Gamma-irradiation effects on phosphatidylcholine multilayer liposomes: calorimetric, NMR, and spectrofluorimetric studies.

abstract：:A new model for the survival of bacteria exposed to ionizing radiation is constructed in the framework of a target theory based on microdosimetric concepts, where single- and double-strand breaks of DNA and their repair in vivo can be described consistently in terms of the microdosimetric quantity j (number of effecti...

journal_title：Radiation research

authors： Iwanami S,Oda N

更新日期：1985-04-01 00:00:00

abstract：:To accurately quantify the number of single-strand breaks (SSBs) induced in plasmid DNA molecules after irradiation, a new type of assay methodology has been explored. The new method is based on the TUNEL (terminal deoxynucleotide transferase dUTP nick end-labeling) assay that was adopted for use under ELISA (enzyme-l...

journal_title：Radiation research

authors： Smiałek MA,Moore SA,Mason NJ,Shuker DE

更新日期：2009-11-01 00:00:00

abstract：:New Zealand rabbits, fasted for 12 hours, were subjected to 500 rads of whole-body irradiation. K+-palmitate-1-14C oxidation was assayed with the 600 X g supernatant of thymus and liver homogenates, in the presence of ATP, at various time intervals from irradiation. For a period of 24 hours following irradiation, oxid...

journal_title：Radiation research

authors： Miras CJ,Mantzos JD,Legakis NJ,Levis GM

更新日期：1968-11-01 00:00:00

abstract：:Both plant senescence and plant response to ionizing radiation involve changes in gene expression and epigenetic profiles, that rely on the formation of reactive oxygen species. However, how the developmental stage of a plant affects its response to ionizing radiation has not been extensively studied. In this study, o...

journal_title：Radiation research

authors： Sidler C,Li D,Kovalchuk O,Kovalchuk I

更新日期：2015-02-01 00:00:00

abstract：:Cytokines function in many roles that are highly relevant to radiation research. This review focuses on how cytokines are structurally organized, how they are induced by radiation, and how they orchestrate mesenchymal, epithelial and immune cell interactions in irradiated tissues. Pro-inflammatory cytokines are the ...

journal_title：Radiation research

authors： Schaue D,Kachikwu EL,McBride WH

更新日期：2012-12-01 00:00:00

abstract：:Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approximately 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a ...

journal_title：Radiation research

authors： Choofong S,Cloutier P,Sanche L,Wagner JR

更新日期：2016-11-01 00:00:00

abstract：:The present study was undertaken to assess the protective effect of dimethyl sulfoxide (DMSO) against the induction and rejoining of DNA double-strand breaks (DSBs) and inactivation of V79-4 Chinese hamster cells by both high- and low-linear energy transfer (LET) radiations. The cells were exposed under aerobic condit...

journal_title：Radiation research

authors： deLara CM,Jenner TJ,Townsend KM,Marsden SJ,O'Neill P

更新日期：1995-10-01 00:00:00

abstract：:The purpose of this study was to develop a rat orthotopic lung tumor model with a solitary intrapulmonary nodule to study the effects of high-dose radiation. A549-Luc non-small cell lung cancer (NSCLC) cells were implanted into nude rats in the intercostal space between ribs 5 and 6 of the right lung. Bioluminescence ...

journal_title：Radiation research

authors： Saha D,Watkins L,Yin Y,Thorpe P,Story MD,Song K,Raghavan P,Timmerman R,Chen B,Minna JD,Solberg TD

更新日期：2010-07-01 00:00:00

abstract：:Chinese hamster V79 cells grown for several hours in suspension culture form spheroids which are more resistant to killing by ionizing radiation than cells grown on petri dishes, a phenomenon known as the "contact effect." Previous results using the alkali-unwinding assay as a measure of DNA damage have implicated dif...

journal_title：Radiation research

authors： Olive PL

更新日期：1989-01-01 00:00:00

abstract：:After DNA damage, caspases cleave and activate proteins involved in cell death by apoptosis but also cleave and inactivate proteins implicated in DNA repair. Here we report a rapid onset of Rad51 cleavage by caspase 3 in BRCA2-defective mouse and human cells. This rapid cleavage was reduced markedly by transfer of ful...

