The Development of Technology for Effective Respiratory-Gated Irradiation Using an Image-Guided Small Animal Irradiator.

abstract：:The present study demonstrates the usefulness of immunochemical assays for quantitating modified bases in oxidized and X-irradiated DNA. Escherichia coli, phi X174 RF I, PM2, and M13 DNA containing thymine glycols introduced by OsO4 oxidation were used as antigens in a direct enzyme-linked immunosorbent assay (ELISA)....

journal_title：Radiation research

authors： Hubbard K,Huang H,Laspia MF,Ide H,Erlanger BF,Wallace SS

更新日期：1989-05-01 00:00:00

abstract：:Trypanothione is a unique diglutathionyl-spermidine conjugate found in abundance in trypanosomes but not in other eukaryotes. Because trypanothione is a naturally occurring polyamine thiol reminiscent of the synthetic drug amifostine, it may be a useful protector against radiation and oxidative stress. For these reaso...

journal_title：Radiation research

authors： Fitzgerald MP,Madsen JM,Coleman MC,Teoh ML,Westphal SG,Spitz DR,Radi R,Domann FE

更新日期：2010-09-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...

journal_title：Radiation research

authors： Ivey RG,Moore HD,Voytovich UJ,Thienes CP,Lorentzen TD,Pogosova-Agadjanyan EL,Frayo S,Izaguirre VK,Lundberg SJ,Hedin L,Badiozamani KR,Hoofnagle AN,Stirewalt DL,Wang P,Georges GE,Gopal AK,Paulovich AG

更新日期：2011-03-01 00:00:00

abstract：:Single crystals of guanine hydrobromide monohydrate, in which the guanine base is protonated at N7, were X-irradiated at 8 and 65 K. Using K-band ESR, ENDOR, and field-swept-ENDOR (FSE) techniques, the crystals were studied between 8 K and room temperature. There was evidence for five different radicals, RI-RV, immedi...

journal_title：Radiation research

authors： Hole EO,Sagstuen E,Nelson WH,Close DM

更新日期：1991-02-01 00:00:00

abstract：:We have previously used NotI as the marker enzyme (recognizing GCGGCCGC) in a genome scanning approach for detection of mutations induced in mouse spermatogonia and estimated the mutation induction rate as about 0.7 x 10(-5) per locus per Gy. To see whether different parts of the genome have different sensitivities fo...

journal_title：Radiation research

authors： Asakawa J,Nakamura N,Katayama H,Cullings HM

更新日期：2007-08-01 00:00:00

abstract：:In previous studies we determined a gene expression signature in baboons for predicting the severity of hematological acute radiation syndrome. We subsequently validated a set of eight of these genes in leukemia patients undergoing total-body irradiation. In the current study, we addressed the effect of intra-individu...

journal_title：Radiation research

authors： Agbenyegah S,Abend M,Atkinson MJ,Combs SE,Trott KR,Port M,Majewski M

更新日期：2018-09-01 00:00:00

abstract：:Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need t...

journal_title：Radiation research

authors： Robbins ME,Brunso-Bechtold JK,Peiffer AM,Tsien CI,Bailey JE,Marks LB

更新日期：2012-04-01 00:00:00

abstract：:Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-partic...

journal_title：Radiation research

authors： Weller RE,Buschbom RL,Dagle GE,Park JF,Ragan HA,Watson CR

更新日期：1996-12-01 00:00:00

abstract：:There is strong evidence that biological response to ionizing radiation has a contribution from unirradiated "bystander" cells that respond to signals emitted by irradiated cells. We discuss here an approach incorporating a radiobiological bystander response, superimposed on a direct response due to direct energy depo...

journal_title：Radiation research

authors： Brenner DJ,Little JB,Sachs RK

更新日期：2001-03-01 00:00:00

abstract：:The severe combined immune deficiency (SCID) mouse shows two kinds of phenotypic abnormalities, a high radiosensitivity and an abnormal immunoglobulin gene recombination. A genetic study has revealed that a mutation exists in chromosome 16. However, several attempts to isolate the gene responsible for these phenotypes...

