Theory of survival of bacteria exposed to ionizing radiation. I. X and gamma rays.

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:A study has been made of methods for rapidly inactivating cells of E. coli at neutral pH to prevent enzymatic, chemical, or physical modification to DNA damaged by irradiation. The radiation was delivered in a fraction of a second using an electron accelerator. Cell inactivation was with ethanol or a solution (CSE) co...

journal_title：Radiation research

authors： Tilby MJ,Loverock PS

更新日期：1983-11-01 00:00:00

abstract：:The purpose of this paper is to validate a metabolic model describing the kinetics of tritium in man. The validation is based on measurements of background levels of loose and bound tritium in Italian subjects and their diets. Model predictions are compared with empirical measurements of tritium in human urine and tis...

journal_title：Radiation research

authors： Travis CC,Etnier EL,Hetrick DM

更新日期：1984-12-01 00:00:00

abstract：:To determine whether systemic administration of MnSOD-PL protected mice from the acute hematopoietic syndrome and delayed death after total-body irradiation (TBI), C57BL/ 6J mice were injected intravenously with 100 microl liposomes containing 100 microg of human MnSOD-transgene plasmid 24 h prior to irradiation with ...

journal_title：Radiation research

authors： Epperly MW,Dixon T,Wang H,Schlesselman J,Franicola D,Greenberger JS

更新日期：2008-10-01 00:00:00

abstract：:A yeast-based frameshift/stop codon assay for examining ATM (ataxia telangiectasia mutated) mutations was established. Each of six fragments of a PCR-amplified coding sequence for ATM is inserted in frame by homologous recombination into a yeast URA3 fusion protein gene, and the transformants are assayed for growth in...

journal_title：Radiation research

authors： Tsuchida R,Yamada T,Takagi M,Shimada A,Ishioka C,Katsuki Y,Igarashi T,Chessa L,Delia D,Teraoka H,Mizutani S

更新日期：2002-08-01 00:00:00

abstract：:The influence of Trp53 on the radiation-induced elevation of T-cell receptor (TCR) variant fractions was examined in splenic T lymphocytes of Trp53-proficient and -deficient mice. Wild-type Trp53+/+, heterozygous Trp53+/- and null Trp53-/- mice were exposed to 3 Gy of X rays at 8 weeks of age. The fraction of TCR-defe...

journal_title：Radiation research

authors： Igari K,Igari Y,Okazaki R,Kato F,Ootsuyama A,Norimura T

更新日期：2006-07-01 00:00:00

abstract：:Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and with...

journal_title：Radiation research

authors： Furusawa Y,Wei ZL,Sakurai H,Tabuchi Y,Li P,Zhao QL,Nomura T,Saiki I,Kondo T

更新日期：2012-06-01 00:00:00

abstract：:The effect of transgenerational exposure to low dose rate (2.4 and 21 mGy/day) gamma irradiation on the yield of DNA double-strand breaks and oxidized guanine (8-hydroxyguanine) has been studied in the muscle and liver tissue of a model organism, the Japanese medaka fish. We found the level of unrepaired 8-hydroxyguan...

journal_title：Radiation research

authors： Grygoryev D,Moskalenko O,Hinton TG,Zimbrick JD

更新日期：2013-09-01 00:00:00

abstract：:Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to DNA crosslinking agents. Clinically, FA is associated with high risk for marrow failure, leukemia and head and neck squamous cell carcinoma (HNSCC). Radiosensitivity in FA patients compromises the use of tota...

journal_title：Radiation research

authors： Bernard ME,Kim H,Berhane H,Epperly MW,Franicola D,Zhang X,Houghton F,Shields D,Wang H,Bakkenist CJ,Frantz MC,Forbeck EM,Goff JP,Wipf P,Greenberger JS

更新日期：2011-11-01 00:00:00

abstract：:We present measurements of low-energy (<18 eV) electron-stimulated desorption of anions from acetamide (CH(3)CONH(2)) and dimethyl disulfide [DMDS: (CH(3)S)(2)] films. Electron irradiation of physisorbed CH(3)CONH(2) produces H(-), CH(3)(-) and O(-) anions, whereas the H(-), CH(2)(-), CH(3)(-), S(-), SH(-) and SCH(3)(...

