Identification of genes responsive to gamma radiation in rat hepatocytes and rat liver by cDNA array gene expression analysis.

abstract：:Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A dissolved in soybean oil to protect against the biological effects caused by internal radionuclides is investigated. The radiochemicals examined are DNA-binding 125...

journal_title：Radiation research

authors： Harapanhalli RS,Narra VR,Yaghmai V,Azure MT,Goddu SM,Howell RW,Rao DV

更新日期：1994-07-01 00:00:00

abstract：:The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to ma...

journal_title：Radiation research

authors： Hill MA,Thompson JM,Kavanagh A,Tullis IDC,Newman RG,Prentice J,Beech J,Gilchrist S,Smart S,Fokas E,Vojnovic B

更新日期：2017-09-01 00:00:00

abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...

journal_title：Radiation research

authors： Takahashi S,Patrick G

更新日期：1987-06-01 00:00:00

abstract：:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...

journal_title：Radiation research

authors： Wang K,Zha Y,Lei H,Xu X

更新日期：2018-02-01 00:00:00

abstract：:There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sa...

journal_title：Radiation research

authors： Cheda A,Wrembel-Wargocka J,Lisiak E,Nowosielska EM,Marciniak M,Janiak MK

更新日期：2004-03-01 00:00:00

abstract：:The modification of methylglyoxal bis(guanylhydrazone) (MGBG) by 42 degrees C hyperthermia-and/or radiation-induced cell killing was examined in Chinese hamster V-79 cells. At concentrations of more than 10 microM, cell survival decreased exponentially with increased MGBG exposure times. Cell lethality of MGBG (10 mic...

journal_title：Radiation research

authors： Miyakoshi J,Heki S

更新日期：1983-12-01 00:00:00

abstract：:The effects of X irradiation on oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells derived from different regions of the perinatal central nervous system (CNS) of rats were investigated in vitro. The O-2A progenitor cells can differentiate into either oligodendrocytes or type-2 astrocytes. The depletion of these...

journal_title：Radiation research

authors： van der Maazen RW,Kleiboer BJ,Verhagen I,van der Kogel AJ

更新日期：1991-10-01 00:00:00

abstract：:A total of 155 primary bone sarcomas were found in 131 of the 246 beagles injected with 226Ra and 5 primary bone sarcomas were found in 4 of the 158 unexposed controls. Of these 155 bone sarcomas, 146 (94%) were osteosarcomas and 9 were non-osteosarcomas. An additional 31 primary bone sarcomas (28 osteosarcomas) devel...

journal_title：Radiation research

authors： White RG,Raabe OG,Culbertson MR,Parks NJ,Samuels SJ,Rosenblatt LS

更新日期：1994-03-01 00:00:00

abstract：:The repair of double-strand breaks in mammalian cells is carried out by two pathways: homologous recombination and nonhomologous end joining. The factors that regulate the mechanism through which a specific repair pathway is activated are still not clearly defined. To study whether the complexity of the double-strand ...

journal_title：Radiation research

authors： Mladenov E,Kalev P,Anachkova B

更新日期：2009-04-01 00:00:00

abstract：:The effects of the methylxanthine, caffeine, on heat sensitization was investigated using Chinese hamster ovary (CHO) cells. Caffeine sensitized CHO cells to heat killing by reducing both the shoulder and the slope of the 44 degrees C survival curve. Heating was performed in suspension by addition of cells to preheate...

journal_title：Radiation research

authors： Coss RA,Smith NN

更新日期：1991-09-01 00:00:00

abstract：:The immunocytochemical response to DNA damage induced by low-energy bismuth and carbon ions was investigated in normal human fibroblasts. Inside the nuclei, the traversing charged particles lead to the accumulation of proteins related to DNA lesions and repair along the ion trajectories. Irradiation under a standard g...

journal_title：Radiation research

authors： Jakob B,Scholz M,Taucher-Scholz G

更新日期：2003-05-01 00:00:00

abstract：:It was reported by others that hands-free accessories increase the absorption of RF energy in a human head compared to a handset alone. The results of this study show that the opposite is observed when proper dosimetric methods are employed. It is pointed out that for correct estimation of the exposure level it is nec...

