Abstract：
:Using atomic force microscopy (AFM), we have investigated neutron-induced DNA double-strand breaks in plasmids in aqueous solution. AFM permits direct measurement of individual DNA molecules with an accuracy of a few nanometers. Furthermore, the analysis of the DNA fragment size distribution is non-parametric, whereas other methods are dependent on the model. Neutron irradiation of DNA results in the generation of many short fragments, an observation not made for damage induced by low-LET radiation. These data provide clear experimental evidence for the existence of clustered DNA double-strand breaks and demonstrate that short DNA fragments may be produced by such radiations in the absence of a nucleosomal DNA structure.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Pang D,Berman BL,Chasovskikh S,Rodgers JE,Dritschilo Asubject
Has Abstractpub_date
1998-12-01 00:00:00pages
612-8issue
6eissn
0033-7587issn
1938-5404journal_volume
150pub_type
杂志文章abstract：:In the analysis of the effects of radiation or drugs on clonogenic survival data of mammalian cells, it is often advantageous to compare entire dose-response curves generated under different experimental conditions rather than to conduct single-dose comparisons. We propose a two-stage method for the global comparison ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:Here we report that suramin sensitizes LM217, MDA-MB-468, T98G and A431 cells to ionizing radiation. Suramin sensitized cells to X radiation in a dose-dependent fashion, and longer exposure to suramin before X irradiation resulted in more efficient sensitization. The dose-modifying factors calculated from the survival...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3217
更新日期：2004-09-01 00:00:00
abstract：:We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7-9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardio...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15130.1
更新日期：2019-05-01 00:00:00
abstract：:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0501.1
更新日期：2007-01-01 00:00:00
abstract：:To evaluate whether DNA alterations in mature spermatozoa could stem from DNA damage induced in immature germ cells, testis cells and spermatozoa were analyzed by the comet assay and by the sperm chromatin structure assay 14, 45 and 100 days after in vivo X irradiation of the testes. These times were selected, accordi...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3053
更新日期：2003-10-01 00:00:00
abstract：:In this study, we investigated the effect of (131)I gelatin microspheres ((131)I-GMSs) on human hepatocellular carcinoma cells (HepG2) in nude mice (Balb/c) and the biodistribution of (131)I-GMSs after intratumoral injection. The treatment group and control group animals received intratumoral injections of 1 mCi (131)...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13539.1
更新日期：2014-04-01 00:00:00
abstract：:The effect of exposure of human epidermal keratinocytes to ionizing radiation, both in vivo and in vitro, on the expression of the epidermal growth factor receptor (EGF-R) was studied on the protein, mRNA, and functional levels. Quantitative fluorometry of short-term organ cultures incubated with a monoclonal antibody...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:To determine whether systemic administration of MnSOD-PL protected mice from the acute hematopoietic syndrome and delayed death after total-body irradiation (TBI), C57BL/ 6J mice were injected intravenously with 100 microl liposomes containing 100 microg of human MnSOD-transgene plasmid 24 h prior to irradiation with ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr1286.1
更新日期：2008-10-01 00:00:00
abstract：:Groups of rats were administered different doses of X rays (7.5 and 15 Gy), and the effect on the permeability of their lungs was evaluated during a time frame within which radiation pneumonitis develops. Sham-exposed animals served as controls. End points surveyed included lung weight and increases in the total prote...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radiation-induced mutator phenotype, end points of mitochondrial function...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1617.1
更新日期：2009-12-01 00:00:00
abstract：:Nearly 2% of the male population of Estonia aged 20-39 years were sent to Chernobyl to assist in the cleanup activities after the reactor accident. A cohort of 4,833 cleanup workers was assembled based on multiple and independent sources of information. Information obtained from 3,704 responses to a detailed questionn...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT ut...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14018.1
更新日期：2015-09-01 00:00:00
abstract：:To investigate the effects of ionizing radiation on an isolated neuronal network without complicating systemic factors, slices of hippocampus from the guinea pig were isolated and studied in vitro. Slices were irradiated with a 60Co source and compared to paired, sham-irradiated controls. Electrophysiological activity...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:We collected initial quantitative information on the effects of high-dose carbon (12C) ions compared to photons on vascular damage in anaplastic rat prostate tumors, with the goal of elucidating differences in response to high-LET radiation, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Syngene...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15459.1
更新日期：2020-01-01 00:00:00
