An orthotopic lung tumor model for image-guided microirradiation in rats.

abstract：:Previous investigations have demonstrated an increased release of von Willebrand factor (VWF; also known as vWF) in endothelial cells after high single-dose irradiation in vitro. We have also found increased levels of Vwf protein in mouse glomeruli after a high single dose of renal irradiation in vivo. In addition, in...

journal_title：Radiation research

authors： van Kleef E,Verheij M,te Poele H,Oussoren Y,Dewit L,Stewart F

更新日期：2000-10-01 00:00:00

abstract：:The effectiveness of 5-fluorouracil (5-FU), FT-207 and FT-207 + uracil in combination with two repetitions of 43 degrees C hyperthermia in the treatment of the Meth-A-Fibrosarcoma and Sarcoma-180 was examined in vivo in BALB/c mice. The antitumor effect was evaluated in terms of inhibition of tumor growth by measuring...

journal_title：Radiation research

authors： Harada S,Ping L,Obara T,Oikawa H,Miyata M,Matsuo M,Takahashi T,Yanagisawa T

更新日期：1995-05-01 00:00:00

abstract：:The interaction function gamma(chi), which was introduced in the theory of dual radiation action as the probability that two energy transfers separated by distance chi combine with each other to produce a lesion, was estimated with sparsely ionizing radiation (60Co gamma rays and 40 kV X rays). Gamma(chi) was deduced ...

journal_title：Radiation research

authors： Nenoi M,Kanai T,Ito A

更新日期：1987-10-01 00:00:00

abstract：:Proton exposure induces mutations and cancer, which are presumably linked. Because protons are abundant in the space environment and significant uncertainties exist for the effects of space travel on human health, the purpose of this study was to identify the types of mutations induced by exposure of mammalian cells t...

journal_title：Radiation research

authors： Turker MS,Grygoryev D,Dan C,Eckelmann B,Lasarev M,Gauny S,Kwoh E,Kronenberg A

更新日期：2013-05-01 00:00:00

abstract：:Ion microscopy was used for subcellular quantitative imaging of the isotopes 10B and 11B in the same cell to evaluate boron delivery using a mixture of two neutron capture therapy drugs, p-boronophenylalanine-fructose (BPA-F) and sodium borocaptate (BSH). The application of 10B-labeled BPA-F and 11B-labeled BSH allowe...

journal_title：Radiation research

authors： Chandra S,Lorey II DR,Smith DR

更新日期：2002-06-01 00:00:00

abstract：:The late effects of heavy-ion irradiation on the spinal cord of the rat were investigated histologically and morphometrically. After a single exposure of each animal's lower thoracic and lumbar spinal cord to a carbon-ion beam, the animals were observed clinically for up to 69 weeks and their spinal cords were examine...

journal_title：Radiation research

authors： Okada S,Okeda R,Matsushita S,Kawano A

更新日期：1998-09-01 00:00:00

abstract：:In the double-strand break (DSB) model, the initial slope (alpha) of the survival curve is determined by the number of DSBs remaining unrepaired at a certain time after irradiation. There are three types of calculations which confirm the validity of this approach. First, the model quite reasonably predicts the low-LET...

journal_title：Radiation research

authors： Ostashevsky JY

更新日期：1993-02-01 00:00:00

abstract：:A standard Fricke dosimeter was used to measure the absorbed dose via the oxidation yields of Fe3+ ions in an aqueous environment induced by soft X rays within the "water window" spectral range. We also exploited the property of a neutral solution containing terephthalic acid as a tool for selective detection of OH ra...

journal_title：Radiation research

authors： Vyšín L,Wachulak P,Toufarová M,Medvedev N,Voronkov RA,Bartnik A,Fiedorowicz H,Juha L

更新日期：2020-04-01 00:00:00

abstract：:Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation...

journal_title：Radiation research

authors： Yan C,Luo L,Urata Y,Goto S,Guo CY,Li TS

更新日期：2017-02-22 00:00:00

abstract：:Infusions of boronophenylalanine-fructose complex (BPA-F), at doses up to 900 mg/kg of BPA and 860 mg/kg of fructose, have been used to deliver boron to cancer tissue for boron neutron capture therapy (BNCT). In patients with phenylketonuria (PKU), phenylalanine accumulates, which is harmful in the long run. PKU has b...

journal_title：Radiation research

authors： Laakso J,Ruokonen I,Lapatto R,Kallio M

更新日期：2003-11-01 00:00:00

abstract：:Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promis...