journal_title：Radiation research

authors： Brown ET,Robinson-Benion C,Holt JT

更新日期：2008-05-01 00:00:00

abstract：:The widely distributed xanthine oxidoreductase (XOR) system has been shown to be modulated upon exposure of animals to ionizing radiation through the conversion of xanthine dehydrogenase (XDH) into xanthine oxidase (XO). In the present work, radiomodification of the XOR system by phenylmethylsulfonyl fluoride (PMSF) a...

journal_title：Radiation research

authors： Srivastava M,Kale RK

更新日期：2000-07-01 00:00:00

abstract：:The high-energy neutron component of the space radiation environment in thick structures such as the International Space Station contributes to the total radiation dose received by an astronaut. Detector design constraints such as size and mass have limited the energy range of neutron spectrum measurements in orbit to...

journal_title：Radiation research

authors： Kinnison JD,Maurer RH,Roth DR,Haight RC

更新日期：2003-02-01 00:00:00

abstract：:The mechanisms underlying hepatocellular damage after irradiation are obscure. We identified genes induced by radiation in isolated rat hepatocytes in vitro by cDNA array gene expression analysis and then screened in vivo experiments with those same genes using real-time PCR and Western blotting. Hepatocytes were irra...

journal_title：Radiation research

authors： Christiansen H,Batusic D,Saile B,Hermann RM,Dudas J,Rave-Frank M,Hess CF,Schmidberger H,Ramadori G

更新日期：2006-03-01 00:00:00

abstract：:The (11)B(p,alpha)(8)Be* nuclear reaction was assessed for its ability to quantitatively map the in vivo subcellular distribution of boron within gliosarcomas treated with a boronated neutron capture therapy agent. Intracranial 9L gliosarcomas were produced in Fischer 344 rats. Fourteen days later, the majority of the...

journal_title：Radiation research

authors： Bench G,Grant PG,Ueda DL,Autry-Conwell SA,Hou Y,Boggan JE

更新日期：2003-12-01 00:00:00

abstract：:The relationship between apoptosis induced by gamma radiation and glutathione in cells of two human cancer cell lines, HeLa from cervix carcinoma and MCF-7 from mammary carcinoma, was examined. MCF-7 cells appeared to be more radioresistant than HeLa cells, and radiation-induced apoptosis, which was monitored by asses...

journal_title：Radiation research

authors： Rosi A,Grande S,Luciani AM,Palma A,Giovannini C,Guidoni L,Sapora O,Viti V

更新日期：2007-03-01 00:00:00

abstract：:The relationship between intracellular and extracellular pH was investigated in a murine tumor and normal tissue, prior to and following glucose injection. Isotransplants of the murine tumor FSa-II in the dorsum of the hind foot and leg muscle, were investigated in nonanesthetized mice. Extracellular pH was measured w...

journal_title：Radiation research

authors： Gerweck LE,Rhee JG,Koutcher JA,Song CW,Urano M

更新日期：1991-05-01 00:00:00

abstract：:Using five transplantable murine tumors (SCC-VII, B16F1, KHT-C, KHT-LP1, RIF-1), measurements of tumor hypoxia have been made with two techniques which have the potential to be used for assessing oxygenation in human tumors (the Eppendorf pO2 Histograph and binding of [3H]misonidazole) and have been compared with an e...

journal_title：Radiation research

authors： Kavanagh MC,Sun A,Hu Q,Hill RP

更新日期：1996-04-01 00:00:00

abstract：:The concept of curvature in dose-response relationships figures prominently in radiation biology, encompassing a wide range of interests including radiation protection, radiotherapy and fundamental models of radiation action. In this context, the ability to detect even small amounts of curvature becomes important. Sta...

journal_title：Radiation research

authors： Shuryak I,Loucas BD,Cornforth MN

更新日期：2017-01-01 00:00:00

abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...

journal_title：Radiation research

authors： Baddour AAD,Apodaca LA,Alikhani L,Lu C,Minasyan H,Batra RS,Acharya MM,Baulch JE

更新日期：2020-01-01 00:00:00

abstract：:The radiation risk of skin cancer by histological types has been evaluated in the atomic bomb survivors. We examined 80,158 of the 120,321 cohort members who had their radiation dose estimated by the latest dosimetry system (DS02). Potential skin tumors diagnosed from 1958 to 1996 were reviewed by a panel of pathologi...

