1H NMR studies of gamma-irradiated polynucleotides and DNA in N2O-saturated aqueous solutions: release of undamaged and modified bases.

abstract：:Hyperthermic sensitivities of Escherichia coli B/r and Bs-1 were determined for lag-, midlog-, and stationary-phase cells at 47, 48, and 49 degrees C. In both strains midlog-phase cells were strikingly more heat sensitive (100-fold greater killing after 4 h at 48 degrees C) than stationary-phase cells, with intermedia...

journal_title：Radiation research

authors： Yatvin MB,Gipp JJ,Klessig DR,Dennis WH

更新日期：1986-04-01 00:00:00

abstract：:Sequential examinations were done on the pulmonary cytokinetics and pulmonary lesions in rats after inhalation exposure to (239)PuO(2) aerosols to investigate the pathogenesis of lung tumors. Total cell yields of lavaged bronchoalveolar cells as well as the estimated numbers of pulmonary alveolar macrophages were sign...

journal_title：Radiation research

authors： Oghiso Y,Yamada Y

更新日期：2000-09-01 00:00:00

abstract：:The use of tritium-labeled thymidine (3H-TdR) in biological research made it necessary to develop a quick and accurate method for determination of tritium activity in tissue. After 3H-TdR incorporation into the root tip meristem of Vicia faba, total 3H activity as well as 3H-DNA activity was measured by liquid scintil...

journal_title：Radiation research

authors： Scheuermann W,Tägder K

更新日期：1968-12-01 00:00:00

abstract：:Effects of 250-kV X rays on epidermal Langerhans cells were studied in CBA/CaH mice. One group received 20 Gy to the feet, another 8 Gy to the whole body, and a third both the 8 Gy whole-body and a 12 Gy local dose to the feet. Mice from each group and controls were sacrificed at intervals from 1 to 64 days later. ATP...

journal_title：Radiation research

authors： Cole S,Lewkowicz SJ,Townsend KM

更新日期：1984-12-01 00:00:00

abstract：:Damage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormones on regeneration ...

journal_title：Radiation research

authors： Ishihara H,Tanaka I,Yakumaru H,Tanaka M,Satoh A,Ishiwata A,Yokochi K,Kurematsu A,Ueda J,Shibata T,Hachiya M,Akashi M

更新日期：2011-03-01 00:00:00

abstract：:The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-assessment performances using gene expression assays. Lithium-heparin...

journal_title：Radiation research

authors： Badie C,Kabacik S,Balagurunathan Y,Bernard N,Brengues M,Faggioni G,Greither R,Lista F,Peinnequin A,Poyot T,Herodin F,Missel A,Terbrueggen B,Zenhausern F,Rothkamm K,Meineke V,Braselmann H,Beinke C,Abend M

更新日期：2013-08-01 00:00:00

abstract：:The incidence of breast cancer was determined in 4940 women treated for tuberculosis between 1925 and 1954 in Massachusetts. Among 2573 women examined by X-ray fluoroscopy an average of 88 times during lung collapse therapy and followed for an average of 30 years, 147 breast cancers occurred in contrast to 113.6 expec...

journal_title：Radiation research

authors： Boice JD Jr,Preston D,Davis FG,Monson RR

更新日期：1991-02-01 00:00:00

abstract：:The present study demonstrates the usefulness of immunochemical assays for quantitating modified bases in oxidized and X-irradiated DNA. Escherichia coli, phi X174 RF I, PM2, and M13 DNA containing thymine glycols introduced by OsO4 oxidation were used as antigens in a direct enzyme-linked immunosorbent assay (ELISA)....

journal_title：Radiation research

authors： Hubbard K,Huang H,Laspia MF,Ide H,Erlanger BF,Wallace SS

更新日期：1989-05-01 00:00:00

abstract：:Biological response to ionizing radiation depends not only on the type of radiation and dose, but also on the duration and dose rate of treatment. For a given radiation dose, the biological response may differ based on duration and dose rate. We studied the properties of two human cell lines, M059K glioma and U2OS ost...

