Abstract：
:miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.
journal_name
J Adv Resjournal_title
Journal of advanced researchauthors
Chakraborty C,Sharma AR,Sharma G,Lee SSdoi
10.1016/j.jare.2020.08.012subject
Has Abstractpub_date
2020-08-29 00:00:00pages
127-138eissn
2090-1232issn
2090-1224pii
S2090-1232(20)30196-Xjournal_volume
28pub_type
杂志文章,评审abstract：:The oxidation behavior of two types of inhomogeneous nickel was investigated in air at 1273 K for a total oxidation time of 100 h. The two types were porous sintered-nickel and microstructurally inhomogeneous cast-nickel. The porous-nickel samples were fabricated by compacting Ni powder followed by sintering in vacuum...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.08.004
更新日期：2017-11-01 00:00:00
abstract：:The increase in prevalence of antimicrobial-resistant bacteria (ARB) is currently a serious threat, thus there is a need for new antimicrobial compounds to combat infections caused by these ARB. An antimicrobial-producing bacterium, Burkholderia paludis was recently isolated and was able to produce a type of sideropho...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.05.007
更新日期：2017-07-01 00:00:00
abstract：:The current study was designed to investigate the potential effect of Spirulina platensis, Arthrospira platensis, (SP) on tissue protection of Nile tilapia (Oreochromis niloticus) through estimation of P53 level. Five isonitrogenous and isocaloric rations containing graded levels of dried SP 5, 7.5,10, 15, and 20 g/kg...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2013.03.009
更新日期：2014-01-01 00:00:00
abstract：:This paper presents a fast and simple method for human action recognition. The proposed technique relies on detecting interest points using SIFT (scale invariant feature transform) from each frame of the video. A fine-tuning step is used here to limit the number of interesting points according to the amount of details...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2013.11.007
更新日期：2015-03-01 00:00:00
abstract：:This paper proposes an accurate, computationally efficient, and spectrum-free formulation of the heat diffusion smoothing on 3D shapes, represented as triangle meshes. The idea behind our approach is to apply a [Formula: see text]-degree Padé-Chebyshev rational approximation to the solution of the heat diffusion equat...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2014.09.003
更新日期：2015-05-01 00:00:00
abstract：:The objective of this paper is to study the optimal control problem for the fractional tuberculosis (TB) infection model including the impact of diabetes and resistant strains. The governed model consists of 14 fractional-order (FO) equations. Four control variables are presented to minimize the cost of interventions....
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2019.01.007
更新日期：2019-01-19 00:00:00
abstract：:The optimization of a novel programmable data-flow crypto processor dedicated to security applications is considered. An architecture based on assigning basic functional units to four synchronous regions was proposed in a previous work. In this paper, the problem of selecting the number of synchronous regions and the ...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.11.002
更新日期：2017-11-04 00:00:00
abstract：:Plants in nature are constantly exposed to a variety of abiotic and biotic stresses which limits their growth and production. Enhancing crop yield and production to feed exponentially growing global population in a sustainable manner by reduced chemical fertilization and agrochemicals will be a big challenge. Recently...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2020.04.014
更新日期：2020-04-29 00:00:00
abstract：:The association between hepatitis C virus (HCV) infection and type 2 diabetes (T2D) has been known for over 20 years. Cross-sectional and longitudinal studies have shown a higher prevalence and incidence, respectively, of T2D in patients with chronic HCV infection. HCV induces glucose metabolism alterations mostly int...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2016.11.003
更新日期：2017-03-01 00:00:00
abstract：:In this paper, we studied the progression of shallow water waves relevant to the variable coefficient Korteweg-de Vries (vcKdV) equation. We investigated two kinds of cases: when the dispersion and nonlinearity coefficients are proportional, and when they are not linearly dependent. In the first case, it was shown tha...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2014.02.004
更新日期：2015-07-01 00:00:00
abstract：:Alpha-Synuclein (aSyn) is a chameleon-like protein. Its overexpression and intracellular deposition defines neurodegenerative α-synucleinopathies including Parkinson's disease. Whether aSyn up-regulation is the cause or the protective reaction to α-synucleinopathies remains unresolved. Remarkably, the accumulation of ...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.01.009
更新日期：2020-01-22 00:00:00
abstract：:A computational algorithm is developed for estimating accurately the attitude of a robotic arm which moves along a predetermined path. This algorithm requires preliminary input data obtained in the static mode to yield phase observables for the precise, 3-axis attitude determination of a swinging manipulator in the dy...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.03.005
更新日期：2017-07-01 00:00:00
abstract：:Inflammatory breast cancer (IBC) is a highly metastatic and fatal form of breast cancer. In fact, IBC is characterized by specific morphological, phenotypic, and biological properties that distinguish it from non-IBC. The aggressive behavior of IBC being more common among young women and the low survival rate alarmed ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2013.06.004
更新日期：2014-09-01 00:00:00
abstract：:The clinical manifestations of schistosomiasis pass by acute, sub acute and chronic stages that mirror the immune response to infection. The later includes in succession innate, TH1 and TH2 adaptive stages, with an ultimate establishment of concomitant immunity. Some patients may also develop late complications, or su...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2013.01.005
更新日期：2013-09-01 00:00:00
