Bystander cell death and stress response is inhibited by the radical scavenger α(1)-microglobulin in irradiated cell cultures.

abstract：:Keratinocyte growth factor (FGF7, also known as KGF) ameliorates the radiation response of mouse oral mucosa and other epithelial tissues. However, the precise mechanisms remain unclear. The aim of the present study was to investigate the effect of FGF7 on the survival and colony size of normal human epidermal keratin...

journal_title：Radiation research

authors： Slonina D,Hoinkis C,Dörr W

更新日期：2001-12-01 00:00:00

abstract：:Caffeine is a model radiosensitizing agent that is thought to work by abrogating the radiation-induced G(2)-phase checkpoint. In this study, we examined the effect that various concentrations of caffeine had on cell cycle checkpoints and apoptosis in cells of a human lung carcinoma cell line and found that a concentra...

journal_title：Radiation research

authors： Qi W,Qiao D,Martinez JD

更新日期：2002-02-01 00:00:00

abstract：:At the Swiss Institute for Nuclear Research (SIN) cancer patients are irradiated with negatively charged pi mesons using a 60-beam medical pion generator, the Piotron. A low-pressure tissue-equivalent proportional counter was used to measure absorbed dose and microdosimetric spectra. A method was developed to allow di...

journal_title：Radiation research

authors： Schuhmacher H,Menzel HG,Blattmann H,Muth H

更新日期：1985-01-01 00:00:00

abstract：:Therapeutic gain factors (TGFs) have been determined for three spontaneous tumors of the C3H mouse treated by photons + normobaric oxygen (O2(1) ATA), photons + hyperbaric oxygen (O2 3 ATA), photons + misonidazole, or fast neutrons. The tumors were early generation isotransplants of spontaneous tumors: MCaIV, a mammar...

journal_title：Radiation research

authors： Suit HD,Sedlacek R,Silver G,Hsieh CC,Epp ER,Ngo FQ,Roberts WK,Verhey L

更新日期：1988-12-01 00:00:00

abstract：:The relationship between apoptosis induced by gamma radiation and glutathione in cells of two human cancer cell lines, HeLa from cervix carcinoma and MCF-7 from mammary carcinoma, was examined. MCF-7 cells appeared to be more radioresistant than HeLa cells, and radiation-induced apoptosis, which was monitored by asses...

journal_title：Radiation research

authors： Rosi A,Grande S,Luciani AM,Palma A,Giovannini C,Guidoni L,Sapora O,Viti V

更新日期：2007-03-01 00:00:00

abstract：:It is commonly accepted that ionizing radiation induces genomic instability by changes in genomic structure, epigenetic regulation and gene expression. Human endogenous retroviruses (HERV)-R also are often differentially expressed between normal and disease tissues under unstable genomic conditions and are implicated ...

journal_title：Radiation research

authors： Lee JR,Ahn K,Kim YJ,Jung YD,Kim HS

更新日期：2012-11-01 00:00:00

abstract：:This work provides a description of a new interaction, cross-section-based model for radiation-induced cellular inactivation, sublethal damage, DNA repair and cell survival, with the ability to more accurately elucidate different radiation-response phenomena. The principal goal of this work is to describe the damage-i...

journal_title：Radiation research

authors： Brahme A

更新日期：2020-09-16 00:00:00

abstract：:The effect of transgenerational exposure to low dose rate (2.4 and 21 mGy/day) gamma irradiation on the yield of DNA double-strand breaks and oxidized guanine (8-hydroxyguanine) has been studied in the muscle and liver tissue of a model organism, the Japanese medaka fish. We found the level of unrepaired 8-hydroxyguan...

journal_title：Radiation research

authors： Grygoryev D,Moskalenko O,Hinton TG,Zimbrick JD

更新日期：2013-09-01 00:00:00

abstract：:Exposure to ionizing radiation alone or combined with traumatic tissue injury is a crucial life-threatening factor in nuclear and radiological incidents. Radiation injuries occur at the molecular, cellular, tissue and systemic levels; their mechanisms, however, remain largely unclear. Exposure to radiation combined wi...