journal_title：Radiation research

authors： Abdoul-Carime H,Cecchini S,Sanche L

更新日期：2002-07-01 00:00:00

abstract：:Differentiation of Friend erythroleukemia cells (FELC) was induced with 1.5% dimethyl sulfoxide (DMSO) in the culture medium. Cell growth, erythroid differentiation, and radiosensitivity of the proliferative capacity of the cells were measured and compared to a noninduced control culture of identical age. Induced cell...

journal_title：Radiation research

authors： Einspenner M,Boulton JE,Borsa J

更新日期：1984-01-01 00:00:00

abstract：:Male rabbits were exposed to a single irradiation dose of 1000-5000 rad when 12, 15, 16, and 17 months old and were killed when 18 months old (i.e., 1, 2, 3, and 6 months after irradiation). Even after this long interval after irradiation, abdominal aortic prostacyclin formation was significantly depressed, whereas th...

journal_title：Radiation research

authors： Sinzinger H,Cromwell M,Firbas W

更新日期：1984-03-01 00:00:00

abstract：:The objective of this study was to determine whether a deficiency for either one of two repair processes influences the phenomenon of enhancement of radiation-induced cell killing by carboplatin which has been reported previously in one cell line (V79) and which is presumably a result of an interaction between these t...

journal_title：Radiation research

authors： Yang L,Douple EB,O'Hara JA,Crabtree RA,Eastman A

更新日期：1995-11-01 00:00:00

abstract：:Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell ("initiation"), followed by the clonal expansion of this cell ("promotion") and by the acquisition of other genetic alterations leading to malignancy ("progression"). The initiation ...

journal_title：Radiation research

authors： Trosko JE,Chang CC,Madhukar BV

更新日期：1990-09-01 00:00:00

abstract：:A computer model that simulates the killing of exponentially growing cells by low-dose-rate radiation is described. The model incorporates cell killing by single-hit damage and double-hit (sublethal) damage, as well as repair of sublethal damage, delay of cell cycle progression, blockage and increased sensitivity of c...

journal_title：Radiation research

authors： Dillehay LE

更新日期：1990-11-01 00:00:00

abstract：:It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments with concomitant changes in dendritic complexity, spine density and inflammatio...

journal_title：Radiation research

authors： Hinzman CP,Baulch JE,Mehta KY,Gill K,Limoli CL,Cheema AK

更新日期：2018-11-01 00:00:00

abstract：:The dependence of relative biological effectiveness (RBE) on photon energy is a topic of extensive discussions. The increasing amount of in vitro data in the low-energy region indicates this to be a complex dependence that is influenced by the end point and cell line studied. In the present investigation, the RBE of 1...

journal_title：Radiation research

authors： Lehnert A,Dörr W,Lessmann E,Pawelke J

更新日期：2008-03-01 00:00:00

abstract：:To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver ...

journal_title：Radiation research

authors： Ono T,Ikehata H,Hosoi Y,Shung BS,Kurishita A,Wang X,Yamamoto K,Suzuki T,Sofuni T

更新日期：1997-08-01 00:00:00

abstract：:Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of <0.3 mIU/liter, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels. The accident at the Chornobyl (Chernobyl) nuclear plant in Ukraine on April 26, 1986 exposed large numbe...

journal_title：Radiation research

authors： Hatch M,Furukawa K,Brenner A,Olinjyk V,Ron E,Zablotska L,Terekhova G,McConnell R,Markov V,Shpak V,Ostroumova E,Bouville A,Tronko M

更新日期：2010-12-01 00:00:00

abstract：:While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with acceler...

journal_title：Radiation research

authors： Nomura T,Sakai K,Ogata H,Magae J

更新日期：2013-06-01 00:00:00

abstract：:The widely distributed xanthine oxidoreductase (XOR) system has been shown to be modulated upon exposure of animals to ionizing radiation through the conversion of xanthine dehydrogenase (XDH) into xanthine oxidase (XO). In the present work, radiomodification of the XOR system by phenylmethylsulfonyl fluoride (PMSF) a...

