abstract：:miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRN...

journal_title：Journal of advanced research

authors： Chakraborty C,Sharma AR,Sharma G,Lee SS

更新日期：2020-08-29 00:00:00

abstract：Introduction:Defecation is a complex process that is difficult to study and analyze. Objectives:Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. Methods:The 12-cm-long Fecobionics device contained pressure sensors, m...

journal_title：Journal of advanced research

authors： Sun D,Liao D,Chen SC,Wong C,Wah Leung W,Futaba K,Mak T,Ng S,Gregersen H

更新日期：2020-07-11 00:00:00

abstract：:LncRNA (Long non-coding RNA) ZFAS1 (zinc finger antisense 1) functions as the oncogene in multiple cancers, including gastric cancer. However, its function and underlying mechanism in the GCA (gastric cardia adenocarcinoma), the most aggressive type of gastric cancer, remain unknown. We demonstrated here that the LncR...

journal_title：Journal of advanced research

authors： Zhu T,Wang Z,Wang G,Hu Z,Ding H,Li R,Sun J

更新日期：2020-06-24 00:00:00

abstract：Introduction:Numerous studies have shown the ability of low-energy acoustic waves such as focused ultrasound or shockwave to transiently open blood-brain barrier (BBB) and facilitate drug delivery to the brain. Preclinical and clinical evidences have well demonstrated the efficacy and safety in treating various brain d...

journal_title：Journal of advanced research

authors： Liao WH,Hsiao MY,Kung Y,Liu HL,Béra JC,Inserra C,Chen WS

更新日期：2020-06-21 00:00:00

abstract：:This paper studies the active damping of the oscillations of lightly damped linear systems whose parameters are indeterminate or may change through time. Systems with an arbitrary number of vibration modes are considered. Systems described by partial differential equations, that yield an infinite number of vibration m...

journal_title：Journal of advanced research

authors： Feliu-Batlle V,Feliu-Talegon D,San-Millan A

更新日期：2020-06-20 00:00:00

abstract：:Transplanted neural stem cells promote neural tissue regeneration and functional recovery primarily by releasing paracrine factors. Exosomes act as important secreted paracrine molecules to deliver therapeutic agents involved in cellular functions. Here, we focused on the role of exosomes (hNSC-Exo) derived from human...

journal_title：Journal of advanced research

authors： Zhang G,Zhu Z,Wang H,Yu Y,Chen W,Waqas A,Wang Y,Chen L

更新日期：2020-05-25 00:00:00

abstract：Background:The vascular endothelium represents a fundamental mechanical and biological barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes in its integrity are associated to several cardiovascular diseases, including hypertension, atherosclerosis, hyperhomocysteinemia, diabetes, ...

journal_title：Journal of advanced research

authors： Citi V,Martelli A,Gorica E,Brogi S,Testai L,Calderone V

更新日期：2020-05-19 00:00:00

abstract：:Inorganic or inorganic-organic hybrid nanomaterials have great potential for applications in the biomedical fields. Biological half-life is an essential pharmacokinetic parameter for these materials to function in vivo. Compared to inductively coupled plasma mass spectrometry (ICP-MS), which is the gold standard, lase...

journal_title：Journal of advanced research

authors： Chu Y,Zhang Z,He Q,Chen F,Sheng Z,Zhang D,Jin H,Jiang F,Guo L

更新日期：2020-05-16 00:00:00

abstract：:The aim of this work is to present numerical treatments to a complex order fractional nonlinear one-dimensional problem of Burgers' equations. A new parameter σ ...

journal_title：Journal of advanced research

authors： Sweilam NH,Al-Mekhlafi SM,Baleanu D

更新日期：2020-05-15 00:00:00

abstract：:Plants in nature are constantly exposed to a variety of abiotic and biotic stresses which limits their growth and production. Enhancing crop yield and production to feed exponentially growing global population in a sustainable manner by reduced chemical fertilization and agrochemicals will be a big challenge. Recently...

journal_title：Journal of advanced research

authors： Kumar A,Dubey A

更新日期：2020-04-29 00:00:00

abstract：:This paper reveals and analyzes the frequency bifurcation phenomena in the fractional-order inductive power transfer (FOIPT) system with series-series compensation topology. Using fractional calculus theory and electric circuit theory, the circuit model of the series-series compensated FOIPT system is first proposed, ...

