Ret, Abl1 (cAbl) and Trp53 gene fragmentations in comet-FISH assay act as in vivo biomarkers of radiation exposure in C57BL/6 and CBA/J mice.

abstract：:Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy ...

journal_title：Radiation research

authors： Fanton JW,Golden JG

更新日期：1991-05-01 00:00:00

abstract：:Alteration of adhesion molecule expression on endothelial cells has a direct connection with ionizing radiation-induced atherosclerosis, which is an adverse effect observed after radiotherapy. However, minimal attention has been given to monocytes/macrophages role in atherosclerosis development, which are exposed to t...

journal_title：Radiation research

authors： Yuan Y,Lee SH,Wu S

更新日期：2013-01-01 00:00:00

abstract：:We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7-9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardio...

journal_title：Radiation research

authors： Unthank JL,Ortiz M,Trivedi H,Pelus LM,Sampson CH,Sellamuthu R,Fisher A,Chua HL,Plett A,Orschell CM,Cohen EP,Miller SJ

更新日期：2019-05-01 00:00:00

abstract：:Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...

journal_title：Radiation research

authors： Chomentowski M,Kellerer AM,Pierce DA

更新日期：2000-03-01 00:00:00

abstract：:In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there e...

journal_title：Radiation research

authors： DiCarlo AL,Tamarat R,Rios CI,Benderitter M,Czarniecki CW,Allio TC,Macchiarini F,Maidment BW,Jourdain JR

更新日期：2017-08-01 00:00:00

abstract：:Normal human fibroblasts in plateau phase ( congruent with 95% G(1) phase) were stained with the vital nuclear dye Hoechst 33342 (blue fluorescence) or the vital cytoplasmic dye Cell Tracker Orange (orange fluorescence) and plated at a ratio of 1:1. Only the blue-fluorescing nuclei were microbeam-irradiated with a def...

journal_title：Radiation research

authors： Ponnaiya B,Jenkins-Baker G,Brenner DJ,Hall EJ,Randers-Pehrson G,Geard CR

更新日期：2004-10-01 00:00:00

abstract：:A study has been made of methods for rapidly inactivating cells of E. coli at neutral pH to prevent enzymatic, chemical, or physical modification to DNA damaged by irradiation. The radiation was delivered in a fraction of a second using an electron accelerator. Cell inactivation was with ethanol or a solution (CSE) co...

journal_title：Radiation research

authors： Tilby MJ,Loverock PS

更新日期：1983-11-01 00:00:00

abstract：:We tested the possibility that hyperthermia kills HA-1 cells in a manner analogous to growth factor deprivation. HA-1 cells were inactivated by serum starvation when incubated in Eagle's MEM at a density of 40 cells/cm2 or less. Cells became resistant to the absence of serum when the cell density was greater than 400 ...

journal_title：Radiation research

authors： Lin PP,Hahn GM

更新日期：1988-03-01 00:00:00

abstract：:We demonstrate by western analysis that the expression levels of TP53 (formerly known as p53), CDKN1A (formerly known as p21Waf1), CDC2 (formerly known as p34cdc2), CCNB1 (cyclin B1) and RAD51 are significantly modulated in confluent, density-inhibited human diploid cell populations exposed to doses where only a small...

journal_title：Radiation research

authors： Azzam EI,de Toledo SM,Gooding T,Little JB

更新日期：1998-11-01 00:00:00

abstract：:We studied heat-induced apoptosis and loss of clonogenicity in Rat-1 fibroblasts, thermotolerant Rat-1 (TT Rat-1), Rat-1 transfected with the human hsp-70 gene (M21) and Rat-1 transfected with the human c-myc proto-oncogene (Rat-1:myc). Relative to Rat-1, TT Rat-1 and M21 cells are heat-resistant, but Rat-1:myc cells ...

journal_title：Radiation research

authors： Li WX,Chen CH,Ling CC,Li GC

更新日期：1996-03-01 00:00:00

abstract：:The presence of oxygen-deficient tumor cells is a critical issue in cancer therapy. To identify tumor hypoxia, tissue partial oxygen pressure (pO2) can be measured directly. The OxyLite system allows determination of pO2 in tumors and permits continuous measurements of pO2 at a fixed point. In this study, this system ...

journal_title：Radiation research

authors： Wen B,Urano M,O'Donoghue JA,Ling CC

更新日期：2006-09-01 00:00:00

abstract：:Radiation sensitivity was measured by the micronucleus assay in T lymphocytes of the spleen and in fibroblasts derived from three inbred strains of mice, BALB/c, A/J and C3H/He. A linear correlation between the surviving fraction and the micronucleus frequency was obtained. There were clear differences in the radiosen...

journal_title：Radiation research

authors： Kinashi Y,Ono K,Abe M

更新日期：1997-10-01 00:00:00

abstract：:Metallothionein (MT), the synthesis of which can be induced by metalloelement administration, is a known radical scavenger. This study investigated the possible protective effect of MT against acute radiation injury. Manganese chloride (10 mg of manganese/kg) was administered intraperitoneally to male C3H/He mice 24 h...

journal_title：Radiation research

authors： Murata R,Nishimura Y,Hiraoka M,Abe M,Satoh M

更新日期：1995-09-01 00:00:00

abstract：:Single crystals of guanine hydrochloride monohydrate, guanine hydrochloride dihydrate and anhydrous guanine dihydrochloride, doped with thioguanine, were irradiated with X and gamma rays. In all three systems the dominant radicals were associated with thioguanine. In the former two systems the stabilized species is th...