journal_title：Radiation research

authors： Srivastava M,Kale RK

更新日期：2000-07-01 00:00:00

abstract：:The effects of reoxygenation on repair of potentially lethal radiation damage were investigated using MG-63 human osteosarcoma cells in vitro. When exponentially growing MG-63 cells were cultured under hypoxic conditions for 24 h, cells stopped growing and remained at a low density. The hypoxic cells were then reoxyge...

journal_title：Radiation research

authors： Iizuka M,Ando K,Aruga T,Furusawa Y,Itsukaichi H,Fukutsu K,Nagasawa H,Moriya H

更新日期：1997-02-01 00:00:00

abstract：:The physical and biological basis of our model to calculate the biological effects of charged particles, termed the local effect model (LEM), has recently been questioned in a commentary by R. Katz. Major objections were related to the definition of the target size and the use of the term cross section. Here we show t...

journal_title：Radiation research

authors： Scholz M,Kraft G

更新日期：2004-05-01 00:00:00

abstract：:Evaluation of the probability of biological phenomena per cell by colony formation, requires knowledge not only of the number of cells at risk but also of their microdistribution. In the present study, the influence of cellular multiplicity (number of cells per potential colony-forming unit) on the determination of ra...

journal_title：Radiation research

authors： Gerweck LE,Dullea R,Zaidi ST,Budach W,Hartford A

更新日期：1994-06-01 00:00:00

abstract：:Information on early internal radiation doses in Fukushima after the nuclear power plant accident on March 11, 2011, is quite limited due to initial organizational difficulties, high background radiation and contamination of radiation measuring devices. In Nagasaki, approximately 1,200 km away from Fukushima, the inte...

journal_title：Radiation research

authors： Matsuda N,Kumagai A,Ohtsuru A,Morita N,Miura M,Yoshida M,Kudo T,Takamura N,Yamashita S

更新日期：2013-06-01 00:00:00

abstract：:To characterize the differences in the radiosensitivity of individual populations of human hematopoietic stem/progenitor cells (HSPCs), we examined the relationship among cell surface antigens, clonogenic potential and radiation survival. The expressions of CD34, CD38, CD45RA, CD110 and Tie-2, early differentiation pa...

journal_title：Radiation research

authors： Takahashi K,Monzen S,Hayashi N,Kashiwakura I

更新日期：2010-02-01 00:00:00

abstract：:The potential for radiogenic neoplasia from charged-particle irradiation has been estimated using the Harderian gland of the mouse as a test system. Particles ranging in Z from Z = 1 (proton) to Z = 41 (niobium), in energy from 228 to 670A MeV, and in LET from 0.4 to 464 keV/microns were produced at the Lawrence Berke...

journal_title：Radiation research

authors： Alpen EL,Powers-Risius P,Curtis SB,DeGuzman R

更新日期：1993-12-01 00:00:00

abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...

journal_title：Radiation research

authors： Beinke C,Barnard S,Boulay-Greene H,De Amicis A,De Sanctis S,Herodin F,Jones A,Kulka U,Lista F,Lloyd D,Martigne P,Moquet J,Oestreicher U,Romm H,Rothkamm K,Valente M,Meineke V,Braselmann H,Abend M

更新日期：2013-08-01 00:00:00

abstract：:The immune response of guinea pigs to Q fever vaccine following 75 to 250 R (60 to 180 rads) of acute whole-body irradiations was investigated. Complement-fixing (CF) antibody titers and protection against febrile response to challenge with virulent Coxiella burnetii were studied. Exposures ranging from 75 to 250 R, 2...

journal_title：Radiation research

authors： Reynolds SL,Whitford HW,Blemly NR,Staab EV,Craig CP

更新日期：1968-10-01 00:00:00

abstract：:The induction of chromosome aberrations in human lymphocytes irradiated in vitro with X rays generated at a tube voltage of 29 kV was examined to assess the maximum low-dose RBE (RBE(M)) relative to higher-energy X rays or 60Co gamma rays. Since blood was taken from the same male donor whose blood had been used for pr...

journal_title：Radiation research

authors： Schmid E,Regulla D,Kramer HM,Harder D

更新日期：2002-12-01 00:00:00