Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study.

abstract：:The mechanisms underlying the hyper-radiosensitivity of AT cells were investigated by analyzing chromosome aberrations in the G(2) and M phases of the cell cycle using a combination of chemically induced premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with chromosome painting prob...

journal_title：Radiation research

authors： Kawata T,Ito H,George K,Wu H,Uno T,Isobe K,Cucinotta FA

更新日期：2003-05-01 00:00:00

abstract：:A historical cohort mortality study was conducted among 28,008 white male employees who had worked for at least 1 month in Oak Ridge, Tennessee, during World War II. The workers were employed at two plants that were producing enriched uranium and a research and development laboratory. Vital status was ascertained thro...

journal_title：Radiation research

authors： Frome EL,Cragle DL,McLain RW

更新日期：1990-08-01 00:00:00

abstract：:Changes in the free-cell population of the lungs of two strains of mice (SAS/4 and CBA/H) were studied up to 4 months after inhalation exposure to a sized fraction of 239PuO2 particles (1.5 micron AMAD) to give initial alveolar depositions (IADs) ranging from 17 to 810 Bq. A sample of the free-cell population of the l...

journal_title：Radiation research

authors： Moores SR,Talbot RJ,Evans N,Lambert BE

更新日期：1986-03-01 00:00:00

abstract：:Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and with...

journal_title：Radiation research

authors： Furusawa Y,Wei ZL,Sakurai H,Tabuchi Y,Li P,Zhao QL,Nomura T,Saiki I,Kondo T

更新日期：2012-06-01 00:00:00

abstract：:Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing doubl...

journal_title：Radiation research

authors： Box HC,Freund HG,Budzinski EE,Wallace JC,Maccubbin AE

更新日期：1995-01-01 00:00:00

abstract：:The present study demonstrates the usefulness of immunochemical assays for quantitating modified bases in oxidized and X-irradiated DNA. Escherichia coli, phi X174 RF I, PM2, and M13 DNA containing thymine glycols introduced by OsO4 oxidation were used as antigens in a direct enzyme-linked immunosorbent assay (ELISA)....

journal_title：Radiation research

authors： Hubbard K,Huang H,Laspia MF,Ide H,Erlanger BF,Wallace SS

更新日期：1989-05-01 00:00:00

abstract：:Clustered DNA damage is considered an important factor in determining the biological consequences of ionizing radiation. In this study, we successfully estimated the localization of abasic sites (APs) in DNA exposed to ionizing radiation using fluorescence resonance energy transfer (FRET) without any involvement of re...

journal_title：Radiation research

authors： Akamatsu K,Shikazono N,Saito T

更新日期：2015-01-01 00:00:00

abstract：:Trypanothione is a unique diglutathionyl-spermidine conjugate found in abundance in trypanosomes but not in other eukaryotes. Because trypanothione is a naturally occurring polyamine thiol reminiscent of the synthetic drug amifostine, it may be a useful protector against radiation and oxidative stress. For these reaso...

journal_title：Radiation research

authors： Fitzgerald MP,Madsen JM,Coleman MC,Teoh ML,Westphal SG,Spitz DR,Radi R,Domann FE

更新日期：2010-09-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) is an aggressive disease with a high risk of recurrence and death. Here, we present a novel strategy to enhance the radiotherapy of TNBC by combining gold nanoparticles (AuNPs) with pentamidine, a clinically approved anti-parasitic agent with anti-cancer properties. The radiosensit...

journal_title：Radiation research

authors： Her S,Cui L,Bristow RG,Allen C

更新日期：2016-05-01 00:00:00

abstract：:The effect of both hyperthermia and verapamil on cytotoxicity and transport of melphalan was studied in a pleiotropic drug-resistant Chinese hamster ovary cell line (CHRC5) and in the drug-sensitive parent line (AuxB1). The CHRC5 cell line was selected for resistance to colchicine but is also cross-resistant to other ...

journal_title：Radiation research

authors： Averill-Bates DA,Courtemanche B

更新日期：1995-07-01 00:00:00

abstract：:Although conclusive evidence has been obtained for the presence of radiation-induced bystander effects, the mechanisms that trigger and regulate these processes are still largely unknown. The bystander effect may play a critical role in determining the biological effectiveness of low-dose exposures, but questions on h...

journal_title：Radiation research

authors： Schettino G,Folkard M,Michael BD,Prise KM

更新日期：2005-03-01 00:00:00

abstract：:We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions. Here we present data...

journal_title：Radiation research

authors： Desai N,Davis E,O'Neill P,Durante M,Cucinotta FA,Wu H

更新日期：2005-10-01 00:00:00

abstract：:The effect of ionizing radiation on the survival of bovine aortic endothelial (BAE) cells was determined by the in vitro colony formation method. The BAE cells were cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% calf serum, antibiotics, and growth factors obtained from the culture of mouse...

journal_title：Radiation research

authors： Rhee JG,Lee I,Song CW

更新日期：1986-05-01 00:00:00

abstract：:We describe a rapid assay to predict intrinsic radiosensitivity of normal tissues based on the radiation-induced cytotoxic response of a number of types of white blood cells. Twenty-four hours after irradiation, leukocytes were prepared for analysis by flow cytometry. Radiation-induced cytotoxicity was characterized b...

journal_title：Radiation research

authors： Crompton NE,Ozsahin M

更新日期：1997-01-01 00:00:00

abstract：:The filter elution technique using nondenaturing conditions is widely used to assay DNA double-strand break (DSB) induction and repair. It has been reported that in the measurement of strand breaks higher rates of elution and of initial rejoining are obtained at pH 9.6 compared to pH 7.2. In the present experiments ne...

