow cytometry, but the kinetics of mutant expression and the histogram region for mutant selection have not been studied in detail. CHO A(L) cells were analyzed by flow cytometry for CD59 e...

journal_title：Radiation research

authors： Ross CD,Fox MH

更新日期：2008-11-01 00:00:00

abstract：:A recently developed method for the direct measurement of the restricted dose mean LET (cutoff energy = 500 eV) of an unspecified photon or electron radiation field with the high-pressure ionization chamber has been utilized to investigate the variation of this radiobiologically important parameter outside the primary...

journal_title：Radiation research

authors： Makrigiorgos G,Antonadou D

更新日期：1987-04-01 00:00:00

abstract：:Single crystals of anhydrous inosine were studied subsequent to exposure to high and low doses of X radiation at 10 K using K-band, EPR, ENDOR, and field-swept-ENDOR (FSE) techniques. Immediately following high radiation doses at 10 K at least eight different radicals, RI-RVIII, were observed. All radicals, except for...

journal_title：Radiation research

authors： Hole EO,Nelson WH,Sagstuen E,Close DM

更新日期：1992-05-01 00:00:00

abstract：:The effect of acute exposure to ultrawideband (UWB) electromagnetic radiation on the Primate Equilibrium Platform (PEP) task, where the monkey's task is to manipulate a joystick control to compensate for the random perturbations in the pitch plane that are generated by a computer at unpredictable intervals, was examin...

journal_title：Radiation research

authors： Sherry CJ,Blick DW,Walters TJ,Brown GC,Murphy MR

更新日期：1995-07-01 00:00:00

abstract：:Abstract Pataky, K., Villanueva, G., Liani, A., Zgheib, O., Jenkins, N., Halazonetis, D. J., Halazonetis, T. D. and Brugger, J. Microcollimator for Micrometer-Wide Stripe Irradiation of Cells Using 20-30 keV X Rays. Radiat. Res. 172, 252-259 (2009). The exposure of subnuclear compartments of cells to ionizing radiatio...

journal_title：Radiation research

authors： Pataky K,Villanueva G,Liani A,Zgheib O,Jenkins N,Halazonetis DJ,Halazonetis TD,Brugger J

更新日期：2009-08-01 00:00:00

abstract：:The molecular basis of radiotherapy-related multidrug resistance (MDR) is still unclear. Here we report on a study investigating the effect of fractionated irradiation on expression of the MDR-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance-related protein ...

journal_title：Radiation research

authors： Bottke D,Koychev D,Busse A,Heufelder K,Wiegel T,Thiel E,Hinkelbein W,Keilholz U

更新日期：2008-07-01 00:00:00

abstract：:In previous studies, flavonoids, orientin and vicenin, that were isolated from the leaf extract of Ocimum sanctum, were found to protect mice against radiation injury. Several flavonoids are known to be good antioxidants. Therefore, the effect of orientin and vicenin on radiation-induced lipid peroxidation in vivo and...

journal_title：Radiation research

authors： Uma Devi P,Ganasoundari A,Vrinda B,Srinivasan KK,Unnikrishnan MK

更新日期：2000-10-01 00:00:00

abstract：:To determine the linear energy transfer (LET) dependence of the biological effects of densely ionizing radiation in relation to changes in the ionization density along the track, we measured the yields and spectrum of clustered DNA damages induced by charged particles of different atomic number but similar kinetic ene...

journal_title：Radiation research

authors： Keszenman DJ,Sutherland BM

更新日期：2010-08-01 00:00:00

abstract：:Oncogenic transformation of C3H 10T1/2 cells was determined after exposure to graded doses of 4.3-MeV alpha particles LET = 101 keV/microns. The source of alpha particles was 244Cm and the irradiation was done in an irradiation chamber built for the purpose. Graded doses in the range of 0.2 to 300 cGy were studied wit...

journal_title：Radiation research

authors： Bettega D,Calzolari P,Chiorda GN,Tallone-Lombardi L

更新日期：1992-07-01 00:00:00

abstract：:The nature of the primary biochemical defect in the human radiosensitive and cancer-prone syndrome, ataxia telangiectasia (AT), has remained obscure despite many efforts to elucidate it. In this study, AT complementation group D cells and a nearly isogenic corrected AT-hamster hybrid derivative have been analyzed for ...

journal_title：Radiation research

authors： Kysela BP,Lohrer H,Arrand JE

更新日期：1995-12-01 00:00:00

abstract：:The aim of this study was to test the efficacy of captopril, an angiotensin-converting enzyme inhibitor and a known suppressor of fibrosis, in preventing late radiation-induced cardiac pathology. Myocardial functional, histochemical and ultrastructural-morphometric studies were done on perfused hearts of rats isolated...

journal_title：Radiation research

authors： Yarom R,Harper IS,Wynchank S,van Schalkwyk D,Madhoo J,Williams K,Salie R,Genade S,Lochner A

更新日期：1993-02-01 00:00:00

abstract：:Bcl-X(S) is a pro-apoptosis member of the Bcl2 family that has been shown to induce cell death and enhance chemosensitivity. We have investigated the effect of Bcl-X(S) overexpression on radiation sensitivity. Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and ...

journal_title：Radiation research

authors： Morgan MA,Poynter JN,Maybaum J,Lawrence TS

更新日期：2004-05-01 00:00:00

abstract：:This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 L...

journal_title：Radiation research

authors： Ozasa K,Shimizu Y,Suyama A,Kasagi F,Soda M,Grant EJ,Sakata R,Sugiyama H,Kodama K

