Abstract：
:Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced. The role of chemotherapeutic agents in causing SCLE has been investigated with the taxanes being the most common anticancer agents. However, recent data emerging point toward antiestrogen therapies as a causative factor not only for SCLE but also for a variety of autoimmune disorders. This is a report of a case of a 42 year old woman who developed clinical manifestations of SCLE after letrozole treatment in whom remission of the cutaneous manifestations was noticed upon discontinuation of the drug. In addition, an extensive review of the English literature has been performed regarding the association of antiestrogen therapy with autoimmune disorders. In conclusion, Oncologists should be aware of the potential development of autoimmune reactions in breast cancer patients treated with aromatase inhibitors.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Zarkavelis G,Kollas A,Kampletsas E,Vasiliou V,Kaltsonoudis E,Drosos A,Khaled H,Pavlidis Ndoi
10.1016/j.jare.2016.04.001subject
Has Abstractpub_date
2016-09-01 00:00:00pages
719-726issue
5eissn
2090-1232issn
2090-1224pii
S2090-1232(16)30021-2journal_volume
7pub_type
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