journal_title：Radiation research

authors： Kiang JG,Zhai M,Bolduc DL,Smith JT,Anderson MN,Ho C,Lin B,Jiang S

更新日期：2017-11-01 00:00:00

abstract：:The adaptive response to ionizing radiation may be mediated by the induction of antioxidant defense mechanisms, accelerated repair or altered cell cycle progression after the conditioning dose. To gain new insight into the mechanism of the adaptive response, nondividing lymphocytes and fibroblasts were used to elimina...

journal_title：Radiation research

authors： Cramers P,Atanasova P,Vrolijk H,Darroudi F,van Zeeland AA,Huiskamp R,Mullenders LH,Kleinjans JC

更新日期：2005-10-01 00:00:00

abstract：:Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promis...

journal_title：Radiation research

authors： Mueller AK,Lindner K,Hummel R,Haier J,Watson DI,Hussey DJ

更新日期：2016-06-01 00:00:00

abstract：:Reverse-biased silicon p-n junction arrays using Silicon-On-Insulator technology have been proposed as microdosimeters. The performance of such detectors in boron neutron capture therapy (BNCT) is discussed. This work provides the first reported measurements using boron-coated silicon diode arrays as microdosimeters i...

journal_title：Radiation research

authors： Bradley PD,Rosenfeld AB,Allen B,Coderre J,Capala J

更新日期：1999-03-01 00:00:00

abstract：:To determine whether different agents that enhance the expression of potentially lethal X-ray damage (PLD) interact with the same or different lesions (or spectrum of lesions), cell killing was measured in three kinds of experiments: (1) When cells were irradiated in G1 phase and treated with caffeine or hydroxyurea a...

journal_title：Radiation research

authors： Beetham KL,Tolmach LJ

更新日期：1991-11-01 00:00:00

abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...

journal_title：Radiation research

authors： Beinke C,Barnard S,Boulay-Greene H,De Amicis A,De Sanctis S,Herodin F,Jones A,Kulka U,Lista F,Lloyd D,Martigne P,Moquet J,Oestreicher U,Romm H,Rothkamm K,Valente M,Meineke V,Braselmann H,Abend M

更新日期：2013-08-01 00:00:00

abstract：:Recent evidence has shown that translocation frequencies decline over time. This phenomenon might be explained by the co-occurrence of translocations in cells that also contain dicentrics, in which case translocations would be eliminated as a by-product of selection against dicentrics. Alternatively, a fraction of tra...

journal_title：Radiation research

authors： Gardner SN,Tucker JD

更新日期：2002-05-01 00:00:00

abstract：:We report results for chromosomal aberrations in human peripheral blood lymphocytes after they were exposed to high-energy iron ions with or without shielding at the HIMAC, AGS and NSRL accelerators. Isolated lymphocytes were exposed to iron ions with energies between 200 and 5000 MeV/nucleon in the 0.1-1-Gy dose rang...

journal_title：Radiation research

authors： Durante M,George K,Gialanella G,Grossi G,La Tessa C,Manti L,Miller J,Pugliese M,Scampoli P,Cucinotta FA

更新日期：2005-10-01 00:00:00

abstract：:The lactose operon functions under the control of the repressor-operator system. Binding of the repressor to the operator prevents the expression of the structural genes. This interaction can be destroyed by the binding of an inducer to the repressor. If ionizing radiations damage the partners, a dramatic dysfunction ...

journal_title：Radiation research

authors： Gillard N,Spotheim-Maurizot M,Charlier M

更新日期：2005-04-01 00:00:00

abstract：:Oncogenic transformation of C3H 10T1/2 cells was determined after exposure to graded doses of 4.3-MeV alpha particles LET = 101 keV/microns. The source of alpha particles was 244Cm and the irradiation was done in an irradiation chamber built for the purpose. Graded doses in the range of 0.2 to 300 cGy were studied wit...

journal_title：Radiation research

authors： Bettega D,Calzolari P,Chiorda GN,Tallone-Lombardi L

更新日期：1992-07-01 00:00:00

abstract：:We show here that the arrests of cells in G2 phase of the cell cycle induced by either staurosporine or ionizing radiation are closely related phenomena governed by a common kinase signaling pathway. The protein kinase inhibitor staurosporine induces a complete G2-phase arrest in exponentially growing TK6 human lympho...

journal_title：Radiation research

authors： Crompton NE,Hain J,Jaussi R,Burkart W

更新日期：1993-09-01 00:00:00

abstract：:Biological response to ionizing radiation depends not only on the type of radiation and dose, but also on the duration and dose rate of treatment. For a given radiation dose, the biological response may differ based on duration and dose rate. We studied the properties of two human cell lines, M059K glioma and U2OS ost...