journal_title：Radiation research

authors： Bit-Babik G,Chou CK,Faraone A,Gessner A,Kanda M,Balzano Q

更新日期：2003-04-01 00:00:00

abstract：:A dose-response relationship was established in normal unanesthetized cats for emetic incidence, latency to onset of vomiting, and duration of emetic activity over a period of 24 h after whole-body exposure to 60Co radiation at selected doses between 7.5 and 90 Gy. Each episode of vomiting, i.e., retching and expulsio...

journal_title：Radiation research

authors： Borison HL,McCarthy LE,Douple EB,Johnson J,Borison R

更新日期：1987-03-01 00:00:00

abstract：:To accurately quantify the number of single-strand breaks (SSBs) induced in plasmid DNA molecules after irradiation, a new type of assay methodology has been explored. The new method is based on the TUNEL (terminal deoxynucleotide transferase dUTP nick end-labeling) assay that was adopted for use under ELISA (enzyme-l...

journal_title：Radiation research

authors： Smiałek MA,Moore SA,Mason NJ,Shuker DE

更新日期：2009-11-01 00:00:00

abstract：:This paper evaluates the global vitamin D effective UV (UV(vitd)) irradiances under cloudy conditions at a subtropical, southern hemisphere site. The UV(vitd) irradiances were analyzed on a horizontal plane and sampled at 5-min intervals over 18 months so that a wide range of parameters including cloud conditions, sol...

journal_title：Radiation research

authors： Turnbull DJ,Parisi AV,Schouten PW

更新日期：2010-05-01 00:00:00

abstract：:Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources. The influence of cel...

journal_title：Radiation research

authors： Hawkins RB,Inaniwa T

更新日期：2014-07-01 00:00:00

abstract：:In the 400-MHz 1H NMR spectra of gamma-irradiated, N2O-saturated aqueous solutions of polyuridylic acid (polyU), polycytidylic acid (polyC), polyadenylic acid (polyA), and single-stranded DNA from calf thymus, well-resolved signals of the undamaged free bases were identified. Upon incubation of the solutions at 95 deg...

journal_title：Radiation research

authors： Hildenbrand K,Mirtsch S,Schulte-Frohlinde D

更新日期：1993-06-01 00:00:00

abstract：:The effect of both hyperthermia and verapamil on cytotoxicity and transport of melphalan was studied in a pleiotropic drug-resistant Chinese hamster ovary cell line (CHRC5) and in the drug-sensitive parent line (AuxB1). The CHRC5 cell line was selected for resistance to colchicine but is also cross-resistant to other ...

journal_title：Radiation research

authors： Averill-Bates DA,Courtemanche B

更新日期：1995-07-01 00:00:00

abstract：:Radiation-induced endothelial cell apoptosis is involved in the development of many radiation injuries, including radiation-induced skin ulcers. The proangiogenic growth factors basic fibroblast growth factor (bFGF, NUDT6) and VEGF enhance endothelial cell survival. In the present study, we used primary cultured human...

journal_title：Radiation research

authors： Gu Q,Wang D,Wang X,Peng R,Liu J,Jiang T,Wang Z,Wang S,Deng H

更新日期：2004-06-01 00:00:00

abstract：:The effects of 60Co gamma rays on calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers and neuropeptide Y (NPY)-immunoreactive nerve fibers were examined in mesenteric blood vessels of rats. Using a free-floating immunostaining streptavidin-biotin peroxidase complex method combined with a nickel-enhancem...

journal_title：Radiation research

authors： Zhang CG,Cai WQ,Li Y,Huang WQ,Su HC

更新日期：1998-01-01 00:00:00

abstract：:Astronauts traveling outside Earth's magnetosphere risk exposure to charged particle radiation that may cause neurophysiological changes and behavioral deficits. Although proton particles comprise a large portion of the space radiation environment, little has been published on the effects of low-dose proton radiation ...

journal_title：Radiation research

authors： Bellone JA,Rudobeck E,Hartman RE,Szücs A,Vlkolinský R

更新日期：2015-08-01 00:00:00

abstract：:Here we report that suramin sensitizes LM217, MDA-MB-468, T98G and A431 cells to ionizing radiation. Suramin sensitized cells to X radiation in a dose-dependent fashion, and longer exposure to suramin before X irradiation resulted in more efficient sensitization. The dose-modifying factors calculated from the survival...

