Abstract：
:Human gliomas are among the most aggressive tumors, and they respond poorly to treatment. The efficacy of surgical, radiation and chemotherapy treatment of these tumors is limited by the development of resistance. Interventions aimed at altering the response of these tumors to radiation or chemotherapy treatments are needed to improve survival rate and prognosis. Glioblastomas are generally p53 (TP53) functional tumors; however, DNA repair pathways are activated in these tumors instead of the pathways to apoptosis. Thus resistance to treatment is seen in the ability of these tumors to overcome cell death. We present data that demonstrate that U87MG glioblastoma cells transduced with a dominant-negative p53 adenovirus construct become sensitized to radiation-induced mitotic catastrophe through abrogation of G(2)/M checkpoint control and overaccumulation of cyclin B1. These findings suggest that interventions abrogating the G(2)/M checkpoint sensitize these cells to radiation-induced mitotic catastrophe and may represent a novel mechanism to increase the efficacy of radiation in wild-type p53 gliomas that are resistant to apoptosis.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Ianzini F,Domann FE,Kosmacek EA,Phillips SL,Mackey MAdoi
10.1667/0033-7587(2007)168[183:HGUCTW]2.0.CO;2subject
Has Abstractpub_date
2007-08-01 00:00:00pages
183-92issue
2eissn
0033-7587issn
1938-5404pii
0033-7587-168-2-183journal_volume
168pub_type
杂志文章abstract：:Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with acceler...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2977.1
更新日期：2013-06-01 00:00:00
abstract：:The immune response of guinea pigs to Q fever vaccine following 75 to 250 R (60 to 180 rads) of acute whole-body irradiations was investigated. Complement-fixing (CF) antibody titers and protection against febrile response to challenge with virulent Coxiella burnetii were studied. Exposures ranging from 75 to 250 R, 2...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1968-10-01 00:00:00
abstract：:The distribution and kinetics of proximal tubular cells with abnormally large nuclei, which were observed in irradiated mouse kidneys before any other obvious histological effects, were investigated. Six months after the administration of 13 or 15 Gy, little histopathological change was noted, in the kidneys of C3H mi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:To estimate the effect of 50 Hz magnetic-field exposure on genome-wide gene expression, the yeast Saccharomyces cerevisiae was used as a model for eukaryotes. 2D PAGE (about 1,000 spots) for protein and cDNA microarray (about 5,900 genes) analysis for mRNA were performed. The cells were exposed to 50 Hz vertical magne...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3006
更新日期：2003-07-01 00:00:00
abstract：:The hypothesis of boron neutron capture therapy (BNCT) research has been that the short-range, high-linear energy transfer radiation produced by the capture of thermal neutrons by (10)B will potentially control tumor and spare normal tissue only if the boron compound selectively targets tumor tissue within the treatme...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3592.1
更新日期：2006-08-01 00:00:00
abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:New Zealand rabbits, fasted for 12 hours, were subjected to 500 rads of whole-body irradiation. K+-palmitate-1-14C oxidation was assayed with the 600 X g supernatant of thymus and liver homogenates, in the presence of ATP, at various time intervals from irradiation. For a period of 24 hours following irradiation, oxid...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1968-11-01 00:00:00
abstract：:Mice were irradiated with 1 Gy of fission neutrons. At intervals up to 15 days after irradiation undifferentiated spermatogonia were counted in whole mounts of seminiferous tubules in up to eight stages of the epithelial cycle. From Day 6 onward lower numbers of spermatogonia were found in the areas which were in stag...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:A significant fraction of DNA damage produced by ionizing radiation comes from free radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl radical, the principal damaging species, produces single-strand breaks and a plethora of base and sugar lesions that can be cytotoxic or muta...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：:Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes to radiation. The transcriptional response of quiescent primary fibroblasts and keratinocytes exposed to from 10 cGy to 5 Gy and ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1677.1
更新日期：2009-07-01 00:00:00
abstract：:Cytokines function in many roles that are highly relevant to radiation research. This review focuses on how cytokines are structurally organized, how they are induced by radiation, and how they orchestrate mesenchymal, epithelial and immune cell interactions in irradiated tissues. Pro-inflammatory cytokines are the ...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/RR3031.1
更新日期：2012-12-01 00:00:00
abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1519.1
更新日期：2009-09-01 00:00:00
abstract：:The functional and morphological response of the remaining hypertrophied kidney in unilaterally nephrectomized rats to single doses of 0-20 Gy X rays was investigated. Functional and histological end points were assessed serially 4-24 weeks postirradiation. Renal irradiation led to time- and dose-dependent reductions ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0481:trotti]2.0.co;2
更新日期：2001-03-01 00:00:00