journal_title：Radiation research

authors： Nakajima H,Furukawa C,Chang YC,Ogata H,Magae J

更新日期：2017-08-01 00:00:00

abstract：:We present theoretical arguments to explain observations of a "reversal" of the RBE at relatively large doses; that is, the RBE of high-LET vs low-LET radiation is less than one. Numerical examples are given and the results of Bogo et al. (Radiat. Res. 118, 341-352, 1989) are discussed qualitatively. ...

journal_title：Radiation research

authors： Zaider M,Rossi HH

更新日期：1992-04-01 00:00:00

abstract：:Puskin, J. S. What Can Epidemiology Tell Us about Risks at Low Doses? Radiat. Res. 169, 122-124 (2008). Limitations on statistical power preclude direct detection and quantification of radiogenic cancer risks at very low (environmental) levels of low-LET radiation through epidemiological studies. Given this limitation...

journal_title：Radiation research

authors： Puskin JS

更新日期：2008-01-01 00:00:00

abstract：:A nested case-control study was conducted among workers at five U.S. nuclear facilities to evaluate leukemia mortality risk (excluding chronic lymphocytic) from ionizing radiation using worksite doses and adjusting for potential confounding. Conditional logistic regression was used to estimate the relative risk (RR) o...

journal_title：Radiation research

authors： Schubauer-Berigan MK,Daniels RD,Fleming DA,Markey AM,Couch JR,Ahrenholz SH,Burphy JS,Anderson JL,Tseng CY

更新日期：2007-02-01 00:00:00

abstract：:The recent demonstration of nanoscale scintillators has led to interest in the combination of radiation and photodynamic therapy. In this model, scintillating nanoparticles conjugated to photosensitizers and molecular targeting agents would enhance the targeting and improve the efficacy of radiotherapy and extend the ...

journal_title：Radiation research

authors： Morgan NY,Kramer-Marek G,Smith PD,Camphausen K,Capala J

更新日期：2009-02-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells became thermotolerant after treatment with either heat for 10 min at 45.5 degrees C or incubation in 100 microM sodium arsenite for 1 h at 37 degrees C. Thermotolerance was tested using heat treatment at 45 degrees C or 43 degrees C administered 6-12 h after the inducing agent. At 45 ...

journal_title：Radiation research

authors： Lee YJ,Perlaky L,Dewey WC,Armour EP,Corry PM

更新日期：1990-03-01 00:00:00

abstract：:Data are presented for a subset of lymphocytes characterized by FISH as missing painted chromosomal material. These lymphocytes occur in both control and irradiated subjects. These cells have a much greater frequency of one-way translocations than cells in which all of the painted chromosomal material is present. Thei...

journal_title：Radiation research

authors： Edwards A,Maznik N,Moquet J,Hone P,Vinnikov V,Lloyd D,Cox R

更新日期：2002-04-01 00:00:00

abstract：:Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortm...

journal_title：Radiation research

authors： Chernikova SB,Wells RL,Elkind MM

更新日期：1999-02-01 00:00:00

abstract：:The statistical distribution of the number of ion pairs per ionizing event in a small volume simulating a tissue sphere was obtained by applying the Expectation-Maximization (EM) algorithm to experimental spectra measured by exposing a Rossi-type spherical proportional counter to gamma radiation. The normalized experi...

journal_title：Radiation research

authors： Obelić B,Srdoc D,Djurić PM,Marino SA

更新日期：1998-05-01 00:00:00

abstract：:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here...

journal_title：Radiation research

authors： Yokoyama K,Miyatake S,Kajimoto Y,Kawabata S,Doi A,Yoshida T,Okabe M,Kirihata M,Ono K,Kuroiwa T

更新日期：2007-01-01 00:00:00

abstract：:The model of radiation action that is presented relates the surviving fraction of irradiated cells to unrepaired DNA double-strand breaks (DSBs). The following assumptions are made in the model: (i) A DNA fragment created by the induced DSBs may move out of its chromosome (become lost), and the probability of that pro...

journal_title：Radiation research

authors： Ostashevsky JY

更新日期：1989-06-01 00:00:00