Abstract：
:A dose of heat which renders 98% of a population of Chinese hamster ovary cells reproductively dead has no significant effect on their Na+, K+, or Mg2+ content by 28 h postheat. In contrast, the cellular Ca2+ content increases in a dose-dependent manner as observed at 22 h after heating for 15-35 min at 45 degrees C. However, the rates of both influx and efflux of Ca2+ were reduced by heating. Increasing the cellular Ca2+ content by incubating the cells in high extracellular Ca2+, either at the time of heating or for a period of 22 h following heat, does not potentiate the lethal effect of heat. Completely blocking the heat-induced increase in Ca2+ content by incubating the cells in medium containing a low Ca2+ concentration does not protect the cells. Therefore, we conclude that heat does not produce any significant changes in the Na+, K+, or Mg2+ content of cells and that the heat-induced increase in Ca2+ does not play an important role in hyperthermic cell killing.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Vidair CA,Dewey WCsubject
Has Abstractpub_date
1986-02-01 00:00:00pages
187-200issue
2eissn
0033-7587issn
1938-5404journal_volume
105pub_type
杂志文章abstract：:Both plant senescence and plant response to ionizing radiation involve changes in gene expression and epigenetic profiles, that rely on the formation of reactive oxygen species. However, how the developmental stage of a plant affects its response to ionizing radiation has not been extensively studied. In this study, o...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13840.1
更新日期：2015-02-01 00:00:00
abstract：:Results from several laboratories, including ours, have suggested that measurements of radiation-induced DNA strand breaks and DNA-protein crosslinks (DPCs) may be used to estimate the hypoxic fraction or fractional hypoxic volume of tumors and normal tissues. This suggestion has been predicted on both published and u...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:To determine whether different agents that enhance the expression of potentially lethal X-ray damage (PLD) interact with the same or different lesions (or spectrum of lesions), cell killing was measured in three kinds of experiments: (1) When cells were irradiated in G1 phase and treated with caffeine or hydroxyurea a...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Most plutonium-induced bone tumors in beagles arise in trabecular bone sites surrounded by hematopoietic tissue. The microvasculature and the relative incorporation of 241Pu (a low energy beta emitter) on trabecular bone surfaces from red and fatty marrow sites were studied in the adult beagle. The vascular volume, as...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:The linear no-threshold extrapolation from a dose-response relationship for ionizing radiation derived at higher doses to doses for which regulatory standards are proposed is being challenged by some scientists and defended by others. It appears that the risks associated with exposures to doses of interest are below t...
journal_title：Radiation research
pub_type：
doi：
更新日期：1998-12-01 00:00:00
abstract：:The present paper describes experiments conducted over the last several years which have focused primarily on the development of mammary tumors in BALB/c mice after neutron and gamma irradiation. Time-dose relationships for induction of mammary and lung tumors following irradiation with fission-spectrum neutrons and 1...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:To study the acquired radioresistance of tumor cells, a model system of two cell lines, Djungarian hamster fibroblasts (DH-TK-) and their radioresistant progeny, was established. The progeny of irradiated cells were isolated by treating the parental cell monolayer with a single dose of 20 Gy (PIC-20). The genetic and ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3443.1
更新日期：2005-12-01 00:00:00
abstract：:The basic 30-nm chromatin fiber in the mammalian cell consists of an unknown (possibly helical) arrangement of nucleosomes, with about 1.2 kb of DNA per 10-nm length of fiber. Track-structure considerations suggest that interactions of single delta rays or high-LET particles with the chromatin fiber might result in th...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Fluorescence in situ hybridization procedures were used to examine the influence of chromosome locus on the frequency and type of chromosome aberrations induced by 60Co gamma rays in the human lymphoblastoid cell line TK6. Aberrations involving the X chromosome were compared to those involving the similarly sized auto...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Plateau-phase A549 cells exhibit a high capacity for repair of potentially lethal radiation damage (PLD). Previously it was found that PLD repair could be partially inhibited by increasing the extracellular pH (pHe) of the spent medium from its normal value of 6.7-6.8 to 7.6 during postirradiation holding. The present...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:A recent publication by Leith et al. (Cancer Res. 51, 4111-4113, 1991) showed that administration of epidermal growth factor (EGF) (0.25 mg/kg; q.i.d. x 7) to mice bearing xenografted A431 human epidermoid cancers produced increased tumor growth and a reduction of the percentage of hypoxic cells within neoplasms. In c...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:These experiments were designed to study the kinetics and magnitude of cell repair and repopulation in tissues whose damage results in the tumor bed effect. The right hind thighs of mice were irradiated with single doses or two equal gamma-ray fractions. Interfraction intervals ranging from 30 min to 24 h (to measure ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radiation-induced mutator phenotype, end points of mitochondrial function...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1617.1
更新日期：2009-12-01 00:00:00