abstract：Introduction:Defecation is a complex process that is difficult to study and analyze. Objectives:Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. Methods:The 12-cm-long Fecobionics device contained pressure sensors, m...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.07.002
更新日期：2020-07-11 00:00:00
abstract：:Carob samples from seven different Mediterranean countries (Cyprus, Greece, Italy, Spain, Turkey, Jordan and Palestine) were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Seed and flesh samples of indigenous and foreign cultivars, both authentic and commercial, were examined. The spectra were recorded...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.12.001
更新日期：2017-12-24 00:00:00
abstract：:The paper presents an analysis of roadway factors and posted speed limits that affect the operating speed at multi-lane highways in Egypt. Field data on multi-lane highways in Egypt are used in this investigation. The analysis considers two categories of highways. The first consists of two desert roads (Cairo-Alexandr...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2012.08.014
更新日期：2013-11-01 00:00:00
abstract：:This work aimed to evaluate the analgesic efficacy of intra-articular injection of magnesium sulphate (4%) compared with equivalent volume of bupivacaine (0.5%) after outpatient knee arthroscopic meniscectomy. Forty patients were randomly assigned to two groups. Group M (n = 20) received intra-articular magnesium sulp...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2012.07.001
更新日期：2013-07-01 00:00:00
abstract：:The signaling properties of the gasotransmitter molecule hydrogen sulfide (H2S), which is endogenously generated in plant cells, are mainly observed during persulfidation, a protein post-translational modification (PTM) that affects redox-sensitive cysteine residues. There is growing experimental evidence that H2S in ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2020.03.011
更新日期：2020-03-29 00:00:00
abstract：:In this research work, a comparative evaluation on the mechanical and microstructural characteristics of aluminium based single and hybrid reinforced nanocomposites was carried out. The manufacture of a single reinforced nanocomposite was conducted with the distribution of 2 wt.% nano alumina particles (avg. particle ...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2017.02.005
更新日期：2017-07-01 00:00:00
abstract：:This paper presents a new methodology for the modeling and control of power systems based on an uncertain polytopic linear parameter-varying (LPV) approach using parameter set mapping with principle component analysis (PCA). An LPV representation of the power system dynamics is generated by linearization of its differ...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2016.10.006
更新日期：2017-01-01 00:00:00
abstract：:Aluminum (Al) is an element widely distributed in soils, even though Al3+ is one of the most detrimental cations to plant growth. The effect of nitric oxide (NO) precursors on indole-3-acetic acid (IAA) flow towards roots upon Al treatment is herein reported using two Triticum aestivum (wheat) cultivars with recognize...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2018.08.002
更新日期：2018-08-30 00:00:00
abstract：:This paper reveals and analyzes the frequency bifurcation phenomena in the fractional-order inductive power transfer (FOIPT) system with series-series compensation topology. Using fractional calculus theory and electric circuit theory, the circuit model of the series-series compensated FOIPT system is first proposed, ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2020.04.010
更新日期：2020-04-24 00:00:00
abstract：:This study was carried out to investigate the prevalence and monthly intensity of Rhinoestrus (R) spp. among donkeys slaughtered at Giza Zoo abattoir, Egypt. A total of 144 donkeys were examined at postmortem through two visits per month from January 2010 to December 2010. All donkeys were infested with one or more la...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2014.12.003
更新日期：2015-11-01 00:00:00
abstract：:The present study investigates the entrapment of terbinafine hydrochloride (TH) in ethosomal vesicles via unsonicated and sonication method. Carbopol 934P was incorporated in the best formulation, F6, obtained by sonication method. The formulated ethosomal gel obtained as such i.e. F6(∗) was exploited to achieve a zer...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2016.03.003
更新日期：2016-05-01 00:00:00
abstract：:Renal cell carcinoma is rarely diagnosed during pregnancy. Its management is a real challenge due to the sparse literature and lack of standard guidelines. In this situation, the diagnosis is often delayed as the clinical presentation might resemble other pregnancy-related disorders but it should be one of the diagnos...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2016.03.007
更新日期：2016-07-01 00:00:00
abstract：:Breast cancer (BC) incidence is progressively increasing in Egypt. However, there is insufficient knowledge of the acquired somatic mutations in Egyptian BC patients which limit our understanding of its progression. To the best of our knowledge, this is the first Egyptian cohort to sequence a multiple-gene panel of ca...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.04.001
更新日期：2020-04-03 00:00:00
abstract：:Inorganic or inorganic-organic hybrid nanomaterials have great potential for applications in the biomedical fields. Biological half-life is an essential pharmacokinetic parameter for these materials to function in vivo. Compared to inductively coupled plasma mass spectrometry (ICP-MS), which is the gold standard, lase...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2020.05.001
更新日期：2020-05-16 00:00:00
abstract：:Kresoxim-methyl and its two thermolabile metabolites, BF 490-2 and BF 490-9, were analyzed in pear using a pepper leaf matrix protection to maintain the metabolites inside the gas chromatography system. Samples were extracted with a mixture of ethyl acetate and n-hexane (1:1, v/v) and purified and/or separated using a...
journal_title：Journal of advanced research
pub_type： 杂志文章
doi：10.1016/j.jare.2013.05.003
更新日期：2014-05-01 00:00:00
abstract：:This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also reviewed and discussed. ...
journal_title：Journal of advanced research
pub_type： 杂志文章,评审
doi：10.1016/j.jare.2016.09.001
更新日期：2016-11-01 00:00:00