更新日期：2012-03-01 00:00:00

abstract：:These experiments were designed to study the kinetics and magnitude of cell repair and repopulation in tissues whose damage results in the tumor bed effect. The right hind thighs of mice were irradiated with single doses or two equal gamma-ray fractions. Interfraction intervals ranging from 30 min to 24 h (to measure ...

journal_title：Radiation research

authors： Terry NH,Ang KK,Hunter NR,Milas L

更新日期：1988-06-01 00:00:00

abstract：:Human erythrocytes were isolated from the blood of healthy donors and then incubated in the presence of suspensions of alpha-tocopherol for 30 min at 37 degrees C. Unabsorbed tocopherol was removed by centrifugation using several washes of isotonic phosphate-buffered saline. Washed erythrocytes were resuspended to 0.0...

journal_title：Radiation research

authors： Brown MA

更新日期：1983-08-01 00:00:00

abstract：:We have manipulated the extracellular Ca2+ concentration (1.8 mM in normal Dulbecco's modified Eagle's medium) to test whether the resulting effect on intracellular free Ca2+ homeostasis was similar in heat-sterilized and nonheated mouse NIH-3T3 cells. The responsiveness of the intracellular free Ca2+ concentration to...

journal_title：Radiation research

authors： Wang ZH,Vidair CA,Dewey WC

更新日期：1991-10-01 00:00:00

abstract：:Cisplatin and binuclear rhodium (Rh2) carboxylates appear to potentiate radiation-induced killing of Salmonella typhimurium cells largely as a consequence of one-electron reduction that leads to an active radiolytic product. This conclusion is supported by results from experiments wherein the hydrated electron and the...

journal_title：Radiation research

authors： Richmond RC,Mahtani HK

更新日期：1991-07-01 00:00:00

abstract：:Animal models of hematopoietic and gastrointestinal acute radiation syndromes (ARS) have been characterized to develop medical countermeasures. Acute radiation-induced decrease of intestinal absorptive function has been correlated to a decrease in the number of intestinal crypt cells resulting from apoptosis and enter...

journal_title：Radiation research

authors： Bujold K,Hauer-Jensen M,Donini O,Rumage A,Hartman D,Hendrickson HP,Stamatopoulos J,Naraghi H,Pouliot M,Ascah A,Sebastian M,Pugsley MK,Wong K,Authier S

更新日期：2016-07-01 00:00:00

abstract：:Human peripheral blood samples collected from three healthy human volunteers were exposed in vitro to pulsed-wave 2450 MHz radiofrequency (RF) radiation for 2 h. The RF radiation was generated with a net forward power of 21 W and transmitted from a standard gain rectangular antenna horn in a vertically downward direct...

journal_title：Radiation research

authors： Vijayalaxmi,Leal BZ,Szilagyi M,Prihoda TJ,Meltz ML

更新日期：2000-04-01 00:00:00

abstract：:Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid], and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of 137Cs radiation. No signific...

journal_title：Radiation research

authors： Verhey LJ,Sedlacek R

更新日期：1983-01-01 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...

journal_title：Radiation research

authors： Ivey RG,Moore HD,Voytovich UJ,Thienes CP,Lorentzen TD,Pogosova-Agadjanyan EL,Frayo S,Izaguirre VK,Lundberg SJ,Hedin L,Badiozamani KR,Hoofnagle AN,Stirewalt DL,Wang P,Georges GE,Gopal AK,Paulovich AG

更新日期：2011-03-01 00:00:00

abstract：:Rat females were exposed to a single 4.0-Gy gamma-ray dose and treated postradiation with a mixture of ATP-AET-mexamine at daily doses of 24, 12, and 3 mg/kg body wt, respectively, in drinking water throughout the period of their survival. With the radiation dose used, life shortening appeared primarily attributable t...

journal_title：Radiation research

authors： Benova DK,Kiradzhiev GD,Troitskaya MN,Anisimov VN

更新日期：1985-01-01 00:00:00

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with acceler...

journal_title：Radiation research

authors： Nomura T,Sakai K,Ogata H,Magae J

更新日期：2013-06-01 00:00:00

abstract：:The radiosensitivity of cultured HeLa cells was increased upon depletion of the natural cellular polyamines putrescine, spermidine and spermine through treatment of cultures with inhibitors of polyamine biosynthesis. This increased radiosensitivity was manifested as a decrease in the D0 and by the absence of a shoulde...

journal_title：Radiation research

authors： Snyder RD,Schroeder KK

更新日期：1994-01-01 00:00:00

abstract：:To estimate the effect of 50 Hz magnetic-field exposure on genome-wide gene expression, the yeast Saccharomyces cerevisiae was used as a model for eukaryotes. 2D PAGE (about 1,000 spots) for protein and cDNA microarray (about 5,900 genes) analysis for mRNA were performed. The cells were exposed to 50 Hz vertical magne...

journal_title：Radiation research

authors： Nakasono S,Laramee C,Saiki H,McLeod KJ

更新日期：2003-07-01 00:00:00

abstract：:A new model for the survival of bacteria exposed to ionizing radiation is constructed in the framework of a target theory based on microdosimetric concepts, where single- and double-strand breaks of DNA and their repair in vivo can be described consistently in terms of the microdosimetric quantity j (number of effecti...

journal_title：Radiation research

authors： Iwanami S,Oda N

更新日期：1985-04-01 00:00:00