abstract：:Human blood cultures were exposed to a 1.9 GHz continuous-wave (CW) radiofrequency (RF) field for 2 h using a series of six circularly polarized, cylindrical waveguides. Mean specific absorption rates (SARs) of 0.0, 0.1, 0.26, 0.92, 2.4 and 10 W/kg were achieved, and the temperature within the cultures during a 2-h ex...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2002)158[0523:ddamii]2.0.co;2
更新日期：2002-10-01 00:00:00
abstract：:Plateau-phase A549 cells exhibit a high capacity for repair of potentially lethal radiation damage (PLD). Previously it was found that PLD repair could be partially inhibited by increasing the extracellular pH (pHe) of the spent medium from its normal value of 6.7-6.8 to 7.6 during postirradiation holding. The present...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:The capacity of plateau-phase Chinese hamster V79 and normal and transformed C3H-10T1/2 cells for repair of potentially lethal radiation damage (PLD) was evaluated for cells irradiated alone or given combined treatments of heat and radiation. The data show that all cell lines tested could repair PLD and that transform...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Energy deposition clusters in the nanometer scale have been investigated systematically in electron, proton, and alpha-particle tracks. The mean absolute frequency distributions of ionization clusters in nanometer sites have been computed. For locally multiply damaged sites and especially for double-strand breaks, the...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:We report here on a qualitative and quantitative comparison of four kinetic photon cell survival models. The commonly used linear-quadratic model extended by a dose protraction factor, the lethal potentially lethal model, the repair misrepair model and the recently reported Giant LOop Binary LEsion (GLOBLE) model are ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13862.1
更新日期：2015-11-01 00:00:00
abstract：:A plasma membrane-rich fraction has been separated from liver cells and cells of two solid rat tumors. D23 hepatoma and MC7 sarcoma. On the basis of marker enzyme activity the membranes separating at the 31-41% interface on the discontinuous sucrose gradient were enriched 15- to 19-fold. No significant differences in ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:This report presents data for survival of mouse intestinal crypt cells, mouse testes weight loss as an indicator of survival of spermatogonial stem cells, and survival of rat 9L spheroid cells after irradiation in the plateau region of unmodified particle beams ranging in mass from 4He to 139La. The LET values range f...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Human cancers have multiple alterations in cell signaling pathways that promote resistance to cytotoxic therapy such as X rays. Parthenolide is a sesquiterpene lactone that has been shown to inhibit several pro-survival cell signaling pathways, induce apoptosis, and enhance chemotherapy-induced cell killing. We invest...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1128.1
更新日期：2007-12-01 00:00:00
abstract：:Gleevec, a selective tyrosine kinase inhibitor, retarded the growth of anaplastic thyroid cancer cell lines in vitro and in vivo through selective inhibition of ABL tyrosine kinase activity. In the present study, we investigated the ability of Gleevec to modulate the in vitro and in vivo radiation response of anaplast...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3466.1
更新日期：2006-01-01 00:00:00
abstract：:The investigation of fragment length distributions of plasmid DNA gives insight into the influence of localized energy distribution on the induction of DNA damage, particularly the clustering of double-strand breaks. We present an approach that determines the fragment length distributions of plasmid DNA after heavy-io...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1028.1
更新日期：2008-06-01 00:00:00
abstract：:We have investigated how radiation quality affects the induction of chromosomal aberrations in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated high charge and energy (HZE) particles including oxygen, neon, silicon, titanium and iron. Chromosome damage was assessed using thr...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3291.1
更新日期：2013-07-01 00:00:00
abstract：:The modifying effects of m-aminobenzamide (m-ABA), an inhibitor of poly(ADP-ribose) synthesis, on 42 degrees C hyperthermia- and/or radiation-induced cell killing were examined in Chinese hamster V-79 cells. When cells were exposed to 42 degrees C hyperthermia in combination with m-ABA (10 mM), cell survival decreased...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:A recent publication by Leith et al. (Cancer Res. 51, 4111-4113, 1991) showed that administration of epidermal growth factor (EGF) (0.25 mg/kg; q.i.d. x 7) to mice bearing xenografted A431 human epidermoid cancers produced increased tumor growth and a reduction of the percentage of hypoxic cells within neoplasms. In c...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3203
更新日期：2004-08-01 00:00:00
abstract：:To characterize the role of the cerebrovascular response in the development of brain injury after focal irradiation, 125I sources were implanted in frontal white matter of the brain of normal dogs; dose was 20 Gy, 7.5 mm from the source. Cerebral blood flow, vascular volume and mean transit time of blood were quantifi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:The relationships between DNA damage and the survival of murine bone marrow cells irradiated in situ were examined. Cell survival was assayed by the ability of bone marrow cells from irradiated mice to form colonies in vitro (CFU-C). DNA double-strand breaks (DSBs) were measured by neutral (nondenaturing) filter eluti...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