journal_title：Radiation research

authors： Mueller AK,Lindner K,Hummel R,Haier J,Watson DI,Hussey DJ

更新日期：2016-06-01 00:00:00

abstract：:We have previously observed time- and dose-dependent increases in matrix metalloproteinase 2 (Mmp2) protein levels in rat tubule epithelial cells (NRK52E) after irradiation. However, the mechanism(s) involved remains unclear. In the present study, irradiating NRK52E cells with 0-20 Gy gamma rays was associated with ti...

journal_title：Radiation research

authors： Zhao W,Goswami PC,Robbins ME

更新日期：2004-04-01 00:00:00

abstract：:Radiation-induced complications in bone and cartilage are of increasing concern due to potential long-term effects in cancer survivors. Healthy articular cartilage may be exposed to radiation during either chondrosarcoma treatment or in-field radiotherapy of tumors located in close proximity to articulation. Cartilage...

journal_title：Radiation research

authors： Saintigny Y,Cruet-Hennequart S,Hamdi DH,Chevalier F,Lefaix JL

更新日期：2015-02-01 00:00:00

abstract：:Diethylenetriaminepentaacetic acid (DTPA) is currently still the only known chelating drug that can be used for decorporation of internalized plutonium (Pu) and americium (Am). It is generally assumed that chelation occurs only in biological fluids, thus preventing Pu/Am deposition in target tissues. We postulate that...

journal_title：Radiation research

authors： Grémy O,Laurent D,Coudert S,Griffiths NM,Miccoli L

更新日期：2016-06-01 00:00:00

abstract：:We have studied the effect on sister chromatid exchange (SCE) induction in 9L rat brain tumor cells caused by combination treatment with BCNU and X rays. Over the dose and concentration ranges used in these experiments, BCNU induced relatively large numbers of SCEs, while X rays induced few SCEs. When cells were X irr...

journal_title：Radiation research

authors： Tofilon PJ,Deen DF

更新日期：1984-01-01 00:00:00

abstract：:The molecular structure of mutants induced in human lymphoblast cells by 500 cGy X rays in the presence of the radioprotector cysteamine (25 mM) has been compared with that induced by an equally mutagenic treatment of 150 cGy X rays alone. Sets of mutants at the hypoxanthine-guanine phosphoribosyl transferase locus we...

journal_title：Radiation research

authors： Liber HL,Benforado K,Little JB

更新日期：1989-05-01 00:00:00

abstract：:In the 400-MHz 1H NMR spectra of gamma-irradiated, N2O-saturated aqueous solutions of polyuridylic acid (polyU), polycytidylic acid (polyC), polyadenylic acid (polyA), and single-stranded DNA from calf thymus, well-resolved signals of the undamaged free bases were identified. Upon incubation of the solutions at 95 deg...

journal_title：Radiation research

authors： Hildenbrand K,Mirtsch S,Schulte-Frohlinde D

更新日期：1993-06-01 00:00:00

abstract：:Most plutonium-induced bone tumors in beagles arise in trabecular bone sites surrounded by hematopoietic tissue. The microvasculature and the relative incorporation of 241Pu (a low energy beta emitter) on trabecular bone surfaces from red and fatty marrow sites were studied in the adult beagle. The vascular volume, as...

journal_title：Radiation research

authors： Smith JM,Miller SC,Jee WS

更新日期：1984-08-01 00:00:00

abstract：:FLASH radiation therapy (FLASH-RT) reference dosimetry to obtain traceability, repeatability and stability of irradiations cannot be performed with conventional dosimetric methods, such as monitor chambers or ionization chambers. Until now, only passive dosimeters have provided the necessary dosimetric data. Alanine d...

journal_title：Radiation research

authors： Gondré M,Jorge PG,Vozenin MC,Bourhis J,Bochud F,Bailat C,Moeckli R

更新日期：2020-12-01 00:00:00

abstract：:The lineal energy distribution and several other dosimetric parameters were measured for the neutrons emitted from a replica of the Hiroshima bomb to determine their usefulness in biological experiments designed to estimate the effectiveness of actual Hiroshima neutrons. The "Little-Boy" replica (LBR) was constructed ...

journal_title：Radiation research

authors： Straume T,McDonald JC,Pederson RA,Brenner DJ,Dobson RL

更新日期：1991-11-01 00:00:00

abstract：:Involvement of gap junctional intercellular communication (GJIC) in bystander responses of confluent human fibroblasts irradiated with a carbon-ion beam was investigated. It was found that the lower the radiation dose, the higher the yield of radiation-induced micronuclei per nuclear traversal, suggesting the existenc...

