Abstract:
:The effects of ionizing radiation, with or without the anti-angiogenic agent anginex (Ax), on multiple myeloma growth were tested in a SCID-rab mouse model. Mice carrying human multiple myeloma cell-containing pre-implanted bone grafts were treated weekly with various regimens for 8 weeks. Rapid multiple myeloma growth, assessed by bioluminescence intensity (IVIS), human lambda Ig light chain level in serum (ELISA), and the volume of bone grafts (caliper), was observed in untreated mice. Tumor burden in mice receiving combined therapy was reduced to 59% (by caliper), 43% (by ELISA), and 2% (by IVIS) of baseline values after 8 weeks of treatment. Ax or radiation alone slowed but did not stop tumor growth. Four weeks after the withdrawal of the treatments, tumor burden remained minimal in mice given Ax + radiation but increased noticeably in the other three groups. Multiple myeloma suppression by Ax + radiation was accompanied by a marked decrease in the number and activity of osteoclasts in bone grafts assessed by histology. Bone graft integrity was preserved by Ax + radiation but was lost in the other three groups, as assessed by microCT imaging and radiography. These results suggest that radiotherapy, when primed by anti-angiogenic agents, may be a potent therapy for focal multiple myeloma.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Jia D,Koonce NA,Halakatti R,Li X,Yaccoby S,Swain FL,Suva LJ,Hennings L,Berridge MS,Apana SM,Mayo K,Corry PM,Griffin RJdoi
10.1667/RR1734.1subject
Has Abstractpub_date
2010-06-01 00:00:00pages
809-17issue
6eissn
0033-7587issn
1938-5404journal_volume
173pub_type
杂志文章abstract::1. A survival curve for the colony-forming ability of mouse bone marrow cells irradiated in vivo with Co60 gamma-rays has been obtained. The curve may be characterized by D0 of 95 rads and an extrapolation number of 1.5. 2. Comparison with the survival curve obtained for irradiated in vitro indicated a statistically s...
journal_title:Radiation research
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更新日期:1962-06-01 00:00:00
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journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
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journal_title:Radiation research
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更新日期:2019-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1968-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-10 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3289
更新日期:2005-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::The natural survival, relative to properly chosen controls, of 26 beagle dogs injected once intravenously with an average of 0.58 +/- 0.04 kBq 239Pu/kg, 23 dogs injected with 2.31 +/- 0.43 kBq 226Ra/kg, 13 dogs injected with 1.84 +/- 0.26 kBq 228Ra/kg, 12 dogs injected with 0.56 +/- 0.030 kBq 228Th/kg, and 12 dogs inj...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estro...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::The effect of X irradiation on the respiration of rat thymocytes was studied. An increase in the rate of O2 uptake was observed 1 h after cells were irradiated with doses of 6-10 Gy. The radiation-induced increase in respiration could be blocked by oligomycin, an inhibitor of mitochondrial ATP synthase, suggesting con...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Current therapeutic approaches for treatment of exposure to radiation involve the use of antioxidants, chelating agents, recombinant growth factors and transplantation of stem cells (e.g., hematopoietic stem cell transplantation). However, exposure to high-dose radiation is associated with severe damage to the vascula...
journal_title:Radiation research
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00