Computer programs for the analysis of cellular survival data.

abstract：:Radiation-induced heart disease (RIHD) is a serious side effect of radiotherapy for intrathoracic and chest wall tumors. The threshold dose for development of clinically significant RIHD is believed to be lower than previously assumed. Therefore, research into mechanisms of RIHD has gained substantial momentum. RIHD b...

journal_title：Radiation research

authors： Boerma M

更新日期：2012-07-01 00:00:00

abstract：:The effect of ionizing radiation (137Cs) on processing and transport of ribosomal RNA (rRNA) was studied by pulse-labeling HeLa S3 cells with [3H]uridine immediately prior to irradiation. This approach permits kinetic analysis of processing of 45 S rRNA (radiolabeled predominantly prior to irradiation) into its 28 S a...

journal_title：Radiation research

authors： Fuchs P,Krolak JM,McClain D,Minton KW

更新日期：1990-01-01 00:00:00

abstract：:Radiation sensitivity was measured by the micronucleus assay in T lymphocytes of the spleen and in fibroblasts derived from three inbred strains of mice, BALB/c, A/J and C3H/He. A linear correlation between the surviving fraction and the micronucleus frequency was obtained. There were clear differences in the radiosen...

journal_title：Radiation research

authors： Kinashi Y,Ono K,Abe M

更新日期：1997-10-01 00:00:00

abstract：:The acute effects of proton whole-body irradiation on the distribution and function of leukocyte populations in the spleen and blood were examined and compared to the effects of photons derived from a (60)Co gamma-ray source. Adult female C57BL/6 mice were exposed to a single dose (3 Gy at 0.4 Gy/min) of protons at sp...

journal_title：Radiation research

authors： Kajioka EH,Andres ML,Li J,Mao XW,Moyers MF,Nelson GA,Slater JM,Gridley DS

更新日期：2000-05-01 00:00:00

abstract：:Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need t...

journal_title：Radiation research

authors： Robbins ME,Brunso-Bechtold JK,Peiffer AM,Tsien CI,Bailey JE,Marks LB

更新日期：2012-04-01 00:00:00

abstract：:Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic regimens or when combined with ionizing radiation (radiosensitization). While it is known that mismatches in DNA are necessary for dFdCyd radiosensitization, the critical event resulting in radiosensitization has not been identifie...

journal_title：Radiation research

authors： Im MM,Flanagan SA,Ackroyd JJ,Knapp B,Kramer A,Shewach DS

更新日期：2016-11-01 00:00:00

abstract：:The radiation risk of skin cancer by histological types has been evaluated in the atomic bomb survivors. We examined 80,158 of the 120,321 cohort members who had their radiation dose estimated by the latest dosimetry system (DS02). Potential skin tumors diagnosed from 1958 to 1996 were reviewed by a panel of pathologi...

journal_title：Radiation research

authors： Sugiyama H,Misumi M,Kishikawa M,Iseki M,Yonehara S,Hayashi T,Soda M,Tokuoka S,Shimizu Y,Sakata R,Grant EJ,Kasagi F,Mabuchi K,Suyama A,Ozasa K

更新日期：2014-05-01 00:00:00

abstract：:The purpose of this work was to determine how fractionated radiation used in the treatment of tumors affects the ability of cancer as well as normal cells to repair induced DNA double-strand breaks (DSBs) and how cells that have lost this ability die. Lymphocytic leukemia cells (MOLT4) were used as an experimental mod...

journal_title：Radiation research

authors： Rezáčová M,Rudolfová G,Tichý A,Bačíková A,Mutná D,Havelek R,Vávrová J,Odrážka K,Lukášová E,Kozubek S

更新日期：2011-06-01 00:00:00

abstract：:The increasing use of mobile phones by children and teenagers has raised concerns about their safety. Addressing such concerns is difficult, because no data are available on possible effects from long-term exposure to radiofrequency (RF) fields during the development of the nervous system. Possible morphological and f...