journal_title：Radiation research

authors： Nakajima H,Furukawa C,Chang YC,Ogata H,Magae J

更新日期：2017-08-01 00:00:00

abstract：:The efficacy of photodynamic therapy is dependent upon the optical dose rate or upon the fractionation schedule on the light. These effects are thought to be limited by the time required for oxygen diffusion from the capillaries, since this therapy can consume oxygen faster than it can be supplied to tissues distant f...

journal_title：Radiation research

authors： Pogue BW,Hasan T

更新日期：1997-05-01 00:00:00

abstract：:Determinations of the LET distribution, phi(L), of charged particles within a spacecraft in low-Earth orbit have been made. One method used a cylindrical tissue-equivalent proportional counter (TEPC), with the assumption that for each measured event, lineal energy, y, is equal to LET and thus phi(L) = phi(y). The othe...

journal_title：Radiation research

authors： Doke T,Hayashi T,Borak TB

更新日期：2001-09-01 00:00:00

abstract：:After DNA damage, caspases cleave and activate proteins involved in cell death by apoptosis but also cleave and inactivate proteins implicated in DNA repair. Here we report a rapid onset of Rad51 cleavage by caspase 3 in BRCA2-defective mouse and human cells. This rapid cleavage was reduced markedly by transfer of ful...

journal_title：Radiation research

authors： Brown ET,Robinson-Benion C,Holt JT

更新日期：2008-05-01 00:00:00

abstract：:The repair of X-ray-induced DNA damage related to the proliferating cell nuclear antigen (PCNA) was characterized in human diploid fibroblasts by an indirect immunofluorescence method. PCNA staining induced by X rays was lost after DNase I treatment but not after RNase treatment. The staining was not induced when ATP ...

journal_title：Radiation research

authors： Miura M,Sasaki T,Takasaki Y

更新日期：1996-01-01 00:00:00

abstract：:We have used Escherichia coli B/r to test the proposal that hydroxyl radicals (.OH) are major contributors to lethal damage when bacteria in equilibrium with air or 100% nitrogen are exposed to ionizing radiation. In addition, we have tested the hypothesis that oxygen sensitizes bacterial cells to radiation by reactin...

journal_title：Radiation research

authors： Ewing D,Kubala GJ

更新日期：1987-02-01 00:00:00

abstract：:A rare T-cell subpopulation, CD4-8- alpha beta T cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4+ or CD8+ T cells. In the present study, the frequencies of CD4-8-T cells in peripheral-blood alpha beta T cells in 409 atomic bomb survivors (160 estimated to ...

journal_title：Radiation research

authors： Kusunoki Y,Kyoizumi S,Hirai Y,Fujita S,Akiyama M

更新日期：1994-07-01 00:00:00

abstract：:Thymic explant cultures were used to study the radiosensitivity of nonlymphoid thymic components in dogs. Thymic fragments from fetal (50 days gestation), newborn, and juvenile (70 days old) dogs were irradiated in vitro at 0, 0.5, 1, 2, or 4 Gy prior to culture. Colonies were classified as epithelial, spindle, or mix...

journal_title：Radiation research

authors： Milisen WB,Benjamin SA,Miller GK

更新日期：1988-07-01 00:00:00

abstract：:We have studied the effect on sister chromatid exchange (SCE) induction in 9L rat brain tumor cells caused by combination treatment with BCNU and X rays. Over the dose and concentration ranges used in these experiments, BCNU induced relatively large numbers of SCEs, while X rays induced few SCEs. When cells were X irr...

journal_title：Radiation research

authors： Tofilon PJ,Deen DF

更新日期：1984-01-01 00:00:00

abstract：:The severe combined immune deficiency (SCID) mouse shows two kinds of phenotypic abnormalities, a high radiosensitivity and an abnormal immunoglobulin gene recombination. A genetic study has revealed that a mutation exists in chromosome 16. However, several attempts to isolate the gene responsible for these phenotypes...

journal_title：Radiation research

authors： Itoh M,Hamatani K,Komatsu K,Araki R,Takayama K,Abe M

更新日期：1993-06-01 00:00:00

abstract：:This report compares the deterministic effects from an alpha-particle-emitting radionuclide, (239)PuO(2), and a beta-particle emitter, (144)Ce in fused aluminosilicate particles (FAP). The studies were conducted in beagle dogs of both genders exposed by inhalation to aerosols of the radionuclides. The initial lung bur...

