Lipid composition of the membranes from cells of two rat tumors and its relationship to tumor thermosensitivity.

abstract：:A historical cohort mortality study was conducted among 28,008 white male employees who had worked for at least 1 month in Oak Ridge, Tennessee, during World War II. The workers were employed at two plants that were producing enriched uranium and a research and development laboratory. Vital status was ascertained thro...

journal_title：Radiation research

authors： Frome EL,Cragle DL,McLain RW

更新日期：1990-08-01 00:00:00

abstract：:In boron neutron capture therapy, the absorbed dose from the (10)B(n,alpha)(7)Li reaction depends on the (10)B concentration and (10)B distribution in the irradiated volume. Thus compounds used in BNCT should have tumor-specific uptake and low accumulation in normal tissues. This study compares in a mouse model the (1...

journal_title：Radiation research

authors： Wittig A,Huiskamp R,Moss RL,Bet P,Kriegeskotte C,Scherag A,Hilken G,Sauerwein WA

更新日期：2009-10-01 00:00:00

abstract：:Cell-cell contact is thought to be critically involved in mechanisms leading to radioresistance. Here, we assessed the influence of confluent compared to subconfluent cell culture conditions and the radiosensitizing ability of E-cadherin inhibition alone or in combination with C225-mediated EGFR inhibition in human sq...

journal_title：Radiation research

authors： Mazzeo E,Hehlgans S,Valentini V,Baumann M,Cordes N

更新日期：2012-09-01 00:00:00

abstract：:Effects of 250-kV X rays on epidermal Langerhans cells were studied in CBA/CaH mice. One group received 20 Gy to the feet, another 8 Gy to the whole body, and a third both the 8 Gy whole-body and a 12 Gy local dose to the feet. Mice from each group and controls were sacrificed at intervals from 1 to 64 days later. ATP...

journal_title：Radiation research

authors： Cole S,Lewkowicz SJ,Townsend KM

更新日期：1984-12-01 00:00:00

abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...

journal_title：Radiation research

authors： Takahashi S,Patrick G

更新日期：1987-06-01 00:00:00

abstract：:Data are presented for a subset of lymphocytes characterized by FISH as missing painted chromosomal material. These lymphocytes occur in both control and irradiated subjects. These cells have a much greater frequency of one-way translocations than cells in which all of the painted chromosomal material is present. Thei...

journal_title：Radiation research

authors： Edwards A,Maznik N,Moquet J,Hone P,Vinnikov V,Lloyd D,Cox R

更新日期：2002-04-01 00:00:00

abstract：:We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated ...

journal_title：Radiation research

authors： Asakawa J,Kuick R,Kodaira M,Nakamura N,Katayama H,Pierce D,Funamoto S,Preston D,Satoh C,Neel JV,Hanash S

更新日期：2004-04-01 00:00:00

abstract：:The International Commission on Radiation Protection (ICRP) has lowered the dose limits for workers and for the general public exposed to ionizing radiation. Consequently, a reliable dosimetric method for monitoring possible radiation-induced damage is of great importance in radioprotection. The counting of dicentric ...

journal_title：Radiation research

authors： Amendola R,Basso E,Pacifici PG,Piras E,Giovanetti A,Volpato C,Romeo G

更新日期：2006-05-01 00:00:00

abstract：:A total of 1170 rats comprised of 65 male and 65 female Han Wistar rats per group were exposed for 2 h/day, 5 days/ week for up to 104 weeks to GSM or DCS wireless communication signals at three nominal SARs of 0.44, 1.33 and 4.0 W/kg. A preliminary study confirmed that the highest exposure level was below that which ...

journal_title：Radiation research

authors： Smith P,Kuster N,Ebert S,Chevalier HJ

更新日期：2007-10-01 00:00:00

abstract：:There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern comp...

journal_title：Radiation research

authors： Sproull M,Kramp T,Tandle A,Shankavaram U,Camphausen K

更新日期：2015-07-01 00:00:00

abstract：:Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation c...

