Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to 224Ra alpha particles.

abstract：:In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The comparative effects of liposomal and free DTP...

journal_title：Radiation research

authors： Grémy O,Miccoli L,Lelan F,Bohand S,Cherel M,Mougin-Degraef M

更新日期：2018-05-01 00:00:00

abstract：:The presence of low levels of oxygen may have profound effects on the cytotoxic activity of radiation, radiosensitizers, and bioreductive alkylating agents. As others have shown, low oxygen tensions may significantly alter rates of cellular and chemical oxygen consumption. When experiments are performed at very low ox...

journal_title：Radiation research

authors： Marshall RS,Koch CJ,Rauth AM

更新日期：1986-10-01 00:00:00

abstract：:These assessment of the consequences of irradiation on chromatin is complicated by endogenous nucleases. Isolation and prolonged storage of rat liver nuclei in buffers containing divalent metal ions activates these enzymes and promotes the degradation of chromatin. Irradiation of rat liver nuclei to dose levels of 20,...

journal_title：Radiation research

authors： Gelderblom D,Smit BJ,Böhm L

更新日期：1984-08-01 00:00:00

abstract：:Clinicians involved in conventional radiation therapy are very concerned about the dose-response relationships of normal tissues. Before proceeding to new clinical protocols, radiation biologists involved with conformal proton therapy believe it is necessary to quantify the dose response and tolerance of the organs an...

journal_title：Radiation research

authors： Kubínová L,Mao X,Janácek J,Archambeau JO

更新日期：2003-07-01 00:00:00

abstract：:To characterize the differences in the radiosensitivity of individual populations of human hematopoietic stem/progenitor cells (HSPCs), we examined the relationship among cell surface antigens, clonogenic potential and radiation survival. The expressions of CD34, CD38, CD45RA, CD110 and Tie-2, early differentiation pa...

journal_title：Radiation research

authors： Takahashi K,Monzen S,Hayashi N,Kashiwakura I

更新日期：2010-02-01 00:00:00

abstract：:To understand the biophysical mechanism(s) underlying the induction of cell death by the decay of the Auger electron emitter iodine-125 in DNA, Chinese hamster V79 lung fibroblasts were labeled with 5-[(125)I]iodo-2'-deoxyuridine ((125)IdU) for two doubling times and frozen and stored at -135 degrees C in the presence...

journal_title：Radiation research

authors： Walicka MA,Ding Y,Adelstein SJ,Kassiss AI

更新日期：2000-09-01 00:00:00

abstract：:Both plant senescence and plant response to ionizing radiation involve changes in gene expression and epigenetic profiles, that rely on the formation of reactive oxygen species. However, how the developmental stage of a plant affects its response to ionizing radiation has not been extensively studied. In this study, o...

journal_title：Radiation research

authors： Sidler C,Li D,Kovalchuk O,Kovalchuk I

更新日期：2015-02-01 00:00:00

abstract：:The severe combined immune deficiency (SCID) mouse shows two kinds of phenotypic abnormalities, a high radiosensitivity and an abnormal immunoglobulin gene recombination. A genetic study has revealed that a mutation exists in chromosome 16. However, several attempts to isolate the gene responsible for these phenotypes...

journal_title：Radiation research

authors： Itoh M,Hamatani K,Komatsu K,Araki R,Takayama K,Abe M

更新日期：1993-06-01 00:00:00

abstract：:The purpose of this study was to develop a rat orthotopic lung tumor model with a solitary intrapulmonary nodule to study the effects of high-dose radiation. A549-Luc non-small cell lung cancer (NSCLC) cells were implanted into nude rats in the intercostal space between ribs 5 and 6 of the right lung. Bioluminescence ...

journal_title：Radiation research

authors： Saha D,Watkins L,Yin Y,Thorpe P,Story MD,Song K,Raghavan P,Timmerman R,Chen B,Minna JD,Solberg TD