journal_title：Radiation research

authors： Shao C,Furusawa Y,Aoki M,Ando K

更新日期：2003-09-01 00:00:00

abstract：:The goal of this study was to make a comparison between stereotactic brachytherapy implants and linear accelerator-based radiosurgery of brain tumors with respect to physical dose distributions and radiobiological efficacy. Twenty-four treatment plans made for irradiation of brain tumors with low-dose-rate (125)I brac...

journal_title：Radiation research

authors： Viola A,Major T,Julow J

更新日期：2006-06-01 00:00:00

abstract：:This study was designed to determine whether patients taking angiotensin-converting enzyme (ACE) inhibitors while receiving radiation therapy for lung cancer are protected from developing symptomatic radiation pneumonitis. The records of 213 eligible patients receiving thoracic irradiation for lung cancer with curativ...

journal_title：Radiation research

authors： Wang LW,Fu XL,Clough R,Sibley G,Fan M,Bentel GC,Marks LB,Anscher MS

更新日期：2000-04-01 00:00:00

abstract：:The model of radiation action that is presented relates the surviving fraction of irradiated cells to unrepaired DNA double-strand breaks (DSBs). The following assumptions are made in the model: (i) A DNA fragment created by the induced DSBs may move out of its chromosome (become lost), and the probability of that pro...

journal_title：Radiation research

authors： Ostashevsky JY

更新日期：1989-06-01 00:00:00

abstract：:The hypothesis of boron neutron capture therapy (BNCT) research has been that the short-range, high-linear energy transfer radiation produced by the capture of thermal neutrons by (10)B will potentially control tumor and spare normal tissue only if the boron compound selectively targets tumor tissue within the treatme...

journal_title：Radiation research

authors： Trivillin VA,Heber EM,Nigg DW,Itoiz ME,Calzetta O,Blaumann H,Longhino J,Schwint AE

更新日期：2006-08-01 00:00:00

abstract：:In a scenario involving a nuclear detonation during war or a terrorist attack, acute radiation exposure combined with thermal and blast effects results in severe skin injury. Although the cutaneous injury in such a scenario may not be lethal, it may lead to inflammation, delayed wound healing and loss of the skin barr...

journal_title：Radiation research

authors： Albrecht H,Yang HY,Kiuru M,Maksaereekul S,Durbin-Johnson B,Wong MS,Stevenson TR,Rocke DM,Isseroff RR

更新日期：2018-04-01 00:00:00

abstract：:The effect of acute exposure to ultrawideband (UWB) electromagnetic radiation on the Primate Equilibrium Platform (PEP) task, where the monkey's task is to manipulate a joystick control to compensate for the random perturbations in the pitch plane that are generated by a computer at unpredictable intervals, was examin...

journal_title：Radiation research

authors： Sherry CJ,Blick DW,Walters TJ,Brown GC,Murphy MR

更新日期：1995-07-01 00:00:00

abstract：:We examined the effects of X irradiation on activation of the promoter of the human HSP70B gene, which is activated only after heat shock. The HSP70B promoter was ligated to the bacterial beta-galactosidase (beta-gal) gene, and the reporter plasmid was transfected into NCI-H1299 carcinoma cells. The expression of the ...

journal_title：Radiation research

authors： Suzuki K,Kodama S,Watanabe M

更新日期：1998-02-01 00:00:00

abstract：:The Escherichia coli nth gene encodes endonuclease III, which catalyses the glycolytic removal of various oxidized thymine residues from DNA. A truncated version of nth, with the prokaryotic regulatory sequences removed, was ligated into the retrovirus-based vector pZipneoSV(X)1 and transfected into the radiosensitive...

journal_title：Radiation research

authors： Harrison L,Skorvaga M,Cunningham RP,Hendry JH,Margison GP

更新日期：1992-10-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells became thermotolerant after treatment with either heat for 10 min at 45.5 degrees C or incubation in 100 microM sodium arsenite for 1 h at 37 degrees C. Thermotolerance was tested using heat treatment at 45 degrees C or 43 degrees C administered 6-12 h after the inducing agent. At 45 ...

journal_title：Radiation research

authors： Lee YJ,Perlaky L,Dewey WC,Armour EP,Corry PM

更新日期：1990-03-01 00:00:00