journal_title：Radiation research

authors： Milano MT,Bernhard WA

更新日期：1999-08-01 00:00:00

abstract：:The effects of (56)Fe particles and (137)Cs gamma radiation were compared in TK6 and WTK1 human lymphoblasts, two related cell lines which differ in TP53 status and in the ability to rejoin DNA double-strand breaks. Both cell lines were more sensitive to the cytotoxic and clastogenic effects of (56)Fe particles than t...

journal_title：Radiation research

authors： Evans HH,Horng MF,Evans TE,Jordan R,Schwartz JL

更新日期：2001-08-01 00:00:00

abstract：:Impaired fluid and electrolyte transport in the intestine is a well-recognized characteristic of radiation-induced pathologies in the gastrointestinal tract. The aim of this study was to investigate the responsiveness of the epithelium of the colon of the rat to electrical and pharmacological (serotonin, carbachol) st...

journal_title：Radiation research

authors： François A,Dublineau I,Lebrun F,Ksas B,Griffiths NM

更新日期：1999-04-01 00:00:00

abstract：:After DNA damage, caspases cleave and activate proteins involved in cell death by apoptosis but also cleave and inactivate proteins implicated in DNA repair. Here we report a rapid onset of Rad51 cleavage by caspase 3 in BRCA2-defective mouse and human cells. This rapid cleavage was reduced markedly by transfer of ful...

journal_title：Radiation research

authors： Brown ET,Robinson-Benion C,Holt JT

更新日期：2008-05-01 00:00:00

abstract：:The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...

journal_title：Radiation research

authors： Kochevar IE,Walsh AA,Held KD,Gallo RL,Mirro J

更新日期：1990-05-01 00:00:00

abstract：:Single crystals of guanine hydrochloride monohydrate, guanine hydrochloride dihydrate and anhydrous guanine dihydrochloride, doped with thioguanine, were irradiated with X and gamma rays. In all three systems the dominant radicals were associated with thioguanine. In the former two systems the stabilized species is th...

journal_title：Radiation research

authors： Herak JN,Sanković K,Krilov D,Hüttermann J

更新日期：1999-03-01 00:00:00

abstract：:Radiation exposure leads to a risk for long-term deterministic and stochastic late effects. Two individuals exposed to protracted photon radiation in the radiological accident at the Lilo Military site in Georgia in 1997 received follow-up treatment and resection of several chronic radiation ulcers in the Bundeswehr H...

journal_title：Radiation research

authors： Scherthan H,Abend M,Müller K,Beinke C,Braselmann H,Zitzelsberger H,Köhn FM,Pillekamp H,Schiener R,Das O,Peter RU,Herzog G,Tzschach A,Dörr HD,Fliedner TM,Meineke V

更新日期：2007-05-01 00:00:00

abstract：:The purpose of this work was to determine how fractionated radiation used in the treatment of tumors affects the ability of cancer as well as normal cells to repair induced DNA double-strand breaks (DSBs) and how cells that have lost this ability die. Lymphocytic leukemia cells (MOLT4) were used as an experimental mod...

journal_title：Radiation research

authors： Rezáčová M,Rudolfová G,Tichý A,Bačíková A,Mutná D,Havelek R,Vávrová J,Odrážka K,Lukášová E,Kozubek S

更新日期：2011-06-01 00:00:00

abstract：:Solid thymidylyl-(3'-->5')-thymidine (dTpdT) was irradiated in a vacuum with monochromatic photons from 150 to 300 nm; the photoproducts were analyzed quantitatively by high-performance liquid chromatography. The results of the experiment were as follows: (1) above 210 nm the major photoproducts were three dithymine p...

journal_title：Radiation research

authors： Saitou M,Hieda K

更新日期：1994-11-01 00:00:00

abstract：:Clustered damage sites other than double-strand breaks (DSBs) have the potential to contribute to deleterious effects of ionizing radiation, such as cell killing and mutagenesis. In the companion article (Semenenko et al., Radiat. Res. 164, 180-193, 2005), a general Monte Carlo framework to simulate key steps in the b...

