Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity.

abstract：:Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Ca...

journal_title：Radiation research

authors： Boissière A,Champion C,Touati A,Hervé du Penhoat MA,Sabatier L,Chatterjee A,Chetioui A

更新日期：2007-04-01 00:00:00

abstract：:The anoxic sensitization of bacterial spores by added H2O2 has been studied. Two mechanistic pathways for damage from H2O2 were found; one of these requires the presence of OH radicals. For this kind of damage, the relationship between H2O2 and OH appears to be that they are reactants. O-2 (and/or HO2), the product of...

journal_title：Radiation research

authors： Ewing D

更新日期：1983-04-01 00:00:00

abstract：:Previously, we described the radiation-induced (RI) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) effect as the increased MTT metabolization at the intermediate dose region after the irradiation of an MCF-7/6 cell monolayer with an X-ray dose gradient. We wondered if the cell monolayer at the inte...

journal_title：Radiation research

authors： Blockhuys S,Vanhoecke B,Smet J,De Paepe B,Van Coster R,Bracke M,De Wagter C

更新日期：2013-04-01 00:00:00

abstract：:Current therapeutic approaches for treatment of exposure to radiation involve the use of antioxidants, chelating agents, recombinant growth factors and transplantation of stem cells (e.g., hematopoietic stem cell transplantation). However, exposure to high-dose radiation is associated with severe damage to the vascula...

journal_title：Radiation research

authors： Rafii S,Ginsberg M,Scandura J,Butler JM,Ding BS

更新日期：2016-08-01 00:00:00

abstract：:The flow cytometry mutation assay is based on detecting mutations in the CD59 gene on human chromosome 11 in CHO A(L) cells with flow cytometry, but the kinetics of mutant expression and the histogram region for mutant selection have not been studied in detail. CHO A(L) cells were analyzed by flow cytometry for CD59 e...

journal_title：Radiation research

authors： Ross CD,Fox MH

更新日期：2008-11-01 00:00:00

abstract：:Both plant senescence and plant response to ionizing radiation involve changes in gene expression and epigenetic profiles, that rely on the formation of reactive oxygen species. However, how the developmental stage of a plant affects its response to ionizing radiation has not been extensively studied. In this study, o...

journal_title：Radiation research

authors： Sidler C,Li D,Kovalchuk O,Kovalchuk I

更新日期：2015-02-01 00:00:00

abstract：:To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estro...

journal_title：Radiation research

authors： Kearney T,Hughes A,Hanson RN,DeSombre ER

更新日期：1999-05-01 00:00:00

abstract：:Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radiation-induced mutator phenotype, end points of mitochondrial function...

journal_title：Radiation research

authors： Dayal D,Martin SM,Owens KM,Aykin-Burns N,Zhu Y,Boominathan A,Pain D,Limoli CL,Goswami PC,Domann FE,Spitz DR

更新日期：2009-12-01 00:00:00

abstract：:Dose-response curves for micronucleus (MN) formation were measured in Chinese hamster V79 and xrs6 (Ku80(-)) cells and in human mammary epithelial MCF10A cells in the dose range of 0.05-1 Gy. The Chinese hamster cells were exposed to 1 GeV/nucleon iron ions, 600 MeV/nucleon iron ions, and 300 MeV/nucleon iron ions (LE...

journal_title：Radiation research

authors： Groesser T,Chun E,Rydberg B

更新日期：2007-12-01 00:00:00

abstract：:Previous studies showed that a 6-week pretreatment of rats with testosterone plus estradiol enhanced the recovery of spermatogenesis 9 weeks after gamma irradiation, resulting in a dose-modifying factor (DMF) of about 2. To test whether the effect of the hormone treatment was mediated through changes in oxygen tension...

journal_title：Radiation research

authors： Wilson G,Kangasniemi M,Meistrich ML

更新日期：1999-07-01 00:00:00

abstract：:Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid], and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of 137Cs radiation. No signific...

journal_title：Radiation research

authors： Verhey LJ,Sedlacek R

更新日期：1983-01-01 00:00:00

abstract：:We have developed a new detection method for measuring distributions of energy depositions from particles characterized by low linear energy transfers (LETs). In particular, we have developed a detection system to measure energy depositions produced by electrons and photons on nanometer scales. The detector is based u...

journal_title：Radiation research

authors： Evans TM,Wang CK

更新日期：1999-01-01 00:00:00

abstract：:Pulmonary carcinomas were recorded in a life-span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality-corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon-daughter inhalations in the sa...

journal_title：Radiation research

authors： Chmelevsky D,Kellerer AM,Lafuma J,Morin M,Masse R

更新日期：1984-06-01 00:00:00

abstract：:This experiment was performed to determine whether ionizing radiation is essential for maximum growth rate in a ciliated protozoan. When extraneous ionizing radiation was reduced to 0.15 mrad/day, the reproduction rate of Tetrahymena pyriformis was significantly less (P less than 0.01) than it was at near ambient leve...

journal_title：Radiation research

authors： Luckey TD

更新日期：1986-11-01 00:00:00

abstract：:Radiation-induced cell death is thought to be caused by nuclear DNA damage that cannot be repaired. However, in this study we found that a delayed increase of mitochondrial reactive oxygen species (ROS) is responsible for some of the radiation-induced cell death in normal human fibroblast cells. We have previously rep...

