Abstract:
:Isogenic Escherichia coli strains carrying single DNA-repair mutations were compared for their capacity for (i) the repair of X-ray-induced DNA double-strand breaks (DSB) as measured using neutral sucrose gradients; (ii) medium-dependent resistance, i.e., a recA-dependent X-ray survival phenomenon that correlates closely with the capacity for repairing DSB; and (iii) the growth medium-dependent, recA-dependent repair of X-ray-induced DNA single-strand breaks (SSB) as measured using alkaline sucrose gradients (about 80% of these SSB are actually parts of DSB). These three capacities were measured to quantitate more accurately the involvement of the various genes in the repair of DSB over a wide dose range. The mutations tested were grouped into five classes according to their effect on the repair of X-ray-induced DSB: (I) the recA, recB, recC, and lexA mutants were completely deficient; (II) the radB and recN mutants were about 90% deficient; (III) the recF and recJ mutants were about 70% deficient; (IV) the radA and uvrD mutants were about 30% deficient; and (V) the umuC mutant resembled the wild-type strains in its capacity for the repair of DSB.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Sargentini NJ,Smith KCsubject
Has Abstractpub_date
1986-07-01 00:00:00pages
58-72issue
1eissn
0033-7587issn
1938-5404journal_volume
107pub_type
杂志文章abstract::The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced ...
journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Radiation research
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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更新日期:2010-08-01 00:00:00
abstract::We investigated delayed reproductive death and chromosome bridge formation in mitotic cells in colonies of normal human embryonic cells which survived exposure to 6 Gy of X rays. Eighteen primary clones each derived from control and irradiated cultures were isolated and secondary colonies were grown up. Six of the pri...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1667/0033-7587(2000)153[0479:pddihb]2.0.co;2
更新日期:2000-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)153[0508:rcobat]2.0.co;2
更新日期:2000-05-01 00:00:00
abstract::There is experimental evidence that ultrasoft X rays (0.1-5 keV) show a higher biological effectiveness than high-energy photons. Similar to high-LET radiation, this is attributed to a rather localized dose distribution associated with a considerably smaller range of secondary electrons, which results in an increasing...
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Radiation research
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更新日期:2009-06-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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更新日期:2018-09-01 00:00:00
abstract::We studied the LET and ion species dependence of the RBE for cell killing to clarify the differences in the biological effects caused by the differences in the track structure that result from the different energy depositions for different ions. Normal human skin fibroblasts were irradiated with heavy-ion beams such a...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3360
更新日期:2005-05-01 00:00:00
abstract::Changes in the free-cell population of the lungs of two strains of mice (SAS/4 and CBA/H) were studied up to 4 months after inhalation exposure to a sized fraction of 239PuO2 particles (1.5 micron AMAD) to give initial alveolar depositions (IADs) ranging from 17 to 810 Bq. A sample of the free-cell population of the l...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract::The growth of certain UV-radiation-induced tumors is suppressed by T lymphocytes, but it has been proposed that non-T lymphocytes stimulate the growth of several of these tumors. In this study, the indirect effects of X irradiation on the growth of one such tumor in T-cell-deficient nude mice was tested. Even when the...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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更新日期:2009-11-01 00:00:00
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journal_title:Radiation research
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更新日期:2008-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00