Abstract：
:Eisenia fetida were exposed continuously to (60)Co gamma radiation during two generations (F(0) and F(1)). Adult F(0) reproduction capacity (i.e., number of cocoons produced, hatchability and number of F(1) hatchlings) in controls and at five dose rates (0.18, 1.7, 4, 11 and 43 mGy/h) was measured over a 13-week exposure period. Survival, growth and sexual maturation of F(1) hatchlings were observed for 11 weeks. F(1) adults were exposed for a further 13 weeks to determine their reproduction capacity. There was no radiation-induced effect on the cocoon production rate in either F(0) or F(1). For F(0), hatchability of cocoons produced during the first 4 weeks was reduced to 60% at 43 mGy/h (98% in controls), and none of the cocoons produced at 5-13 weeks hatched. At 11 mGy/h the cocoon hatchability was reduced to 25% at 9-13 weeks. In addition, the number of hatchlings per hatched cocoon was reduced at 11 and 43 mGy/h. Correspondingly, at these dose rates, the total number of F(1) hatchlings per adult F(0) was significantly lower than in the control. This number was also reduced at 4 mGy/h, but the effect was of borderline significance. For adult F(1), the hatchability of cocoons at 11 mGy/h was reduced to 45-69% during the 13-week exposure period. The number of hatchlings (F(2)) per cocoon and the total number of F(2) individuals produced was also reduced. However, and in contrast to the results observed for F(0), hatchability increased with time, suggesting a possible acclimatization or adaptation of the F(1) individuals. In conclusion, chronic irradiation reduced the reproduction capacity of E. fetida, but extensive exposure periods (13 weeks) were needed for these effects to be expressed. The lowest dose rates at which an effect was observed were 4 mGy/h in F(0) and 11 mGy/h in F(1).
journal_name
Radiat Resjournal_title
Radiation researchauthors
Hertel-Aas T,Oughton DH,Jaworska A,Bjerke H,Salbu B,Brunborg Gdoi
10.1667/RR1012.1subject
Has Abstractpub_date
2007-11-01 00:00:00pages
515-26issue
5eissn
0033-7587issn
1938-5404pii
RR1012journal_volume
168pub_type
杂志文章abstract：:Previous work from our laboratory suggested that neuronal chromatin structure may be altered immediately after exposure to ionizing radiation. In the present study, whole brains of 4-month-old male Fisher 344 rats were irradiated with a dose of 25 Gy. The kinetics of restoring the chromatin structure to its unirradiat...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:Evaluation of the probability of biological phenomena per cell by colony formation, requires knowledge not only of the number of cells at risk but also of their microdistribution. In the present study, the influence of cellular multiplicity (number of cells per potential colony-forming unit) on the determination of ra...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:The modification of methylglyoxal bis(guanylhydrazone) (MGBG) by 42 degrees C hyperthermia-and/or radiation-induced cell killing was examined in Chinese hamster V-79 cells. At concentrations of more than 10 microM, cell survival decreased exponentially with increased MGBG exposure times. Cell lethality of MGBG (10 mic...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:The potential carcinogenic effects of internally deposited alpha-particle-emitting nuclides, notably plutonium, in the liver in humans are unknown but are of concern in relation to exposures from the nuclear industry. However, patients injected with the radiographic contrast medium Thorotrast are chronically exposed t...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:Gleevec, a selective tyrosine kinase inhibitor, retarded the growth of anaplastic thyroid cancer cell lines in vitro and in vivo through selective inhibition of ABL tyrosine kinase activity. In the present study, we investigated the ability of Gleevec to modulate the in vitro and in vivo radiation response of anaplast...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3466.1
更新日期：2006-01-01 00:00:00
abstract：:On future missions into deep space, astronauts will be required to work more autonomously than on previous missions, and thus their ability to perform executive functions could be critical to mission success. In this study, we determined the effect that ≤15 cGy of 600 MeV/n 56Fe particles has on attentional set-shifti...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15085.1
更新日期：2018-12-01 00:00:00
abstract：:There is strong evidence that biological response to ionizing radiation has a contribution from unirradiated "bystander" cells that respond to signals emitted by irradiated cells. We discuss here an approach incorporating a radiobiological bystander response, superimposed on a direct response due to direct energy depo...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0402:tbeiro]2.0.co;2
更新日期：2001-03-01 00:00:00
abstract：:The presence of oxygen-deficient tumor cells is a critical issue in cancer therapy. To identify tumor hypoxia, tissue partial oxygen pressure (pO2) can be measured directly. The OxyLite system allows determination of pO2 in tumors and permits continuous measurements of pO2 at a fixed point. In this study, this system ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3602.1
更新日期：2006-09-01 00:00:00
abstract：:Human gliomas are among the most aggressive tumors, and they respond poorly to treatment. The efficacy of surgical, radiation and chemotherapy treatment of these tumors is limited by the development of resistance. Interventions aimed at altering the response of these tumors to radiation or chemotherapy treatments are ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2007)168[183:HGUCTW]2.0.CO;2
更新日期：2007-08-01 00:00:00
abstract：:Bcl-X(S) is a pro-apoptosis member of the Bcl2 family that has been shown to induce cell death and enhance chemosensitivity. We have investigated the effect of Bcl-X(S) overexpression on radiation sensitivity. Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3169
更新日期：2004-05-01 00:00:00
abstract：:A standard Fricke dosimeter was used to measure the absorbed dose via the oxidation yields of Fe3+ ions in an aqueous environment induced by soft X rays within the "water window" spectral range. We also exploited the property of a neutral solution containing terephthalic acid as a tool for selective detection of OH ra...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15520.1