journal_title：Radiation research

authors： Herak JN,Sanković K,Krilov D,Hüttermann J

更新日期：1999-03-01 00:00:00

abstract：:C57BL/6J male mice were inoculated with 5 X 10(5) B16a melanoma cells. Seven days post-inoculation, when the tumor had grown to 8.0-10.0 mm in diameter, 120 tumor-bearing mice were randomly divided into three groups: (1) sham-irradiated controls, (2) mice receiving 200 cGy five times a week for 6 weeks, and (3) mice r...

journal_title：Radiation research

authors： Shen RN,Hornback NB,Shidnia H,Lu L,Montebello JF,Brahmi Z

更新日期：1988-05-01 00:00:00

abstract：:Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...

journal_title：Radiation research

authors： Latre L,Genescà A,Martín M,Ribas M,Egozcue J,Blasco MA,Tusell L

更新日期：2004-08-01 00:00:00

abstract：:After exposure to 10 or 20 J/m2 UVC light, cells of the UMN-PIE-1181 line, an embryonic cell line derived from the Indian meal moth, Plodia interpunctella, exhibited a rapid and prolonged depression in the rate of incorporation of [3H]thymidine, whereas cells of the TN-368 line, an ovarian cell line derived from Trich...

journal_title：Radiation research

authors： Styer SC,Griffiths TD

更新日期：1992-04-01 00:00:00

abstract：:Cognitive impairments after brain irradiation seriously affect quality of life for patients, and there is currently no effective treatment. In this study using an irradiated rat model, the role of electroacupuncture was investigated for treatment of radiation-induced brain injury. Animals received 10 Gy exposure to th...

journal_title：Radiation research

authors： Fan XW,Liu HH,Wang HB,Chen F,Yang Y,Chen Y,Guan SK,Wu KL

更新日期：2017-06-01 00:00:00

abstract：:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT ut...

journal_title：Radiation research

authors： Prezado Y,Deman P,Varlet P,Jouvion G,Gil S,Le Clec'H C,Bernard H,Le Duc G,Sarun S

更新日期：2015-09-01 00:00:00

abstract：:The response of the testes of two strains of adult rats (Sprague-Dawley and Wistar) to graded single doses and split doses of 230 kVp X rays has been investigated. A marked difference was noted between the strains in the response of the clonogenic spermatogonia to irradiation, as measured histologically by the repopul...

journal_title：Radiation research

authors： Delic JI,Schlappack OK,Harwood JR,Stanley JA

更新日期：1987-10-01 00:00:00

abstract：:We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated ...

journal_title：Radiation research

authors： Asakawa J,Kuick R,Kodaira M,Nakamura N,Katayama H,Pierce D,Funamoto S,Preston D,Satoh C,Neel JV,Hanash S

更新日期：2004-04-01 00:00:00

abstract：:Therapeutic gain factors (TGFs) have been determined for three spontaneous tumors of the C3H mouse treated by photons + normobaric oxygen (O2(1) ATA), photons + hyperbaric oxygen (O2 3 ATA), photons + misonidazole, or fast neutrons. The tumors were early generation isotransplants of spontaneous tumors: MCaIV, a mammar...

journal_title：Radiation research

authors： Suit HD,Sedlacek R,Silver G,Hsieh CC,Epp ER,Ngo FQ,Roberts WK,Verhey L

更新日期：1988-12-01 00:00:00

abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...

journal_title：Radiation research

authors： Takahashi S,Patrick G

更新日期：1987-06-01 00:00:00

abstract：:The statistical distribution of the number of ion pairs per ionizing event in a small volume simulating a tissue sphere was obtained by applying the Expectation-Maximization (EM) algorithm to experimental spectra measured by exposing a Rossi-type spherical proportional counter to gamma radiation. The normalized experi...

journal_title：Radiation research

authors： Obelić B,Srdoc D,Djurić PM,Marino SA

更新日期：1998-05-01 00:00:00

abstract：:Characteristic of damage introduced in DNA by ionizing radiation is the induction of a wide range of lesions. Single-strand breaks (SSBs) and base damages outnumber double-strand breaks (DSBs). If unrepaired, these lesions can lead to DSBs and increased mutagenesis. XRCC1 and DNA polymerase beta (polbeta) are thought ...

journal_title：Radiation research

authors： Vens C,Hofland I,Begg AC

更新日期：2007-09-01 00:00:00

abstract：:The effects of 60Co gamma rays on calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers and neuropeptide Y (NPY)-immunoreactive nerve fibers were examined in mesenteric blood vessels of rats. Using a free-floating immunostaining streptavidin-biotin peroxidase complex method combined with a nickel-enhancem...

journal_title：Radiation research

authors： Zhang CG,Cai WQ,Li Y,Huang WQ,Su HC

更新日期：1998-01-01 00:00:00

abstract：:Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approximately 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a ...

journal_title：Radiation research

authors： Choofong S,Cloutier P,Sanche L,Wagner JR

更新日期：2016-11-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:Cancer mortality in relation to radiation dose was evaluated among 4153 women treated with intrauterine radium (226Ra) capsules for benign gynecologic bleeding disorders between 1925 and 1965. Average follow up was 26.5 years (maximum = 59.9 years). Overall, 2763 deaths were observed versus 2687 expected based on U.S....

journal_title：Radiation research

authors： Inskip PD,Monson RR,Wagoner JK,Stovall M,Davis FG,Kleinerman RA,Boice JD Jr

更新日期：1990-09-01 00:00:00

abstract：:Radiation therapy is an essential component of cancer treatment. Currently, tumor control and normal tissue complication probabilities derived from a general patient population guide radiation treatment. Its outcome could be improved if radiation biomarkers could be incorporated into approaches to treatment. A substan...

journal_title：Radiation research

authors： Prasanna PGS,Narayanan D,Zhang K,Rahbar A,Coleman CN,Vikram B

更新日期：2020-03-01 00:00:00