Correlations of cell surface antigens with individual differences in radiosensitivity in human hematopoietic stem/progenitor cells.

abstract：:A plasma membrane-rich fraction has been separated from liver cells and cells of two solid rat tumors. D23 hepatoma and MC7 sarcoma. On the basis of marker enzyme activity the membranes separating at the 31-41% interface on the discontinuous sucrose gradient were enriched 15- to 19-fold. No significant differences in ...

journal_title：Radiation research

authors： Barker CJ,Bowler K

更新日期：1991-01-01 00:00:00

abstract：:The late effects of heavy-ion irradiation on the spinal cord of the rat were investigated histologically and morphometrically. After a single exposure of each animal's lower thoracic and lumbar spinal cord to a carbon-ion beam, the animals were observed clinically for up to 69 weeks and their spinal cords were examine...

journal_title：Radiation research

authors： Okada S,Okeda R,Matsushita S,Kawano A

更新日期：1998-09-01 00:00:00

abstract：:The percentage of T lymphocytes of atomic bomb survivors showed no change as a function of age or exposure dose. The percentage of T cells was slightly lower in malignant-tumor patients than in the control group, but was significantly higher in the group with chromosomal aberrations than in the control group. The perc...

journal_title：Radiation research

authors： Akiyama M,Yamakido M,Kobuke K,Dock DS,Hamilton HB,Awa AA,Kato H

更新日期：1983-03-01 00:00:00

abstract：:Ionizing radiation induces clustered DNA damage sites, whereby two or more individual DNA lesions are formed within one or two helical turns of DNA by a single radiation track. A subset of DNA clustered damage sites exist in which the lesions are located in tandem on the same DNA strand. Recent studies have establishe...

journal_title：Radiation research

authors： Lomax ME,Salje H,Cunniffe S,O'Neill P

更新日期：2005-01-01 00:00:00

abstract：:The effect of ionizing radiation on the survival of bovine aortic endothelial (BAE) cells was determined by the in vitro colony formation method. The BAE cells were cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% calf serum, antibiotics, and growth factors obtained from the culture of mouse...

journal_title：Radiation research

authors： Rhee JG,Lee I,Song CW

更新日期：1986-05-01 00:00:00

abstract：:Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy ...

journal_title：Radiation research

authors： Fanton JW,Golden JG

更新日期：1991-05-01 00:00:00

abstract：:Cytoglobin is a recently identified vertebrate globin whose functions include scavenging reactive oxygen and nitrosative species. In tumor cells, CYGB may function as a tumor suppressor gene. Here we show that knockdown of cytoglobin expression can sensitize human glioma cells to oxidative stress induced by chemical i...

journal_title：Radiation research

authors： Fang J,Ma I,Allalunis-Turner J

更新日期：2011-08-01 00:00:00

abstract：:This study evaluated the phagocytic and bactericidal activities of peripheral blood leukocytes from Hiroshima and Nagasaki atomic bomb survivors for Staphylococcus aureus. The data were analyzed by multiple linear regression for age, sex, radiation exposure, city of exposure, and neutrophil counts. No significant radi...

journal_title：Radiation research

authors： Sasagawa S,Yoshimoto Y,Toyota E,Neriishi S,Yamakido M,Matsuo M,Hosoda Y,Finch SC

更新日期：1990-10-01 00:00:00

abstract：:The potential for radiogenic neoplasia from charged-particle irradiation has been estimated using the Harderian gland of the mouse as a test system. Particles ranging in Z from Z = 1 (proton) to Z = 41 (niobium), in energy from 228 to 670A MeV, and in LET from 0.4 to 464 keV/microns were produced at the Lawrence Berke...

journal_title：Radiation research

authors： Alpen EL,Powers-Risius P,Curtis SB,DeGuzman R

更新日期：1993-12-01 00:00:00

abstract：:Four programs have been written to enable radiobiologists to build a computer data base of cellular dose-survival data, calculate cell survival with a correction for cell multiplicity at the time of irradiation, fit various survival models to the data by iteratively weighted least squares, and calculate the ratio of s...