journal_title：Radiation research

authors： Sugiyama H,Misumi M,Kishikawa M,Iseki M,Yonehara S,Hayashi T,Soda M,Tokuoka S,Shimizu Y,Sakata R,Grant EJ,Kasagi F,Mabuchi K,Suyama A,Ozasa K

更新日期：2014-05-01 00:00:00

abstract：:The relative biological effectiveness was determined using sex-linked recessive lethals induced in Drosophila spermatozoa as the biological effect. The sex-linked recessive lethal test, a measure of mutations induced in germ cells and transmitted through successive generations, yields a linear dose-response curve in t...

journal_title：Radiation research

authors： Byrne BJ,Lee WR

更新日期：1989-03-01 00:00:00

abstract：:Mixed radiation fields comprise the most common form of radiation exposure. Given their relevance in radiation protection, cancer radiotherapy and space research, accurate predictions of the corresponding radiation effects are essential. The local effect model (LEM) allows the prediction of cell survival after ion irr...

journal_title：Radiation research

authors： Pfuhl T,Friedrich T,Scholz M

更新日期：2020-02-01 00:00:00

abstract：:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 typ...

journal_title：Radiation research

authors： Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Y

更新日期：2003-06-01 00:00:00

abstract：:Keratinocyte growth factor (FGF7, also known as KGF) ameliorates the radiation response of mouse oral mucosa and other epithelial tissues. However, the precise mechanisms remain unclear. The aim of the present study was to investigate the effect of FGF7 on the survival and colony size of normal human epidermal keratin...

journal_title：Radiation research

authors： Slonina D,Hoinkis C,Dörr W

更新日期：2001-12-01 00:00:00

abstract：:Experiments were performed with three different cell lines, mouse fibroblast LM cells, HeLa S3 cells, and Ehrlich Ascites Tumor (EAT) cells, to establish the possible importance of hyperthermic-induced alterations in cellular K+ content in the mechanism of cell killing by heat. At different time points after the hyper...

journal_title：Radiation research

authors： Ruifrok AC,Kanon B,Konings AW

更新日期：1987-02-01 00:00:00

abstract：:Experiments were performed to determine whether diurnal variations in apoptosis in the mouse small intestine after irradiation with 2.5 Gy gamma rays depended on the time of day that the mice were irradiated, the time of day that the mice were sacrificed or the interval between irradiation and sacrifice. Experiments w...

journal_title：Radiation research

authors： Ruifrok AC,Weil MM,Thames HD,Mason KA

更新日期：1998-04-01 00:00:00

abstract：:The induction of thymic lymphomas by whole-body X irradiation with four doses of 1.8 Gy (total dose: 7.2 Gy) in C57BL/6 mice was suppressed from a high frequency (90%) to 63% by preirradiation with 0.075 Gy X rays given 6 h before each 1.8-Gy irradiation. This level was further suppressed to 43% by continuous whole-bo...

journal_title：Radiation research

authors： Ina Y,Tanooka H,Yamada T,Sakai K

更新日期：2005-02-01 00:00:00

abstract：:Plateau-phase A549 cells exhibit a high capacity for repair of potentially lethal radiation damage (PLD). Previously it was found that PLD repair could be partially inhibited by increasing the extracellular pH (pHe) of the spent medium from its normal value of 6.7-6.8 to 7.6 during postirradiation holding. The present...

journal_title：Radiation research

authors： Jayanth VR,Bayne MT,Varnes ME

更新日期：1994-08-01 00:00:00

abstract：:The human breast is sensitive to radiation carcinogenesis, and genomic instability occurs early in breast cancer development. This study tests the hypothesis that ionizing radiation elicits genomic instability in finite life-span human mammary epithelial cells (HMEC) and asks whether densely ionizing radiation is a mo...

journal_title：Radiation research

authors： Sudo H,Garbe J,Stampfer MR,Barcellos-Hoff MH,Kronenberg A

更新日期：2008-07-01 00:00:00

abstract：:We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas ...

journal_title：Radiation research

authors： Berrada M,Yang Z,Lehnert SM

更新日期：2004-07-01 00:00:00