journal_title：Radiation research

authors： Semenenko VA,Stewart RD

更新日期：2005-08-01 00:00:00

abstract：:While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with acceler...

journal_title：Radiation research

authors： Nomura T,Sakai K,Ogata H,Magae J

更新日期：2013-06-01 00:00:00

abstract：:After a planned or unplanned radiation exposure, determination of absorbed dose has great clinical importance, informing treatment and triage decisions in the exposed individuals. Biodosimetry approaches allow for determination of dose in the absence of physical measurement apparatus. The current state-of-the-art biod...

journal_title：Radiation research

authors： Pujol-Canadell M,Young E,Smilenov L

更新日期：2019-05-01 00:00:00

abstract：:Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell ("initiation"), followed by the clonal expansion of this cell ("promotion") and by the acquisition of other genetic alterations leading to malignancy ("progression"). The initiation ...

journal_title：Radiation research

authors： Trosko JE,Chang CC,Madhukar BV

更新日期：1990-09-01 00:00:00

abstract：:Cytoglobin is a recently identified vertebrate globin whose functions include scavenging reactive oxygen and nitrosative species. In tumor cells, CYGB may function as a tumor suppressor gene. Here we show that knockdown of cytoglobin expression can sensitize human glioma cells to oxidative stress induced by chemical i...

journal_title：Radiation research

authors： Fang J,Ma I,Allalunis-Turner J

更新日期：2011-08-01 00:00:00

abstract：:The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to ma...

journal_title：Radiation research

authors： Hill MA,Thompson JM,Kavanagh A,Tullis IDC,Newman RG,Prentice J,Beech J,Gilchrist S,Smart S,Fokas E,Vojnovic B

更新日期：2017-09-01 00:00:00

abstract：:Nuclear protein and DNA content of HeLa cells was determined as a function of time following hyperthermia by staining isolated nuclei with two fluorescent dyes: fluorescein isothiocyanate (FITC) for protein content and propidium iodide (PI) for DNA content. Bivariate FITC and PI histograms were obtained by flow cytome...

journal_title：Radiation research

authors： Roti Roti JL,Uygur N,Higashikubo R

更新日期：1986-08-01 00:00:00

abstract：:The modification of methylglyoxal bis(guanylhydrazone) (MGBG) by 42 degrees C hyperthermia-and/or radiation-induced cell killing was examined in Chinese hamster V-79 cells. At concentrations of more than 10 microM, cell survival decreased exponentially with increased MGBG exposure times. Cell lethality of MGBG (10 mic...

journal_title：Radiation research

authors： Miyakoshi J,Heki S

更新日期：1983-12-01 00:00:00

abstract：:The goal of this study was to make a comparison between stereotactic brachytherapy implants and linear accelerator-based radiosurgery of brain tumors with respect to physical dose distributions and radiobiological efficacy. Twenty-four treatment plans made for irradiation of brain tumors with low-dose-rate (125)I brac...

journal_title：Radiation research

authors： Viola A,Major T,Julow J

更新日期：2006-06-01 00:00:00

abstract：:The induction of intracellular DNA strand breaks by X rays and various heavy charged particles was measured by the alkaline unwinding and alkaline and neutral filter elution techniques. No variations in strand break induction were found between the different cell lines under investigation. For a given particle, both t...

journal_title：Radiation research

authors： Heilmann J,Rink H,Taucher-Scholz G,Kraft G

更新日期：1993-07-01 00:00:00

abstract：:Characteristic of damage introduced in DNA by ionizing radiation is the induction of a wide range of lesions. Single-strand breaks (SSBs) and base damages outnumber double-strand breaks (DSBs). If unrepaired, these lesions can lead to DSBs and increased mutagenesis. XRCC1 and DNA polymerase beta (polbeta) are thought ...

journal_title：Radiation research

authors： Vens C,Hofland I,Begg AC

更新日期：2007-09-01 00:00:00