journal_title：Radiation research

authors： Albright N

更新日期：1987-11-01 00:00:00

abstract：:The relationship between apoptosis induced by gamma radiation and glutathione in cells of two human cancer cell lines, HeLa from cervix carcinoma and MCF-7 from mammary carcinoma, was examined. MCF-7 cells appeared to be more radioresistant than HeLa cells, and radiation-induced apoptosis, which was monitored by asses...

journal_title：Radiation research

authors： Rosi A,Grande S,Luciani AM,Palma A,Giovannini C,Guidoni L,Sapora O,Viti V

更新日期：2007-03-01 00:00:00

abstract：:Experiments were performed with three different cell lines, mouse fibroblast LM cells, HeLa S3 cells, and Ehrlich Ascites Tumor (EAT) cells, to establish the possible importance of hyperthermic-induced alterations in cellular K+ content in the mechanism of cell killing by heat. At different time points after the hyper...

journal_title：Radiation research

authors： Ruifrok AC,Kanon B,Konings AW

更新日期：1987-02-01 00:00:00

abstract：:Monte Carlo simulations are used in the development of a nanotechnology-based multi-pixel beam array small animal microirradiation system. The microirradiation system uses carbon nanotube field emission technology to generate arrays of individually controllable X-ray pixel beams that electronically form irregular irra...

journal_title：Radiation research

authors： Schreiber EC,Chang SX

更新日期：2009-03-01 00:00:00

abstract：:Our goal was to determine whether esophageal progenitor cells could be isolated from adult mouse esophagus or bone marrow and shown to home to and proliferate in the irradiated esophagus of recipient mice. Esophageal progenitor cells were isolated from adult male C3H/HeNsd or C57BL/6J green fluorescent protein (GFP(+)...

journal_title：Radiation research

authors： Epperly MW,Guo H,Shen H,Niu Y,Zhang X,Jefferson M,Sikora CA,Greenberger JS

更新日期：2004-09-01 00:00:00

abstract：:The effects of ionizing radiation, with or without the anti-angiogenic agent anginex (Ax), on multiple myeloma growth were tested in a SCID-rab mouse model. Mice carrying human multiple myeloma cell-containing pre-implanted bone grafts were treated weekly with various regimens for 8 weeks. Rapid multiple myeloma growt...

journal_title：Radiation research

authors： Jia D,Koonce NA,Halakatti R,Li X,Yaccoby S,Swain FL,Suva LJ,Hennings L,Berridge MS,Apana SM,Mayo K,Corry PM,Griffin RJ

更新日期：2010-06-01 00:00:00

abstract：:A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after gamma irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a...

journal_title：Radiation research

authors： Mühlmann-Díaz MC,Bedford JS

更新日期：1995-08-01 00:00:00

abstract：:Angiogenesis defines the many steps involved in the growth and migration of endothelial cell-derived blood vessels. This process is necessary for the growth and metastasis of tumors, and considerable effort is being expended to find inhibitors of tumor angiogenesis. This usually involves screening of potential anti-an...

journal_title：Radiation research

authors： Newton DL,Kaur G,Rhim JS,Sausville EA,Rybak SM

更新日期：2001-01-01 00:00:00

abstract：:Fluorescence in situ hybridization procedures were used to examine the influence of chromosome locus on the frequency and type of chromosome aberrations induced by 60Co gamma rays in the human lymphoblastoid cell line TK6. Aberrations involving the X chromosome were compared to those involving the similarly sized auto...

journal_title：Radiation research

authors： Jordan R,Schwartz JL

更新日期：1994-03-01 00:00:00

abstract：:The effect of hypoxia on the induction of and recovery from damage by radiation alone and in combination with heat has been investigated using plateau-phase Chinese hamster ovary (CHO) cells. Postirradiation hypoxia reduced the potentially lethal damage recovery (PLDR) in cells irradiated under an euoxic state and com...

journal_title：Radiation research

authors： Rao BS,Hopwood LE

更新日期：1985-02-01 00:00:00

abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...

journal_title：Radiation research

authors： Sanchez MC,Nelson GA,Green LM

更新日期：2010-12-01 00:00:00

abstract：:Irradiation from internally deposited radionuclides induces malignant tumors. Ingested long-lived radionuclides accumulate in specific organs that are irradiated throughout life. To elucidate why the development of malignant tumors requires long-term internal exposure, of the order of decades, despite the fact that ir...