abstract：:We describe a rapid assay to predict intrinsic radiosensitivity of normal tissues based on the radiation-induced cytotoxic response of a number of types of white blood cells. Twenty-four hours after irradiation, leukocytes were prepared for analysis by flow cytometry. Radiation-induced cytotoxicity was characterized b...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The model of radiation action that is presented relates the surviving fraction of irradiated cells to unrepaired DNA double-strand breaks (DSBs). The following assumptions are made in the model: (i) A DNA fragment created by the induced DSBs may move out of its chromosome (become lost), and the probability of that pro...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:It has been suggested that fibrosis which develops after irradiation is caused by increases in vascular permeability. Plasma proteins leak into irradiated tissue where fibrinogen may be converted into fibrin which is gradually replaced by fibrous tissue. Vascular and fibrotic changes in mouse lung were investigated af...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:There are public concerns regarding possible carcinogenic or cancer-promoting effects of electromagnetic fields (EMFs) from mobile phones and base stations. The objective of the present study was to investigate whether chronic exposure to EMFs of the UMTS (Universal Mobile Telecommunication System) influences the deve...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0857.1
更新日期：2007-07-01 00:00:00
abstract：:Many of these deaths could be prevented if there were better screening methods to uncover the disease when it is limited and most responsive to intervention. Novel biomarkers of early-stage disease are therefore needed. By applying the principle of "oncology recapitulates ontogeny", we have discovered three homeobox (...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0235:pcdtma]2.0.co;2
更新日期：2001-01-01 00:00:00
abstract：:Abstract The present study was undertaken to investigate the ability of dietary supplements to reduce the formation and severity of cataracts in mice irradiated with high-energy protons or iron ions, which are important components of the radiation encountered by astronauts during space travel. The mice were exposed to...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1398.1
更新日期：2010-03-01 00:00:00
abstract：:The effect of transgenerational exposure to low dose rate (2.4 and 21 mGy/day) gamma irradiation on the yield of DNA double-strand breaks and oxidized guanine (8-hydroxyguanine) has been studied in the muscle and liver tissue of a model organism, the Japanese medaka fish. We found the level of unrepaired 8-hydroxyguan...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3190.1
更新日期：2013-09-01 00:00:00
abstract：:Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortm...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:Damage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormones on regeneration ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2154.1
更新日期：2011-03-01 00:00:00
abstract：:Radiation sensitivity was measured by the micronucleus assay in T lymphocytes of the spleen and in fibroblasts derived from three inbred strains of mice, BALB/c, A/J and C3H/He. A linear correlation between the surviving fraction and the micronucleus frequency was obtained. There were clear differences in the radiosen...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Hemodynamic shear stress is defined as the physical force exerted by the continuous flow of blood in the vascular system. Endothelial cells, which line the inner layer of blood vessels, sense this physiological force through mechanotransduction signaling and adapt to maintain structural and functional homeostasis. Hem...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14410.1
更新日期：2016-08-01 00:00:00
abstract：:It is commonly accepted that ionizing radiation induces genomic instability by changes in genomic structure, epigenetic regulation and gene expression. Human endogenous retroviruses (HERV)-R also are often differentially expressed between normal and disease tissues under unstable genomic conditions and are implicated ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2888.1
更新日期：2012-11-01 00:00:00
abstract：:Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation c...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:Chinese hamster ovary cells in suspension cultures were heated for various times at 41.5, 43.5, and 45.5 degrees C, and quantitative determinations of microblebbing and macroblebbing of the cell membrane were performed for cells maintained at 4, 25, and 37 degrees C after hyperthermia. The percentage of cells with ble...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Studies were conducted to determine the effects of BeSO4 or X rays, alone and in combination, on cell cycle kinetics, cell killing, and the production of chromosome aberrations in Chinese hamster ovary (CHO) cells. The concentration of BeSO4 required to kill 50% of CHO cells exposed to BeSO4 for 20 h was determined to...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Survival of colony-forming units-spleen (CFU-S) was measured after single doses of photons or heavy charged particles from the BEVALAC. The purposes were to define the radiosensitivity to heavy ions used medically and to evaluate relationships between relative biological effectiveness (RBE) and dose-averaged linear en...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:There is growing scientific, regulatory and public concern over anthropogenic input of radionuclides to the aquatic environment, especially given the issues surrounding existing nuclear waste, future energy demand and past or potential nuclear accidents. A change in the approach to how we protect the environment from ...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/rr2687.1
更新日期：2012-05-01 00:00:00