更新日期：2020-04-01 00:00:00
abstract：:Plutonium is considered to be a carcinogen because it emits alpha particles that may result in the irradiation of stem cell population. In the present study we show that plutonium can also catalyze reactions that induce hydroxyl radicals in the absence of significant alpha-particle irradiation. Using the low specific ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and with...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr2792.1
更新日期：2012-06-01 00:00:00
abstract：:Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy and environmental nuclear contamination as well as for Earth-orbit and space missions. Analyses of transcriptome prof...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1389.1
更新日期：2009-01-01 00:00:00
abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3235.1
更新日期：2013-08-01 00:00:00
abstract：:Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)153[0289:rddita]2.0.co;2
更新日期：2000-03-01 00:00:00
abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14574.1
更新日期：2017-10-01 00:00:00
abstract：:The relationship between intracellular and extracellular pH was investigated in a murine tumor and normal tissue, prior to and following glucose injection. Isotransplants of the murine tumor FSa-II in the dorsum of the hind foot and leg muscle, were investigated in nonanesthetized mice. Extracellular pH was measured w...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:To understand the biophysical mechanism(s) underlying the induction of cell death by the decay of the Auger electron emitter iodine-125 in DNA, Chinese hamster V79 lung fibroblasts were labeled with 5-[(125)I]iodo-2'-deoxyuridine ((125)IdU) for two doubling times and frozen and stored at -135 degrees C in the presence...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)154[0326:todiiq]2.0.co;2
更新日期：2000-09-01 00:00:00
abstract：:Fanconi anemia is a genetically heterogeneous recessive disease characterized mainly by bone marrow failure and cancer predisposition. Although it is accepted that Fanconi cells are highly sensitive to DNA crosslinking agents, their response to ionizing radiation is still unclear. Using pulsed-field gel electrophoresi...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3395.1
更新日期：2005-11-01 00:00:00
abstract：:An analytical expression is developed for calculating the average energy deposited by an ion in a volume with dimensions less than the range of the secondary electrons produced. The expression is obtained by including two additional terms in an energy-restricted linear-energy-transfer equation. The usual energy-restri...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:The recent demonstration of nanoscale scintillators has led to interest in the combination of radiation and photodynamic therapy. In this model, scintillating nanoparticles conjugated to photosensitizers and molecular targeting agents would enhance the targeting and improve the efficacy of radiotherapy and extend the ...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/RR1470.1
更新日期：2009-02-01 00:00:00
abstract：:There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodel...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14403.2
更新日期：2016-11-01 00:00:00
abstract：:Irradiation from internally deposited radionuclides induces malignant tumors. Ingested long-lived radionuclides accumulate in specific organs that are irradiated throughout life. To elucidate why the development of malignant tumors requires long-term internal exposure, of the order of decades, despite the fact that ir...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1492.1
更新日期：2009-04-01 00:00:00
abstract：:Inhalation and ingestion of 137Cs and other long-lived radionuclides can occur after large-scale accidental or malicious radioactive contamination incidents, resulting in a complex temporal pattern of radiation dose/dose rate, influenced by radionuclide pharmacokinetics and chemical properties. High-throughput radiati...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RADE-20-00042.1
更新日期：2020-10-16 00:00:00
abstract：:To determine whether systemic administration of MnSOD-PL protected mice from the acute hematopoietic syndrome and delayed death after total-body irradiation (TBI), C57BL/ 6J mice were injected intravenously with 100 microl liposomes containing 100 microg of human MnSOD-transgene plasmid 24 h prior to irradiation with ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr1286.1
更新日期：2008-10-01 00:00:00
abstract：:Cell-cell contact is thought to be critically involved in mechanisms leading to radioresistance. Here, we assessed the influence of confluent compared to subconfluent cell culture conditions and the radiosensitizing ability of E-cadherin inhibition alone or in combination with C225-mediated EGFR inhibition in human sq...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr2855.1
更新日期：2012-09-01 00:00:00
abstract：:Very low doses of ionizing radiation, 5 to 100 mGy, can induce adaptive responses characterized by elevation in cell survival and reduction in micronuclei formation. Utilizing these end points, RKO human colon carcinoma and transformed mouse embryo fibroblasts (MEF), wild-type or knockout cells missing TNF receptors 1...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3126.2
更新日期：2013-02-01 00:00:00
abstract：:Hypoxic BP-8 murine sarcoma cells were exposed to misonidazole and/or radiation and the kinetics and extent of cell death were evaluated with the [125I]iododeoxyuridine-prelabeling assay. Cell death after treatment with lethal doses of misonidazole was rapid and essentially complete within 2 or 3 days after drug expos...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:The distribution and kinetics of proximal tubular cells with abnormally large nuclei, which were observed in irradiated mouse kidneys before any other obvious histological effects, were investigated. Six months after the administration of 13 or 15 Gy, little histopathological change was noted, in the kidneys of C3H mi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