journal_title：Radiation research

authors： Yamamoto Y,Usuda N,Takatsuji T,Kuwahara Y,Fukumoto M

更新日期：2009-04-01 00:00:00

abstract：:To characterize the role of the cerebrovascular response in the development of brain injury after focal irradiation, 125I sources were implanted in frontal white matter of the brain of normal dogs; dose was 20 Gy, 7.5 mm from the source. Cerebral blood flow, vascular volume and mean transit time of blood were quantifi...

journal_title：Radiation research

authors： Gobbel GT,Seilhan TM,Fike JR

更新日期：1992-05-01 00:00:00

abstract：:The response of the testes of two strains of adult rats (Sprague-Dawley and Wistar) to graded single doses and split doses of 230 kVp X rays has been investigated. A marked difference was noted between the strains in the response of the clonogenic spermatogonia to irradiation, as measured histologically by the repopul...

journal_title：Radiation research

authors： Delic JI,Schlappack OK,Harwood JR,Stanley JA

更新日期：1987-10-01 00:00:00

abstract：:Fanconi anemia is a genetically heterogeneous recessive disease characterized mainly by bone marrow failure and cancer predisposition. Although it is accepted that Fanconi cells are highly sensitive to DNA crosslinking agents, their response to ionizing radiation is still unclear. Using pulsed-field gel electrophoresi...

journal_title：Radiation research

authors： Casado JA,Núñez MI,Segovia JC,Ruiz de Almodóvar JM,Bueren JA

更新日期：2005-11-01 00:00:00

abstract：:The effect of acute exposure to ultrawideband (UWB) electromagnetic radiation on the Primate Equilibrium Platform (PEP) task, where the monkey's task is to manipulate a joystick control to compensate for the random perturbations in the pitch plane that are generated by a computer at unpredictable intervals, was examin...

journal_title：Radiation research

authors： Sherry CJ,Blick DW,Walters TJ,Brown GC,Murphy MR

更新日期：1995-07-01 00:00:00

abstract：:The purpose of this study was to determine the antimutagenicity of WR-1065 added after irradiation of cells of cell lines differing in their ability to rejoin radiation-induced DNA double-strand breaks (DSBs). The postirradiation antimutagenicity of WR-1065 at the thymidine kinase locus was demonstrated for L5178Y (LY...

journal_title：Radiation research

authors： Evans HH,Horng MF,Ricanati M,McCoy EC

更新日期：1999-04-01 00:00:00

abstract：:This study demonstrates that mice, similar to humans, have a common mitochondrial DNA deletion (3,860 bp) that encodes 5 transfer RNA genes and 5 polypeptide genes that is related to aging, tissue type and radiotoxicity. Our research indicates that the deletion ratio in the liver was significantly higher than in the b...

journal_title：Radiation research

authors： Zhang SB,Maguire D,Zhang M,Zhang Z,Zhang A,Yin L,Zhang L,Huang L,Vidyasagar S,Swarts S,Okunieff P

更新日期：2013-10-01 00:00:00

abstract：:Previous investigations have demonstrated an increased release of von Willebrand factor (VWF; also known as vWF) in endothelial cells after high single-dose irradiation in vitro. We have also found increased levels of Vwf protein in mouse glomeruli after a high single dose of renal irradiation in vivo. In addition, in...

journal_title：Radiation research

authors： van Kleef E,Verheij M,te Poele H,Oussoren Y,Dewit L,Stewart F

更新日期：2000-10-01 00:00:00

abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...

journal_title：Radiation research

authors： Baddour AAD,Apodaca LA,Alikhani L,Lu C,Minasyan H,Batra RS,Acharya MM,Baulch JE

更新日期：2020-01-01 00:00:00

abstract：:Dose-response curves for micronucleus (MN) formation were measured in Chinese hamster V79 and xrs6 (Ku80(-)) cells and in human mammary epithelial MCF10A cells in the dose range of 0.05-1 Gy. The Chinese hamster cells were exposed to 1 GeV/nucleon iron ions, 600 MeV/nucleon iron ions, and 300 MeV/nucleon iron ions (LE...

journal_title：Radiation research

authors： Groesser T,Chun E,Rydberg B

更新日期：2007-12-01 00:00:00