journal_title：Radiation research

authors： Kumlin T,Iivonen H,Miettinen P,Juvonen A,van Groen T,Puranen L,Pitkäaho R,Juutilainen J,Tanila H

更新日期：2007-10-01 00:00:00

abstract：:There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern comp...

journal_title：Radiation research

authors： Sproull M,Kramp T,Tandle A,Shankavaram U,Camphausen K

更新日期：2015-07-01 00:00:00

abstract：:Irradiation from internally deposited radionuclides induces malignant tumors. Ingested long-lived radionuclides accumulate in specific organs that are irradiated throughout life. To elucidate why the development of malignant tumors requires long-term internal exposure, of the order of decades, despite the fact that ir...

journal_title：Radiation research

authors： Yamamoto Y,Usuda N,Takatsuji T,Kuwahara Y,Fukumoto M

更新日期：2009-04-01 00:00:00

abstract：:Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...

journal_title：Radiation research

authors： Latre L,Genescà A,Martín M,Ribas M,Egozcue J,Blasco MA,Tusell L

更新日期：2004-08-01 00:00:00

abstract：:A study has been made of methods for rapidly inactivating cells of E. coli at neutral pH to prevent enzymatic, chemical, or physical modification to DNA damaged by irradiation. The radiation was delivered in a fraction of a second using an electron accelerator. Cell inactivation was with ethanol or a solution (CSE) co...

journal_title：Radiation research

authors： Tilby MJ,Loverock PS

更新日期：1983-11-01 00:00:00

abstract：:Male rabbits were exposed to a single irradiation dose of 1000-5000 rad when 12, 15, 16, and 17 months old and were killed when 18 months old (i.e., 1, 2, 3, and 6 months after irradiation). Even after this long interval after irradiation, abdominal aortic prostacyclin formation was significantly depressed, whereas th...

journal_title：Radiation research

authors： Sinzinger H,Cromwell M,Firbas W

更新日期：1984-03-01 00:00:00

abstract：:Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell ("initiation"), followed by the clonal expansion of this cell ("promotion") and by the acquisition of other genetic alterations leading to malignancy ("progression"). The initiation ...

journal_title：Radiation research

authors： Trosko JE,Chang CC,Madhukar BV

更新日期：1990-09-01 00:00:00

abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...

journal_title：Radiation research

authors： Sanchez MC,Nelson GA,Green LM

更新日期：2010-12-01 00:00:00

abstract：:Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in Sfpi1 on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of the Sfpi1 gene (DSG) and point mutation of the allele Sfpi1 gene (PMASG). In this study, we ...

journal_title：Radiation research

authors： Ojima M,Hirouchi T,Etani R,Ariyoshi K,Fujishima Y,Kai M

更新日期：2019-12-01 00:00:00

abstract：:Puskin, J. S. What Can Epidemiology Tell Us about Risks at Low Doses? Radiat. Res. 169, 122-124 (2008). Limitations on statistical power preclude direct detection and quantification of radiogenic cancer risks at very low (environmental) levels of low-LET radiation through epidemiological studies. Given this limitation...

journal_title：Radiation research

authors： Puskin JS

更新日期：2008-01-01 00:00:00

abstract：:The ability of the aminothiol WR-1065 [N-(2-mercaptoethyl)-1,3-diaminopropane] to protect L5178Y (LY) cells against the cytotoxic and mutagenic effects of exposure to accelerated (56)Fe ions (1.08 GeV/nucleon) was determined. It was found that while WR-1065 reduced the mutagenicity in both cell lines when it was prese...

journal_title：Radiation research

authors： Evans HH,Evans TE,Horng MF

更新日期：2002-07-01 00:00:00

abstract：:Currently, there is a serious absence of pharmaceutically attractive small molecules that mitigate the lethal effects of an accidental or intentional public exposure to toxic doses of ionizing radiation. Moreover, cellular systems that emulate the radiobiologically relevant cell populations and that are suitable for h...

journal_title：Radiation research

authors： Zellefrow CD,Sharlow ER,Epperly MW,Reese CE,Shun T,Lira A,Greenberger JS,Lazo JS