journal_title：Journal of advanced research

authors： Shu X,Zhang B,Rong C,Jiang Y

更新日期：2020-04-24 00:00:00

abstract：:Breast cancer (BC) incidence is progressively increasing in Egypt. However, there is insufficient knowledge of the acquired somatic mutations in Egyptian BC patients which limit our understanding of its progression. To the best of our knowledge, this is the first Egyptian cohort to sequence a multiple-gene panel of ca...

journal_title：Journal of advanced research

authors： Nassar A,Abouelhoda M,Mansour O,Loutfy SA,Hafez MM,Gomaa M,Bahnassy A,El-Din Youssef AS,Lotfy MM,Ismail H,Ahmed OS,Abou-Bakr AA,Zekri AN

更新日期：2020-04-03 00:00:00

abstract：:The signaling properties of the gasotransmitter molecule hydrogen sulfide (H2S), which is endogenously generated in plant cells, are mainly observed during persulfidation, a protein post-translational modification (PTM) that affects redox-sensitive cysteine residues. There is growing experimental evidence that H2S in ...

journal_title：Journal of advanced research

authors： Corpas FJ,Palma JM

更新日期：2020-03-29 00:00:00

abstract：:The band topology in condensed matter has attracted widespread attention in recent years. Due to the band inversion, topological nodal line semimetals (TNLSs) have band crossing points (BCPs) around the Fermi level, forming a nodal line. In this work, by means of first-principles, we observe that the synthesized NaAlG...

journal_title：Journal of advanced research

authors： Wang X,Ding G,Cheng Z,Surucu G,Wang XL,Yang T

更新日期：2020-01-31 00:00:00

abstract：:Alpha-Synuclein (aSyn) is a chameleon-like protein. Its overexpression and intracellular deposition defines neurodegenerative α-synucleinopathies including Parkinson's disease. Whether aSyn up-regulation is the cause or the protective reaction to α-synucleinopathies remains unresolved. Remarkably, the accumulation of ...

journal_title：Journal of advanced research

authors： Rodríguez-Losada N,de la Rosa J,Larriva M,Wendelbo R,Aguirre JA,Castresana JS,Ballaz SJ

更新日期：2020-01-22 00:00:00

abstract：:Histone posttranslational modifications (HPTMs) play important roles in eukaryotic transcriptional regulation. Recently, it has been suggested that combinatorial modification codes that comprise two or more HPTMs can recruit readers of HPTMs, performing complex regulation of gene expression. However, the characterizat...

journal_title：Journal of advanced research

authors： Chen P,Guo Z,Chen C,Tian S,Bai X,Zhai G,Ma Z,Wu H,Zhang K

更新日期：2019-11-13 00:00:00

abstract：:Genetic disorders have been shown to co-occur in individual patient. A Thai boy with features of osteogenesis imperfecta (OI) and combined pituitary hormone deficiency (CPHD) was identified. The causative mutations were investigated by whole exome and Sanger sequencing. Pathogenicity and pathomechanism of the variants...

journal_title：Journal of advanced research

authors： Hemwong N,Phokaew C,Srichomthong C,Tongkobpetch S,Srilanchakon K,Supornsilchai V,Suphapeetiporn K,Porntaveetus T,Shotelersuk V

更新日期：2019-10-21 00:00:00

abstract：:Bacteria establish complex, compositionally consistent communities on healthy leaves. Ecological processes such as dispersal, diversification, ecological drift, and selection as well as leaf surface physicochemistry and topology impact community assembly. Since the leaf surface is an oligotrophic environment, species ...

journal_title：Journal of advanced research

authors： Schlechter RO,Miebach M,Remus-Emsermann MNP

更新日期：2019-03-14 00:00:00

abstract：:Epilepsy is one of the most well-known neurological conditions worldwide. One-third of adult epileptic patients do not respond to antiepileptic drugs or surgical treatment and therefore suffer from the resistant type of epilepsy. Stem cells have been given substantial consideration in the field of epilepsy therapeutic...