journal_title：Radiation research

authors： Flick MB,Warters RL,Yasui LS,Krisch RE

更新日期：1989-09-01 00:00:00

abstract：:Experiments were performed to determine whether diurnal variations in apoptosis in the mouse small intestine after irradiation with 2.5 Gy gamma rays depended on the time of day that the mice were irradiated, the time of day that the mice were sacrificed or the interval between irradiation and sacrifice. Experiments w...

journal_title：Radiation research

authors： Ruifrok AC,Weil MM,Thames HD,Mason KA

更新日期：1998-04-01 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding ...

journal_title：Radiation research

authors： Hale ML,Briggs R,McCarthy KF

更新日期：1991-02-01 00:00:00

abstract：:Single crystals of disodium beta-glycerophosphate pentahemihydrate (betaGP), Na2x(HO)CH2CH(PO(4)2-)CH2(OH)x5 1/2H2O, were X-irradiated at 77 and 280 K. EPR, ENDOR and FSE techniques were used to study the formation of free radicals in these irradiated crystals to characterize possible reaction mechanisms leading to de...

journal_title：Radiation research

authors： Baine TJ,Sagstuen E

更新日期：1998-08-01 00:00:00

abstract：:X rays have been shown to induce two forms of potentially lethal damage (PLD), "fast-repairing" PLD and "slowly repairing" PLD, whose repair is completed in 1 h and 4-6 h, respectively. In this study three modes of treatment with hypertonic solutions containing different NaCl concentrations for different durations (0....

journal_title：Radiation research

authors： Ikebuchi M,Kimura H,Hill CK,Aoyama T

更新日期：1995-01-01 00:00:00

abstract：:Induction of interphase death was examined in Chinese hamster ovary cells exposed to accelerated heavy ions (carbon, neon, argon and iron) of various linear energy transfers (LETs) (10-2000 keV/microm). The fraction of cells that underwent interphase death was determined by observing individual cells with time-lapse p...

journal_title：Radiation research

authors： Sasaki H,Yatagai F,Kanai T,Furusawa Y,Hanaoka F,Zhu WG,Mehnati P

更新日期：1997-11-01 00:00:00

abstract：:Individual differences in response to radiation are well known, but the molecular basis for these differences is not well understood, and molecular indicators that are useful in assessing individual variation are lacking. Cells from patients developing unexpected radiation responses have occasionally been analyzed for...

journal_title：Radiation research

authors： Ford BN,Wilkinson D,Thorleifson EM,Tracy BL

更新日期：2001-11-01 00:00:00

abstract：:The growth of certain UV-radiation-induced tumors is suppressed by T lymphocytes, but it has been proposed that non-T lymphocytes stimulate the growth of several of these tumors. In this study, the indirect effects of X irradiation on the growth of one such tumor in T-cell-deficient nude mice was tested. Even when the...

journal_title：Radiation research

authors： Seung LP,Weichselbaum RR,Toledano A,Schreiber K,Schreiber H

更新日期：1996-12-01 00:00:00

abstract：:The effects of 2.45-GHz continuous-wave microwaves (SAR = 130 mW/g) on the expression of the interferon-regulated enzymes 2'-5'-oligoadenylate (2-5A) synthetase(s) and 2-5A-dependent endoribonuclease (RNase L) were studied in murine L929 cells. Cells growing as monolayers were removed from the substratum and placed in...

journal_title：Radiation research

authors： Krause D,Mullins JM,Penafiel LM,Meister R,Nardone RM

更新日期：1991-08-01 00:00:00

abstract：:The incidence of breast cancer was determined in 4940 women treated for tuberculosis between 1925 and 1954 in Massachusetts. Among 2573 women examined by X-ray fluoroscopy an average of 88 times during lung collapse therapy and followed for an average of 30 years, 147 breast cancers occurred in contrast to 113.6 expec...

journal_title：Radiation research

authors： Boice JD Jr,Preston D,Davis FG,Monson RR

更新日期：1991-02-01 00:00:00

abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...

journal_title：Radiation research

authors： Baddour AAD,Apodaca LA,Alikhani L,Lu C,Minasyan H,Batra RS,Acharya MM,Baulch JE

更新日期：2020-01-01 00:00:00

abstract：:The mechanisms underlying hepatocellular damage after irradiation are obscure. We identified genes induced by radiation in isolated rat hepatocytes in vitro by cDNA array gene expression analysis and then screened in vivo experiments with those same genes using real-time PCR and Western blotting. Hepatocytes were irra...

journal_title：Radiation research

authors： Christiansen H,Batusic D,Saile B,Hermann RM,Dudas J,Rave-Frank M,Hess CF,Schmidberger H,Ramadori G

更新日期：2006-03-01 00:00:00

abstract：:The use of tritium-labeled thymidine (3H-TdR) in biological research made it necessary to develop a quick and accurate method for determination of tritium activity in tissue. After 3H-TdR incorporation into the root tip meristem of Vicia faba, total 3H activity as well as 3H-DNA activity was measured by liquid scintil...

journal_title：Radiation research

authors： Scheuermann W,Tägder K

更新日期：1968-12-01 00:00:00

abstract：:Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently, the range of science projects requiring an underground experiment site has gr...

journal_title：Radiation research

authors： Morciano P,Cipressa F,Porrazzo A,Esposito G,Tabocchini MA,Cenci G

更新日期：2018-09-01 00:00:00

abstract：:Cellular and molecular repair was studied at 23 degrees C using split-dose recovery and alkaline elution techniques, respectively, as a function of cellular oxygen and nutrient conditions. Hypoxic cells (0.001% O2) in full medium showed a partial reduction in the level of sublethal damage (SLD) repair relative to aera...

journal_title：Radiation research

authors： Spiro IJ,Kennedy KA,Stickler R,Ling CC

更新日期：1985-01-01 00:00:00