Abstract:
:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT utilizes a combination of spatial fractionation of the dose and submillimetric (600 μm) field sizes with an array ("comb") of parallel thin beams ("teeth"). The dose profiles in MBRT consist of peaks and valleys. In contrast, the seamless irradiations of the several squared centimeter field sizes employed in standard radiotherapy result in homogeneous dose distributions (and consequently, flat dose profiles). The innovative dose delivery methods employed in MBRT, unlike standard radiation therapy, have demonstrated remarkable normal tissue sparing. In this pilot work, we investigated the tolerance of the rat brain after whole-brain MBRT irradiation. A dose escalation was used to study the tissue response as a function of dose, so that a threshold could be established: doses as high as 100 Gy in one fraction were still well tolerated by the rat brain. This finding suggests that MBRT may be used to deliver higher and potentially curative radiation doses in clinical practice.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Prezado Y,Deman P,Varlet P,Jouvion G,Gil S,Le Clec'H C,Bernard H,Le Duc G,Sarun Sdoi
10.1667/RR14018.1subject
Has Abstractpub_date
2015-09-01 00:00:00pages
314-21issue
3eissn
0033-7587issn
1938-5404pii
10.1667/RR14018.1journal_volume
184pub_type
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journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
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更新日期:1989-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
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更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:
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doi:
更新日期:1994-09-01 00:00:00
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doi:
更新日期:1995-02-01 00:00:00
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doi:
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更新日期:1997-12-01 00:00:00
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