journal_title：Radiation research

authors： Muggenburg BA,Hahn FF,Ménache MG,Guilmette RA,Boecker BB

更新日期：1999-12-01 00:00:00

abstract：:Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Ca...

journal_title：Radiation research

authors： Boissière A,Champion C,Touati A,Hervé du Penhoat MA,Sabatier L,Chatterjee A,Chetioui A

更新日期：2007-04-01 00:00:00

abstract：:The recent demonstration of nanoscale scintillators has led to interest in the combination of radiation and photodynamic therapy. In this model, scintillating nanoparticles conjugated to photosensitizers and molecular targeting agents would enhance the targeting and improve the efficacy of radiotherapy and extend the ...

journal_title：Radiation research

authors： Morgan NY,Kramer-Marek G,Smith PD,Camphausen K,Capala J

更新日期：2009-02-01 00:00:00

abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...

journal_title：Radiation research

authors： Thome C,Mitz C,Hulley EN,Somers CM,Manzon RG,Wilson JY,Boreham DR

更新日期：2017-10-01 00:00:00

abstract：:We studied the LET and ion species dependence of the RBE for cell killing to clarify the differences in the biological effects caused by the differences in the track structure that result from the different energy depositions for different ions. Normal human skin fibroblasts were irradiated with heavy-ion beams such a...

journal_title：Radiation research

authors： Tsuruoka C,Suzuki M,Kanai T,Fujitaka K

更新日期：2005-05-01 00:00:00

abstract：:The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initiall...

journal_title：Radiation research

authors： Marino SA

更新日期：2017-04-01 00:00:00

abstract：:The interaction function gamma(chi), which was introduced in the theory of dual radiation action as the probability that two energy transfers separated by distance chi combine with each other to produce a lesion, was estimated with sparsely ionizing radiation (60Co gamma rays and 40 kV X rays). Gamma(chi) was deduced ...

journal_title：Radiation research

authors： Nenoi M,Kanai T,Ito A

更新日期：1987-10-01 00:00:00

abstract：:Proton exposure induces mutations and cancer, which are presumably linked. Because protons are abundant in the space environment and significant uncertainties exist for the effects of space travel on human health, the purpose of this study was to identify the types of mutations induced by exposure of mammalian cells t...

journal_title：Radiation research

authors： Turker MS,Grygoryev D,Dan C,Eckelmann B,Lasarev M,Gauny S,Kwoh E,Kronenberg A

更新日期：2013-05-01 00:00:00

abstract：:This study was undertaken to determine if structural alterations of the bulk chromatin and the amount of protein associated with the nuclear matrix in cerebellar neurons depend on radiation dose and a cell's state of oxygenation. After irradiation with 2.5 to 25.0 Gy under both aerobic and anoxic conditions, the sensi...

journal_title：Radiation research

authors： Jaberaboansari A,Landis MR,Wallen CA,Wheeler KT

更新日期：1989-07-01 00:00:00

abstract：:Growth retardation due to exposure to the atomic bomb has been evaluated using repeated measurements of stature from 10 to 18 years of age. A highly significant growth retardation due to the DS86 uterine dose was observed in all trimesters combined and in the first and second trimesters of pregnancy. In the first trim...

journal_title：Radiation research

authors： Otake M,Fujikoshi Y,Schull WJ,Izumi S

更新日期：1993-04-01 00:00:00

abstract：:The survival of synchronous G1 or asynchronous Chinese hamster ovary cells in vitro to heat treatment may depend on the cellular population density at the time of heating and/or as the cells are cultured after heating. The addition of lethally irradiated feeder cells may increase survival at 10(-3) by as much as 10- t...

journal_title：Radiation research

authors： Highfield DP,Holahan EV,Holahan PK,Dewey WC

更新日期：1984-01-01 00:00:00

abstract：:Radioprotection in vitro by sulfhydryl (SH)-containing compounds is usually greater in aerated than in hypoxic cells. This observation has been cited recently as one of the reasons for the relatively greater effectiveness of radioprotectors such as WR-2721 in normal tissues compared to tumor cells. It is demonstrated ...

journal_title：Radiation research

authors： Held KD

更新日期：1985-03-01 00:00:00