journal_title：Radiation research

authors： Itoh M,Hamatani K,Komatsu K,Araki R,Takayama K,Abe M

更新日期：1993-06-01 00:00:00

abstract：:We recently reported that daily dietary supplementation with 100 µg selenium (a dose exceeding a rat's nutritional requirement by about 33-fold) initiated immediately after total-body irradiation (TBI) and maintained for 21 weeks mitigates radiation nephropathy in a rat model as indicated by blood urea nitrogen (BUN) ...

journal_title：Radiation research

authors： Sieber F,Muir SA,Cohen EP,Fish BL,Mäder M,Schock AM,Althouse BJ,Moulder JE

更新日期：2011-09-01 00:00:00

abstract：:In a scenario involving a nuclear detonation during war or a terrorist attack, acute radiation exposure combined with thermal and blast effects results in severe skin injury. Although the cutaneous injury in such a scenario may not be lethal, it may lead to inflammation, delayed wound healing and loss of the skin barr...

journal_title：Radiation research

authors： Albrecht H,Yang HY,Kiuru M,Maksaereekul S,Durbin-Johnson B,Wong MS,Stevenson TR,Rocke DM,Isseroff RR

更新日期：2018-04-01 00:00:00

abstract：:To compare the effects of exposure to a near-resonant frequency of microwaves at two orientations with a higher frequency exposure, five rhesus monkeys were exposed for 4 hr to 225 MHz, electric field oriented parallel to the long axis of the body (225 MHz-E), and to 225 MHz, magnetic field orientation (225 MHz-H), or...

journal_title：Radiation research

authors： Lotz WG

更新日期：1985-04-01 00:00:00

abstract：:Given the distinct characteristics of low-energy electrons (LEEs), particularly at energies less than 30 eV, they can be applied to a wide range of therapeutic modalities to improve cancer treatment. LEEs have been shown to efficiently produce complex molecular damage resulting in substantial cellular toxicities. Sinc...

journal_title：Radiation research

authors： Rezaee M,Hill RP,Jaffray DA

更新日期：2017-08-01 00:00:00

abstract：:In an effort to identify proteomic changes that may be useful for radiation biodosimetry, human cells of hematological origin were treated with ionizing radiation or mock-irradiated and then harvested at different times after treatment. Protein lysates were generated from these cells and evaluated by Western blotting ...

journal_title：Radiation research

authors： Ivey RG,Subramanian O,Lorentzen TD,Paulovich AG

更新日期：2009-05-01 00:00:00

abstract：:The potential for radiogenic neoplasia from charged-particle irradiation has been estimated using the Harderian gland of the mouse as a test system. Particles ranging in Z from Z = 1 (proton) to Z = 41 (niobium), in energy from 228 to 670A MeV, and in LET from 0.4 to 464 keV/microns were produced at the Lawrence Berke...

journal_title：Radiation research

authors： Alpen EL,Powers-Risius P,Curtis SB,DeGuzman R

更新日期：1993-12-01 00:00:00

abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...

journal_title：Radiation research

authors： Monzen S,Osuda K,Miyazaki Y,Hayashi N,Takahashi K,Kashiwakura I

更新日期：2009-09-01 00:00:00

abstract：:Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is partially manifested by increased leukocyte-endothelial (L/E) intera...

journal_title：Radiation research

authors： Ashcraft KA,Choudhury KR,Birer SR,Hendargo HC,Patel P,Eichenbaum G,Dewhirst MW

更新日期：2018-07-01 00:00:00

abstract：:Synchrotron microbeam radiation treatment (MRT) is a preclinical radiotherapy technique with considerable clinical promise, although some of the underlying radiobiology of MRT is still not well understood. In recently reported studies, it has been suggested that MRT elicits a different tumor immune profile compared to...

journal_title：Radiation research

authors： Ibahim MJ,Yang Y,Crosbie JC,Stevenson A,Cann L,Paiva P,Rogers PA

更新日期：2016-01-01 00:00:00

abstract：:Phosphorylated ATM immunofluorescence staining was used to investigate the dose-response relationship for the number of DNA double-strand breaks (DSBs) induced in primary normal human fibroblasts irradiated with doses from 1.2 to 200 mGy. The induction of DSBs showed a supralinear dose-response relationship. Radiation...