journal_title：Radiation research

authors： Hosoi Y,Matsumoto Y,Enomoto A,Morita A,Green J,Nakagawa K,Naruse K,Suzuki N

更新日期：2004-09-01 00:00:00

abstract：:The effects of reoxygenation on repair of potentially lethal radiation damage were investigated using MG-63 human osteosarcoma cells in vitro. When exponentially growing MG-63 cells were cultured under hypoxic conditions for 24 h, cells stopped growing and remained at a low density. The hypoxic cells were then reoxyge...

journal_title：Radiation research

authors： Iizuka M,Ando K,Aruga T,Furusawa Y,Itsukaichi H,Fukutsu K,Nagasawa H,Moriya H

更新日期：1997-02-01 00:00:00

abstract：:Numerous studies have shown that histone deacetylase inhibitors (HDACis) improve cellular acetylation while also enhancing the radiation sensitivity. In this work, however, we confirmed that low-dose trichostatin A (TSA) as a typical HDACi could reduce rather than increase the radiosensitivity of cancer cells, while t...

journal_title：Radiation research

authors： Zhang F,Shao C,Chen Z,Li Y,Jing X,Huang Q

更新日期：2021-01-29 00:00:00

abstract：:The present study was undertaken to standardize a dichlorofluorescein (DCF) assay for measurement of radiation-induced oxidation of dichlorofluorescin (DCFH) substrate in MCF-10 cells. This assay was highly sensitive and capable of detecting increased DCFH oxidation in the cells exposed to gamma radiation at doses as ...

journal_title：Radiation research

authors： Wan XS,Zhou Z,Ware JH,Kennedy AR

更新日期：2005-02-01 00:00:00

abstract：:Single crystals of disodium beta-glycerophosphate pentahemihydrate (betaGP), Na2x(HO)CH2CH(PO(4)2-)CH2(OH)x5 1/2H2O, were X-irradiated at 77 and 280 K. EPR, ENDOR and FSE techniques were used to study the formation of free radicals in these irradiated crystals to characterize possible reaction mechanisms leading to de...

journal_title：Radiation research

authors： Baine TJ,Sagstuen E

更新日期：1998-08-01 00:00:00

abstract：:The functional and morphological response of the remaining hypertrophied kidney in unilaterally nephrectomized rats to single doses of 0-20 Gy X rays was investigated. Functional and histological end points were assessed serially 4-24 weeks postirradiation. Renal irradiation led to time- and dose-dependent reductions ...

journal_title：Radiation research

authors： Robbins ME,O'Malley Y,Zhao W,Davis CS,Bonsib SM

更新日期：2001-03-01 00:00:00

abstract：:Ionizing radiation induces bistranded clustered damages--two or more abasic sites, oxidized bases and strand breaks on opposite DNA strands within a few helical turns. Since clusters are refractory to repair and are potential sources of double-strand breaks (DSBs), they are potentially lethal and mutagenic. Although i...

journal_title：Radiation research

authors： Hada M,Sutherland BM

更新日期：2006-02-01 00:00:00

abstract：:The investigation of fragment length distributions of plasmid DNA gives insight into the influence of localized energy distribution on the induction of DNA damage, particularly the clustering of double-strand breaks. We present an approach that determines the fragment length distributions of plasmid DNA after heavy-io...

journal_title：Radiation research

authors： Elsässer T,Brons S,Psonka K,Scholz M,Gudowska-Nowak E,Taucher-Scholz G

更新日期：2008-06-01 00:00:00

abstract：:Radiation-induced cell death is thought to be caused by nuclear DNA damage that cannot be repaired. However, in this study we found that a delayed increase of mitochondrial reactive oxygen species (ROS) is responsible for some of the radiation-induced cell death in normal human fibroblast cells. We have previously rep...

journal_title：Radiation research

authors： Kobashigawa S,Kashino G,Suzuki K,Yamashita S,Mori H

更新日期：2015-04-01 00:00:00