更新日期：2010-07-01 00:00:00

abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...

journal_title：Radiation research

authors： Takahashi S,Patrick G

更新日期：1987-06-01 00:00:00

abstract：:The objective of this study was to determine whether a deficiency for either one of two repair processes influences the phenomenon of enhancement of radiation-induced cell killing by carboplatin which has been reported previously in one cell line (V79) and which is presumably a result of an interaction between these t...

journal_title：Radiation research

authors： Yang L,Douple EB,O'Hara JA,Crabtree RA,Eastman A

更新日期：1995-11-01 00:00:00

abstract：:We investigated the regeneration of rat thymus after sublethal X irradiation (6 Gy). The number of thymocytes was much lower on day 3 after irradiation, and many apoptotic cells were observed. However, by day 5, there had been a rapid proliferation of thymocytes. Since cytokines are considered to be important regulato...

journal_title：Radiation research

authors： Mizutani N,Fujikura Y,Wang YH,Tamechika M,Tokuda N,Sawada T,Fukumoto T

更新日期：2002-03-01 00:00:00

abstract：:Soil microorganisms in general and biocontrol agents in particular are very sensitive to UV light. The packaging of biocontrol microorganisms into cellular solids has been developed as a means of reducing loss caused by exposure to environmental UV radiation. The bacterial and fungal biocontrol agents Pantoea agglomer...

journal_title：Radiation research

authors： Zohar-Perez C,Chernin L,Chet I,Nussinovitch A

更新日期：2003-08-01 00:00:00

abstract：:Ionizing radiation induces clustered DNA damage sites, whereby two or more individual DNA lesions are formed within one or two helical turns of DNA by a single radiation track. A subset of DNA clustered damage sites exist in which the lesions are located in tandem on the same DNA strand. Recent studies have establishe...

journal_title：Radiation research

authors： Lomax ME,Salje H,Cunniffe S,O'Neill P

更新日期：2005-01-01 00:00:00

abstract：:Radiation-induced heart disease (RIHD) is a serious side effect of radiotherapy for intrathoracic and chest wall tumors. The threshold dose for development of clinically significant RIHD is believed to be lower than previously assumed. Therefore, research into mechanisms of RIHD has gained substantial momentum. RIHD b...

journal_title：Radiation research

authors： Boerma M

更新日期：2012-07-01 00:00:00

abstract：:The current status of particle radiotherapy from a historical perspective is presented. This is done with a personal view and contains personal references and memories during the development of particle radiotherapy. The particles covered are fast neutrons, neutron capture therapy, protons, helium ions, pions and heav...

journal_title：Radiation research

authors： Raju MR

更新日期：1996-04-01 00:00:00

abstract：:Comparatively high exposures to power-frequency electric and magnetic fields produce established biological effects that are explained by accepted mechanisms and that form the basis of exposure guidelines. Lower exposures to magnetic fields (< 1 microT average in the home) are classified as "possibly carcinogenic" on ...

journal_title：Radiation research

authors： Swanson J,Kheifets L

更新日期：2006-04-01 00:00:00

abstract：:Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes to radiation. The transcriptional response of quiescent primary fibroblasts and keratinocytes exposed to from 10 cGy to 5 Gy and ...

journal_title：Radiation research

authors： Warters RL,Packard AT,Kramer GF,Gaffney DK,Moos PJ

更新日期：2009-07-01 00:00:00

abstract：:Exposure to ionizing radiation alone or combined with traumatic tissue injury is a crucial life-threatening factor in nuclear and radiological incidents. Radiation injuries occur at the molecular, cellular, tissue and systemic levels; their mechanisms, however, remain largely unclear. Exposure to radiation combined wi...

journal_title：Radiation research

authors： Kiang JG,Zhai M,Bolduc DL,Smith JT,Anderson MN,Ho C,Lin B,Jiang S

更新日期：2017-11-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:The physical and biological basis of our model to calculate the biological effects of charged particles, termed the local effect model (LEM), has recently been questioned in a commentary by R. Katz. Major objections were related to the definition of the target size and the use of the term cross section. Here we show t...

