Repair of DNA broken ends is similar in embryonic fibroblasts with and without telomerase.

abstract：:Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-partic...

journal_title：Radiation research

authors： Weller RE,Buschbom RL,Dagle GE,Park JF,Ragan HA,Watson CR

更新日期：1996-12-01 00:00:00

abstract：:A radiation-induced bystander response, which is generally defined as a cellular response that is induced in nonirradiated cells that received bystander signals from directly irradiated cells within an irradiated cell population. In our earlier X-ray microbeam studies, bystander cell killing in normal human fibroblast...

journal_title：Radiation research

authors： Tomita M,Maeda M,Kobayashi K,Matsumoto H

更新日期：2013-02-01 00:00:00

abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...

journal_title：Radiation research

authors： Baddour AAD,Apodaca LA,Alikhani L,Lu C,Minasyan H,Batra RS,Acharya MM,Baulch JE

更新日期：2020-01-01 00:00:00

abstract：:Pepleomycin is a derivative of bleomycin, which is less toxic to the host but possesses greater antitumor activity. Experiments are described here in which Chinese hamster V-79 cells in culture and a murine squamous cell carcinoma in vivo have been used to obtain survival curves for pepleomycin alone or in combination...

journal_title：Radiation research

authors： Sakamoto K,Komatsu K,Matsumoto Y

更新日期：1985-05-01 00:00:00

abstract：:The distribution and kinetics of proximal tubular cells with abnormally large nuclei, which were observed in irradiated mouse kidneys before any other obvious histological effects, were investigated. Six months after the administration of 13 or 15 Gy, little histopathological change was noted, in the kidneys of C3H mi...

journal_title：Radiation research

authors： Otsuka M,Meistrich ML,Brock WA

更新日期：1988-07-01 00:00:00

abstract：:Cognitive impairments after brain irradiation seriously affect quality of life for patients, and there is currently no effective treatment. In this study using an irradiated rat model, the role of electroacupuncture was investigated for treatment of radiation-induced brain injury. Animals received 10 Gy exposure to th...

journal_title：Radiation research

authors： Fan XW,Liu HH,Wang HB,Chen F,Yang Y,Chen Y,Guan SK,Wu KL

更新日期：2017-06-01 00:00:00

abstract：:Bcl-X(S) is a pro-apoptosis member of the Bcl2 family that has been shown to induce cell death and enhance chemosensitivity. We have investigated the effect of Bcl-X(S) overexpression on radiation sensitivity. Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and ...

journal_title：Radiation research

authors： Morgan MA,Poynter JN,Maybaum J,Lawrence TS

更新日期：2004-05-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key functional element in the DNA-PK complex that drives nonhomologous end joining (NHEJ), the predominant DNA double-strand break (DSB) repair mechanism operating to rejoin such breaks in mammalian cells after exposure to ionizing radiation. It h...

journal_title：Radiation research

authors： Nagasawa H,Little JB,Lin YF,So S,Kurimasa A,Peng Y,Brogan JR,Chen DJ,Bedford JS,Chen BP

更新日期：2011-01-01 00:00:00

abstract：:An induction-type radiofrequency generator was used to heat thigh implants of the VX2 rabbit carcinoma. The tumor temperature could be easily raised to over 50 degrees C, while the temperature of normal adjacent muscle generally remained at about 43 degrees C. The marked hypovascularity of the tumor, as demonstrated a...

journal_title：Radiation research

authors： Bookstein JJ

更新日期：1983-02-01 00:00:00

abstract：:The stable free radical 4-oxo-2,2,6,6-tetramethylpiperidinooxy (2,2,6,6-tetramethylpiperidone-N-oxyl, TEMPONE) in nitrous oxide-saturated aqueous formate solution has been shown to be a quantitative dosimeter for in situ radiolysis electron spin resonance (ESR) studies. The bleach of the TEMPONE ESR signal is proporti...

journal_title：Radiation research

authors： Madden KP

更新日期：1997-03-01 00:00:00

abstract：:The purpose of this study was to determine the antimutagenicity of WR-1065 added after irradiation of cells of cell lines differing in their ability to rejoin radiation-induced DNA double-strand breaks (DSBs). The postirradiation antimutagenicity of WR-1065 at the thymidine kinase locus was demonstrated for L5178Y (LY...

journal_title：Radiation research

authors： Evans HH,Horng MF,Ricanati M,McCoy EC

更新日期：1999-04-01 00:00:00

abstract：:A new model for the survival of bacteria exposed to ionizing radiation is constructed in the framework of a target theory based on microdosimetric concepts, where single- and double-strand breaks of DNA and their repair in vivo can be described consistently in terms of the microdosimetric quantity j (number of effecti...

journal_title：Radiation research

authors： Iwanami S,Oda N

更新日期：1985-04-01 00:00:00

abstract：:An analysis was conducted of 27,982 deaths among 106,020 persons employed at four Federal nuclear plants in Oak Ridge, Tennessee, between 1943 and 1985. The main objectives were to extend the evaluation of the health effects of employment in the nuclear industry in Oak Ridge to include most workers who were omitted fr...

journal_title：Radiation research

authors： Frome EL,Cragle DL,Watkins JP,Wing S,Shy CM,Tankersley WG,West CM

更新日期：1997-07-01 00:00:00

abstract：:Single crystals of the co-crystalline complex of 1-methyluracil and 9-ethyladenine were X-irradiated and studied using EPR, ENDOR and FSE spectroscopic techniques at 10 K. All together seven radicals were identified, and experimental evidence for at least one more species, as well as for a very low population of radic...