更新日期：2012-09-01 00:00:00

abstract：:We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7-9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardio...

journal_title：Radiation research

authors： Unthank JL,Ortiz M,Trivedi H,Pelus LM,Sampson CH,Sellamuthu R,Fisher A,Chua HL,Plett A,Orschell CM,Cohen EP,Miller SJ

更新日期：2019-05-01 00:00:00

abstract：:This report compares the deterministic effects from an alpha-particle-emitting radionuclide, (239)PuO(2), and a beta-particle emitter, (144)Ce in fused aluminosilicate particles (FAP). The studies were conducted in beagle dogs of both genders exposed by inhalation to aerosols of the radionuclides. The initial lung bur...

journal_title：Radiation research

authors： Muggenburg BA,Hahn FF,Ménache MG,Guilmette RA,Boecker BB

更新日期：1999-12-01 00:00:00

abstract：:The widely distributed xanthine oxidoreductase (XOR) system has been shown to be modulated upon exposure of animals to ionizing radiation through the conversion of xanthine dehydrogenase (XDH) into xanthine oxidase (XO). In the present work, radiomodification of the XOR system by phenylmethylsulfonyl fluoride (PMSF) a...

journal_title：Radiation research

authors： Srivastava M,Kale RK

更新日期：2000-07-01 00:00:00

abstract：:A statistical technique is given which can be used to estimate the parameters of the two-component model for cell survival from quantal response multifraction data. The method is a nonlinear logistic regression and relies on a mild assumption relating the probability of death to cell survival level. The method is demo...

journal_title：Radiation research

authors： Taylor JM,Withers HR

更新日期：1985-12-01 00:00:00

abstract：:Human erythrocytes were isolated from the blood of healthy donors and then incubated in the presence of suspensions of alpha-tocopherol for 30 min at 37 degrees C. Unabsorbed tocopherol was removed by centrifugation using several washes of isotonic phosphate-buffered saline. Washed erythrocytes were resuspended to 0.0...

journal_title：Radiation research

authors： Brown MA

更新日期：1983-08-01 00:00:00

abstract：:We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions. Here we present data...

journal_title：Radiation research

authors： Desai N,Davis E,O'Neill P,Durante M,Cucinotta FA,Wu H

更新日期：2005-10-01 00:00:00

abstract：:Exposure to ionizing radiation or a variety of chemical agents is known to increase the risk of developing malignancy and many tumors have been linked to inflammatory processes. In most studies, the potentially harmful effects of ionizing radiation or other agents are considered in isolation, mainly due to the large n...

journal_title：Radiation research

authors： McAllister KA,Lorimore SA,Wright EG,Coates PJ

更新日期：2012-05-01 00:00:00

abstract：:To accurately quantify the number of single-strand breaks (SSBs) induced in plasmid DNA molecules after irradiation, a new type of assay methodology has been explored. The new method is based on the TUNEL (terminal deoxynucleotide transferase dUTP nick end-labeling) assay that was adopted for use under ELISA (enzyme-l...

journal_title：Radiation research

authors： Smiałek MA,Moore SA,Mason NJ,Shuker DE

更新日期：2009-11-01 00:00:00

abstract：:Cell-cell contact is thought to be critically involved in mechanisms leading to radioresistance. Here, we assessed the influence of confluent compared to subconfluent cell culture conditions and the radiosensitizing ability of E-cadherin inhibition alone or in combination with C225-mediated EGFR inhibition in human sq...

journal_title：Radiation research

authors： Mazzeo E,Hehlgans S,Valentini V,Baumann M,Cordes N

更新日期：2012-09-01 00:00:00

abstract：:A new model for the survival of bacteria exposed to ionizing radiation is constructed in the framework of a target theory based on microdosimetric concepts, where single- and double-strand breaks of DNA and their repair in vivo can be described consistently in terms of the microdosimetric quantity j (number of effecti...

journal_title：Radiation research

authors： Iwanami S,Oda N

更新日期：1985-04-01 00:00:00