journal_title：Radiation research

authors： Kobashigawa S,Kashino G,Suzuki K,Yamashita S,Mori H

更新日期：2015-04-01 00:00:00

abstract：:Recent evidence has shown that translocation frequencies decline over time. This phenomenon might be explained by the co-occurrence of translocations in cells that also contain dicentrics, in which case translocations would be eliminated as a by-product of selection against dicentrics. Alternatively, a fraction of tra...

journal_title：Radiation research

authors： Gardner SN,Tucker JD

更新日期：2002-05-01 00:00:00

abstract：:Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes to radiation. The transcriptional response of quiescent primary fibroblasts and keratinocytes exposed to from 10 cGy to 5 Gy and ...

journal_title：Radiation research

authors： Warters RL,Packard AT,Kramer GF,Gaffney DK,Moos PJ

更新日期：2009-07-01 00:00:00

abstract：:The effects of 2.45-GHz continuous-wave microwaves (SAR = 130 mW/g) on the expression of the interferon-regulated enzymes 2'-5'-oligoadenylate (2-5A) synthetase(s) and 2-5A-dependent endoribonuclease (RNase L) were studied in murine L929 cells. Cells growing as monolayers were removed from the substratum and placed in...

journal_title：Radiation research

authors： Krause D,Mullins JM,Penafiel LM,Meister R,Nardone RM

更新日期：1991-08-01 00:00:00

abstract：:The interaction function gamma(chi), which was introduced in the theory of dual radiation action as the probability that two energy transfers separated by distance chi combine with each other to produce a lesion, was estimated with sparsely ionizing radiation (60Co gamma rays and 40 kV X rays). Gamma(chi) was deduced ...

journal_title：Radiation research

authors： Nenoi M,Kanai T,Ito A

更新日期：1987-10-01 00:00:00

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:Flynn, A. A., Green, A. J., Pedley, R. B., Boxer, G. M., Boden, R. and Begent, R. H. J. A Mouse Model for Calculating the Absorbed Beta-Particle Dose from (131)I- and (90)Y-Labeled Immunoconjugates, Including a Method for Dealing with Heterogeneity in Kidney and Tumor. Radiat. Res. 156, 28-35 (2001). Conventional inte...

journal_title：Radiation research

authors： Flynn AA,Green AJ,Pedley RB,Boxer GM,Boden R,Begent RH

更新日期：2001-07-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:The relationships between DNA damage and the survival of murine bone marrow cells irradiated in situ were examined. Cell survival was assayed by the ability of bone marrow cells from irradiated mice to form colonies in vitro (CFU-C). DNA double-strand breaks (DSBs) were measured by neutral (nondenaturing) filter eluti...

journal_title：Radiation research

authors： Petrovecki M,Prager A,Terry NH,Murray D

更新日期：1994-06-01 00:00:00

abstract：:There has been ongoing debate and discussion concerning whether the funding source influenced the outcome of research on human health effects from exposure to radiofrequency fields (RF, electromagnetic waves that carry energy as they propagate in air and dense media). In a study of 225 publications, in which we sought...

journal_title：Radiation research

authors： Vijayalaxmi,Prihoda TJ

更新日期：2019-10-01 00:00:00

abstract：:If the limited life span of hematopoietic tissues in vitro is due to a finite proliferative capacity of individual stem cells, one might expect tissues of young donors to possess a greater proliferative capacity and to contain a larger population of primitive stem cells than those of older donors. To test this hypothe...

journal_title：Radiation research

authors： Schmidt CM,Doran GA,Crouse DA,Sharp JG

更新日期：1987-10-01 00:00:00

abstract：:While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the jo...

journal_title：Radiation research

authors： Egawa H,Furukawa K,Preston D,Funamoto S,Yonehara S,Matsuo T,Tokuoka S,Suyama A,Ozasa K,Kodama K,Mabuchi K

更新日期：2012-09-01 00:00:00

abstract：:Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues to identify reliable biomarkers of individual radiation sensitivity. Herein, w...

journal_title：Radiation research

authors： Bryant J,White L,Coen N,Shields L,McClean B,Meade AD,Lyng FM,Howe O

更新日期：2020-06-01 00:00:00

abstract：:Characteristic of damage introduced in DNA by ionizing radiation is the induction of a wide range of lesions. Single-strand breaks (SSBs) and base damages outnumber double-strand breaks (DSBs). If unrepaired, these lesions can lead to DSBs and increased mutagenesis. XRCC1 and DNA polymerase beta (polbeta) are thought ...

journal_title：Radiation research

authors： Vens C,Hofland I,Begg AC

更新日期：2007-09-01 00:00:00

abstract：:We have used Escherichia coli B/r to test the proposal that hydroxyl radicals (.OH) are major contributors to lethal damage when bacteria in equilibrium with air or 100% nitrogen are exposed to ionizing radiation. In addition, we have tested the hypothesis that oxygen sensitizes bacterial cells to radiation by reactin...

journal_title：Radiation research

authors： Ewing D,Kubala GJ

更新日期：1987-02-01 00:00:00

abstract：:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 typ...

journal_title：Radiation research

authors： Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Y

更新日期：2003-06-01 00:00:00