journal_title：Journal of advanced research

authors： Ali SO,Shahin NN,Safar MM,Rizk SM

更新日期：2019-01-31 00:00:00

abstract：:The study question was whether the use of high-viscosity glass-ionomer with chlorhexidine (HVGIC/CHX) for the Atraumatic Restorative Treatment (ART) prepared cavities could achieve a higher restoration survival percentage and be more effective for preventing dentine carious lesions adjacent to the restoration than the...

journal_title：Journal of advanced research

authors： Mobarak EH,Shabayek MM,El-Deeb HA,Mulder J,Hassan FM,Van der Sanden WJM,Frencken JE

更新日期：2019-01-31 00:00:00

abstract：:The objective of this paper is to study the optimal control problem for the fractional tuberculosis (TB) infection model including the impact of diabetes and resistant strains. The governed model consists of 14 fractional-order (FO) equations. Four control variables are presented to minimize the cost of interventions....

journal_title：Journal of advanced research

authors： Sweilam NH,Al-Mekhlafi SM,Baleanu D

更新日期：2019-01-19 00:00:00

abstract：:Necrophagous insects are mostly known through forensic entomology. Indeed, experimental data investigating the effect of temperature on larval development underlies post-mortem interval estimations. However, such developmental studies rarely considered the behavior of maggots. In contrast, previous results supposed th...

journal_title：Journal of advanced research

authors： Aubernon C,Hedouin V,Charabidze D

更新日期：2018-12-08 00:00:00

abstract：:Aluminum (Al) is an element widely distributed in soils, even though Al3+ is one of the most detrimental cations to plant growth. The effect of nitric oxide (NO) precursors on indole-3-acetic acid (IAA) flow towards roots upon Al treatment is herein reported using two Triticum aestivum (wheat) cultivars with recognize...

journal_title：Journal of advanced research

authors： Faria-Lopes RO,Muniz DR,Chaves IS,França MGC,Modolo LV

更新日期：2018-08-30 00:00:00

abstract：:World population is expected to reach 9.7 billion by 2050, which makes a great challenge the achievement of food security. The use of urease inhibitors in agricultural practices has long been explored as one of the strategies to guarantee food supply in enough amounts. This is due to the fact that urea, one of the mos...

journal_title：Journal of advanced research

authors： Modolo LV,da-Silva CJ,Brandão DS,Chaves IS

更新日期：2018-04-17 00:00:00

abstract：:Carob samples from seven different Mediterranean countries (Cyprus, Greece, Italy, Spain, Turkey, Jordan and Palestine) were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Seed and flesh samples of indigenous and foreign cultivars, both authentic and commercial, were examined. The spectra were recorded...

journal_title：Journal of advanced research

authors： Christou C,Agapiou A,Kokkinofta R

更新日期：2017-12-24 00:00:00

abstract：:The freshwater Testudine species have gained importance in recent years, as most of their population is threatened due to exploitation for delicacy and pet trade. In this regard, Lissemys punctata, a freshwater terrapin, predominantly distributed in Asian countries has gained its significance for the study. A pilot st...

journal_title：Journal of advanced research

authors： Lalitha R,Chandavar VR

更新日期：2017-11-21 00:00:00

abstract：:The optimization of a novel programmable data-flow crypto processor dedicated to security applications is considered. An architecture based on assigning basic functional units to four synchronous regions was proposed in a previous work. In this paper, the problem of selecting the number of synchronous regions and the ...

journal_title：Journal of advanced research

authors： El-Hadidi MT,Elsayed HM,Osama K,Bakr M,Aslan HK

更新日期：2017-11-04 00:00:00

abstract：:The oxidation behavior of two types of inhomogeneous nickel was investigated in air at 1273 K for a total oxidation time of 100 h. The two types were porous sintered-nickel and microstructurally inhomogeneous cast-nickel. The porous-nickel samples were fabricated by compacting Ni powder followed by sintering in vacuum...

journal_title：Journal of advanced research

authors： Mohamed LZ,Ghanem WA,El Kady OA,Lotfy MM,Ahmed HA,Elrefaie FA

更新日期：2017-11-01 00:00:00

abstract：:Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individual...

journal_title：Journal of advanced research

authors： Watanabe MS,Theodoro TR,Coelho NL,Mendes A,Leonel MLP,Mader AM,Nader HB,Glina S,Pinhal MAS