journal_title：Radiation research

authors： Sagstuen E,Hole EO,Nelson WH,Close DM

更新日期：1998-02-01 00:00:00

abstract：:The effects of (56)Fe particles and (137)Cs gamma radiation were compared in TK6 and WTK1 human lymphoblasts, two related cell lines which differ in TP53 status and in the ability to rejoin DNA double-strand breaks. Both cell lines were more sensitive to the cytotoxic and clastogenic effects of (56)Fe particles than t...

journal_title：Radiation research

authors： Evans HH,Horng MF,Evans TE,Jordan R,Schwartz JL

更新日期：2001-08-01 00:00:00

abstract：:Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing doubl...

journal_title：Radiation research

authors： Box HC,Freund HG,Budzinski EE,Wallace JC,Maccubbin AE

更新日期：1995-01-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) is an aggressive disease with a high risk of recurrence and death. Here, we present a novel strategy to enhance the radiotherapy of TNBC by combining gold nanoparticles (AuNPs) with pentamidine, a clinically approved anti-parasitic agent with anti-cancer properties. The radiosensit...

journal_title：Radiation research

authors： Her S,Cui L,Bristow RG,Allen C

更新日期：2016-05-01 00:00:00

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:Three experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without...

journal_title：Radiation research

authors： Pappas BA,Anisman H,Ings R,Hill DA

更新日期：1983-12-01 00:00:00

abstract：:A novel technique has been employed to investigate the simultaneous damage to DNA components induced by soft X rays (1.5 keV) and low-energy electrons (0-30 eV) in thin films of thymidine deposited on glass and tantalum substrates and irradiated under atmospheric pressure and temperature. The films were surrounded by ...

journal_title：Radiation research

authors： Alizadeh E,Sanz AG,Madugundu GS,García G,Wagner JR,Sanche L

更新日期：2014-06-01 00:00:00

abstract：:There are public concerns regarding possible carcinogenic or cancer-promoting effects of electromagnetic fields (EMFs) from mobile phones and base stations. The objective of the present study was to investigate whether chronic exposure to EMFs of the UMTS (Universal Mobile Telecommunication System) influences the deve...

journal_title：Radiation research

authors： Sommer AM,Bitz AK,Streckert J,Hansen VW,Lerchl A

更新日期：2007-07-01 00:00:00

abstract：:Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation c...

journal_title：Radiation research

authors： Milano MT,Bernhard WA

更新日期：1999-08-01 00:00:00

abstract：:A significant fraction of DNA damage produced by ionizing radiation comes from free radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl radical, the principal damaging species, produces single-strand breaks and a plethora of base and sugar lesions that can be cytotoxic or muta...

journal_title：Radiation research

authors： Wallace SS

更新日期：1998-11-01 00:00:00

abstract：:The severe combined immune deficiency (SCID) mouse shows two kinds of phenotypic abnormalities, a high radiosensitivity and an abnormal immunoglobulin gene recombination. A genetic study has revealed that a mutation exists in chromosome 16. However, several attempts to isolate the gene responsible for these phenotypes...

journal_title：Radiation research

authors： Itoh M,Hamatani K,Komatsu K,Araki R,Takayama K,Abe M

更新日期：1993-06-01 00:00:00

abstract：:The susceptibility to inducible SOS repair of 5,6-dihydroxy-dihydrothymine (t') damage in single-stranded phi X174 DNA has been measured. Following exposure to osmium tetroxide, which introduces t' damage in DNA under the conditions used, biological survival of the DNA infected into spheroplasts of Escherichia coli wh...

journal_title：Radiation research

authors： Achey PM,Wright CF

更新日期：1983-03-01 00:00:00

abstract：:It has been suggested that fibrosis which develops after irradiation is caused by increases in vascular permeability. Plasma proteins leak into irradiated tissue where fibrinogen may be converted into fibrin which is gradually replaced by fibrous tissue. Vascular and fibrotic changes in mouse lung were investigated af...

journal_title：Radiation research

authors： Law MP

更新日期：1985-07-01 00:00:00

abstract：:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT ut...

journal_title：Radiation research

authors： Prezado Y,Deman P,Varlet P,Jouvion G,Gil S,Le Clec'H C,Bernard H,Le Duc G,Sarun S

更新日期：2015-09-01 00:00:00

abstract：:A computer model that simulates the killing of exponentially growing cells by low-dose-rate radiation is described. The model incorporates cell killing by single-hit damage and double-hit (sublethal) damage, as well as repair of sublethal damage, delay of cell cycle progression, blockage and increased sensitivity of c...

journal_title：Radiation research

authors： Dillehay LE

更新日期：1990-11-01 00:00:00

abstract：:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here...

journal_title：Radiation research

authors： Yokoyama K,Miyatake S,Kajimoto Y,Kawabata S,Doi A,Yoshida T,Okabe M,Kirihata M,Ono K,Kuroiwa T

更新日期：2007-01-01 00:00:00

abstract：:This experiment was performed to determine whether ionizing radiation is essential for maximum growth rate in a ciliated protozoan. When extraneous ionizing radiation was reduced to 0.15 mrad/day, the reproduction rate of Tetrahymena pyriformis was significantly less (P less than 0.01) than it was at near ambient leve...

journal_title：Radiation research

authors： Luckey TD

更新日期：1986-11-01 00:00:00