解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.02.036
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteri...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.02.004
更新日期:2013-05-01 00:00:00
abstract::It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data includi...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.01.016
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Blood glucose fluctuations have been found to be relevant to the progression of atherosclerosis in patients with type 2 diabetes and to be more detrimental for the development of atherosclerosis than the sustained hyperglycemia. We aim at evaluating the effect of blunted daily acute glucose fluctuations by DP...
journal_title:Atherosclerosis
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.atherosclerosis.2012.12.018
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.01.018
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.01.029
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.atherosclerosis.2013.01.045
更新日期:2013-04-01 00:00:00
abstract::The negative correlation between percent flow-mediated dilation (FMD%) and baseline diameter (D(base)) has only recently been recognised as a fundamental ratio-scaling problem, which is not resolved by significance-testing of D(base) inequality between groups/conditions, nor by covariate-adjusting FMD% itself by D(bas...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.11.027
更新日期:2013-02-01 00:00:00
abstract::The ATP-binding cassette transporter G1 (ABCG1) plays an important role in reverse cholesterol transport by exporting cholesterol to high density lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the presence or absence of twelve amino acids between the ATP cassette and the transmembrane do...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.12.009
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Postprandial lipemia influences the development of atherosclerosis. Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated. METHODS:To investigate if age is ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.052
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) have been implicated in development of atherosclerosis. MMPs are activated in patients with acute coronary syndrome (ACS). However, little data exist regarding the correlation between circulating levels of MMPs and plaque volume (PV) in patients with ACS. We therefore evaluat...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2012.10.063
更新日期:2013-01-01 00:00:00
abstract::Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study coh...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.058
更新日期:2013-01-01 00:00:00
abstract:AIMS:This study was set up to compare the accuracy, sensitivity and specificity of gene expression results between the Illumina HumanHT-12 v3 Expression BeadChip (GWE) and the TaqMan qRT-PCR low-density array (LDA) in atherosclerotic plaques. METHODS:Gene expression levels of 196 genes were determined from 22 atherosc...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.078
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To examine whether serum concentrations of carotenoids are related to the risk of sudden cardiac death (SCD) in middle-aged men. METHODS:The study population consisted of 1031 Finnish men aged 46-65 years of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids wer...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.077
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.038
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Atherosclerosis is an inflammatory process resulting from the interaction between genetic and environmental factors. Leukotrienes are inflammatory mediators generated from arachidonic acid, and genetic polymorphisms involved in leukotriene metabolism are implicated in atherosclerosis. The objectives of this s...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.048
更新日期:2013-01-01 00:00:00
abstract::The aim of this study is to assess the relationship of epicardial adipose tissue (EAT) and plaque vulnerability. We consecutively enrolled 82 patients with coronary artery disease (CAD). A symptom-related vessel was imaged by virtual histology intravascular ultrasound (VH-IVUS). In 60 out of 82 patients, all three ves...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.11.001
更新日期:2013-01-01 00:00:00
abstract::Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2012.08.018
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-cholestero...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.atherosclerosis.2012.09.001
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Lipoprotein(a) [Lp(a)] consists of apolipoprotein B-100 (apoB-100) as part of an LDL-like particle and the covalently linked glycoprotein apolipoprotein(a) [apo(a)]. Detailed mechanisms of its biosynthesis, assembly, secretion and catabolism are still poorly understood. To address the Lp(a) assembly mechanism...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.09.031
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.025
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSES:Pulse wave analysis (PWV), a marker of aortic stiffness, has independent predictive value for cardiovascular morbidity and mortality in both healthy and high-risk populations, especially fatal stroke, and for long-term functional stroke prognosis. Whether arterial stiffness and wave reflection a...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.09.024
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Sulforaphane, a naturally occurring organosulfur compound in broccoli, has chemopreventive properties in cancer. However, the effects of sulforaphane in vascular diseases have not been examined. We therefore aimed to investigate the effects of sulforaphane on vascular smooth muscle cell (VSMC) proliferation a...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.07.040
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Mutations in the LDL receptor gene are the major cause of familial hypercholesterolaemia (FH) but it has been previously shown that the simple finding of a variation in the coding sequence of the LDLR does not confirm that it is the actual cause of FH. The pathogenicity of five missense alterations in the LD...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.08.017
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.08.029
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:Atherosclerosis is a chronic disease characterized by two main features, lipid retention and inflammation. The 12/15-lipoxygenases play a two-faced role in atherosclerosis with pro-inflammatory effects through oxidation of LDL and anti-inflammatory effects through lipid mediator synthesis. In cells involved ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.07.022
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To determine whether endogenous sex hormones (estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)) are longitudinally associated with progression of atherosclerosis among women at midlife. METHODS:249 Pre- or early peri-menopausal women (42-57 years) ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.07.025
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke; however it is rather neglected. Vessel wall visualization by high resolution magnetic resonance imaging (HRMRI) might provide more accurate information. METHODS:A total of 219 consecutive patients with acute ischemic stroke underwent MR...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.07.037
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesions. METHODS ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.05.040
更新日期:2012-10-01 00:00:00
abstract::The pathogenesis of retinal vein occlusion (RVO), has not been well understood. Recent data have shown the efficacy of an anticoagulant therapy with LMWHs in the treatment of acute RVO suggesting the presence of a hypercoagulable state in these patients. New global tests for detection of hypercoagulability and hypofib...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.06.053
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To investigate SCM-198 (also known as "leonurine"), a compound in Herba leonuri, as well as its effect on the progression of atherosclerosis in hypercholesterolemic rabbits and underlying mechanisms. METHODS:Thirty New Zealand male White rabbits (5 groups, n = 6) were fed either a normal diet or a high-chole...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.06.066
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.04.006
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to examine the prevalence and risk factors for cerebral infarction (CI) and carotid artery stenosis (CAS) in patients with peripheral arterial disease (PAD) compared with normal controls. METHOD:A cross-sectional analysis was performed in 857 subjects (PAD: 543, controls: 314). C...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.05.019
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:We investigated the separate impact of metabolic syndrome (MS) and altered glucose tolerance on early markers of vascular injuries. METHODS:Intima-media thickness (IMT) and pulse wave analysis (PWA), were evaluated in 132 overweight or obese subjects, with (MS(+)) or without (MS(-)) MS; subjects were further...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.05.008
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E4 is associated with an increased inflammatory burden in s...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.04.021
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:The distribution of atherosclerotic lesions changes with age in human and rabbit aortas. We investigated if this can be explained by changes in patterns of blood flow and wall shear stress. METHODS:The luminal geometry of thoracic aortas from immature and mature rabbits was obtained by micro-CT of vascular c...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.04.020
更新日期:2012-07-01 00:00:00
abstract::The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2011.11.034
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...
journal_title:Atherosclerosis
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.atherosclerosis.2011.12.007
更新日期:2012-06-01 00:00:00
abstract:AIMS:Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. METHODS AND RESULTS:Absolute concentrations of iron, copper, zinc and calcium, and p...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.03.015
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. METHODS AND RESULTS:We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.02.032
更新日期:2012-06-01 00:00:00