更新日期：2017-07-01 00:00:00

abstract：:A computational algorithm is developed for estimating accurately the attitude of a robotic arm which moves along a predetermined path. This algorithm requires preliminary input data obtained in the static mode to yield phase observables for the precise, 3-axis attitude determination of a swinging manipulator in the dy...

journal_title：Journal of advanced research

authors： Raskaliyev A,Patel S,Sobh T

更新日期：2017-07-01 00:00:00

abstract：:In this research work, a comparative evaluation on the mechanical and microstructural characteristics of aluminium based single and hybrid reinforced nanocomposites was carried out. The manufacture of a single reinforced nanocomposite was conducted with the distribution of 2 wt.% nano alumina particles (avg. particle ...

journal_title：Journal of advanced research

authors： Kannan C,Ramanujam R

更新日期：2017-07-01 00:00:00

abstract：:The increase in prevalence of antimicrobial-resistant bacteria (ARB) is currently a serious threat, thus there is a need for new antimicrobial compounds to combat infections caused by these ARB. An antimicrobial-producing bacterium, Burkholderia paludis was recently isolated and was able to produce a type of sideropho...

journal_title：Journal of advanced research

authors： Ong KS,Cheow YL,Lee SM

更新日期：2017-07-01 00:00:00

abstract：:The association between hepatitis C virus (HCV) infection and type 2 diabetes (T2D) has been known for over 20 years. Cross-sectional and longitudinal studies have shown a higher prevalence and incidence, respectively, of T2D in patients with chronic HCV infection. HCV induces glucose metabolism alterations mostly int...

journal_title：Journal of advanced research

authors： Gastaldi G,Goossens N,Clément S,Negro F

更新日期：2017-03-01 00:00:00

abstract：:This paper presents a new methodology for the modeling and control of power systems based on an uncertain polytopic linear parameter-varying (LPV) approach using parameter set mapping with principle component analysis (PCA). An LPV representation of the power system dynamics is generated by linearization of its differ...

journal_title：Journal of advanced research

authors： Jabali MB,Kazemi MH

更新日期：2017-01-01 00:00:00

abstract：:This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also reviewed and discussed. ...

journal_title：Journal of advanced research

authors： Shawali AS

更新日期：2016-11-01 00:00:00

abstract：:The present study aimed to develop the predictive models of average tool-workpiece interface temperature in hard turning of AISI 1060 steels by coated carbide insert. The Response Surface Methodology (RSM) and Artificial Neural Network (ANN) were employed to predict the temperature in respect of cutting speed, feed ra...

journal_title：Journal of advanced research

authors： Mia M,Dhar NR

更新日期：2016-11-01 00:00:00

abstract：:Limited progress has been made in the quest to identify both selective and non-toxic T-type calcium channel blocking compounds. The present research work was directed toward slaking the same by identifying the selective three dimensional (3D) pharmacophore map for T-type calcium channel blockers (CCBs). Using HipHop m...

journal_title：Journal of advanced research

authors： Gandhi T,Melge AR,Gopi Mohan C

更新日期：2016-11-01 00:00:00

abstract：:The dynamical properties of nanogels of xanthan gum (XG) with hydrodynamic radius controlled in a size range from 5 nm to 35 nm, were studied at the different XG concentrations in water/sodium bis-2-ethylhexyl-sulfosuccinate (AOT)/decane reverse micelles (RMs) vs. mass fraction of nano-droplet (MFD) at W = 40, using d...

journal_title：Journal of advanced research

authors： Rahdar A,Almasi-Kashi M

更新日期：2016-09-01 00:00:00

abstract：:Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced...

journal_title：Journal of advanced research

authors： Zarkavelis G,Kollas A,Kampletsas E,Vasiliou V,Kaltsonoudis E,Drosos A,Khaled H,Pavlidis N

更新日期：2016-09-01 00:00:00

abstract：:Renal cell carcinoma is rarely diagnosed during pregnancy. Its management is a real challenge due to the sparse literature and lack of standard guidelines. In this situation, the diagnosis is often delayed as the clinical presentation might resemble other pregnancy-related disorders but it should be one of the diagnos...

journal_title：Journal of advanced research

authors： Khaled H,Lahloubi NA,Rashad N

更新日期：2016-07-01 00:00:00