abstract：:Prior to whole-liver irradiation (0, 15, 25 Gy) rats were not treated, placed on a protein-deficient diet for 2 weeks, administered cyclophosphamide, and/or depleted of intracellular glutathione by injection with buthionine sulfoximide and diethyl maleate. At various times (0 to 84 days) after 0- and 25-Gy liver irrad...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:A statistical technique is given which can be used to estimate the parameters of the two-component model for cell survival from quantal response multifraction data. The method is a nonlinear logistic regression and relies on a mild assumption relating the probability of death to cell survival level. The method is demo...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:The purpose of this paper is to validate a metabolic model describing the kinetics of tritium in man. The validation is based on measurements of background levels of loose and bound tritium in Italian subjects and their diets. Model predictions are compared with empirical measurements of tritium in human urine and tis...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:Tissue oxygenation influences the radiation response of tumors. To further investigate the underlying mechanisms of tumor hypoxia, the spatial distribution of hypoxic cells in relation to the vasculature was studied. In a panel of three human glioma xenograft lines (E2, E102, E106) with different growth characteristic...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2002)157[0626:qaovpo]2.0.co;2
更新日期：2002-06-01 00:00:00
abstract：:Caffeine is a model radiosensitizing agent that is thought to work by abrogating the radiation-induced G(2)-phase checkpoint. In this study, we examined the effect that various concentrations of caffeine had on cell cycle checkpoints and apoptosis in cells of a human lung carcinoma cell line and found that a concentra...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2002)157[0166:citigp]2.0.co;2
更新日期：2002-02-01 00:00:00
abstract：:New Zealand rabbits, fasted for 12 hours, were subjected to 500 rads of whole-body irradiation. K+-palmitate-1-14C oxidation was assayed with the 600 X g supernatant of thymus and liver homogenates, in the presence of ATP, at various time intervals from irradiation. For a period of 24 hours following irradiation, oxid...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1968-11-01 00:00:00
abstract：:The alveolar type II cell is one of the critical cells for radiation damage in the lungs after inhalation of radioactive aerosols. With the aid of a Quantimet-970 image analyzer and a VAX-11/780 computer, we calculated the radiation dose to rat alveolar type II cells from alpha particles emitted by 239PuO2. A series o...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:Peroxidation of unconjugated polyunsaturated fatty acids such as linolenic acid proceeds through a free radical chain mechanism and is accompanied by the formation of conjugated dienes such as hydroperoxides. In an investigation of radiation-induced oxidation of aqueous linolenate, we have measured two indexes of pero...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)153[0201:eotfod]2.0.co;2
更新日期：2000-02-01 00:00:00
abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15566.1
更新日期：2020-07-08 00:00:00
abstract：:In a patient with Morbus Hodgkin, structural aberrations of the chromosome type in peripheral lymphocytes were analyzed during radiation therapy (accumulated target dose 44.6 Gy: 22 fractions of 1.8 Gy each and 2 fractions of 2.5 Gy each at the end of the therapy). The blood was sampled about 5 min after a fraction an...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:Chinese hamster ovary cells in suspension cultures were heated for various times at 41.5, 43.5, and 45.5 degrees C, and quantitative determinations of microblebbing and macroblebbing of the cell membrane were performed for cells maintained at 4, 25, and 37 degrees C after hyperthermia. The percentage of cells with ble...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15413.1
更新日期：2020-01-01 00:00:00
abstract：:In pathogen-free mice, but not standard conventionally housed laboratory rodents, two distinctly different modes of early radiation lethality can be identified by modifying the irradiation technique (total-body versus abdominal irradiation) or by therapeutic intervention such as rescue of total-body-irradiated mice wi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:The health consequences of exposure to low-dose radiation combined with a solar particle event during space travel remain unresolved. The goal of this study was to determine whether protracted radiation exposure alters gene expression and oxidative burst capacity in the liver, an organ vital in many biological process...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1155.1
更新日期：2008-03-01 00:00:00
abstract：:Current therapeutic approaches for treatment of exposure to radiation involve the use of antioxidants, chelating agents, recombinant growth factors and transplantation of stem cells (e.g., hematopoietic stem cell transplantation). However, exposure to high-dose radiation is associated with severe damage to the vascula...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/RR14461.1
更新日期：2016-08-01 00:00:00
abstract：:We demonstrate by western analysis that the expression levels of TP53 (formerly known as p53), CDKN1A (formerly known as p21Waf1), CDC2 (formerly known as p34cdc2), CCNB1 (cyclin B1) and RAD51 are significantly modulated in confluent, density-inhibited human diploid cell populations exposed to doses where only a small...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