journal_title：Radiation research

authors： Scholz M,Kraft G

更新日期：2004-05-01 00:00:00

abstract：:Astronauts traveling outside Earth's magnetosphere risk exposure to charged particle radiation that may cause neurophysiological changes and behavioral deficits. Although proton particles comprise a large portion of the space radiation environment, little has been published on the effects of low-dose proton radiation ...

journal_title：Radiation research

authors： Bellone JA,Rudobeck E,Hartman RE,Szücs A,Vlkolinský R

更新日期：2015-08-01 00:00:00

abstract：:Neurons are essential components of neural circuits and provide brain function organization. We previously reported that X irradiation induces apoptosis in immature neurons. To the best of our knowledge, there have been few reports investigating the effects of X irradiation on mature neurons. We analyzed the effects o...

journal_title：Radiation research

authors： Shirai K,Mizui T,Suzuki Y,Okamoto M,Hanamura K,Yoshida Y,Hino M,Noda SE,Al-jahdari WS,Chakravarti A,Shirao T,Nakano T

更新日期：2013-06-01 00:00:00

abstract：:As a follow-up to the two previous surveys of radiation therapy among the atomic bomb survivors, a large-scale survey was performed to document (1) the number of radiation therapy treatments received by the atomic bomb survivors and (2) the types of radiation treatments conducted in Hiroshima and Nagasaki. The previou...

journal_title：Radiation research

authors： Kato K,Antoku S,Russell WJ,Fujita S,Pinkston JA,Hayabuchi N,Hoshi M,Kodama K

更新日期：1998-06-01 00:00:00

abstract：:There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sa...

journal_title：Radiation research

authors： Cheda A,Wrembel-Wargocka J,Lisiak E,Nowosielska EM,Marciniak M,Janiak MK

更新日期：2004-03-01 00:00:00

abstract：:A biophysical model has been developed that is based on the assumptions that an interphase chromosome occupies a spherical territory and that chromosome exchanges are formed by the misrejoining of two DNA double-strand breaks induced within a defined interaction distance. The model is used to explain the relative freq...

journal_title：Radiation research

authors： Wu H

更新日期：2001-11-01 00:00:00

abstract：:Through a detailed study of cell cycle progression, protein expression, and kinase activity in gamma-irradiated synchronized cultures of human skin fibroblasts, distinct mechanisms of initiation and maintenance of G2-phase and subsequent G1-phase arrests have been elucidated. Normal and E6-expressing fibroblasts were ...

journal_title：Radiation research

authors： DeSimone JN,Bengtsson U,Wang X,Lao XY,Redpath JL,Stanbridge EJ

更新日期：2003-01-01 00:00:00

abstract：:The influence of Trp53 on the radiation-induced elevation of T-cell receptor (TCR) variant fractions was examined in splenic T lymphocytes of Trp53-proficient and -deficient mice. Wild-type Trp53+/+, heterozygous Trp53+/- and null Trp53-/- mice were exposed to 3 Gy of X rays at 8 weeks of age. The fraction of TCR-defe...

journal_title：Radiation research

authors： Igari K,Igari Y,Okazaki R,Kato F,Ootsuyama A,Norimura T

更新日期：2006-07-01 00:00:00

abstract：:Using atomic force microscopy (AFM), we have investigated neutron-induced DNA double-strand breaks in plasmids in aqueous solution. AFM permits direct measurement of individual DNA molecules with an accuracy of a few nanometers. Furthermore, the analysis of the DNA fragment size distribution is non-parametric, whereas...

journal_title：Radiation research

authors： Pang D,Berman BL,Chasovskikh S,Rodgers JE,Dritschilo A

更新日期：1998-12-01 00:00:00