journal_title：Radiation research

authors： Ojima M,Ban N,Kai M

更新日期：2008-09-01 00:00:00

abstract：:Experiments were performed with three different cell lines, mouse fibroblast LM cells, HeLa S3 cells, and Ehrlich Ascites Tumor (EAT) cells, to establish the possible importance of hyperthermic-induced alterations in cellular K+ content in the mechanism of cell killing by heat. At different time points after the hyper...

journal_title：Radiation research

authors： Ruifrok AC,Kanon B,Konings AW

更新日期：1987-02-01 00:00:00

abstract：:We show here that the arrests of cells in G2 phase of the cell cycle induced by either staurosporine or ionizing radiation are closely related phenomena governed by a common kinase signaling pathway. The protein kinase inhibitor staurosporine induces a complete G2-phase arrest in exponentially growing TK6 human lympho...

journal_title：Radiation research

authors： Crompton NE,Hain J,Jaussi R,Burkart W

更新日期：1993-09-01 00:00:00

abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...

journal_title：Radiation research

authors： Beinke C,Barnard S,Boulay-Greene H,De Amicis A,De Sanctis S,Herodin F,Jones A,Kulka U,Lista F,Lloyd D,Martigne P,Moquet J,Oestreicher U,Romm H,Rothkamm K,Valente M,Meineke V,Braselmann H,Abend M

更新日期：2013-08-01 00:00:00

abstract：:FLASH radiation therapy (FLASH-RT) reference dosimetry to obtain traceability, repeatability and stability of irradiations cannot be performed with conventional dosimetric methods, such as monitor chambers or ionization chambers. Until now, only passive dosimeters have provided the necessary dosimetric data. Alanine d...

journal_title：Radiation research

authors： Gondré M,Jorge PG,Vozenin MC,Bourhis J,Bochud F,Bailat C,Moeckli R

更新日期：2020-12-01 00:00:00

abstract：:Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell ("initiation"), followed by the clonal expansion of this cell ("promotion") and by the acquisition of other genetic alterations leading to malignancy ("progression"). The initiation ...

journal_title：Radiation research

authors： Trosko JE,Chang CC,Madhukar BV

更新日期：1990-09-01 00:00:00

abstract：:The molecular basis of radiotherapy-related multidrug resistance (MDR) is still unclear. Here we report on a study investigating the effect of fractionated irradiation on expression of the MDR-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance-related protein ...

journal_title：Radiation research

authors： Bottke D,Koychev D,Busse A,Heufelder K,Wiegel T,Thiel E,Hinkelbein W,Keilholz U

更新日期：2008-07-01 00:00:00

abstract：:Radiation-induced complications of the respiratory system are a common side effect of thoracic radiotherapy with no viable treatment option. Here, we investigated the potential therapeutic effect of the orphan drug pirfenidone for treating radiation-induced pulmonary fibrosis. C57BL/6 mice received a single fraction o...

journal_title：Radiation research

authors： Qin W,Liu B,Yi M,Li L,Tang Y,Wu B,Yuan X

更新日期：2018-10-01 00:00:00

abstract：:In the double-strand break (DSB) model, the initial slope (alpha) of the survival curve is determined by the number of DSBs remaining unrepaired at a certain time after irradiation. There are three types of calculations which confirm the validity of this approach. First, the model quite reasonably predicts the low-LET...

journal_title：Radiation research

authors： Ostashevsky JY

更新日期：1993-02-01 00:00:00

abstract：:Two very different techniques for measuring the energy of neutrons in the energy range 0.1-10 MeV are presented and compared. A recoil-proton spectrometer is used to determine the energy spectra of neutrons produced by the d(4)-Be and p(4)-Be reactions down to the low-energy threshold of 0.7 MeV. The same radiation fi...

journal_title：Radiation research

authors： Folkard M,Makrigiorgos G,Roper MJ,Waker AJ,Michael BD

更新日期：1989-04-01 00:00:00