Abstract:
:This report presents data for survival of mouse intestinal crypt cells, mouse testes weight loss as an indicator of survival of spermatogonial stem cells, and survival of rat 9L spheroid cells after irradiation in the plateau region of unmodified particle beams ranging in mass from 4He to 139La. The LET values range from 1.6 to 953 keV/microns. These studies examine the RBE-LET relationship for two normal tissues and for an in vitro tissue model, multicellular spheroids. When the RBE values are plotted as a function of LET, the resulting curve is characterized by a region in which RBE increases with LET, a peak RBE at an LET value of 100 keV/microns, and a region of decreasing RBE at LETs greater than 100 keV/microns. Inactivation cross sections (sigma) for these three biological systems have been calculated from the exponential terminal slope of the dose-response relationship for each ion. For this determination the dose is expressed as particle fluence and the parameter sigma indicates effect per particle. A plot of sigma versus LET shows that the curve for testes weight loss is shifted to the left, indicating greater radiosensitivity at lower LETs than for crypt cell and spheroid cell survival. The curves for cross section versus LET for all three model systems show similar characteristics with a relatively linear portion below 100 keV/microns and a region of lessened slope in the LET range above 100 keV/microns for testes and spheroids. The data indicate that the effectiveness per particle increases as a function of LET and, to a limited extent, Z, at LET values greater than 100 keV/microns. Previously published results for spread Bragg peaks are also summarized, and they suggest that RBE is dependent on both the LET and the Z of the particle.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Rodriguez A,Alpen EL,Powers-Risius Psubject
Has Abstractpub_date
1992-11-01 00:00:00pages
184-92issue
2eissn
0033-7587issn
1938-5404journal_volume
132pub_type
杂志文章abstract::There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern comp...
journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::Using an electron storage ring as a source of radiation, the wavelength dependence of inactivation and membrane damage in yeast cells (Saccharomyces cerevisiae) was investigated in the range from 145 to 254 nm, with special reference to the effects of vacuum-uv radiation. The cells were irradiated on a Millipore filte...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1677.1
更新日期:2009-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR3592.1
更新日期:2006-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3396
更新日期:2005-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14193.1
更新日期:2016-06-01 00:00:00
abstract::The nature of the primary biochemical defect in the human radiosensitive and cancer-prone syndrome, ataxia telangiectasia (AT), has remained obscure despite many efforts to elucidate it. In this study, AT complementation group D cells and a nearly isogenic corrected AT-hamster hybrid derivative have been analyzed for ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times i...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Chinese hamster ovary (CHO) cells became thermotolerant after treatment with either heat for 10 min at 45.5 degrees C or incubation in 100 microM sodium arsenite for 1 h at 37 degrees C. Thermotolerance was tested using heat treatment at 45 degrees C or 43 degrees C administered 6-12 h after the inducing agent. At 45 ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14305.1
更新日期:2016-07-01 00:00:00
abstract::Wistar rats (36) were exposed daily throughout pregnancy to a power density level of 35 mW/cm2 of 6000-MHz microwave radiation (11), sham irradiated (10), or used as control animals (15). Litters were culled to a maximum of eight F1a offspring/litter (total = 124) on Postnatal Day 1 and subjected to a series of reflex...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2235.1
更新日期:2010-09-01 00:00:00
abstract::Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radiation-induced mutator phenotype, end points of mitochondrial function...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1617.1
更新日期:2009-12-01 00:00:00
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journal_title:Radiation research
pub_type: 历史文章,杂志文章
doi:
更新日期:1995-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章,评审
doi:
更新日期:1998-11-01 00:00:00
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pub_type:
doi:10.1667/rr2959.1
更新日期:2012-04-01 00:00:00
abstract::Previous studies showed that a 6-week pretreatment of rats with testosterone plus estradiol enhanced the recovery of spermatogenesis 9 weeks after gamma irradiation, resulting in a dose-modifying factor (DMF) of about 2. To test whether the effect of the hormone treatment was mediated through changes in oxygen tension...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::Three somatic mutation assays were evaluated in men exposed to low-dose, whole-body, ionizing radiation. Blood samples were obtained between 1992 and 1999 from 625 Russian Chernobyl cleanup workers and 182 Russian controls. The assays were chromosome translocations in lymphocytes detected by FISH, hypoxanthine phospho...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0424:tsgbac]2.0.co;2
更新日期:2002-10-01 00:00:00
abstract::We have assessed the effects of two radiomodifying conditions, glutathione (GSH) depletion and hypoxia, on the formation and repair of radiation-induced chromatin damage, specifically DNA-protein cross-links (DPC). As measured by a nitrocellulose filter-binding assay, untreated V79 cells contain a low level of DPC (1-...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Many studies have shown the importance of altered cellular proto-oncogene expression in contributing to changes in cell survival, cell transformation, and cell cycle progression. In these experiments we examined the effects of total-body exposure of BCF1 mice to gamma rays (3 Gy) in modulating expression of cellular o...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Nonhuman organisms are being exposed to ionizing radiations at radionuclide-contaminated sites around the world. Direct methods are seldom available for measuring biologically relevant doses received by these organisms. Here we extend biological dosimetry techniques, which are much better developed for humans and a fe...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)153[0752:ctitab]2.0.co;2
更新日期:2000-06-01 00:00:00
abstract::We investigated the regeneration of rat thymus after sublethal X irradiation (6 Gy). The number of thymocytes was much lower on day 3 after irradiation, and many apoptotic cells were observed. However, by day 5, there had been a rapid proliferation of thymocytes. Since cytokines are considered to be important regulato...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)157[0281:iaaicr]2.0.co;2
更新日期:2002-03-01 00:00:00